ES2531393T3 - Proceso de semisíntesis para la preparación de 10 desacetil-N-desbenzoil-paclitaxel - Google Patents

Proceso de semisíntesis para la preparación de 10 desacetil-N-desbenzoil-paclitaxel Download PDF

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Publication number
ES2531393T3
ES2531393T3 ES09175976T ES09175976T ES2531393T3 ES 2531393 T3 ES2531393 T3 ES 2531393T3 ES 09175976 T ES09175976 T ES 09175976T ES 09175976 T ES09175976 T ES 09175976T ES 2531393 T3 ES2531393 T3 ES 2531393T3
Authority
ES
Spain
Prior art keywords
preparation
deacetyl
paclitaxel
desbenzoyl
semisynthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09175976T
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English (en)
Inventor
Ezio Bombardelli
Bruno Gabetta
Andrea Gambini
Gabriele Fontana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
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Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04425752A external-priority patent/EP1647552A1/en
Priority claimed from EP05007888A external-priority patent/EP1712552A1/en
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of ES2531393T3 publication Critical patent/ES2531393T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Un proceso para la preparación de Docetaxel que comprende: a) preparación de 10-desacetil-7,10-bis tricloroacetilbacatina III (VI)**Fórmula** con un contenido de los correspondientes derivados de 7- o 10-mono-tricloroacetilo inferior al 0.1% como se determina por HPLC, que comprende la cromatografía en sílica gel de la mezcla de reacción usando CH2Cl2 como eluyente; b) conversión de (VI) a Docetaxel.
ES09175976T 2004-10-08 2005-10-07 Proceso de semisíntesis para la preparación de 10 desacetil-N-desbenzoil-paclitaxel Active ES2531393T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61684004P 2004-10-08 2004-10-08
EP04425752A EP1647552A1 (en) 2004-10-08 2004-10-08 Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
EP05007888A EP1712552A1 (en) 2005-04-11 2005-04-11 Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel

Publications (1)

Publication Number Publication Date
ES2531393T3 true ES2531393T3 (es) 2015-03-13

Family

ID=35445727

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09175976T Active ES2531393T3 (es) 2004-10-08 2005-10-07 Proceso de semisíntesis para la preparación de 10 desacetil-N-desbenzoil-paclitaxel
ES05798522T Active ES2333738T3 (es) 2004-10-08 2005-10-07 Procedimiento de semisintesis para la preparacion de 10-desacetil-n-desbenzoil-paclitaxel.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES05798522T Active ES2333738T3 (es) 2004-10-08 2005-10-07 Procedimiento de semisintesis para la preparacion de 10-desacetil-n-desbenzoil-paclitaxel.

Country Status (21)

Country Link
US (3) US7446126B2 (es)
EP (2) EP1797059B1 (es)
JP (2) JP4971169B2 (es)
KR (2) KR101216885B1 (es)
CN (2) CN101704804B (es)
AT (1) ATE451360T1 (es)
AU (2) AU2005291357B2 (es)
CA (2) CA2791783C (es)
DE (1) DE602005018238D1 (es)
DK (2) DK1797059T3 (es)
ES (2) ES2531393T3 (es)
HK (2) HK1108317A1 (es)
IL (2) IL182396A (es)
MX (1) MX2007004157A (es)
NO (2) NO339631B1 (es)
NZ (2) NZ585629A (es)
PL (2) PL2161260T3 (es)
PT (2) PT2161260E (es)
RU (2) RU2510395C2 (es)
SI (2) SI2161260T1 (es)
WO (1) WO2006037653A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
JP2009533330A (ja) * 2006-03-21 2009-09-17 ドクター レディズ ラボラトリーズ リミテッド ドセタキセルの多形体およびプロセス
PL210984B1 (pl) * 2006-10-31 2012-03-30 Inst Farmaceutyczny Sposób wytwarzania docetakselu
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
KR101149600B1 (ko) * 2009-12-31 2012-05-29 주식회사 삼양제넥스바이오 고순도 무수결정형 도세탁셀 제조방법
WO2011139899A2 (en) 2010-05-03 2011-11-10 Teikoku Pharma Usa, Inc. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
EP2959131B1 (en) 2013-02-19 2019-05-29 United Technologies Corporation Composite attachment structure with 3d weave
CN108822062B (zh) * 2018-09-07 2020-08-28 无锡紫杉药业有限公司 一种多西他赛的精制方法
WO2020249507A1 (en) 2019-06-11 2020-12-17 Indena S.P.A. Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2696458B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2718963B1 (fr) * 1994-04-25 1996-05-24 Rhone Poulenc Rorer Sa Nouvelle composition pharmaceutique à base de taxoïdes.
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
ITMI20020782A1 (it) 2002-04-12 2003-10-13 Indena Spa Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
PE20050206A1 (es) * 2003-05-26 2005-03-26 Schering Ag Composicion farmaceutica que contiene un inhibidor de histona deacetilasa
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel

Also Published As

Publication number Publication date
US7446126B2 (en) 2008-11-04
PT1797059E (pt) 2009-12-21
RU2009143794A (ru) 2011-06-10
JP5593342B2 (ja) 2014-09-24
IL208290A0 (en) 2010-12-30
PL2161260T3 (pl) 2015-06-30
RU2007112775A (ru) 2008-10-10
KR20070062533A (ko) 2007-06-15
SI2161260T1 (sl) 2015-05-29
NZ585629A (en) 2012-01-12
BRPI0516566A (pt) 2008-09-09
HK1140490A1 (en) 2010-10-15
WO2006037653A1 (en) 2006-04-13
IL182396A0 (en) 2007-07-24
EP1797059B1 (en) 2009-12-09
EP2161260A1 (en) 2010-03-10
IL208290A (en) 2012-03-29
SI1797059T1 (sl) 2010-02-26
DK1797059T3 (da) 2010-04-06
NZ554344A (en) 2010-09-30
EP2161260B1 (en) 2015-01-21
KR101216885B1 (ko) 2012-12-28
KR101146839B1 (ko) 2012-05-16
CA2582545C (en) 2013-01-08
NO339631B1 (no) 2017-01-16
JP2008515840A (ja) 2008-05-15
AU2005291357B2 (en) 2011-04-14
HK1108317A1 (en) 2008-05-02
MX2007004157A (es) 2007-06-20
CA2791783C (en) 2014-12-09
NO340930B1 (no) 2017-07-17
KR20090038496A (ko) 2009-04-20
PT2161260E (pt) 2015-03-02
EP1797059A1 (en) 2007-06-20
RU2384578C2 (ru) 2010-03-20
CA2582545A1 (en) 2006-04-13
CN101048395A (zh) 2007-10-03
AU2011201419A1 (en) 2011-04-14
JP2012136544A (ja) 2012-07-19
CN100584836C (zh) 2010-01-27
DK2161260T3 (da) 2015-03-16
US20080200700A1 (en) 2008-08-21
ATE451360T1 (de) 2009-12-15
RU2510395C2 (ru) 2014-03-27
CN101704804B (zh) 2015-03-18
US20060079571A1 (en) 2006-04-13
NO20071835L (no) 2007-05-07
IL182396A (en) 2011-12-29
CA2791783A1 (en) 2006-04-13
AU2011201419B2 (en) 2012-01-19
CN101704804A (zh) 2010-05-12
DE602005018238D1 (de) 2010-01-21
PL1797059T3 (pl) 2010-05-31
US8318957B2 (en) 2012-11-27
NO20161147A1 (no) 2007-05-07
US20080167369A1 (en) 2008-07-10
ES2333738T3 (es) 2010-02-26
AU2005291357A1 (en) 2006-04-13
JP4971169B2 (ja) 2012-07-11

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