CY1113176T1 - Παρασκευη ταξανων απο 9-διυδρο-13-ακετυλοβακκατινη iii - Google Patents
Παρασκευη ταξανων απο 9-διυδρο-13-ακετυλοβακκατινη iiiInfo
- Publication number
- CY1113176T1 CY1113176T1 CY20121100935T CY121100935T CY1113176T1 CY 1113176 T1 CY1113176 T1 CY 1113176T1 CY 20121100935 T CY20121100935 T CY 20121100935T CY 121100935 T CY121100935 T CY 121100935T CY 1113176 T1 CY1113176 T1 CY 1113176T1
- Authority
- CY
- Cyprus
- Prior art keywords
- iii
- preparation
- acetylovacatine
- dyhydro
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Η παρούσα εφεύρεση αφορά νέα διαδικασία παρασκευής ενδιάμεσων προϊόντων της 9-διυδροβακκατίνης III, που χρησιμεύουν ως πρόδρομα μόρια για την παρασκευή της πακλιταξέλης, 1, δοσεταξέλης, 2, και αναλόγων αυτών. Ειδικότερα, η διαδικασία περιλαμβάνει τα βήματα (i) της ταυτόχρονης απακετυλίωσης εστέρων στη θέση 10 και 13 της 9-διυδρο-13-ακετυλοβακκατίνης III για το σχηματισμό 9-διυδρο-10-απακετυλοβακκατίνης III' (ii) της προστασίας κάποιας υδροξυ-ομάδας στη θέση 7 της 9-διυδρο-10-απακετυλοβακκατίνης III- και (iii) της ακυλίωσης κάποιας υδροξυ-ομάδας στη θέση 10 για το σχηματισμό του χημικού τύπου II.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66672805P | 2005-03-31 | 2005-03-31 | |
EP06741365A EP1871753B1 (en) | 2005-03-31 | 2006-03-30 | Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113176T1 true CY1113176T1 (el) | 2016-04-13 |
Family
ID=37052916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100935T CY1113176T1 (el) | 2005-03-31 | 2012-10-08 | Παρασκευη ταξανων απο 9-διυδρο-13-ακετυλοβακκατινη iii |
Country Status (7)
Country | Link |
---|---|
US (2) | US8263793B2 (el) |
EP (2) | EP2428510A3 (el) |
CA (1) | CA2599888C (el) |
CY (1) | CY1113176T1 (el) |
PL (1) | PL1871753T3 (el) |
RS (1) | RS52438B (el) |
WO (1) | WO2006102758A1 (el) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006102758A1 (en) | 2005-03-31 | 2006-10-05 | Bioxel Pharma Inc. | Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii |
WO2007051306A1 (en) | 2005-11-04 | 2007-05-10 | Bioxel Pharma Inc. | New methods for the preparation of taxanes using chiral auxiliaries |
EP2183234A4 (en) * | 2007-08-22 | 2012-02-29 | Canada Inc 6570763 | PROCESS FOR CONVERTING 9-DIHYDRO-13-ACETYLBACCATIN III IN DOCETAXEL OR PACLITAXEL |
EP2330100B1 (en) * | 2009-11-04 | 2017-01-11 | Emcure Pharmaceuticals Limited | An improved process for preparation of taxane derivatives |
CN113243374B (zh) | 2012-10-02 | 2022-04-26 | 拜耳农作物科学股份公司 | 作为杀虫剂的杂环化合物 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
US5973160A (en) * | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
CA2119261C (en) * | 1992-12-23 | 2006-01-31 | Michael A. Poss | Novel sidechain-bearing taxanes and intermediates thereof |
US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
FR2706457B1 (fr) * | 1993-06-16 | 1995-07-28 | Rhone Poulenc Rorer Sa | Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs. |
US5405972A (en) * | 1993-07-20 | 1995-04-11 | Florida State University | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes |
US6005120A (en) * | 1993-07-20 | 1999-12-21 | Florida State University | Tricyclic and tetracyclic taxanes |
MA23823A1 (fr) * | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
CA2188190A1 (en) * | 1996-10-18 | 1998-04-18 | Sarala Balachandran | The semi-synthesis of a protected bacatin iii compound |
US5811452A (en) * | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
CA2204197A1 (en) * | 1997-05-01 | 1998-11-01 | Jian Liu | Process for converting 9-dihydro-13-acetylbaccatin iii into taxol and derivatives thereof |
EP1087955A1 (en) | 1998-04-20 | 2001-04-04 | Lolita Zamir | The semi-synthesis of baccatin iii |
CN1243830A (zh) * | 1999-05-18 | 2000-02-09 | 中国科学院昆明植物研究所 | 一种紫杉醇半合成工艺 |
US6175023B1 (en) * | 2000-01-31 | 2001-01-16 | Jian Liu | Synthesis of water soluble 9-dihydro-paclitaxel derivatives from 9-dihydro-13-acetylbaccatin III |
US6916942B2 (en) * | 2000-02-03 | 2005-07-12 | Bristol-Myers Squibb Company | Process for the preparation of C-4 carbonate taxanes |
US6281368B1 (en) * | 2000-03-16 | 2001-08-28 | Napro Biotherapeutics, Inc. | Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III |
US6495705B2 (en) * | 2000-03-16 | 2002-12-17 | Napro Biotherapeutics, Inc. | Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes |
US20010041803A1 (en) * | 2000-03-21 | 2001-11-15 | Kasitu Gertrude C. | Conversion of 9-dihydro-13-acetylbaccatin III to baccatin III and 10-deacetyl baccatin III |
US6812356B2 (en) * | 2002-09-26 | 2004-11-02 | John Findlay | Conversion 9-dihydro-13-acetylbaccatin III into 10-deacetylbaccatin III |
US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
US20050272807A1 (en) * | 2004-06-04 | 2005-12-08 | Phytogen Life Sciences Inc. | Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel |
US20050288520A1 (en) * | 2004-06-25 | 2005-12-29 | Phytogen Life Sciences Inc. | One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel |
WO2006102758A1 (en) | 2005-03-31 | 2006-10-05 | Bioxel Pharma Inc. | Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii |
-
2006
- 2006-03-30 WO PCT/CA2006/000480 patent/WO2006102758A1/en active Application Filing
- 2006-03-30 US US11/909,973 patent/US8263793B2/en not_active Expired - Fee Related
- 2006-03-30 RS RS20120420A patent/RS52438B/en unknown
- 2006-03-30 EP EP11192239A patent/EP2428510A3/en not_active Withdrawn
- 2006-03-30 PL PL06741365T patent/PL1871753T3/pl unknown
- 2006-03-30 EP EP06741365A patent/EP1871753B1/en active Active
- 2006-03-30 CA CA2599888A patent/CA2599888C/en not_active Expired - Fee Related
-
2011
- 2011-02-21 US US13/031,378 patent/US8697894B2/en not_active Expired - Fee Related
-
2012
- 2012-10-08 CY CY20121100935T patent/CY1113176T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL1871753T3 (pl) | 2012-12-31 |
US8697894B2 (en) | 2014-04-15 |
EP1871753A1 (en) | 2008-01-02 |
RS52438B (en) | 2013-02-28 |
CA2599888A1 (en) | 2006-10-05 |
US8263793B2 (en) | 2012-09-11 |
US20090062376A1 (en) | 2009-03-05 |
CA2599888C (en) | 2010-06-15 |
WO2006102758A1 (en) | 2006-10-05 |
EP1871753A4 (en) | 2009-09-02 |
US20110144360A1 (en) | 2011-06-16 |
EP2428510A3 (en) | 2012-06-13 |
EP2428510A2 (en) | 2012-03-14 |
EP1871753B1 (en) | 2012-07-18 |
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