MX2007004157A - Procedimiento de semisintesis para la preparacion de 10-desacetil-n-debenzoil-paclitaxel. - Google Patents

Procedimiento de semisintesis para la preparacion de 10-desacetil-n-debenzoil-paclitaxel.

Info

Publication number
MX2007004157A
MX2007004157A MX2007004157A MX2007004157A MX2007004157A MX 2007004157 A MX2007004157 A MX 2007004157A MX 2007004157 A MX2007004157 A MX 2007004157A MX 2007004157 A MX2007004157 A MX 2007004157A MX 2007004157 A MX2007004157 A MX 2007004157A
Authority
MX
Mexico
Prior art keywords
preparation
deacetyl
paclitaxel
debenzoyl
semisynthesis
Prior art date
Application number
MX2007004157A
Other languages
English (en)
Inventor
Bruno Gabetta
Ezio Bombardelli
Gabriele Fontana
Andrea Gambini
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04425752A external-priority patent/EP1647552A1/en
Priority claimed from EP05007888A external-priority patent/EP1712552A1/en
Application filed by Indena Spa filed Critical Indena Spa
Publication of MX2007004157A publication Critical patent/MX2007004157A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La invencion se refiere a un procedimiento para la preparacion de 10-desacetil-N-debenzoil-paclitaxel, un sinton util para la preparacion de taxanos con actividad anti-tumoral, e intermediarios para la preparacion de los mismos; la invencion tambien describe un procedimiento para la preparacion de docetaxel empezando a partir del compuesto de la formula (1).
MX2007004157A 2004-10-08 2005-10-07 Procedimiento de semisintesis para la preparacion de 10-desacetil-n-debenzoil-paclitaxel. MX2007004157A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61684004P 2004-10-08 2004-10-08
EP04425752A EP1647552A1 (en) 2004-10-08 2004-10-08 Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
EP05007888A EP1712552A1 (en) 2005-04-11 2005-04-11 Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
PCT/EP2005/010822 WO2006037653A1 (en) 2004-10-08 2005-10-07 Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel

Publications (1)

Publication Number Publication Date
MX2007004157A true MX2007004157A (es) 2007-06-20

Family

ID=35445727

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004157A MX2007004157A (es) 2004-10-08 2005-10-07 Procedimiento de semisintesis para la preparacion de 10-desacetil-n-debenzoil-paclitaxel.

Country Status (21)

Country Link
US (3) US7446126B2 (es)
EP (2) EP1797059B1 (es)
JP (2) JP4971169B2 (es)
KR (2) KR101216885B1 (es)
CN (2) CN101704804B (es)
AT (1) ATE451360T1 (es)
AU (2) AU2005291357B2 (es)
CA (2) CA2791783C (es)
DE (1) DE602005018238D1 (es)
DK (2) DK1797059T3 (es)
ES (2) ES2531393T3 (es)
HK (2) HK1108317A1 (es)
IL (2) IL182396A (es)
MX (1) MX2007004157A (es)
NO (2) NO339631B1 (es)
NZ (2) NZ585629A (es)
PL (2) PL2161260T3 (es)
PT (2) PT2161260E (es)
RU (2) RU2510395C2 (es)
SI (2) SI2161260T1 (es)
WO (1) WO2006037653A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
JP2009533330A (ja) * 2006-03-21 2009-09-17 ドクター レディズ ラボラトリーズ リミテッド ドセタキセルの多形体およびプロセス
PL210984B1 (pl) * 2006-10-31 2012-03-30 Inst Farmaceutyczny Sposób wytwarzania docetakselu
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
KR101149600B1 (ko) * 2009-12-31 2012-05-29 주식회사 삼양제넥스바이오 고순도 무수결정형 도세탁셀 제조방법
WO2011139899A2 (en) 2010-05-03 2011-11-10 Teikoku Pharma Usa, Inc. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
EP2959131B1 (en) 2013-02-19 2019-05-29 United Technologies Corporation Composite attachment structure with 3d weave
CN108822062B (zh) * 2018-09-07 2020-08-28 无锡紫杉药业有限公司 一种多西他赛的精制方法
WO2020249507A1 (en) 2019-06-11 2020-12-17 Indena S.P.A. Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2696458B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2718963B1 (fr) * 1994-04-25 1996-05-24 Rhone Poulenc Rorer Sa Nouvelle composition pharmaceutique à base de taxoïdes.
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
ITMI20020782A1 (it) 2002-04-12 2003-10-13 Indena Spa Processo semisintetico per la preparazione di n-debenzoilpaclitaxel
PE20050206A1 (es) * 2003-05-26 2005-03-26 Schering Ag Composicion farmaceutica que contiene un inhibidor de histona deacetilasa
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel

Also Published As

Publication number Publication date
US7446126B2 (en) 2008-11-04
PT1797059E (pt) 2009-12-21
RU2009143794A (ru) 2011-06-10
JP5593342B2 (ja) 2014-09-24
IL208290A0 (en) 2010-12-30
PL2161260T3 (pl) 2015-06-30
RU2007112775A (ru) 2008-10-10
KR20070062533A (ko) 2007-06-15
SI2161260T1 (sl) 2015-05-29
NZ585629A (en) 2012-01-12
BRPI0516566A (pt) 2008-09-09
HK1140490A1 (en) 2010-10-15
WO2006037653A1 (en) 2006-04-13
IL182396A0 (en) 2007-07-24
EP1797059B1 (en) 2009-12-09
EP2161260A1 (en) 2010-03-10
IL208290A (en) 2012-03-29
SI1797059T1 (sl) 2010-02-26
DK1797059T3 (da) 2010-04-06
NZ554344A (en) 2010-09-30
EP2161260B1 (en) 2015-01-21
KR101216885B1 (ko) 2012-12-28
KR101146839B1 (ko) 2012-05-16
CA2582545C (en) 2013-01-08
NO339631B1 (no) 2017-01-16
JP2008515840A (ja) 2008-05-15
AU2005291357B2 (en) 2011-04-14
HK1108317A1 (en) 2008-05-02
CA2791783C (en) 2014-12-09
NO340930B1 (no) 2017-07-17
KR20090038496A (ko) 2009-04-20
PT2161260E (pt) 2015-03-02
EP1797059A1 (en) 2007-06-20
RU2384578C2 (ru) 2010-03-20
CA2582545A1 (en) 2006-04-13
ES2531393T3 (es) 2015-03-13
CN101048395A (zh) 2007-10-03
AU2011201419A1 (en) 2011-04-14
JP2012136544A (ja) 2012-07-19
CN100584836C (zh) 2010-01-27
DK2161260T3 (da) 2015-03-16
US20080200700A1 (en) 2008-08-21
ATE451360T1 (de) 2009-12-15
RU2510395C2 (ru) 2014-03-27
CN101704804B (zh) 2015-03-18
US20060079571A1 (en) 2006-04-13
NO20071835L (no) 2007-05-07
IL182396A (en) 2011-12-29
CA2791783A1 (en) 2006-04-13
AU2011201419B2 (en) 2012-01-19
CN101704804A (zh) 2010-05-12
DE602005018238D1 (de) 2010-01-21
PL1797059T3 (pl) 2010-05-31
US8318957B2 (en) 2012-11-27
NO20161147A1 (no) 2007-05-07
US20080167369A1 (en) 2008-07-10
ES2333738T3 (es) 2010-02-26
AU2005291357A1 (en) 2006-04-13
JP4971169B2 (ja) 2012-07-11

Similar Documents

Publication Publication Date Title
MX2007004157A (es) Procedimiento de semisintesis para la preparacion de 10-desacetil-n-debenzoil-paclitaxel.
MX2008012424A (es) Proceso convergente para la sintesis de derivados de taxanos.
WO2007031548A3 (en) Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof
GB0719180D0 (en) New process
TNSN07196A1 (en) Potentiators of glutamate receptors
MX339476B (es) Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
EA200500203A1 (ru) Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат
PL1758852T3 (pl) Podstawione związki cyklopentenu
TW200640914A (en) Novel processes for the preparation of a benzofuran
WO2005082875A3 (en) Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
TW200833682A (en) Pharmaceutical compounds
ATE517869T1 (de) Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon
HK1159614A1 (en) Caspase inhibitors and uses thereof
MXPA04007396A (es) Proceso para la elaboracion de inhibidores de reductasa hmg-coa.
WO2004033442A3 (en) Novel taxanes and methods related to use and preparation thereof
HU0402466D0 (en) Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
EP2428510A3 (en) Preparation of taxanes from 9-dihydro-13-acetylbaccatin III
TW200716521A (en) Substituted aryl oximes
TW200833322A (en) Method of preparing taxane derivatives and intermediates used therein
MX2007007554A (es) Oxiarenos sustituidos.
WO2006122072A3 (en) Processes for preparing biaryl ureas and analogs thereof
ATE546451T1 (de) Cyclopropancarbonsäureester von acyclovir
NO20064273L (no) Fremgangsmate for semisyntese av deserpidin
EA200800044A1 (ru) Производные 2,5-бисдиамин[1,4]бензохинона
EA200600360A1 (ru) Δ-d-гомостероиды с андрогенным действием

Legal Events

Date Code Title Description
FG Grant or registration