ES2486815T3 - Marcadores de éster de acridinio que tienen modificadores hidrófilos - Google Patents

Marcadores de éster de acridinio que tienen modificadores hidrófilos Download PDF

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Publication number
ES2486815T3
ES2486815T3 ES02013902.8T ES02013902T ES2486815T3 ES 2486815 T3 ES2486815 T3 ES 2486815T3 ES 02013902 T ES02013902 T ES 02013902T ES 2486815 T3 ES2486815 T3 ES 2486815T3
Authority
ES
Spain
Prior art keywords
dmae
nsp
folate
conjugate
tobramycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02013902.8T
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English (en)
Spanish (es)
Inventor
Anand Natrajan
David Sharpe
Qingping Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Application granted granted Critical
Publication of ES2486815T3 publication Critical patent/ES2486815T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES02013902.8T 2001-07-03 2002-06-21 Marcadores de éster de acridinio que tienen modificadores hidrófilos Expired - Lifetime ES2486815T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/898,381 US6664043B2 (en) 2001-07-03 2001-07-03 Acridinium ester labels having hydrophilic modifiers
US898381 2001-07-03

Publications (1)

Publication Number Publication Date
ES2486815T3 true ES2486815T3 (es) 2014-08-19

Family

ID=25409366

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02013902.8T Expired - Lifetime ES2486815T3 (es) 2001-07-03 2002-06-21 Marcadores de éster de acridinio que tienen modificadores hidrófilos

Country Status (6)

Country Link
US (1) US6664043B2 (https=)
EP (1) EP1273917B1 (https=)
JP (2) JP4467869B2 (https=)
AU (1) AU782559B2 (https=)
CA (1) CA2387466A1 (https=)
ES (1) ES2486815T3 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653456B2 (en) * 2001-07-31 2003-11-25 Roche Diagnostics Corporation Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
ATE553089T1 (de) * 2002-08-20 2012-04-15 Quest Diagnostics Invest Inc Hydrophile, chemilumineszente acridiniummarkierungsreagenzien
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
WO2007073486A2 (en) 2005-12-20 2007-06-28 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
EP2118127A4 (en) * 2007-01-31 2010-12-01 Affymax Inc NICKET-BASED LINKER FOR BONDING MODIFYING GROUPS OF POLYPEPTIDES AND OTHER MACROMOLECULES
JP4887319B2 (ja) 2008-03-17 2012-02-29 株式会社日立ハイテクノロジーズ 自動分析装置、及び光電子増倍管を用いた分析システム
WO2009136613A1 (ja) 2008-05-08 2009-11-12 株式会社 日立ハイテクノロジーズ 自動分析装置
JP5124498B2 (ja) 2009-01-30 2013-01-23 株式会社日立ハイテクノロジーズ 自動分析装置
US8778624B2 (en) * 2009-11-16 2014-07-15 Siemens Healthcare Diagnostics Inc. Zwitterion-containing acridinium compounds
ES2618042T3 (es) 2012-07-10 2017-06-20 Siemens Healthcare Diagnostics Inc. Síntesis de compuestos de acridinio mediante n-alquilación de acridanos
WO2014084110A1 (ja) 2012-11-30 2014-06-05 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカーと生理活性物質とを含む化合物またはその塩、及びそれらの製造方法
FR3000551B1 (fr) * 2012-12-27 2015-06-26 Biomerieux Sa Derives de folate, particulierement utiles dans le cadre du dosage de folate(s)
ES2769887T3 (es) 2013-05-14 2020-06-29 Siemens Healthcare Diagnostics Inc Tensioactivos catiónicos degradables y su uso para la mejora de la quimioluminiscencia
CN105378029B (zh) 2013-07-08 2020-12-18 西门子医疗保健诊断公司 具有改进的稳定性和快速发光的亲水高量子产率吖啶酯
JP7003144B2 (ja) * 2017-02-23 2022-02-10 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 化学発光アンドロステンジオンコンジュゲート
CN112368265A (zh) 2018-06-25 2021-02-12 美国西门子医学诊断股份有限公司 9,10-二氢吖啶的n-烷基化
CN109535062B (zh) * 2019-01-10 2021-03-23 中北大学 一种降冰片烯类两性离子单体及其制备方法
CN110850077A (zh) * 2019-11-06 2020-02-28 迪瑞医疗科技股份有限公司 妥布霉素化学发光检测试剂盒及其制备方法
CN112920399A (zh) * 2019-12-05 2021-06-08 广东菲鹏生物有限公司 吖啶化合物标记类固醇激素衍生物及其制备方法和应用
CN112684163B (zh) * 2021-01-29 2022-08-09 安邦（厦门）生物科技有限公司 一种吖啶类化合物标记原料工作液及制备方法
DE112022003796T5 (de) 2021-07-29 2024-06-20 Euroimmun Medizinische Labordiagnostika Ag Verfahren und Reagenzien zur Erhöhung des chemilumineszenten Signals
CN116284978B (zh) * 2022-12-16 2024-09-20 厦门为正生物科技股份有限公司 一种荧光微球及其制备方法与应用
EP4638467A4 (en) * 2022-12-21 2026-03-04 Siemens Healthcare Diagnostics Inc CYCLOSPORINE-ACRIDINIUM ESTERS AND THEIR PRODUCTION AND USE PROCESSES

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE40572T1 (de) * 1985-01-10 1989-02-15 Molecular Diagnostics Inc Photochemisches verfahren zum markieren von nucleinsaeuren zum nachweis in hybridisationsproben.
US5656426A (en) * 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
JPH0286567A (ja) * 1988-09-21 1990-03-27 Ricoh Co Ltd シート後処理制御装置
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
DE4004296A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verbesserte markierte haptene, verfahren zu deren herstellung sowie verwendung dieser markierten haptene in immunoassays
DE4444002A1 (de) * 1994-12-10 1996-06-13 Behringwerke Ag Immunoassays für Haptene und hierfür verwendbare Haptentracer-Antikörper-Komplexe sowie Verfahren zur Herstellung derselben
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
JP2002530678A (ja) * 1998-11-25 2002-09-17 バイエル コーポレイション 化学発光性アクリジニウム化合物を使用するヒドリドの測定
US6187566B1 (en) * 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
JP3819294B2 (ja) * 1999-07-30 2006-09-06 バイエル コーポレイション 燐酸酵素のような加水分解性酵素の化学発光基質
US6242188B1 (en) * 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection

Also Published As

Publication number Publication date
US6664043B2 (en) 2003-12-16
JP4467869B2 (ja) 2010-05-26
JP2010019854A (ja) 2010-01-28
JP2003050204A (ja) 2003-02-21
US20030045716A1 (en) 2003-03-06
EP1273917B1 (en) 2014-05-07
AU782559B2 (en) 2005-08-11
AU4573602A (en) 2003-01-09
EP1273917A3 (en) 2003-09-17
EP1273917A2 (en) 2003-01-08
JP4913195B2 (ja) 2012-04-11
CA2387466A1 (en) 2003-01-03

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