ES2474515T3 - Proceso para la preparación de compuestos quelados - Google Patents
Proceso para la preparación de compuestos quelados Download PDFInfo
- Publication number
- ES2474515T3 ES2474515T3 ES10790972.3T ES10790972T ES2474515T3 ES 2474515 T3 ES2474515 T3 ES 2474515T3 ES 10790972 T ES10790972 T ES 10790972T ES 2474515 T3 ES2474515 T3 ES 2474515T3
- Authority
- ES
- Spain
- Prior art keywords
- metal
- process according
- chelated
- salt
- chelating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 50
- 150000001875 compounds Chemical class 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 229910052751 metal Inorganic materials 0.000 claims abstract description 44
- 239000002184 metal Substances 0.000 claims abstract description 42
- 239000002738 chelating agent Substances 0.000 claims abstract description 38
- 239000007787 solid Substances 0.000 claims abstract description 34
- 239000007788 liquid Substances 0.000 claims abstract description 28
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 22
- 239000000203 mixture Substances 0.000 claims abstract description 22
- 150000003839 salts Chemical class 0.000 claims abstract description 22
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims abstract description 3
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical compound [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910052733 gallium Inorganic materials 0.000 claims abstract description 3
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims abstract description 3
- 229910052723 transition metal Inorganic materials 0.000 claims abstract description 3
- 150000003624 transition metals Chemical class 0.000 claims abstract description 3
- 229920005989 resin Polymers 0.000 claims description 24
- 239000011347 resin Substances 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 229910052688 Gadolinium Inorganic materials 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 9
- 239000008215 water for injection Substances 0.000 claims description 9
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 5
- LYQGMALGKYWNIU-UHFFFAOYSA-K gadolinium(3+);triacetate Chemical group [Gd+3].CC([O-])=O.CC([O-])=O.CC([O-])=O LYQGMALGKYWNIU-UHFFFAOYSA-K 0.000 claims description 5
- 229960003194 meglumine Drugs 0.000 claims description 5
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000005341 cation exchange Methods 0.000 claims description 3
- OCDAWJYGVOLXGZ-VPVMAENOSA-K gadobenate dimeglumine Chemical compound [Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)C(C([O-])=O)COCC1=CC=CC=C1 OCDAWJYGVOLXGZ-VPVMAENOSA-K 0.000 claims description 3
- 150000001455 metallic ions Chemical class 0.000 claims description 3
- 239000012266 salt solution Substances 0.000 claims description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 2
- 229940096814 gadobenate dimeglumine Drugs 0.000 claims description 2
- 229910052738 indium Inorganic materials 0.000 claims description 2
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052747 lanthanoid Inorganic materials 0.000 abstract 1
- 150000002602 lanthanoids Chemical class 0.000 abstract 1
- 239000002609 medium Substances 0.000 description 10
- 238000010828 elution Methods 0.000 description 9
- -1 halide (eg Chemical class 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- 150000002500 ions Chemical class 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000002872 contrast media Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 238000007792 addition Methods 0.000 description 4
- 229920001429 chelating resin Polymers 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- MXZROTBGJUUXID-UHFFFAOYSA-K gadobenic acid Chemical compound [H+].[H+].[Gd+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)C(C([O-])=O)COCC1=CC=CC=C1 MXZROTBGJUUXID-UHFFFAOYSA-K 0.000 description 4
- 238000005342 ion exchange Methods 0.000 description 4
- 230000005298 paramagnetic effect Effects 0.000 description 4
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000003729 cation exchange resin Substances 0.000 description 3
- 238000003926 complexometric titration Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 239000011343 solid material Substances 0.000 description 3
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 229940023913 cation exchange resins Drugs 0.000 description 2
- 238000010668 complexation reaction Methods 0.000 description 2
- 239000000032 diagnostic agent Substances 0.000 description 2
- 229940039227 diagnostic agent Drugs 0.000 description 2
- 238000002059 diagnostic imaging Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 150000004706 metal oxides Chemical class 0.000 description 2
- 238000009206 nuclear medicine Methods 0.000 description 2
- 239000003495 polar organic solvent Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- ACTRVOBWPAIOHC-UHFFFAOYSA-N succimer Chemical compound OC(=O)C(S)C(S)C(O)=O ACTRVOBWPAIOHC-UHFFFAOYSA-N 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- 229910001428 transition metal ion Inorganic materials 0.000 description 2
- ORZHVTYKPFFVMG-UHFFFAOYSA-N xylenol orange Chemical compound OC(=O)CN(CC(O)=O)CC1=C(O)C(C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C=C(CN(CC(O)=O)CC(O)=O)C(O)=C(C)C=2)=C1 ORZHVTYKPFFVMG-UHFFFAOYSA-N 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- FJWGRXKOBIVTFA-UHFFFAOYSA-N 2,3-dibromobutanedioic acid Chemical compound OC(=O)C(Br)C(Br)C(O)=O FJWGRXKOBIVTFA-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 239000007987 MES buffer Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- MXZROTBGJUUXID-UHFFFAOYSA-I [Gd+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)C(C([O-])=O)COCC1=CC=CC=C1 Chemical compound [Gd+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)C(C([O-])=O)COCC1=CC=CC=C1 MXZROTBGJUUXID-UHFFFAOYSA-I 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000061 acid fraction Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical class ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 1
- 229940039231 contrast media Drugs 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- MEANOSLIBWSCIT-UHFFFAOYSA-K gadolinium trichloride Chemical group Cl[Gd](Cl)Cl MEANOSLIBWSCIT-UHFFFAOYSA-K 0.000 description 1
- RJOJUSXNYCILHH-UHFFFAOYSA-N gadolinium(3+) Chemical compound [Gd+3] RJOJUSXNYCILHH-UHFFFAOYSA-N 0.000 description 1
- GXCUBNRUECGTSC-UHFFFAOYSA-K gadolinium(3+);triacetate;hydrate Chemical compound O.[Gd+3].CC([O-])=O.CC([O-])=O.CC([O-])=O GXCUBNRUECGTSC-UHFFFAOYSA-K 0.000 description 1
- CMIHHWBVHJVIGI-UHFFFAOYSA-N gadolinium(III) oxide Inorganic materials [O-2].[O-2].[O-2].[Gd+3].[Gd+3] CMIHHWBVHJVIGI-UHFFFAOYSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229910001867 inorganic solvent Inorganic materials 0.000 description 1
- 239000003049 inorganic solvent Substances 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 229910001507 metal halide Inorganic materials 0.000 description 1
- 150000005309 metal halides Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179438A EP2338874A1 (en) | 2009-12-16 | 2009-12-16 | Process for the preparation of chelated compounds |
| EP09179438 | 2009-12-16 | ||
| PCT/EP2010/069715 WO2011073236A1 (en) | 2009-12-16 | 2010-12-15 | Process for the preparation of chelated compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2474515T3 true ES2474515T3 (es) | 2014-07-09 |
Family
ID=41800716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10790972.3T Active ES2474515T3 (es) | 2009-12-16 | 2010-12-15 | Proceso para la preparación de compuestos quelados |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8987508B2 (enExample) |
| EP (2) | EP2338874A1 (enExample) |
| JP (1) | JP5838164B2 (enExample) |
| KR (1) | KR101766280B1 (enExample) |
| CN (1) | CN102712574B (enExample) |
| AU (1) | AU2010332960C1 (enExample) |
| BR (1) | BR112012014621B8 (enExample) |
| CA (1) | CA2784526C (enExample) |
| ES (1) | ES2474515T3 (enExample) |
| HR (1) | HRP20140430T1 (enExample) |
| IL (1) | IL220414A0 (enExample) |
| MX (1) | MX2012006954A (enExample) |
| NZ (1) | NZ600910A (enExample) |
| PL (1) | PL2513043T3 (enExample) |
| PT (1) | PT2513043E (enExample) |
| RU (1) | RU2533833C2 (enExample) |
| SG (1) | SG181776A1 (enExample) |
| WO (1) | WO2011073236A1 (enExample) |
| ZA (1) | ZA201205192B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ628481A (en) * | 2012-01-11 | 2016-11-25 | Adelaide Res & Innovation Pty | Stabilising and analysing fatty acids in a biological sample stored on solid media |
| CN102603550B (zh) * | 2012-02-16 | 2014-11-26 | 佛山普正医药科技有限公司 | 一种中间体bopta的制备方法 |
| CN103664672B (zh) * | 2013-10-21 | 2016-01-13 | 河北一品制药有限公司 | 一种工业化生产钆喷酸葡胺的制备方法 |
| US10696562B2 (en) * | 2013-12-05 | 2020-06-30 | Colorado School Of Mines | Upgrade of yttrium in a mixed rare earth stream using iminodiacetic acid functionalized resin |
| EP2977369A1 (en) * | 2014-07-24 | 2016-01-27 | Bracco Imaging SPA | Preparation of a solid form of gadobenate dimeglumine |
| GB201421162D0 (en) | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Lanthanide complex formulations |
| GB201421161D0 (en) * | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Metal complex formulations |
| CN109608350B (zh) * | 2018-12-29 | 2021-06-22 | 湖北壮美生物科技有限公司 | 一种工业化制备甘氨酸钙的装置及相应的甘氨酸钙生产方法 |
| WO2020159399A1 (ru) * | 2019-01-31 | 2020-08-06 | Акционерное Общество "Биоамид" | Способ получения комплексной микроэлементной добавки в корма на основе органических соединений железа, марганца, цинка, меди, кобальта |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3172898A (en) * | 1965-03-09 | Process for preparation of metal chelates of aminopolycarboxylic acid compounds | ||
| SU138608A1 (ru) * | 1960-07-14 | 1960-11-30 | Т.В. Лищенко | Способ получени алюминиевой соли этилендиаминтетрауксусной кислоты |
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| DE3580721D1 (de) * | 1984-08-06 | 1991-01-10 | Westinghouse Electric Corp | Verfahren zur trennung von gadoliniumisotopen. |
| US4711768A (en) * | 1984-08-06 | 1987-12-08 | Westinghouse Electric Corp. | Process for the separation of gadolinium isotopes |
| IT1213029B (it) * | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
| DE3922005A1 (de) * | 1989-06-30 | 1991-01-10 | Schering Ag | Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
| AU625529B2 (en) * | 1989-12-22 | 1992-07-16 | E.R. Squibb & Sons, Inc. | 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes |
| US5262018A (en) * | 1991-08-12 | 1993-11-16 | Fmc Corporation | Metals removal from aqueous peroxy acids or peroxy salts |
| IT1269839B (it) | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
| IT1283218B1 (it) * | 1996-03-08 | 1998-04-16 | Bracco Spa | Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi |
| GB9707880D0 (en) * | 1997-04-18 | 1997-06-04 | Nycomed Imaging As | Contrast agent preparation |
| ITMI981583A1 (it) | 1998-07-10 | 2000-01-10 | Bracco Spa | Processo per la preparazione dell'acido 4 -carbossi-5,8,11-tris (carbossimetil)-1-fenil-2-oxa-5,8,11-triazatridecan-13-oico |
| US6342598B1 (en) * | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
| EP1762563A1 (en) | 2005-09-13 | 2007-03-14 | BRACCO IMAGING S.p.A. | Process for the preparation of contrast agents |
| US20090208421A1 (en) * | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
-
2009
- 2009-12-16 EP EP09179438A patent/EP2338874A1/en not_active Withdrawn
-
2010
- 2010-12-15 HR HRP20140430AT patent/HRP20140430T1/hr unknown
- 2010-12-15 NZ NZ600910A patent/NZ600910A/en not_active IP Right Cessation
- 2010-12-15 MX MX2012006954A patent/MX2012006954A/es active IP Right Grant
- 2010-12-15 BR BR112012014621A patent/BR112012014621B8/pt active IP Right Grant
- 2010-12-15 US US13/514,394 patent/US8987508B2/en active Active
- 2010-12-15 CA CA2784526A patent/CA2784526C/en active Active
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- 2010-12-15 JP JP2012543706A patent/JP5838164B2/ja active Active
- 2010-12-15 WO PCT/EP2010/069715 patent/WO2011073236A1/en not_active Ceased
- 2010-12-15 SG SG2012044780A patent/SG181776A1/en unknown
- 2010-12-15 RU RU2012129982/04A patent/RU2533833C2/ru active
- 2010-12-15 KR KR1020127017584A patent/KR101766280B1/ko active Active
- 2010-12-15 PL PL10790972T patent/PL2513043T3/pl unknown
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| RU2012129982A (ru) | 2014-01-27 |
| MX2012006954A (es) | 2012-07-30 |
| IL220414A0 (en) | 2012-08-30 |
| EP2338874A1 (en) | 2011-06-29 |
| CA2784526C (en) | 2014-09-30 |
| KR101766280B1 (ko) | 2017-08-08 |
| US20120245333A1 (en) | 2012-09-27 |
| WO2011073236A1 (en) | 2011-06-23 |
| HRP20140430T1 (hr) | 2014-07-18 |
| EP2513043B1 (en) | 2014-03-26 |
| US8987508B2 (en) | 2015-03-24 |
| US9567350B2 (en) | 2017-02-14 |
| BR112012014621A2 (pt) | 2016-03-01 |
| AU2010332960C1 (en) | 2014-01-23 |
| SG181776A1 (en) | 2012-07-30 |
| JP2013514311A (ja) | 2013-04-25 |
| CN102712574A (zh) | 2012-10-03 |
| KR20120101525A (ko) | 2012-09-13 |
| RU2533833C2 (ru) | 2014-11-20 |
| JP5838164B2 (ja) | 2015-12-24 |
| CA2784526A1 (en) | 2011-06-23 |
| US20150158887A1 (en) | 2015-06-11 |
| PL2513043T3 (pl) | 2014-08-29 |
| ZA201205192B (en) | 2013-03-27 |
| BR112012014621B8 (pt) | 2021-10-26 |
| PT2513043E (pt) | 2014-06-11 |
| EP2513043A1 (en) | 2012-10-24 |
| CN102712574B (zh) | 2014-10-22 |
| NZ600910A (en) | 2015-02-27 |
| AU2010332960B2 (en) | 2013-08-01 |
| AU2010332960A1 (en) | 2012-07-19 |
| BR112012014621B1 (pt) | 2021-10-05 |
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