HRP20140430T1 - Postupak za pripremu keliranih tvari - Google Patents
Postupak za pripremu keliranih tvari Download PDFInfo
- Publication number
- HRP20140430T1 HRP20140430T1 HRP20140430AT HRP20140430T HRP20140430T1 HR P20140430 T1 HRP20140430 T1 HR P20140430T1 HR P20140430A T HRP20140430A T HR P20140430AT HR P20140430 T HRP20140430 T HR P20140430T HR P20140430 T1 HRP20140430 T1 HR P20140430T1
- Authority
- HR
- Croatia
- Prior art keywords
- metal
- chelated
- salt
- liquid composition
- support
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 13
- 238000002360 preparation method Methods 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 title 1
- 239000007788 liquid Substances 0.000 claims 6
- 229910052751 metal Inorganic materials 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- 229910021645 metal ion Inorganic materials 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000002738 chelating agent Substances 0.000 claims 4
- 239000011347 resin Substances 0.000 claims 4
- 229920005989 resin Polymers 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 239000008215 water for injection Substances 0.000 claims 3
- 229910052688 Gadolinium Inorganic materials 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- LYQGMALGKYWNIU-UHFFFAOYSA-K gadolinium(3+);triacetate Chemical group [Gd+3].CC([O-])=O.CC([O-])=O.CC([O-])=O LYQGMALGKYWNIU-UHFFFAOYSA-K 0.000 claims 2
- 150000000921 Gadolinium Chemical class 0.000 claims 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 1
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical compound [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 claims 1
- -1 amino carboxyl Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 150000001768 cations Chemical group 0.000 claims 1
- OCDAWJYGVOLXGZ-VPVMAENOSA-K gadobenate dimeglumine Chemical compound [Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)C(C([O-])=O)COCC1=CC=CC=C1 OCDAWJYGVOLXGZ-VPVMAENOSA-K 0.000 claims 1
- 229940096814 gadobenate dimeglumine Drugs 0.000 claims 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 1
- 229910052733 gallium Inorganic materials 0.000 claims 1
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims 1
- 229910052747 lanthanoid Inorganic materials 0.000 claims 1
- 150000002602 lanthanoids Chemical class 0.000 claims 1
- 229960003194 meglumine Drugs 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000012266 salt solution Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea group Chemical group NC(=S)N UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 1
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
Claims (12)
1. Postupak za pripremu metalom kelirane tvari ili njene soli, obuhvaća korake:
a) dovođenje u dodir tekućeg sastava koji sadrži komponentu metalnog iona sa čvrstom potporom, zbog stvaranja metalom kelirane potpore; i
b) dovođenje u dodir navedene metalom kelirane potpore s tekućim sastavom koji sadrži amino karboksilni kelirajući agens ili njegovu sol,
pri čemu je navedena komponenta metalnog iona odabrana između organskih i anorganskih soli metala bilo u anhidričnom ili hidratiziranom obliku i metalni je ion odabran iz grupe koja se sastoji od: prijelaznog metala, lantanida, aluminija (III), galija (III), indija (III), kositra (II) i olova (II).
2. Postupak u skladu s patentnim zahtjevom 1 nadalje obuhvaća ispiranje s vodenim tekućim medijem metalom kelirane potpore iz koraka a), prije izvođenja koraka b).
3. Postupak u skladu s bilo kjim od patentnih zahtjeva 1 ili 2, pri čemu je ionska čvrsta potpora čvrsta potpora kationskog izmjenjivača.
4. Postupak u skladu s patentnim zahtjevom 3, pri čemu je čvrsta potpora smola derivatizirana funkcionalnostima iminodioctene kiseline ili tioureje.
5. Postupak u skladu s patentnim zahtjevom 1 pri čemu je metalni ion gadolinij (III).
6. Postupak u skladu s patentnim zahtjevom 1 pri čemu je komponenta metalnog iona gadolinij acetat.
7. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 6 pri čemu je tekući sastav u koraku a) i u koraku b) vodena otopina.
8. Postupak u skladu s patentnim zahtjevom 7 pri čemu je tekući sastav voda za injekcije.
9. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 8 pri čemu je pH otopine soli metala sadržan između 3 i 8.
10. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 9, pri čemu tekući sastav koji sadrži amino karboksilni kelirajući agens ili njegvu sol, nadalje obuhvaća meglumin u molarnom omjeru 2:1, u odnosu na kelirajući agens.
11. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 10, pri čemu je kelirajući agens BOPTA ili njegova farmaceutski prihvatljiva sol.
12. Postupak u skladu s bilo kojim od patentnih zahtjeva 8 do 11, za pripremu gadobenat dimeglumina, obuhvaća korake:
a. dovođenja u dodir otopine gadolinij acetata u vodi za injekcije koncentracije 10-100 mM s iminodioctenom funkcionaliziranom smolom pri pH 3-8, zbog stvaranja gadolinijem kelirane smole; i
b. dovođenje u dodir navedene gadolinijem kelirane smole s otopinom BOPTA-meglumin soli 1:2 otopine koncentracije 0.1-0.15 M u vodi za injekcije.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179438A EP2338874A1 (en) | 2009-12-16 | 2009-12-16 | Process for the preparation of chelated compounds |
| PCT/EP2010/069715 WO2011073236A1 (en) | 2009-12-16 | 2010-12-15 | Process for the preparation of chelated compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140430T1 true HRP20140430T1 (hr) | 2014-07-18 |
Family
ID=41800716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140430AT HRP20140430T1 (hr) | 2009-12-16 | 2014-05-12 | Postupak za pripremu keliranih tvari |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8987508B2 (hr) |
| EP (2) | EP2338874A1 (hr) |
| JP (1) | JP5838164B2 (hr) |
| KR (1) | KR101766280B1 (hr) |
| CN (1) | CN102712574B (hr) |
| AU (1) | AU2010332960C1 (hr) |
| BR (1) | BR112012014621B8 (hr) |
| CA (1) | CA2784526C (hr) |
| ES (1) | ES2474515T3 (hr) |
| HR (1) | HRP20140430T1 (hr) |
| IL (1) | IL220414A0 (hr) |
| MX (1) | MX2012006954A (hr) |
| NZ (1) | NZ600910A (hr) |
| PL (1) | PL2513043T3 (hr) |
| PT (1) | PT2513043E (hr) |
| RU (1) | RU2533833C2 (hr) |
| SG (1) | SG181776A1 (hr) |
| WO (1) | WO2011073236A1 (hr) |
| ZA (1) | ZA201205192B (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9645132B2 (en) | 2012-01-11 | 2017-05-09 | Adelaide Research & Innovation Pty Ltd | Stabilising and analysing fatty acids in a biological sample stored on solid media |
| CN102603550B (zh) * | 2012-02-16 | 2014-11-26 | 佛山普正医药科技有限公司 | 一种中间体bopta的制备方法 |
| CN103664672B (zh) * | 2013-10-21 | 2016-01-13 | 河北一品制药有限公司 | 一种工业化生产钆喷酸葡胺的制备方法 |
| US10696562B2 (en) * | 2013-12-05 | 2020-06-30 | Colorado School Of Mines | Upgrade of yttrium in a mixed rare earth stream using iminodiacetic acid functionalized resin |
| EP2977369A1 (en) * | 2014-07-24 | 2016-01-27 | Bracco Imaging SPA | Preparation of a solid form of gadobenate dimeglumine |
| GB201421162D0 (en) | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Lanthanide complex formulations |
| GB201421161D0 (en) * | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Metal complex formulations |
| CN109608350B (zh) * | 2018-12-29 | 2021-06-22 | 湖北壮美生物科技有限公司 | 一种工业化制备甘氨酸钙的装置及相应的甘氨酸钙生产方法 |
| WO2020159399A1 (ru) * | 2019-01-31 | 2020-08-06 | Акционерное Общество "Биоамид" | Способ получения комплексной микроэлементной добавки в корма на основе органических соединений железа, марганца, цинка, меди, кобальта |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3172898A (en) * | 1965-03-09 | Process for preparation of metal chelates of aminopolycarboxylic acid compounds | ||
| SU138608A1 (ru) | 1960-07-14 | 1960-11-30 | Т.В. Лищенко | Способ получени алюминиевой соли этилендиаминтетрауксусной кислоты |
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| EP0173484B1 (en) * | 1984-08-06 | 1990-11-28 | Westinghouse Electric Corporation | Process for the separation of gadelinium isotopes |
| US4711768A (en) * | 1984-08-06 | 1987-12-08 | Westinghouse Electric Corp. | Process for the separation of gadolinium isotopes |
| IT1213029B (it) | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
| DE3922005A1 (de) * | 1989-06-30 | 1991-01-10 | Schering Ag | Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
| AU625529B2 (en) * | 1989-12-22 | 1992-07-16 | E.R. Squibb & Sons, Inc. | 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes |
| US5262018A (en) * | 1991-08-12 | 1993-11-16 | Fmc Corporation | Metals removal from aqueous peroxy acids or peroxy salts |
| IT1269839B (it) * | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
| IT1283218B1 (it) * | 1996-03-08 | 1998-04-16 | Bracco Spa | Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi |
| GB9707880D0 (en) * | 1997-04-18 | 1997-06-04 | Nycomed Imaging As | Contrast agent preparation |
| ITMI981583A1 (it) * | 1998-07-10 | 2000-01-10 | Bracco Spa | Processo per la preparazione dell'acido 4 -carbossi-5,8,11-tris (carbossimetil)-1-fenil-2-oxa-5,8,11-triazatridecan-13-oico |
| US6342598B1 (en) * | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
| EP1762563A1 (en) | 2005-09-13 | 2007-03-14 | BRACCO IMAGING S.p.A. | Process for the preparation of contrast agents |
| US20090208421A1 (en) | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
-
2009
- 2009-12-16 EP EP09179438A patent/EP2338874A1/en not_active Withdrawn
-
2010
- 2010-12-15 BR BR112012014621A patent/BR112012014621B8/pt active IP Right Grant
- 2010-12-15 JP JP2012543706A patent/JP5838164B2/ja active Active
- 2010-12-15 NZ NZ600910A patent/NZ600910A/en unknown
- 2010-12-15 US US13/514,394 patent/US8987508B2/en active Active
- 2010-12-15 ES ES10790972.3T patent/ES2474515T3/es active Active
- 2010-12-15 MX MX2012006954A patent/MX2012006954A/es active IP Right Grant
- 2010-12-15 WO PCT/EP2010/069715 patent/WO2011073236A1/en active Application Filing
- 2010-12-15 RU RU2012129982/04A patent/RU2533833C2/ru active
- 2010-12-15 EP EP10790972.3A patent/EP2513043B1/en active Active
- 2010-12-15 CA CA2784526A patent/CA2784526C/en active Active
- 2010-12-15 AU AU2010332960A patent/AU2010332960C1/en active Active
- 2010-12-15 PT PT107909723T patent/PT2513043E/pt unknown
- 2010-12-15 PL PL10790972T patent/PL2513043T3/pl unknown
- 2010-12-15 SG SG2012044780A patent/SG181776A1/en unknown
- 2010-12-15 CN CN201080061506.3A patent/CN102712574B/zh active Active
- 2010-12-15 KR KR1020127017584A patent/KR101766280B1/ko active IP Right Grant
-
2012
- 2012-06-14 IL IL220414A patent/IL220414A0/en active IP Right Grant
- 2012-07-12 ZA ZA2012/05192A patent/ZA201205192B/en unknown
-
2014
- 2014-05-12 HR HRP20140430AT patent/HRP20140430T1/hr unknown
-
2015
- 2015-02-16 US US14/623,202 patent/US9567350B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PT2513043E (pt) | 2014-06-11 |
| CN102712574A (zh) | 2012-10-03 |
| AU2010332960B2 (en) | 2013-08-01 |
| AU2010332960C1 (en) | 2014-01-23 |
| EP2513043A1 (en) | 2012-10-24 |
| CN102712574B (zh) | 2014-10-22 |
| AU2010332960A1 (en) | 2012-07-19 |
| WO2011073236A1 (en) | 2011-06-23 |
| EP2338874A1 (en) | 2011-06-29 |
| BR112012014621A2 (pt) | 2016-03-01 |
| RU2012129982A (ru) | 2014-01-27 |
| CA2784526C (en) | 2014-09-30 |
| RU2533833C2 (ru) | 2014-11-20 |
| SG181776A1 (en) | 2012-07-30 |
| IL220414A0 (en) | 2012-08-30 |
| ES2474515T3 (es) | 2014-07-09 |
| PL2513043T3 (pl) | 2014-08-29 |
| US9567350B2 (en) | 2017-02-14 |
| JP5838164B2 (ja) | 2015-12-24 |
| US20150158887A1 (en) | 2015-06-11 |
| BR112012014621B8 (pt) | 2021-10-26 |
| NZ600910A (en) | 2015-02-27 |
| US8987508B2 (en) | 2015-03-24 |
| ZA201205192B (en) | 2013-03-27 |
| CA2784526A1 (en) | 2011-06-23 |
| EP2513043B1 (en) | 2014-03-26 |
| KR101766280B1 (ko) | 2017-08-08 |
| KR20120101525A (ko) | 2012-09-13 |
| JP2013514311A (ja) | 2013-04-25 |
| BR112012014621B1 (pt) | 2021-10-05 |
| US20120245333A1 (en) | 2012-09-27 |
| MX2012006954A (es) | 2012-07-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20140430T1 (hr) | Postupak za pripremu keliranih tvari | |
| JP6538185B2 (ja) | 脱硫脱硝剤 | |
| KR20160070129A (ko) | 복합 알코올 아민류 용액을 사용하여 기체 중의 SOx를 제거하는 방법 | |
| CN102580514A (zh) | 强化湿法烟气脱硫工艺添加剂 | |
| ES2859110T3 (es) | Procedimiento para eliminar el SOx del gas mediante el uso de una solución de complejo de poliol | |
| JP5700668B2 (ja) | 二酸化炭素吸収用ポリマー、該ポリマーを利用した二酸化炭素の分離回収方法 | |
| CN103172101A (zh) | 一种碱式碳酸铈的制备方法 | |
| CN102327737A (zh) | 用于湿式石灰石石膏法烟气脱硫工艺的增效剂及其应用 | |
| CA2760188A1 (en) | Resin for precipitation of minerals and salts, methods of manufacture and uses thereof | |
| CN102284227A (zh) | 一种用复合脱碳溶液捕集混合气体中二氧化碳的方法 | |
| CN107149851A (zh) | 一种解吸并固定乙醇胺富液中co2的新方法 | |
| CN103263842A (zh) | 一种湿法脱硫系统的烟气脱硫增效剂及其制备方法和应用 | |
| CN100364646C (zh) | 强化烟气脱硫工艺中石灰石浆液活性的方法及组合添加剂 | |
| CN104689700A (zh) | 一种氧化锌脱硫工艺 | |
| CN109499382B (zh) | 一种反渗透膜用清洗组合物及其制备方法 | |
| CN103143330B (zh) | 一种治理水体中重金属污染的功能化聚乙烯醇吸附剂及其制备方法 | |
| CN104174275A (zh) | 复式离子液体和制备方法及其作为捕集剂的应用 | |
| CN106673400A (zh) | 一种污泥脱水调理剂及其脱水应用 | |
| CN112316669A (zh) | 有机胺脱硫剂及其制备方法和应用 | |
| CN103769061B (zh) | 一种胶原蛋白负载超支化聚酯/金属离子氟化物吸附剂的合成方法 | |
| CN103757652B (zh) | 一种高铁轮对及齿轮箱清洗剂及使用方法 | |
| Yang et al. | Influence of operating parameters on performance of SO2 absorption in fulvic acid solution | |
| WO2022237320A1 (zh) | 一种烟气脱硫脱硝耦合储层增产增注的方法 | |
| CN102604626A (zh) | 高含硫气藏酸压液体 | |
| CN101817531A (zh) | 在硅溶胶中建立防腐体系的处理方法 |