RU2533833C2 - Способ получения хелатных соединений - Google Patents
Способ получения хелатных соединений Download PDFInfo
- Publication number
- RU2533833C2 RU2533833C2 RU2012129982/04A RU2012129982A RU2533833C2 RU 2533833 C2 RU2533833 C2 RU 2533833C2 RU 2012129982/04 A RU2012129982/04 A RU 2012129982/04A RU 2012129982 A RU2012129982 A RU 2012129982A RU 2533833 C2 RU2533833 C2 RU 2533833C2
- Authority
- RU
- Russia
- Prior art keywords
- metal
- salt
- chelate
- solution
- liquid composition
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 44
- 239000013522 chelant Substances 0.000 title claims abstract description 29
- 150000001875 compounds Chemical class 0.000 title claims abstract description 25
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 43
- 229910052751 metal Inorganic materials 0.000 claims abstract description 40
- 239000002184 metal Substances 0.000 claims abstract description 39
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 36
- 239000007787 solid Substances 0.000 claims abstract description 31
- 239000007788 liquid Substances 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- 239000000203 mixture Substances 0.000 claims abstract description 21
- 150000002500 ions Chemical class 0.000 claims abstract description 8
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000002602 lanthanoids Chemical group 0.000 claims abstract description 6
- 229910052747 lanthanoid Inorganic materials 0.000 claims abstract description 5
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000005341 cation exchange Methods 0.000 claims abstract description 4
- OCDAWJYGVOLXGZ-VPVMAENOSA-K gadobenate dimeglumine Chemical compound [Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)C(C([O-])=O)COCC1=CC=CC=C1 OCDAWJYGVOLXGZ-VPVMAENOSA-K 0.000 claims abstract description 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000000524 functional group Chemical group 0.000 claims abstract 2
- 229940096814 gadobenate dimeglumine Drugs 0.000 claims abstract 2
- 239000000243 solution Substances 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 229920005989 resin Polymers 0.000 claims description 26
- 239000011347 resin Substances 0.000 claims description 26
- 239000008215 water for injection Substances 0.000 claims description 12
- 229910052688 Gadolinium Inorganic materials 0.000 claims description 10
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 9
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 8
- 229960003194 meglumine Drugs 0.000 claims description 8
- LYQGMALGKYWNIU-UHFFFAOYSA-K gadolinium(3+);triacetate Chemical compound [Gd+3].CC([O-])=O.CC([O-])=O.CC([O-])=O LYQGMALGKYWNIU-UHFFFAOYSA-K 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 229910044991 metal oxide Inorganic materials 0.000 claims description 3
- 150000004706 metal oxides Chemical class 0.000 claims description 3
- 239000012266 salt solution Substances 0.000 claims description 3
- 229910021644 lanthanide ion Inorganic materials 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 7
- 239000006227 byproduct Substances 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 3
- 150000002736 metal compounds Chemical class 0.000 abstract 1
- 239000002609 medium Substances 0.000 description 11
- -1 halides (e.g. Chemical class 0.000 description 10
- 238000010828 elution Methods 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000000969 carrier Substances 0.000 description 5
- 239000002738 chelating agent Substances 0.000 description 5
- MXZROTBGJUUXID-UHFFFAOYSA-K gadobenic acid Chemical compound [H+].[H+].[Gd+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)C(C([O-])=O)COCC1=CC=CC=C1 MXZROTBGJUUXID-UHFFFAOYSA-K 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 150000001242 acetic acid derivatives Chemical class 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 150000001805 chlorine compounds Chemical class 0.000 description 4
- 230000005298 paramagnetic effect Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003729 cation exchange resin Substances 0.000 description 3
- 229920001429 chelating resin Polymers 0.000 description 3
- 238000003926 complexometric titration Methods 0.000 description 3
- 239000002872 contrast media Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000005342 ion exchange Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 239000011343 solid material Substances 0.000 description 3
- 229910001428 transition metal ion Inorganic materials 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- OEIYJWYTUDFZBH-UHFFFAOYSA-N 2-[2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]ethyl-(carboxymethyl)amino]-3-phenylmethoxypropanoic acid Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)C(C(O)=O)COCC1=CC=CC=C1 OEIYJWYTUDFZBH-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 150000001649 bromium compounds Chemical class 0.000 description 2
- 229940023913 cation exchange resins Drugs 0.000 description 2
- 150000004697 chelate complex Chemical class 0.000 description 2
- 238000010668 complexation reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229960003330 pentetic acid Drugs 0.000 description 2
- 239000003495 polar organic solvent Substances 0.000 description 2
- ACTRVOBWPAIOHC-UHFFFAOYSA-N succimer Chemical compound OC(=O)C(S)C(S)C(O)=O ACTRVOBWPAIOHC-UHFFFAOYSA-N 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- ORZHVTYKPFFVMG-UHFFFAOYSA-N xylenol orange Chemical compound OC(=O)CN(CC(O)=O)CC1=C(O)C(C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C=C(CN(CC(O)=O)CC(O)=O)C(O)=C(C)C=2)=C1 ORZHVTYKPFFVMG-UHFFFAOYSA-N 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- FJWGRXKOBIVTFA-UHFFFAOYSA-N 2,3-dibromobutanedioic acid Chemical compound OC(=O)C(Br)C(Br)C(O)=O FJWGRXKOBIVTFA-UHFFFAOYSA-N 0.000 description 1
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- FCKYPQBAHLOOJQ-UHFFFAOYSA-N Cyclohexane-1,2-diaminetetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)C1CCCCC1N(CC(O)=O)CC(O)=O FCKYPQBAHLOOJQ-UHFFFAOYSA-N 0.000 description 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 description 1
- 239000007987 MES buffer Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 244000191761 Sida cordifolia Species 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- REDXJYDRNCIFBQ-UHFFFAOYSA-N aluminium(3+) Chemical compound [Al+3] REDXJYDRNCIFBQ-UHFFFAOYSA-N 0.000 description 1
- LHIJANUOQQMGNT-UHFFFAOYSA-N aminoethylethanolamine Chemical compound NCCNCCO LHIJANUOQQMGNT-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 229940039231 contrast media Drugs 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- MEANOSLIBWSCIT-UHFFFAOYSA-K gadolinium trichloride Chemical group Cl[Gd](Cl)Cl MEANOSLIBWSCIT-UHFFFAOYSA-K 0.000 description 1
- GXCUBNRUECGTSC-UHFFFAOYSA-K gadolinium(3+);triacetate;hydrate Chemical compound O.[Gd+3].CC([O-])=O.CC([O-])=O.CC([O-])=O GXCUBNRUECGTSC-UHFFFAOYSA-K 0.000 description 1
- 229910052733 gallium Inorganic materials 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 229910001867 inorganic solvent Inorganic materials 0.000 description 1
- 239000003049 inorganic solvent Substances 0.000 description 1
- 239000012500 ion exchange media Substances 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 229910001510 metal chloride Inorganic materials 0.000 description 1
- 229910001507 metal halide Inorganic materials 0.000 description 1
- 150000005309 metal halides Chemical class 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179438A EP2338874A1 (en) | 2009-12-16 | 2009-12-16 | Process for the preparation of chelated compounds |
| EP09179438.8 | 2009-12-16 | ||
| PCT/EP2010/069715 WO2011073236A1 (en) | 2009-12-16 | 2010-12-15 | Process for the preparation of chelated compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012129982A RU2012129982A (ru) | 2014-01-27 |
| RU2533833C2 true RU2533833C2 (ru) | 2014-11-20 |
Family
ID=41800716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012129982/04A RU2533833C2 (ru) | 2009-12-16 | 2010-12-15 | Способ получения хелатных соединений |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8987508B2 (enExample) |
| EP (2) | EP2338874A1 (enExample) |
| JP (1) | JP5838164B2 (enExample) |
| KR (1) | KR101766280B1 (enExample) |
| CN (1) | CN102712574B (enExample) |
| AU (1) | AU2010332960C1 (enExample) |
| BR (1) | BR112012014621B8 (enExample) |
| CA (1) | CA2784526C (enExample) |
| ES (1) | ES2474515T3 (enExample) |
| HR (1) | HRP20140430T1 (enExample) |
| IL (1) | IL220414A0 (enExample) |
| MX (1) | MX2012006954A (enExample) |
| NZ (1) | NZ600910A (enExample) |
| PL (1) | PL2513043T3 (enExample) |
| PT (1) | PT2513043E (enExample) |
| RU (1) | RU2533833C2 (enExample) |
| SG (1) | SG181776A1 (enExample) |
| WO (1) | WO2011073236A1 (enExample) |
| ZA (1) | ZA201205192B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2707070C2 (ru) * | 2014-11-28 | 2019-11-22 | ДжиИ Хелткер АС | Композиции, содержащие комплексы металлов ряда лантаноидов |
| WO2020159399A1 (ru) * | 2019-01-31 | 2020-08-06 | Акционерное Общество "Биоамид" | Способ получения комплексной микроэлементной добавки в корма на основе органических соединений железа, марганца, цинка, меди, кобальта |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ628481A (en) * | 2012-01-11 | 2016-11-25 | Adelaide Res & Innovation Pty | Stabilising and analysing fatty acids in a biological sample stored on solid media |
| CN102603550B (zh) * | 2012-02-16 | 2014-11-26 | 佛山普正医药科技有限公司 | 一种中间体bopta的制备方法 |
| CN103664672B (zh) * | 2013-10-21 | 2016-01-13 | 河北一品制药有限公司 | 一种工业化生产钆喷酸葡胺的制备方法 |
| US10696562B2 (en) * | 2013-12-05 | 2020-06-30 | Colorado School Of Mines | Upgrade of yttrium in a mixed rare earth stream using iminodiacetic acid functionalized resin |
| EP2977369A1 (en) * | 2014-07-24 | 2016-01-27 | Bracco Imaging SPA | Preparation of a solid form of gadobenate dimeglumine |
| GB201421161D0 (en) * | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Metal complex formulations |
| CN109608350B (zh) * | 2018-12-29 | 2021-06-22 | 湖北壮美生物科技有限公司 | 一种工业化制备甘氨酸钙的装置及相应的甘氨酸钙生产方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU138608A1 (ru) * | 1960-07-14 | 1960-11-30 | Т.В. Лищенко | Способ получени алюминиевой соли этилендиаминтетрауксусной кислоты |
| EP0434345A1 (en) * | 1989-12-22 | 1991-06-26 | E.R. SQUIBB & SONS, INC. | 10-(2'-hydroxy-3'-alkoxy)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecanes |
| WO1995032741A1 (en) * | 1994-05-26 | 1995-12-07 | Bracco S.P.A. | Bile acid conjugates, derivatives thereof with metal complexes and related uses |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3172898A (en) * | 1965-03-09 | Process for preparation of metal chelates of aminopolycarboxylic acid compounds | ||
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| DE3580721D1 (de) * | 1984-08-06 | 1991-01-10 | Westinghouse Electric Corp | Verfahren zur trennung von gadoliniumisotopen. |
| US4711768A (en) * | 1984-08-06 | 1987-12-08 | Westinghouse Electric Corp. | Process for the separation of gadolinium isotopes |
| IT1213029B (it) * | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
| DE3922005A1 (de) * | 1989-06-30 | 1991-01-10 | Schering Ag | Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
| US5262018A (en) * | 1991-08-12 | 1993-11-16 | Fmc Corporation | Metals removal from aqueous peroxy acids or peroxy salts |
| IT1283218B1 (it) * | 1996-03-08 | 1998-04-16 | Bracco Spa | Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi |
| GB9707880D0 (en) * | 1997-04-18 | 1997-06-04 | Nycomed Imaging As | Contrast agent preparation |
| ITMI981583A1 (it) | 1998-07-10 | 2000-01-10 | Bracco Spa | Processo per la preparazione dell'acido 4 -carbossi-5,8,11-tris (carbossimetil)-1-fenil-2-oxa-5,8,11-triazatridecan-13-oico |
| US6342598B1 (en) * | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
| EP1762563A1 (en) | 2005-09-13 | 2007-03-14 | BRACCO IMAGING S.p.A. | Process for the preparation of contrast agents |
| US20090208421A1 (en) * | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
-
2009
- 2009-12-16 EP EP09179438A patent/EP2338874A1/en not_active Withdrawn
-
2010
- 2010-12-15 HR HRP20140430AT patent/HRP20140430T1/hr unknown
- 2010-12-15 NZ NZ600910A patent/NZ600910A/en not_active IP Right Cessation
- 2010-12-15 MX MX2012006954A patent/MX2012006954A/es active IP Right Grant
- 2010-12-15 BR BR112012014621A patent/BR112012014621B8/pt active IP Right Grant
- 2010-12-15 US US13/514,394 patent/US8987508B2/en active Active
- 2010-12-15 CA CA2784526A patent/CA2784526C/en active Active
- 2010-12-15 PT PT107909723T patent/PT2513043E/pt unknown
- 2010-12-15 JP JP2012543706A patent/JP5838164B2/ja active Active
- 2010-12-15 WO PCT/EP2010/069715 patent/WO2011073236A1/en not_active Ceased
- 2010-12-15 SG SG2012044780A patent/SG181776A1/en unknown
- 2010-12-15 RU RU2012129982/04A patent/RU2533833C2/ru active
- 2010-12-15 KR KR1020127017584A patent/KR101766280B1/ko active Active
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- 2010-12-15 ES ES10790972.3T patent/ES2474515T3/es active Active
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2707070C2 (ru) * | 2014-11-28 | 2019-11-22 | ДжиИ Хелткер АС | Композиции, содержащие комплексы металлов ряда лантаноидов |
| US10576169B2 (en) | 2014-11-28 | 2020-03-03 | Ge Healthcare As | Lanthanide complex formulations |
| US11400172B2 (en) | 2014-11-28 | 2022-08-02 | Ge Healthcare As | Lanthanide complex formulations |
| US12070511B2 (en) | 2014-11-28 | 2024-08-27 | Ge Healthcare As | Lanthanide complex formulations |
| WO2020159399A1 (ru) * | 2019-01-31 | 2020-08-06 | Акционерное Общество "Биоамид" | Способ получения комплексной микроэлементной добавки в корма на основе органических соединений железа, марганца, цинка, меди, кобальта |
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| RU2012129982A (ru) | 2014-01-27 |
| MX2012006954A (es) | 2012-07-30 |
| IL220414A0 (en) | 2012-08-30 |
| EP2338874A1 (en) | 2011-06-29 |
| CA2784526C (en) | 2014-09-30 |
| KR101766280B1 (ko) | 2017-08-08 |
| US20120245333A1 (en) | 2012-09-27 |
| WO2011073236A1 (en) | 2011-06-23 |
| HRP20140430T1 (hr) | 2014-07-18 |
| EP2513043B1 (en) | 2014-03-26 |
| US8987508B2 (en) | 2015-03-24 |
| US9567350B2 (en) | 2017-02-14 |
| BR112012014621A2 (pt) | 2016-03-01 |
| AU2010332960C1 (en) | 2014-01-23 |
| SG181776A1 (en) | 2012-07-30 |
| JP2013514311A (ja) | 2013-04-25 |
| CN102712574A (zh) | 2012-10-03 |
| KR20120101525A (ko) | 2012-09-13 |
| JP5838164B2 (ja) | 2015-12-24 |
| ES2474515T3 (es) | 2014-07-09 |
| CA2784526A1 (en) | 2011-06-23 |
| US20150158887A1 (en) | 2015-06-11 |
| PL2513043T3 (pl) | 2014-08-29 |
| ZA201205192B (en) | 2013-03-27 |
| BR112012014621B8 (pt) | 2021-10-26 |
| PT2513043E (pt) | 2014-06-11 |
| EP2513043A1 (en) | 2012-10-24 |
| CN102712574B (zh) | 2014-10-22 |
| NZ600910A (en) | 2015-02-27 |
| AU2010332960B2 (en) | 2013-08-01 |
| AU2010332960A1 (en) | 2012-07-19 |
| BR112012014621B1 (pt) | 2021-10-05 |
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