KR101766280B1 - 킬레이트된 화합물의 제조 방법 - Google Patents

킬레이트된 화합물의 제조 방법 Download PDF

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Publication number
KR101766280B1
KR101766280B1 KR1020127017584A KR20127017584A KR101766280B1 KR 101766280 B1 KR101766280 B1 KR 101766280B1 KR 1020127017584 A KR1020127017584 A KR 1020127017584A KR 20127017584 A KR20127017584 A KR 20127017584A KR 101766280 B1 KR101766280 B1 KR 101766280B1
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South Korea
Prior art keywords
metal
chelated
liquid composition
salt
metal ion
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KR1020127017584A
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English (en)
Korean (ko)
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KR20120101525A (ko
Inventor
페데리코 마이사노
페데리코 크리벨린
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브라코 이미징 에스.피.에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020127017584A 2009-12-16 2010-12-15 킬레이트된 화합물의 제조 방법 Active KR101766280B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09179438A EP2338874A1 (en) 2009-12-16 2009-12-16 Process for the preparation of chelated compounds
EP09179438.8 2009-12-16
PCT/EP2010/069715 WO2011073236A1 (en) 2009-12-16 2010-12-15 Process for the preparation of chelated compounds

Publications (2)

Publication Number Publication Date
KR20120101525A KR20120101525A (ko) 2012-09-13
KR101766280B1 true KR101766280B1 (ko) 2017-08-08

Family

ID=41800716

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127017584A Active KR101766280B1 (ko) 2009-12-16 2010-12-15 킬레이트된 화합물의 제조 방법

Country Status (19)

Country Link
US (2) US8987508B2 (enExample)
EP (2) EP2338874A1 (enExample)
JP (1) JP5838164B2 (enExample)
KR (1) KR101766280B1 (enExample)
CN (1) CN102712574B (enExample)
AU (1) AU2010332960C1 (enExample)
BR (1) BR112012014621B8 (enExample)
CA (1) CA2784526C (enExample)
ES (1) ES2474515T3 (enExample)
HR (1) HRP20140430T1 (enExample)
IL (1) IL220414A0 (enExample)
MX (1) MX2012006954A (enExample)
NZ (1) NZ600910A (enExample)
PL (1) PL2513043T3 (enExample)
PT (1) PT2513043E (enExample)
RU (1) RU2533833C2 (enExample)
SG (1) SG181776A1 (enExample)
WO (1) WO2011073236A1 (enExample)
ZA (1) ZA201205192B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ628481A (en) * 2012-01-11 2016-11-25 Adelaide Res & Innovation Pty Stabilising and analysing fatty acids in a biological sample stored on solid media
CN102603550B (zh) * 2012-02-16 2014-11-26 佛山普正医药科技有限公司 一种中间体bopta的制备方法
CN103664672B (zh) * 2013-10-21 2016-01-13 河北一品制药有限公司 一种工业化生产钆喷酸葡胺的制备方法
US10696562B2 (en) * 2013-12-05 2020-06-30 Colorado School Of Mines Upgrade of yttrium in a mixed rare earth stream using iminodiacetic acid functionalized resin
EP2977369A1 (en) * 2014-07-24 2016-01-27 Bracco Imaging SPA Preparation of a solid form of gadobenate dimeglumine
GB201421162D0 (en) 2014-11-28 2015-01-14 Ge Healthcare As Lanthanide complex formulations
GB201421161D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Metal complex formulations
CN109608350B (zh) * 2018-12-29 2021-06-22 湖北壮美生物科技有限公司 一种工业化制备甘氨酸钙的装置及相应的甘氨酸钙生产方法
WO2020159399A1 (ru) * 2019-01-31 2020-08-06 Акционерное Общество "Биоамид" Способ получения комплексной микроэлементной добавки в корма на основе органических соединений железа, марганца, цинка, меди, кобальта

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711768A (en) 1984-08-06 1987-12-08 Westinghouse Electric Corp. Process for the separation of gadolinium isotopes
WO2000030688A2 (en) 1998-11-26 2000-06-02 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as mri contrast agents
US6162947A (en) 1998-07-10 2000-12-19 Dibra S.P.A. Process for the preparation of 4-carboxy-5, 8,11-tris (carboxymethyl)-phenyl-2-oxa-5, 8 11-triazatridecan
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3172898A (en) * 1965-03-09 Process for preparation of metal chelates of aminopolycarboxylic acid compounds
SU138608A1 (ru) * 1960-07-14 1960-11-30 Т.В. Лищенко Способ получени алюминиевой соли этилендиаминтетрауксусной кислоты
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3580721D1 (de) * 1984-08-06 1991-01-10 Westinghouse Electric Corp Verfahren zur trennung von gadoliniumisotopen.
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
DE3922005A1 (de) * 1989-06-30 1991-01-10 Schering Ag Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
US5262018A (en) * 1991-08-12 1993-11-16 Fmc Corporation Metals removal from aqueous peroxy acids or peroxy salts
IT1269839B (it) 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
IT1283218B1 (it) * 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
GB9707880D0 (en) * 1997-04-18 1997-06-04 Nycomed Imaging As Contrast agent preparation
EP1762563A1 (en) 2005-09-13 2007-03-14 BRACCO IMAGING S.p.A. Process for the preparation of contrast agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711768A (en) 1984-08-06 1987-12-08 Westinghouse Electric Corp. Process for the separation of gadolinium isotopes
US6162947A (en) 1998-07-10 2000-12-19 Dibra S.P.A. Process for the preparation of 4-carboxy-5, 8,11-tris (carboxymethyl)-phenyl-2-oxa-5, 8 11-triazatridecan
WO2000030688A2 (en) 1998-11-26 2000-06-02 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as mri contrast agents
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents

Also Published As

Publication number Publication date
RU2012129982A (ru) 2014-01-27
MX2012006954A (es) 2012-07-30
IL220414A0 (en) 2012-08-30
EP2338874A1 (en) 2011-06-29
CA2784526C (en) 2014-09-30
US20120245333A1 (en) 2012-09-27
WO2011073236A1 (en) 2011-06-23
HRP20140430T1 (hr) 2014-07-18
EP2513043B1 (en) 2014-03-26
US8987508B2 (en) 2015-03-24
US9567350B2 (en) 2017-02-14
BR112012014621A2 (pt) 2016-03-01
AU2010332960C1 (en) 2014-01-23
SG181776A1 (en) 2012-07-30
JP2013514311A (ja) 2013-04-25
CN102712574A (zh) 2012-10-03
KR20120101525A (ko) 2012-09-13
RU2533833C2 (ru) 2014-11-20
JP5838164B2 (ja) 2015-12-24
ES2474515T3 (es) 2014-07-09
CA2784526A1 (en) 2011-06-23
US20150158887A1 (en) 2015-06-11
PL2513043T3 (pl) 2014-08-29
ZA201205192B (en) 2013-03-27
BR112012014621B8 (pt) 2021-10-26
PT2513043E (pt) 2014-06-11
EP2513043A1 (en) 2012-10-24
CN102712574B (zh) 2014-10-22
NZ600910A (en) 2015-02-27
AU2010332960B2 (en) 2013-08-01
AU2010332960A1 (en) 2012-07-19
BR112012014621B1 (pt) 2021-10-05

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