ES2394147T3 - Derivados de piridazinona - Google Patents
Derivados de piridazinona Download PDFInfo
- Publication number
- ES2394147T3 ES2394147T3 ES09734854T ES09734854T ES2394147T3 ES 2394147 T3 ES2394147 T3 ES 2394147T3 ES 09734854 T ES09734854 T ES 09734854T ES 09734854 T ES09734854 T ES 09734854T ES 2394147 T3 ES2394147 T3 ES 2394147T3
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- Prior art keywords
- diyl
- formula
- compounds
- salts
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title description 9
- -1 thiazol-diyl Chemical group 0.000 claims abstract description 155
- 150000001875 compounds Chemical class 0.000 claims abstract description 129
- 150000003839 salts Chemical class 0.000 claims abstract description 64
- 239000000203 mixture Substances 0.000 claims abstract description 47
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 12
- 125000001634 furandiyl group Chemical group O1C(=C(C=C1)*)* 0.000 claims abstract description 12
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 10
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 9
- 125000002632 imidazolidinyl group Chemical group 0.000 claims abstract description 6
- 125000002757 morpholinyl group Chemical group 0.000 claims abstract description 6
- 125000000160 oxazolidinyl group Chemical group 0.000 claims abstract description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 6
- 125000004193 piperazinyl group Chemical group 0.000 claims abstract description 6
- 125000003386 piperidinyl group Chemical group 0.000 claims abstract description 6
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims abstract description 6
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- BOWWCYVLAODINC-UHFFFAOYSA-N 3-[1-[[4-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]thiophen-2-yl]methyl]-6-oxopyridazin-3-yl]benzonitrile Chemical compound C1CN(C)CCC1COC1=CN=C(C=2C=C(CN3C(C=CC(=N3)C=3C=C(C=CC=3)C#N)=O)SC=2)N=C1 BOWWCYVLAODINC-UHFFFAOYSA-N 0.000 claims 1
- GZNXOBPNFFVPCS-UHFFFAOYSA-N 3-[1-[[6-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]pyridin-2-yl]methyl]-6-oxopyridazin-3-yl]benzonitrile Chemical compound C1CN(C)CCC1COC1=CN=C(C=2N=C(CN3C(C=CC(=N3)C=3C=C(C=CC=3)C#N)=O)C=CC=2)N=C1 GZNXOBPNFFVPCS-UHFFFAOYSA-N 0.000 claims 1
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- FPYJSJDOHRDAMT-KQWNVCNZSA-N 1h-indole-5-sulfonamide, n-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1h-pyrrol-2-yl]methylene]-2,3-dihydro-n-methyl-2-oxo-, (3z)- Chemical compound C=1C=C2NC(=O)\C(=C/C3=C(C(C(=O)N4CCN(C)CC4)=C(C)N3)C)C2=CC=1S(=O)(=O)N(C)C1=CC=CC(Cl)=C1 FPYJSJDOHRDAMT-KQWNVCNZSA-N 0.000 description 16
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| PCT/EP2009/002137 WO2009129905A1 (de) | 2008-04-21 | 2009-03-24 | Pyridazinonderivate |
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| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) * | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| MX2011006682A (es) | 2008-12-22 | 2011-07-13 | Merck Patent Gmbh | Nuevas formas polimorficas de dihidrogeno-fosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirim idin-2-il]-bencil}-2h-piridazin-3-ona y procesos para su preparacion. |
| CN102532126B (zh) * | 2012-02-10 | 2014-06-18 | 贵州大学 | 2-取代-4-氯-5-[5-取代胺基-2-(1,3,4-噻二唑基)-巯基]-3(2h)-哒嗪酮类衍生物及其制备方法和用途 |
| EP3532467A1 (en) * | 2016-10-26 | 2019-09-04 | Proteostasis Therapeutics, Inc. | Pyridazine derivatives, compositions and methods for modulating cftr |
| ES2946551T3 (es) | 2017-10-17 | 2023-07-20 | Palau Pharma S L U | Síntesis de compuestos de 4-aminopirimidina |
| CN108752322A (zh) * | 2018-09-12 | 2018-11-06 | 广州新民培林医药科技有限公司 | 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用 |
| BR112021008905A2 (pt) | 2018-11-06 | 2021-08-10 | Edgewise Therapeutics, Inc. | compostos de piridazinona e usos dos mesmos |
| AU2019374812B2 (en) | 2018-11-06 | 2025-03-06 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| KR102885525B1 (ko) | 2018-11-06 | 2025-11-13 | 엣지와이즈 테라퓨틱스, 인크. | 피리다지논 화합물 및 이의 용도 |
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| US12435076B2 (en) | 2019-11-01 | 2025-10-07 | Unimatec Co., Ltd. | Fluorine-containing pyrimidine compound and method for producing same |
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| AR069869A1 (es) | 2007-12-21 | 2010-02-24 | Exelixis Inc | Derivados de benzofuro[3,2-d]pirimidinas inhibidores de proteinquinasas,composiciones farmaceuticas que los comprenden y usos de los mismos en el tratamiento del cancer. |
| EP2225239B1 (en) | 2007-12-21 | 2014-10-22 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compounds |
| BRPI0821676A2 (pt) | 2007-12-21 | 2015-06-16 | Astrazeneca Ab | Composto, composição farmacêutica, e, processo para a preparação dos compostos. |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
| PE20091339A1 (es) | 2007-12-21 | 2009-09-26 | Glaxo Group Ltd | Derivados de oxadiazol con actividad sobre receptores s1p1 |
| US7816540B2 (en) | 2007-12-21 | 2010-10-19 | Hoffmann-La Roche Inc. | Carboxyl- or hydroxyl-substituted benzimidazole derivatives |
| CL2008003785A1 (es) | 2007-12-21 | 2009-10-09 | Du Pont | Compuestos derivados de piridazina; composiciones herbicidas que comprenden a dichos compuestos; y método para controlar el crecimiento de la vegetación indeseada. |
| CN101537006B (zh) * | 2008-03-18 | 2012-06-06 | 中国科学院上海药物研究所 | 哒嗪酮类化合物在制备抗肿瘤药物中的用途 |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| WO2009142732A2 (en) * | 2008-05-20 | 2009-11-26 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| DE102008028905A1 (de) * | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| WO2010010150A1 (en) * | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| US20120028988A1 (en) * | 2009-03-30 | 2012-02-02 | Sumitomo Chemical Company, Limited | Use of pyridazinone compound for control of harmful arthropod pests |
| AR082590A1 (es) * | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
-
2008
- 2008-04-21 DE DE102008019907A patent/DE102008019907A1/de not_active Withdrawn
-
2009
- 2009-03-24 EA EA201001648A patent/EA018362B1/ru not_active IP Right Cessation
- 2009-03-24 PL PL09734854T patent/PL2280962T3/pl unknown
- 2009-03-24 JP JP2011505385A patent/JP5576358B2/ja not_active Expired - Fee Related
- 2009-03-24 WO PCT/EP2009/002137 patent/WO2009129905A1/de not_active Ceased
- 2009-03-24 DK DK09734854.4T patent/DK2280962T5/da active
- 2009-03-24 CN CN2009801141150A patent/CN102015694A/zh active Pending
- 2009-03-24 ES ES09734854T patent/ES2394147T3/es active Active
- 2009-03-24 AU AU2009240346A patent/AU2009240346B2/en not_active Ceased
- 2009-03-24 KR KR1020107025412A patent/KR20100137564A/ko not_active Ceased
- 2009-03-24 PT PT97348544T patent/PT2280962E/pt unknown
- 2009-03-24 MX MX2010011454A patent/MX2010011454A/es active IP Right Grant
- 2009-03-24 CA CA2721858A patent/CA2721858C/en active Active
- 2009-03-24 HR HRP20120884AT patent/HRP20120884T1/hr unknown
- 2009-03-24 BR BRPI0911161A patent/BRPI0911161B8/pt not_active IP Right Cessation
- 2009-03-24 US US12/988,666 patent/US8604036B2/en not_active Expired - Fee Related
- 2009-03-24 EP EP09734854A patent/EP2280962B1/de active Active
- 2009-03-24 SI SI200930411T patent/SI2280962T1/sl unknown
- 2009-04-17 AR ARP090101359A patent/AR071208A1/es not_active Application Discontinuation
-
2010
- 2010-09-21 IL IL208336A patent/IL208336A/en active IP Right Grant
- 2010-11-19 ZA ZA2010/08330A patent/ZA201008330B/en unknown
-
2012
- 2012-12-07 CY CY20121101191T patent/CY1113443T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20110034474A1 (en) | 2011-02-10 |
| AU2009240346B2 (en) | 2013-10-10 |
| BRPI0911161A2 (pt) | 2015-10-06 |
| IL208336A (en) | 2016-07-31 |
| JP5576358B2 (ja) | 2014-08-20 |
| CA2721858A1 (en) | 2009-10-29 |
| KR20100137564A (ko) | 2010-12-30 |
| EA018362B1 (ru) | 2013-07-30 |
| EP2280962A1 (de) | 2011-02-09 |
| CN102015694A (zh) | 2011-04-13 |
| DK2280962T3 (da) | 2012-11-19 |
| MX2010011454A (es) | 2010-12-21 |
| PL2280962T3 (pl) | 2013-02-28 |
| EA201001648A1 (ru) | 2011-06-30 |
| BRPI0911161B1 (pt) | 2020-02-11 |
| AR071208A1 (es) | 2010-06-02 |
| HRP20120884T1 (hr) | 2012-11-30 |
| BRPI0911161B8 (pt) | 2021-05-25 |
| US8604036B2 (en) | 2013-12-10 |
| CY1113443T1 (el) | 2016-06-22 |
| CA2721858C (en) | 2016-07-19 |
| JP2011518202A (ja) | 2011-06-23 |
| DE102008019907A1 (de) | 2009-10-22 |
| WO2009129905A1 (de) | 2009-10-29 |
| AU2009240346A1 (en) | 2009-10-29 |
| PT2280962E (pt) | 2012-12-17 |
| IL208336A0 (en) | 2010-12-30 |
| ZA201008330B (en) | 2011-09-28 |
| SI2280962T1 (sl) | 2013-01-31 |
| EP2280962B1 (de) | 2012-10-03 |
| DK2280962T5 (da) | 2013-09-16 |
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