EA018362B1 - Производные пиридазинона - Google Patents
Производные пиридазинона Download PDFInfo
- Publication number
- EA018362B1 EA018362B1 EA201001648A EA201001648A EA018362B1 EA 018362 B1 EA018362 B1 EA 018362B1 EA 201001648 A EA201001648 A EA 201001648A EA 201001648 A EA201001648 A EA 201001648A EA 018362 B1 EA018362 B1 EA 018362B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- formula
- compounds
- pharmaceutically acceptable
- compound
- acceptable salts
- Prior art date
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- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title description 4
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
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- 125000002632 imidazolidinyl group Chemical group 0.000 claims description 7
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| PCT/EP2009/002137 WO2009129905A1 (de) | 2008-04-21 | 2009-03-24 | Pyridazinonderivate |
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| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) * | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| MY160526A (en) | 2008-12-22 | 2017-03-15 | Merck Patent Gmbh | Novel polymorphic forms of 6-(1-methyl-1h-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2h-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof |
| CN102532126B (zh) * | 2012-02-10 | 2014-06-18 | 贵州大学 | 2-取代-4-氯-5-[5-取代胺基-2-(1,3,4-噻二唑基)-巯基]-3(2h)-哒嗪酮类衍生物及其制备方法和用途 |
| WO2018081381A1 (en) * | 2016-10-26 | 2018-05-03 | Proteostasis Therapeutics, Inc | Pyridazine derivatives, compositions and methods for modulating cftr |
| ES2946551T3 (es) | 2017-10-17 | 2023-07-20 | Palau Pharma S L U | Síntesis de compuestos de 4-aminopirimidina |
| CN108752322A (zh) * | 2018-09-12 | 2018-11-06 | 广州新民培林医药科技有限公司 | 一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用 |
| AU2019374812B2 (en) | 2018-11-06 | 2025-03-06 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| EP3877376B1 (en) | 2018-11-06 | 2023-08-23 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| CA3118908A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2021085550A1 (ja) | 2019-11-01 | 2021-05-06 | ユニマテック株式会社 | 含フッ素ピリミジン化合物およびその製造方法 |
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| JP2001192384A (ja) * | 1999-12-13 | 2001-07-17 | Fujisawa Pharmaceut Co Ltd | ピラゾロピリジン化合物およびその医薬上の用途 |
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2008
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- 2009-03-24 EA EA201001648A patent/EA018362B1/ru not_active IP Right Cessation
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- 2009-03-24 EP EP09734854A patent/EP2280962B1/de active Active
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| JP2001192384A (ja) * | 1999-12-13 | 2001-07-17 | Fujisawa Pharmaceut Co Ltd | ピラゾロピリジン化合物およびその医薬上の用途 |
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Also Published As
| Publication number | Publication date |
|---|---|
| HRP20120884T1 (hr) | 2012-11-30 |
| CN102015694A (zh) | 2011-04-13 |
| KR20100137564A (ko) | 2010-12-30 |
| CY1113443T1 (el) | 2016-06-22 |
| BRPI0911161A2 (pt) | 2015-10-06 |
| ES2394147T3 (es) | 2013-01-22 |
| BRPI0911161B1 (pt) | 2020-02-11 |
| CA2721858A1 (en) | 2009-10-29 |
| AU2009240346A1 (en) | 2009-10-29 |
| BRPI0911161B8 (pt) | 2021-05-25 |
| WO2009129905A1 (de) | 2009-10-29 |
| IL208336A0 (en) | 2010-12-30 |
| SI2280962T1 (sl) | 2013-01-31 |
| EA201001648A1 (ru) | 2011-06-30 |
| EP2280962B1 (de) | 2012-10-03 |
| EP2280962A1 (de) | 2011-02-09 |
| ZA201008330B (en) | 2011-09-28 |
| DE102008019907A1 (de) | 2009-10-22 |
| MX2010011454A (es) | 2010-12-21 |
| DK2280962T5 (da) | 2013-09-16 |
| US8604036B2 (en) | 2013-12-10 |
| AU2009240346B2 (en) | 2013-10-10 |
| US20110034474A1 (en) | 2011-02-10 |
| DK2280962T3 (da) | 2012-11-19 |
| JP5576358B2 (ja) | 2014-08-20 |
| IL208336A (en) | 2016-07-31 |
| AR071208A1 (es) | 2010-06-02 |
| PL2280962T3 (pl) | 2013-02-28 |
| JP2011518202A (ja) | 2011-06-23 |
| CA2721858C (en) | 2016-07-19 |
| PT2280962E (pt) | 2012-12-17 |
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