ES2388095A8 - Mejoras en y relativas a composiciones farmacéuticas. - Google Patents

Mejoras en y relativas a composiciones farmacéuticas. Download PDF

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Publication number
ES2388095A8
ES2388095A8 ES201090080A ES201090080A ES2388095A8 ES 2388095 A8 ES2388095 A8 ES 2388095A8 ES 201090080 A ES201090080 A ES 201090080A ES 201090080 A ES201090080 A ES 201090080A ES 2388095 A8 ES2388095 A8 ES 2388095A8
Authority
ES
Spain
Prior art keywords
amount
relating
solution
pharmaceutical compositions
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201090080A
Other languages
English (en)
Other versions
ES2388095A1 (es
ES2388095B1 (es
Inventor
Chris Seldon
Dawn Padfield
Frances Morrissey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norgine BV
Original Assignee
Norgine BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norgine BV filed Critical Norgine BV
Publication of ES2388095A1 publication Critical patent/ES2388095A1/es
Publication of ES2388095A8 publication Critical patent/ES2388095A8/es
Application granted granted Critical
Publication of ES2388095B1 publication Critical patent/ES2388095B1/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/08Ethers or acetals acyclic, e.g. paraformaldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • A61K31/77Polymers containing oxygen of oxiranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10Carbonates; Bicarbonates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/14Alkali metal chlorides; Alkaline earth metal chlorides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Mejoras en y relativas a composiciones farmacéuticas.#La invención proporciona una solución en agua que comprende los siguientes componentes y concentraciones:#(a) N x (70 a 130) g/l de polietilenglicol (PEG) de peso molecular promedio de 2500 a 4500;#(b) N x (1,6 a 4,0) g/l de cloruro de sodio;#(c) N x (0,2 a 0,6) g/l de cloruro de potasio;#(d) N x (0,6 a 2,2) g/l de bicarbonato de sodio;#(e) N x una cantidad de conservante;#(f) opcionalmente N x una cantidad de saborizante; y#(g) opcionalmente N x una cantidad de edulcorante;#donde N se encuentra entre 2 y 8.#La solución es un concentrado para dilución. Se diluye N veces con agua para proporcionar una solución de administración a un sujeto para el tratamiento del estreñimiento o la retención fecal.#Se proveen además soluciones, kits, dosis unitarias y métodos que comprenden o utilizan las soluciones.
ES201090080A 2009-07-30 2010-07-30 Mejoras en y relativas a composiciones farmacéuticas. Active ES2388095B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0913295 2009-07-30
GBGB0913295.2A GB0913295D0 (en) 2009-07-30 2009-07-30 Improvements in and relating to pharmaceutical compositions
PCT/GB2010/001455 WO2011012866A1 (en) 2009-07-30 2010-07-30 Solutions comprising polyethylene glycol and electrolytes

Publications (3)

Publication Number Publication Date
ES2388095A1 ES2388095A1 (es) 2012-10-08
ES2388095A8 true ES2388095A8 (es) 2013-07-01
ES2388095B1 ES2388095B1 (es) 2014-02-05

Family

ID=41067102

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201090080A Active ES2388095B1 (es) 2009-07-30 2010-07-30 Mejoras en y relativas a composiciones farmacéuticas.

Country Status (32)

Country Link
US (2) US20120135090A1 (es)
EP (1) EP2459218B1 (es)
JP (1) JP5708943B2 (es)
KR (1) KR101868834B1 (es)
CN (2) CN103932979B (es)
AR (2) AR077347A1 (es)
AT (1) AT12341U1 (es)
AU (1) AU2010277354B2 (es)
BE (1) BE1019753A5 (es)
BR (1) BR112012001899B8 (es)
CA (1) CA2769247C (es)
CY (1) CY1122081T1 (es)
DK (1) DK2459218T3 (es)
EA (1) EA025112B1 (es)
ES (1) ES2388095B1 (es)
FR (1) FR2948569B3 (es)
GB (3) GB0913295D0 (es)
HK (1) HK1150430A1 (es)
HR (1) HRP20191465T1 (es)
HU (1) HUE046705T2 (es)
IT (1) IT1402374B1 (es)
LT (1) LT2459218T (es)
MX (1) MX337114B (es)
NL (1) NL2005176C2 (es)
NZ (1) NZ597822A (es)
PL (1) PL2459218T3 (es)
PT (1) PT2459218T (es)
RS (1) RS59294B1 (es)
SI (1) SI2459218T1 (es)
TW (1) TWI478716B (es)
WO (1) WO2011012866A1 (es)
ZA (1) ZA201200661B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201200637D0 (en) 2012-01-13 2012-02-29 Norgine Bv Improvements in and relating to compositions
KR101852502B1 (ko) * 2011-01-31 2018-04-26 노어긴 비.브이. 조성물에 관한 개선
TWI535461B (zh) 2011-03-11 2016-06-01 諾金私人有限公司 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法
CN102600201B (zh) * 2012-02-07 2014-07-16 舒泰神(北京)生物制药股份有限公司 用于通便和清肠的药物组合物及其制备方法
US20140065076A1 (en) * 2012-08-30 2014-03-06 Otsuka Pharmaceutical Co. Ltd. Container with concentrated substance and method of using the same
KR20170098980A (ko) 2012-09-11 2017-08-30 노어긴 비.브이. Peg 및 아스코르베이트를 포함하는 조성물
EA201992382A3 (ru) 2013-03-15 2020-05-31 Брейнтри Лабораторис, Инк. Пероральная таблетированная фармацевтическая композиция двойного применения на основе сульфатных солей и способы ее применения
CN112494511A (zh) * 2020-12-06 2021-03-16 天津康哲医药科技发展有限公司 一种聚乙二醇钠钾口服药物制剂的制备

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JP2596764B2 (ja) 1987-11-18 1997-04-02 ルセル森下株式会社 腸管洗浄液剤
US5378470A (en) 1989-07-25 1995-01-03 Henning Berlin Gmbh Rectally administered pharmaceutical preparation
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RU2111741C1 (ru) * 1994-10-27 1998-05-27 Государственный научный центр колопроктологии Министерства здравоохранения и медицинской промышленности Российской Федерации Вещество для общего промывания желудочно-кишечного тракта
US5710183A (en) 1995-07-14 1998-01-20 Halow; George M. Laxative/antidiarrheal composition comprising polyethylene glycol and fiber bulking agent
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US6048901A (en) 1999-04-20 2000-04-11 Braintree Laboratories, Inc. Method of reducing intestinal gas, cramping and anorectal irritation
IL137275A0 (en) 2000-07-12 2001-07-24 Yosefus Azaria Pharmaceutical composition for the treatment of anal fissures
ATE477790T1 (de) 2001-10-29 2010-09-15 Ajinomoto Kk Lösung zur darmreinigung
US6946149B2 (en) 2002-04-30 2005-09-20 Braintree Laboratories, Inc. Salt solution for colon cleansing
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WO2005049049A1 (en) * 2003-11-17 2005-06-02 Braintree Laboratories, Inc. Therapeutic peg solution concentrate
GB0409104D0 (en) * 2004-04-23 2004-05-26 Norgine Europe Bv Compressed pharmaceutical compositions
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Also Published As

Publication number Publication date
ZA201200661B (en) 2012-10-31
JP2013500322A (ja) 2013-01-07
BR112012001899B1 (pt) 2021-05-04
EP2459218A1 (en) 2012-06-06
AR117718A2 (es) 2021-08-25
LT2459218T (lt) 2019-09-25
GB2472324A (en) 2011-02-02
US20140147518A1 (en) 2014-05-29
PL2459218T3 (pl) 2020-03-31
RS59294B1 (sr) 2019-10-31
CA2769247C (en) 2017-10-31
FR2948569B3 (fr) 2012-01-13
CN103932979A (zh) 2014-07-23
KR20120081584A (ko) 2012-07-19
TWI478716B (zh) 2015-04-01
ITMI20101436A1 (it) 2011-01-31
FR2948569A3 (fr) 2011-02-04
GB201108383D0 (en) 2011-06-29
GB2472324A8 (en) 2011-02-23
GB2478076A (en) 2011-08-24
CA2769247A1 (en) 2011-02-03
EP2459218B1 (en) 2019-07-17
AU2010277354A1 (en) 2012-02-16
CN103932979B (zh) 2019-06-14
BR112012001899A2 (pt) 2016-03-15
CY1122081T1 (el) 2020-11-25
BE1019753A5 (fr) 2012-12-04
ES2388095A1 (es) 2012-10-08
CN102548580A (zh) 2012-07-04
US9468686B2 (en) 2016-10-18
JP5708943B2 (ja) 2015-04-30
AT12341U1 (de) 2012-04-15
US20120135090A1 (en) 2012-05-31
GB2472324B (en) 2011-10-05
EA201200220A1 (ru) 2012-06-29
GB201012903D0 (en) 2010-09-15
KR101868834B1 (ko) 2018-06-19
GB2472324C (en) 2012-03-07
NZ597822A (en) 2013-08-30
MX337114B (es) 2016-02-12
TW201109021A (en) 2011-03-16
EA025112B1 (ru) 2016-11-30
SI2459218T1 (sl) 2019-10-30
WO2011012866A1 (en) 2011-02-03
IT1402374B1 (it) 2013-09-04
GB0913295D0 (en) 2009-09-02
DK2459218T3 (da) 2019-10-21
PT2459218T (pt) 2019-09-27
AR077347A1 (es) 2011-08-17
GB2478076B (en) 2012-06-06
NL2005176C2 (en) 2011-05-17
BR112012001899B8 (pt) 2021-05-25
HK1150430A1 (en) 2011-12-30
ES2388095B1 (es) 2014-02-05
HUE046705T2 (hu) 2020-03-30
MX2012001108A (es) 2012-06-01
HRP20191465T1 (hr) 2019-11-15
AU2010277354B2 (en) 2016-02-11
NL2005176A (en) 2011-01-31

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