ES2315681T3 - Composicion de estearato mejorada y metodo de produccion. - Google Patents
Composicion de estearato mejorada y metodo de produccion. Download PDFInfo
- Publication number
- ES2315681T3 ES2315681T3 ES04757378T ES04757378T ES2315681T3 ES 2315681 T3 ES2315681 T3 ES 2315681T3 ES 04757378 T ES04757378 T ES 04757378T ES 04757378 T ES04757378 T ES 04757378T ES 2315681 T3 ES2315681 T3 ES 2315681T3
- Authority
- ES
- Spain
- Prior art keywords
- weight
- alkaline earth
- acid
- composition
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 47
- 238000004519 manufacturing process Methods 0.000 title description 16
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 66
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims abstract description 59
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 34
- 239000000194 fatty acid Substances 0.000 claims abstract description 34
- 229930195729 fatty acid Natural products 0.000 claims abstract description 34
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 34
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 32
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 31
- 235000021314 Palmitic acid Nutrition 0.000 claims abstract description 30
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000008117 stearic acid Substances 0.000 claims abstract description 27
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims abstract description 21
- 229910052751 metal Inorganic materials 0.000 claims abstract description 21
- 239000002184 metal Substances 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 29
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 12
- -1 alkaline earth metal sulfate Chemical class 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 239000000243 solution Substances 0.000 claims description 11
- 239000011777 magnesium Substances 0.000 claims description 10
- 150000001342 alkaline earth metals Chemical group 0.000 claims description 9
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 7
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 7
- 229910052749 magnesium Inorganic materials 0.000 claims description 7
- 150000004682 monohydrates Chemical class 0.000 claims description 7
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 6
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 5
- JLFVIEQMRKMAIT-UHFFFAOYSA-N ac1l9mnz Chemical compound O.O.O JLFVIEQMRKMAIT-UHFFFAOYSA-N 0.000 claims description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 150000004683 dihydrates Chemical group 0.000 abstract description 21
- 239000000344 soap Substances 0.000 abstract description 13
- 239000003513 alkali Substances 0.000 abstract description 2
- 229910001854 alkali hydroxide Inorganic materials 0.000 abstract description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract description 2
- 239000012266 salt solution Substances 0.000 abstract description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 42
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
- 235000019359 magnesium stearate Nutrition 0.000 description 20
- 239000000047 product Substances 0.000 description 18
- 239000000314 lubricant Substances 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 229940063002 magnesium palmitate Drugs 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 150000004677 hydrates Chemical class 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- ABSWXCXMXIZDSN-UHFFFAOYSA-L magnesium;hexadecanoate Chemical compound [Mg+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O ABSWXCXMXIZDSN-UHFFFAOYSA-L 0.000 description 3
- OUOPFMMIKLEKSS-UHFFFAOYSA-N octadecanoic acid;dihydrate Chemical group O.O.CCCCCCCCCCCCCCCCCC(O)=O OUOPFMMIKLEKSS-UHFFFAOYSA-N 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000008149 soap solution Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 2
- 238000000113 differential scanning calorimetry Methods 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 238000005461 lubrication Methods 0.000 description 2
- RJXMFWOTBFWULV-UHFFFAOYSA-L magnesium hexadecanoate octadecanoate dihydrate Chemical compound O.O.[Mg++].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O RJXMFWOTBFWULV-UHFFFAOYSA-L 0.000 description 2
- CYPFMVTZEDNCQV-UHFFFAOYSA-L magnesium;octadecanoate;dihydrate Chemical compound O.O.[Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CYPFMVTZEDNCQV-UHFFFAOYSA-L 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000004684 trihydrates Chemical class 0.000 description 2
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 description 1
- 241000446313 Lamella Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940064790 dilantin Drugs 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 125000005908 glyceryl ester group Chemical group 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 1
- 229940061634 magnesium sulfate heptahydrate Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229960001165 modafinil Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 150000002943 palmitic acids Chemical class 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000008019 pharmaceutical lubricant Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
- 229960001475 zolpidem Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49059603P | 2003-07-28 | 2003-07-28 | |
| US490596P | 2003-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2315681T3 true ES2315681T3 (es) | 2009-04-01 |
Family
ID=34115413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04757378T Expired - Lifetime ES2315681T3 (es) | 2003-07-28 | 2004-07-28 | Composicion de estearato mejorada y metodo de produccion. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7456306B2 (enExample) |
| EP (1) | EP1663165B1 (enExample) |
| JP (1) | JP2007500770A (enExample) |
| CN (1) | CN100379408C (enExample) |
| AT (1) | ATE415950T1 (enExample) |
| AU (1) | AU2004261237B2 (enExample) |
| CA (1) | CA2533896A1 (enExample) |
| DE (1) | DE602004018161D1 (enExample) |
| DK (1) | DK1663165T3 (enExample) |
| ES (1) | ES2315681T3 (enExample) |
| MX (1) | MXPA06000885A (enExample) |
| WO (1) | WO2005011641A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06000885A (es) * | 2003-07-28 | 2006-05-04 | Mallinckrodt Inc | Composicion de estearato mejorada y metodo de produccion de la misma. |
| US20090232896A1 (en) * | 2008-03-11 | 2009-09-17 | Mallinckrodt Inc. | Use of Magnesium Stearate Dihydrate for Lubrication of Solid Pharmaceutical Compositions |
| WO2009114227A1 (en) * | 2008-03-11 | 2009-09-17 | Mallinckrodt Inc. | Use of magnesium stearate dihydrate for lubrication of solid industrial or consumer products |
| CA2727701A1 (en) | 2008-06-12 | 2009-12-17 | 3M Innovative Properties Company | Biocompatible hydrophilic compositions |
| EP2291558B1 (en) * | 2008-06-12 | 2017-07-26 | 3M Innovative Properties Company | Melt blown fine fibers and methods of manufacture |
| AU2010235035B2 (en) | 2009-03-31 | 2014-12-04 | 3M Innovative Properties Company | Dimensionally stable nonwoven fibrous webs and methods of making and using the same |
| US8721943B2 (en) | 2009-12-17 | 2014-05-13 | 3M Innovative Properties Company | Process of making dimensionally stable nonwoven fibrous webs |
| CN102762370B (zh) | 2009-12-17 | 2015-11-25 | 3M创新有限公司 | 尺寸稳定的非织造纤维幅材及其制造和使用方法 |
| CN102372620B (zh) * | 2010-08-17 | 2015-11-25 | 安徽山河药用辅料股份有限公司 | 硬脂酸镁提高其比容和白度的制备方法 |
| CN108479715A (zh) * | 2018-05-04 | 2018-09-04 | 苏州聚康新材料科技有限公司 | 一种凹凸棒/磁性纳米材料的制备方法 |
| JP7110756B2 (ja) * | 2018-06-22 | 2022-08-02 | 日油株式会社 | 脂肪酸マグネシウム塩組成物 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US547729A (en) * | 1895-10-08 | Thill-coupling | ||
| US2313844A (en) * | 1939-12-12 | 1943-03-16 | Du Pont | Method of precipitation |
| US2417071A (en) | 1943-08-14 | 1947-03-11 | Colgate Palmolive Peet Co | Preparation of water-insoluble organic salts |
| US2628202A (en) | 1949-09-23 | 1953-02-10 | Leffingwell Chemical Company | Soap useful for making lubricating greases |
| US2650932A (en) | 1950-04-13 | 1953-09-01 | Nat Lead Co | Method of preparing metallic soaps of fatty acids |
| US2862014A (en) | 1953-05-28 | 1958-11-25 | Ethyl Corp | Organic material |
| US2945051A (en) | 1955-10-19 | 1960-07-12 | American Cyanamid Co | Metallic salts of commercial stearic acid |
| US2857313A (en) | 1956-03-27 | 1958-10-21 | Ciba Pharm Prod Inc | Self-lubricating granulation |
| US3803188A (en) | 1969-07-09 | 1974-04-09 | Norac Co | Manufacture of metallic soaps |
| US3876551A (en) * | 1972-02-14 | 1975-04-08 | Int Flavors & Fragrances Inc | Perfumed aqueous hypochlorite composition and method for preparation of same |
| US4145542A (en) | 1974-06-13 | 1979-03-20 | Otsuka Pharmaceutical Co., Ltd. | 5- 1-Hydroxy-2-(heterocyclic-amino)!alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives |
| US3997692A (en) | 1974-09-16 | 1976-12-14 | Lever Brothers Company | Process of coating calcium sulfate dihydrate detergent filler particles |
| US4060535A (en) | 1976-08-31 | 1977-11-29 | Tenneco Chemicals, Inc. | Process for the production of metal salts of organic acids |
| DE2823002B2 (de) * | 1978-05-26 | 1981-06-04 | Chemische Werke München Otto Bärlocher GmbH, 8000 München | Verfahren zur Herstellung von Metallseifengranulat |
| DE2913592C2 (de) | 1979-04-04 | 1988-11-10 | Chemische Werke München Otto Bärlocher GmbH, 8000 München | Verfahen zur Herstellung von Metallseifen |
| US4307027A (en) | 1979-04-09 | 1981-12-22 | Dart Industries Inc. | Continuous process for preparing dry metallic salts of higher fatty acids |
| US4435857A (en) | 1982-04-02 | 1984-03-13 | Twinoak Products, Inc. | Apparatus for cleansing and disinfecting toilet tanks and bowls |
| US4657784A (en) * | 1986-03-10 | 1987-04-14 | Ecolab Inc. | Process for encapsulating particles with at least two coating layers having different melting points |
| US4777080A (en) * | 1986-10-15 | 1988-10-11 | Kimberly-Clark Corporation | Elastic abrasion resistant laminate |
| US4800082A (en) * | 1987-03-23 | 1989-01-24 | The Dow Chemical Company | Sustained release microbiological control composition |
| JPS6436086A (en) * | 1987-07-31 | 1989-02-07 | Canon Kk | Functional deposition film |
| DE3806192A1 (de) | 1988-02-26 | 1989-09-07 | Neynaber Chemie Gmbh | Verfahren zur herstellung von pulverfoermigen basischen metallseifen |
| JP2668941B2 (ja) * | 1988-05-28 | 1997-10-27 | 日本油脂株式会社 | 金属石鹸の連続製造法 |
| US5028486A (en) | 1988-06-27 | 1991-07-02 | Mallinckrodt Specialty Chemicals Company | Metallic fatty acid pellets and method of manufacture |
| US4990535A (en) | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
| US5032632A (en) * | 1990-05-15 | 1991-07-16 | E. I. Du Pont De Nemours And Company | Oxidation-resistant ethylene vinyl alcohol polymer compositions |
| US5277832A (en) * | 1991-09-12 | 1994-01-11 | Freiborne Industries, Inc. | Recovery of reactive soap lubricants |
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-
2004
- 2004-07-28 MX MXPA06000885A patent/MXPA06000885A/es active IP Right Grant
- 2004-07-28 EP EP04757378A patent/EP1663165B1/en not_active Expired - Lifetime
- 2004-07-28 DE DE602004018161T patent/DE602004018161D1/de not_active Expired - Lifetime
- 2004-07-28 AU AU2004261237A patent/AU2004261237B2/en not_active Ceased
- 2004-07-28 WO PCT/US2004/024485 patent/WO2005011641A2/en not_active Ceased
- 2004-07-28 US US10/558,591 patent/US7456306B2/en not_active Expired - Lifetime
- 2004-07-28 JP JP2006522062A patent/JP2007500770A/ja not_active Withdrawn
- 2004-07-28 CN CNB2004800216636A patent/CN100379408C/zh not_active Expired - Fee Related
- 2004-07-28 AT AT04757378T patent/ATE415950T1/de not_active IP Right Cessation
- 2004-07-28 CA CA002533896A patent/CA2533896A1/en not_active Abandoned
- 2004-07-28 DK DK04757378T patent/DK1663165T3/da active
- 2004-07-28 ES ES04757378T patent/ES2315681T3/es not_active Expired - Lifetime
-
2005
- 2005-06-16 US US11/154,849 patent/US7385068B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060247456A1 (en) | 2006-11-02 |
| JP2007500770A (ja) | 2007-01-18 |
| US20060281937A1 (en) | 2006-12-14 |
| WO2005011641A3 (en) | 2005-04-14 |
| DK1663165T3 (da) | 2009-03-30 |
| WO2005011641A2 (en) | 2005-02-10 |
| CN100379408C (zh) | 2008-04-09 |
| US7456306B2 (en) | 2008-11-25 |
| MXPA06000885A (es) | 2006-05-04 |
| AU2004261237A1 (en) | 2005-02-10 |
| ATE415950T1 (de) | 2008-12-15 |
| CA2533896A1 (en) | 2005-02-10 |
| EP1663165A2 (en) | 2006-06-07 |
| EP1663165B1 (en) | 2008-12-03 |
| US7385068B2 (en) | 2008-06-10 |
| CN1829500A (zh) | 2006-09-06 |
| DE602004018161D1 (de) | 2009-01-15 |
| AU2004261237B2 (en) | 2009-04-23 |
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