JP2007500770A - 改善されたステアレート組成物およびその製法 - Google Patents
改善されたステアレート組成物およびその製法 Download PDFInfo
- Publication number
- JP2007500770A JP2007500770A JP2006522062A JP2006522062A JP2007500770A JP 2007500770 A JP2007500770 A JP 2007500770A JP 2006522062 A JP2006522062 A JP 2006522062A JP 2006522062 A JP2006522062 A JP 2006522062A JP 2007500770 A JP2007500770 A JP 2007500770A
- Authority
- JP
- Japan
- Prior art keywords
- earth metal
- alkaline earth
- composition
- fatty acid
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 61
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 title claims abstract description 54
- 238000004519 manufacturing process Methods 0.000 title claims description 21
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims abstract description 70
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 48
- 239000000194 fatty acid Substances 0.000 claims abstract description 48
- 229930195729 fatty acid Natural products 0.000 claims abstract description 48
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 48
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims abstract description 43
- -1 alkaline earth metal stearate Chemical class 0.000 claims abstract description 43
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 37
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 37
- 235000021314 Palmitic acid Nutrition 0.000 claims abstract description 35
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000008117 stearic acid Substances 0.000 claims abstract description 34
- 150000004683 dihydrates Chemical group 0.000 claims abstract description 28
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 58
- 235000019359 magnesium stearate Nutrition 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 26
- 239000007864 aqueous solution Substances 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 20
- 230000008569 process Effects 0.000 claims description 20
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 10
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 6
- 239000011777 magnesium Substances 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- 239000011575 calcium Substances 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 5
- 150000004682 monohydrates Chemical class 0.000 claims description 5
- 239000007795 chemical reaction product Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 3
- 150000001342 alkaline earth metals Chemical class 0.000 claims 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 4
- 238000010438 heat treatment Methods 0.000 claims 4
- 239000006185 dispersion Substances 0.000 claims 2
- 239000000344 soap Substances 0.000 abstract description 11
- 229910052751 metal Inorganic materials 0.000 abstract description 7
- 239000002184 metal Substances 0.000 abstract description 7
- 229910001854 alkali hydroxide Inorganic materials 0.000 abstract description 3
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract description 3
- 239000012266 salt solution Substances 0.000 abstract description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
- 239000000047 product Substances 0.000 description 18
- 239000000314 lubricant Substances 0.000 description 7
- 229910052783 alkali metal Inorganic materials 0.000 description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 229940063002 magnesium palmitate Drugs 0.000 description 5
- 239000008149 soap solution Substances 0.000 description 5
- 239000007858 starting material Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000000113 differential scanning calorimetry Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- ABSWXCXMXIZDSN-UHFFFAOYSA-L magnesium;hexadecanoate Chemical compound [Mg+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O ABSWXCXMXIZDSN-UHFFFAOYSA-L 0.000 description 2
- CYPFMVTZEDNCQV-UHFFFAOYSA-L magnesium;octadecanoate;dihydrate Chemical compound O.O.[Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CYPFMVTZEDNCQV-UHFFFAOYSA-L 0.000 description 2
- 238000005649 metathesis reaction Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical class [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 150000004684 trihydrates Chemical class 0.000 description 2
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000003637 basic solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229940064790 dilantin Drugs 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 125000005908 glyceryl ester group Chemical group 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- RJXMFWOTBFWULV-UHFFFAOYSA-L magnesium hexadecanoate octadecanoate dihydrate Chemical compound O.O.[Mg++].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O RJXMFWOTBFWULV-UHFFFAOYSA-L 0.000 description 1
- SVIPSMFTDIDKLH-UHFFFAOYSA-L magnesium octadecanoate hydrate Chemical compound O.[Mg++].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O SVIPSMFTDIDKLH-UHFFFAOYSA-L 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 1
- 229940061634 magnesium sulfate heptahydrate Drugs 0.000 description 1
- MPBQUSJTYPZEIZ-UHFFFAOYSA-L magnesium;hexadecanoate;octadecanoate Chemical compound [Mg+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O MPBQUSJTYPZEIZ-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005555 metalworking Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960001165 modafinil Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000006082 mold release agent Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- OUOPFMMIKLEKSS-UHFFFAOYSA-N octadecanoic acid;dihydrate Chemical compound O.O.CCCCCCCCCCCCCCCCCC(O)=O OUOPFMMIKLEKSS-UHFFFAOYSA-N 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 239000008019 pharmaceutical lubricant Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
- 229960001475 zolpidem Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49059603P | 2003-07-28 | 2003-07-28 | |
| PCT/US2004/024485 WO2005011641A2 (en) | 2003-07-28 | 2004-07-28 | Improved stearate composition and method of production thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007500770A true JP2007500770A (ja) | 2007-01-18 |
| JP2007500770A5 JP2007500770A5 (enExample) | 2007-09-13 |
Family
ID=34115413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006522062A Withdrawn JP2007500770A (ja) | 2003-07-28 | 2004-07-28 | 改善されたステアレート組成物およびその製法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7456306B2 (enExample) |
| EP (1) | EP1663165B1 (enExample) |
| JP (1) | JP2007500770A (enExample) |
| CN (1) | CN100379408C (enExample) |
| AT (1) | ATE415950T1 (enExample) |
| AU (1) | AU2004261237B2 (enExample) |
| CA (1) | CA2533896A1 (enExample) |
| DE (1) | DE602004018161D1 (enExample) |
| DK (1) | DK1663165T3 (enExample) |
| ES (1) | ES2315681T3 (enExample) |
| MX (1) | MXPA06000885A (enExample) |
| WO (1) | WO2005011641A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019218328A (ja) * | 2018-06-22 | 2019-12-26 | 日油株式会社 | 脂肪酸マグネシウム塩 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06000885A (es) * | 2003-07-28 | 2006-05-04 | Mallinckrodt Inc | Composicion de estearato mejorada y metodo de produccion de la misma. |
| US20090232896A1 (en) * | 2008-03-11 | 2009-09-17 | Mallinckrodt Inc. | Use of Magnesium Stearate Dihydrate for Lubrication of Solid Pharmaceutical Compositions |
| WO2009114227A1 (en) * | 2008-03-11 | 2009-09-17 | Mallinckrodt Inc. | Use of magnesium stearate dihydrate for lubrication of solid industrial or consumer products |
| CA2727701A1 (en) | 2008-06-12 | 2009-12-17 | 3M Innovative Properties Company | Biocompatible hydrophilic compositions |
| EP2291558B1 (en) * | 2008-06-12 | 2017-07-26 | 3M Innovative Properties Company | Melt blown fine fibers and methods of manufacture |
| AU2010235035B2 (en) | 2009-03-31 | 2014-12-04 | 3M Innovative Properties Company | Dimensionally stable nonwoven fibrous webs and methods of making and using the same |
| US8721943B2 (en) | 2009-12-17 | 2014-05-13 | 3M Innovative Properties Company | Process of making dimensionally stable nonwoven fibrous webs |
| CN102762370B (zh) | 2009-12-17 | 2015-11-25 | 3M创新有限公司 | 尺寸稳定的非织造纤维幅材及其制造和使用方法 |
| CN102372620B (zh) * | 2010-08-17 | 2015-11-25 | 安徽山河药用辅料股份有限公司 | 硬脂酸镁提高其比容和白度的制备方法 |
| CN108479715A (zh) * | 2018-05-04 | 2018-09-04 | 苏州聚康新材料科技有限公司 | 一种凹凸棒/磁性纳米材料的制备方法 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US547729A (en) * | 1895-10-08 | Thill-coupling | ||
| US2313844A (en) * | 1939-12-12 | 1943-03-16 | Du Pont | Method of precipitation |
| US2417071A (en) | 1943-08-14 | 1947-03-11 | Colgate Palmolive Peet Co | Preparation of water-insoluble organic salts |
| US2628202A (en) | 1949-09-23 | 1953-02-10 | Leffingwell Chemical Company | Soap useful for making lubricating greases |
| US2650932A (en) | 1950-04-13 | 1953-09-01 | Nat Lead Co | Method of preparing metallic soaps of fatty acids |
| US2862014A (en) | 1953-05-28 | 1958-11-25 | Ethyl Corp | Organic material |
| US2945051A (en) | 1955-10-19 | 1960-07-12 | American Cyanamid Co | Metallic salts of commercial stearic acid |
| US2857313A (en) | 1956-03-27 | 1958-10-21 | Ciba Pharm Prod Inc | Self-lubricating granulation |
| US3803188A (en) | 1969-07-09 | 1974-04-09 | Norac Co | Manufacture of metallic soaps |
| US3876551A (en) * | 1972-02-14 | 1975-04-08 | Int Flavors & Fragrances Inc | Perfumed aqueous hypochlorite composition and method for preparation of same |
| US4145542A (en) | 1974-06-13 | 1979-03-20 | Otsuka Pharmaceutical Co., Ltd. | 5- 1-Hydroxy-2-(heterocyclic-amino)!alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives |
| US3997692A (en) | 1974-09-16 | 1976-12-14 | Lever Brothers Company | Process of coating calcium sulfate dihydrate detergent filler particles |
| US4060535A (en) | 1976-08-31 | 1977-11-29 | Tenneco Chemicals, Inc. | Process for the production of metal salts of organic acids |
| DE2823002B2 (de) * | 1978-05-26 | 1981-06-04 | Chemische Werke München Otto Bärlocher GmbH, 8000 München | Verfahren zur Herstellung von Metallseifengranulat |
| DE2913592C2 (de) | 1979-04-04 | 1988-11-10 | Chemische Werke München Otto Bärlocher GmbH, 8000 München | Verfahen zur Herstellung von Metallseifen |
| US4307027A (en) | 1979-04-09 | 1981-12-22 | Dart Industries Inc. | Continuous process for preparing dry metallic salts of higher fatty acids |
| US4435857A (en) | 1982-04-02 | 1984-03-13 | Twinoak Products, Inc. | Apparatus for cleansing and disinfecting toilet tanks and bowls |
| US4657784A (en) * | 1986-03-10 | 1987-04-14 | Ecolab Inc. | Process for encapsulating particles with at least two coating layers having different melting points |
| US4777080A (en) * | 1986-10-15 | 1988-10-11 | Kimberly-Clark Corporation | Elastic abrasion resistant laminate |
| US4800082A (en) * | 1987-03-23 | 1989-01-24 | The Dow Chemical Company | Sustained release microbiological control composition |
| JPS6436086A (en) * | 1987-07-31 | 1989-02-07 | Canon Kk | Functional deposition film |
| DE3806192A1 (de) | 1988-02-26 | 1989-09-07 | Neynaber Chemie Gmbh | Verfahren zur herstellung von pulverfoermigen basischen metallseifen |
| JP2668941B2 (ja) * | 1988-05-28 | 1997-10-27 | 日本油脂株式会社 | 金属石鹸の連続製造法 |
| US5028486A (en) | 1988-06-27 | 1991-07-02 | Mallinckrodt Specialty Chemicals Company | Metallic fatty acid pellets and method of manufacture |
| US4990535A (en) | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
| US5032632A (en) * | 1990-05-15 | 1991-07-16 | E. I. Du Pont De Nemours And Company | Oxidation-resistant ethylene vinyl alcohol polymer compositions |
| US5277832A (en) * | 1991-09-12 | 1994-01-11 | Freiborne Industries, Inc. | Recovery of reactive soap lubricants |
| US5434277A (en) * | 1993-04-02 | 1995-07-18 | Industrial Technology Research Institute | Improved metallic soaps of fatty acids for use as photolyzing agents for photodegradable polymer films |
| US5364610A (en) * | 1993-06-15 | 1994-11-15 | P. H. Glatfelter Company | Process for preparation of high opacity precipitated calcium carbonate by reacting sodium carbonate with calcium hydroxide |
| US5997768A (en) | 1993-06-29 | 1999-12-07 | Ciba Specialty Chemicals Corporation | Pelletization of metal soap powders |
| BR9408003A (pt) | 1993-11-08 | 1996-12-03 | Procter & Gamble | Barra para limpeza de pele de isetionato de cocoila destilado e destituído de componentes voláteis |
| DE4404279A1 (de) | 1994-02-10 | 1995-08-17 | Henkel Kgaa | Tablette mit Buildersubstanzen |
| EP0788346B9 (en) * | 1994-03-18 | 2007-02-14 | Supernus Pharmaceuticals, Inc. | Emulsified drug delivery systems |
| US5447729A (en) | 1994-04-07 | 1995-09-05 | Pharmavene, Inc. | Multilamellar drug delivery systems |
| US5631215A (en) * | 1994-07-21 | 1997-05-20 | Henkel Corporation | Process for making high moisture content soap bars |
| US6057139A (en) * | 1995-06-29 | 2000-05-02 | Mcneil-Ppc, Inc. | Preblend of microcrystalline cellulose and lactase for making tablets |
| CA2306908C (en) * | 1997-10-23 | 2004-06-08 | The Procter & Gamble Company | Fatty acids, soaps, surfactant systems, and consumer products based thereon |
| US20010014352A1 (en) | 1998-05-27 | 2001-08-16 | Udit Batra | Compressed tablet formulation |
| DE19840152A1 (de) * | 1998-09-03 | 2000-03-09 | Dresden Arzneimittel | Calciumvalproat enthaltende pharmazeutische Zusammensetzungen mit retardierter Wirkstoff-Freisetzung, Verfahren zu deren Herstellung und deren Verwendung |
| EP1202747A1 (en) | 1999-07-20 | 2002-05-08 | Merck & Co., Inc. | Sustained release drug dispersion delivery device |
| JP2003508420A (ja) * | 1999-09-02 | 2003-03-04 | ノストラム・ファーマスーティカルズ・インコーポレイテッド | 経口投与に適した、制御された放出の経口用量 |
| US6890894B2 (en) * | 2000-02-22 | 2005-05-10 | The Procter & Gamble Company | Fatty acids, soaps surfactant systems, and consumer products based thereon |
| GB0005789D0 (en) | 2000-03-11 | 2000-05-03 | Knoll Ag | Therapeutic agents |
| US7049146B2 (en) | 2000-11-14 | 2006-05-23 | Facet Analytical Services And Technology, Llc | Calibration standards, methods, and kits for water determination |
| WO2002078692A1 (en) | 2001-04-02 | 2002-10-10 | Smithkline Beecham Corporation | Method of treatment |
| WO2003011214A2 (en) | 2001-07-31 | 2003-02-13 | Royer Biomedical, Inc. | Novel methods and formulations for administration of active agents |
| CA2456440A1 (en) | 2001-08-16 | 2003-02-27 | Dover Chemical Corporation | Polymer dispersible polybasic metal carboxylate complexes |
| US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| US6699403B2 (en) * | 2002-03-22 | 2004-03-02 | Geo Specialty Chemicals, Inc. | Supported peroxides |
| DE60335248D1 (de) | 2002-03-29 | 2011-01-20 | Wright Medical Tech Inc | Knochentransplantat-ersatzzusammensetzung |
| AU2004311577A1 (en) | 2003-07-11 | 2005-07-21 | Myriad Genetics, Inc. | Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease |
| MXPA06000885A (es) * | 2003-07-28 | 2006-05-04 | Mallinckrodt Inc | Composicion de estearato mejorada y metodo de produccion de la misma. |
-
2004
- 2004-07-28 MX MXPA06000885A patent/MXPA06000885A/es active IP Right Grant
- 2004-07-28 EP EP04757378A patent/EP1663165B1/en not_active Expired - Lifetime
- 2004-07-28 DE DE602004018161T patent/DE602004018161D1/de not_active Expired - Lifetime
- 2004-07-28 AU AU2004261237A patent/AU2004261237B2/en not_active Ceased
- 2004-07-28 WO PCT/US2004/024485 patent/WO2005011641A2/en not_active Ceased
- 2004-07-28 US US10/558,591 patent/US7456306B2/en not_active Expired - Lifetime
- 2004-07-28 JP JP2006522062A patent/JP2007500770A/ja not_active Withdrawn
- 2004-07-28 CN CNB2004800216636A patent/CN100379408C/zh not_active Expired - Fee Related
- 2004-07-28 AT AT04757378T patent/ATE415950T1/de not_active IP Right Cessation
- 2004-07-28 CA CA002533896A patent/CA2533896A1/en not_active Abandoned
- 2004-07-28 DK DK04757378T patent/DK1663165T3/da active
- 2004-07-28 ES ES04757378T patent/ES2315681T3/es not_active Expired - Lifetime
-
2005
- 2005-06-16 US US11/154,849 patent/US7385068B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019218328A (ja) * | 2018-06-22 | 2019-12-26 | 日油株式会社 | 脂肪酸マグネシウム塩 |
| JP7110756B2 (ja) | 2018-06-22 | 2022-08-02 | 日油株式会社 | 脂肪酸マグネシウム塩組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20060247456A1 (en) | 2006-11-02 |
| US20060281937A1 (en) | 2006-12-14 |
| WO2005011641A3 (en) | 2005-04-14 |
| DK1663165T3 (da) | 2009-03-30 |
| WO2005011641A2 (en) | 2005-02-10 |
| CN100379408C (zh) | 2008-04-09 |
| US7456306B2 (en) | 2008-11-25 |
| ES2315681T3 (es) | 2009-04-01 |
| MXPA06000885A (es) | 2006-05-04 |
| AU2004261237A1 (en) | 2005-02-10 |
| ATE415950T1 (de) | 2008-12-15 |
| CA2533896A1 (en) | 2005-02-10 |
| EP1663165A2 (en) | 2006-06-07 |
| EP1663165B1 (en) | 2008-12-03 |
| US7385068B2 (en) | 2008-06-10 |
| CN1829500A (zh) | 2006-09-06 |
| DE602004018161D1 (de) | 2009-01-15 |
| AU2004261237B2 (en) | 2009-04-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7280318B2 (ja) | 炭酸ランタン水酸化物、ランタンオキシカルボネートならびにその製造および使用方法 | |
| JP2007500770A (ja) | 改善されたステアレート組成物およびその製法 | |
| EP0277738B1 (en) | Anhdrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide | |
| EP0143271B1 (en) | Acid salts of valproic acid | |
| JP5926195B2 (ja) | 直接圧縮可能な水酸化炭酸マグネシウム | |
| US4044149A (en) | Aluminum salts of substituted phenylalkanoic acids and pharmaceutical suspensions prepared therefrom | |
| JP5093907B2 (ja) | 無水第二リン酸カルシウム粒子およびその製造方法 | |
| AU2005277992A1 (en) | Improved stearate composition and method of production thereof | |
| FI71314B (fi) | Foerfarande foer framstaellning av en terapeutiskt anvaendbar beta-(4,5-difenyloxazol-2-yl) propionsyrakalciumsalt | |
| JP4236015B2 (ja) | 新規なＣａ・Ｍｇ複合炭酸塩類、その製造方法及び制酸剤 | |
| JPS60255736A (ja) | ニフエジピン調製物 | |
| US3976674A (en) | Aluminum salts of substituted phenylalkanoic acids | |
| RU2790488C1 (ru) | Способ получения и очистки стеарата магния | |
| WO2005089721A1 (en) | In process conversion method for preparing tannate tablet, capsule or other solid dosage forms | |
| EP1073625B1 (en) | Tilidine mesylate, processes for its preparation and pharmaceutical composition thereof | |
| JP2004189653A (ja) | イブプロフェン含有錠剤 | |
| WO1998027931A2 (en) | Salts of acetaminophen | |
| JP2004505920A5 (enExample) | ||
| RU2619738C2 (ru) | Способ получения биологически активного фторида кальция и способы его применения для профилактики и лечения фтордефицитных состояний у детей и подростков | |
| HU204046B (en) | Process for producing anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenyl)-2-oxindole-1-carboxamide and pharmaceutical compositions comprising same | |
| HU211140A9 (hu) | Az 5-klór-3-(2*tenoil)-2-oxindol-1-karboxamid vízmentes, kristályos nátriumsója |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070726 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070726 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20090730 |