ES2311920T3 - Tiazolopirimidinas sustituidas como analgesicos. - Google Patents
Tiazolopirimidinas sustituidas como analgesicos. Download PDFInfo
- Publication number
- ES2311920T3 ES2311920T3 ES05026811T ES05026811T ES2311920T3 ES 2311920 T3 ES2311920 T3 ES 2311920T3 ES 05026811 T ES05026811 T ES 05026811T ES 05026811 T ES05026811 T ES 05026811T ES 2311920 T3 ES2311920 T3 ES 2311920T3
- Authority
- ES
- Spain
- Prior art keywords
- butyl
- sec
- aryl
- propyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- -1 n-amyl Chemical group 0.000 claims abstract description 168
- 125000003118 aryl group Chemical group 0.000 claims abstract description 94
- 150000001875 compounds Chemical class 0.000 claims abstract description 89
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 75
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 62
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims abstract description 58
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims abstract description 51
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract description 50
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims abstract description 50
- 125000001424 substituent group Chemical group 0.000 claims abstract description 47
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims abstract description 46
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract description 44
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims abstract description 43
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- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 claims abstract description 39
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- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 20
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| DE2001112197 DE10112197A1 (de) | 2001-03-14 | 2001-03-14 | Substituierte Pyrazolo- und Thiazolopyrimidine |
| DE10112197 | 2001-03-14 | ||
| DE10153344 | 2001-10-29 | ||
| DE2001153344 DE10153344A1 (de) | 2001-10-29 | 2001-10-29 | Verwendung von substituierten Pyrazolopyrimidinen als Liganden von Nucleosid-Transport-Proteinen und/oder von Purinorezeptoren |
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Family
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| ES02729998T Expired - Lifetime ES2263779T3 (es) | 2001-03-14 | 2002-03-13 | Pirazolopirimidinas sustituidas. |
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| ES02729998T Expired - Lifetime ES2263779T3 (es) | 2001-03-14 | 2002-03-13 | Pirazolopirimidinas sustituidas. |
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| JP4494205B2 (ja) * | 2002-08-26 | 2010-06-30 | 武田薬品工業株式会社 | カルシウム受容体調節化合物およびその用途 |
| WO2004076450A1 (en) * | 2003-02-27 | 2004-09-10 | J. Uriach Y Compañia S.A. | Pyrazolopyridine derivates |
| GB0404434D0 (en) | 2004-02-27 | 2004-03-31 | Novartis Ag | Organic compounds |
| WO2005112936A1 (en) * | 2004-05-14 | 2005-12-01 | The Regents Of The University Of Michigan | Compositions and methods relating to protein kinase inhibitors |
| TW200618800A (en) * | 2004-08-03 | 2006-06-16 | Uriach Y Compania S A J | Heterocyclic compounds |
| EP1736475A1 (en) * | 2005-06-21 | 2006-12-27 | Ferrer Internacional, S.A. | Halogenated pyrazolo[1,5-a]pyrimidines, processes, uses, compositions and intermediates |
| KR100838692B1 (ko) | 2007-07-11 | 2008-06-16 | 한국화학연구원 | 7-(3′,4′-디알콕시페닐)-4,5,6,7-테트라히드로피라졸로[1,5-ａ]피리미딘 화합물, 이의 제조방법 및 이를 포함하는천식 및 만성폐쇄성 폐질환을 포함한 염증관련 질환,관절염, 아토피 피부염, 암 및 뇌질환의 치료 및 예방을위한 약제학적 조성물 |
| KR20100119776A (ko) * | 2008-01-24 | 2010-11-10 | 알라 캠, 엘엘씨 | 2-알킬아미노-3-아릴설포닐-사이클로알카노[ｅ 또는 ｄ]피라졸로[1,5-Ａ]피리미딘/세로토닌 5-ＨＴ6 수용체의 길항제, 이의 제조방법 및 이의 용도 |
| RU2374249C1 (ru) * | 2008-09-17 | 2009-11-27 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ ЦИКЛОАЛКАНО[е ИЛИ d]ПИРАЗОЛО[1,5-а]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТ6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| US8629154B2 (en) * | 2008-01-24 | 2014-01-14 | Andrey Alexandrovich Ivashchenko | Substituted cycloalcano[e and d] pyrazolo [1,5-a]pyrimidines/antagonists of serotonin 5-HT6 receptors and methods for production and the use thereof |
| RU2369600C1 (ru) * | 2008-01-24 | 2009-10-10 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ5-HT6 РЕЦЕПТОРОВ, АКТИВНЫЙ КОМПОНЕНТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННОЕ СРЕДСТВО И СПОСОБЫ ИХ ПОЛУЧЕНИЯ |
| RU2376291C1 (ru) * | 2008-05-07 | 2009-12-20 | Андрей Александрович Иващенко | ЗАМЕЩЕННЫЕ 3,5-ДИАМИНО-4-СУЛЬФОНИЛ-ПИРАЗОЛЫ И 2-АМИНО-3-СУЛЬФОНИЛ-ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ - АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
| CA2755968C (en) * | 2008-10-06 | 2019-03-19 | Andrey Alexandrovich Ivashchenko | Substituted 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines, serotonin 5-ht6 receptor antagonists and methods for the production and use thereof |
| TW201035103A (en) * | 2008-12-22 | 2010-10-01 | Schering Corp | Gamma secretase modulators |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| CN102775412B (zh) * | 2012-08-21 | 2013-05-01 | 四川大学 | 一种镇静催眠的化合物及其制备方法和用途 |
| CN102977106B (zh) * | 2012-12-12 | 2014-12-10 | 中国药科大学 | 一类具有外周镇痛作用的κ阿片受体激动剂 |
| MX363680B (es) | 2013-03-15 | 2019-03-29 | Chromocell Corp | Compuestos moduladores del canal de sodio (nav1. 7) y sus usos para el tratamiento del dolor neuropatico, nociceptivo o inflamatorio. |
| CN105611923B (zh) * | 2013-09-10 | 2019-08-23 | 卓莫赛尔公司 | 用于治疗疼痛和糖尿病的钠通道调节剂 |
| WO2016123629A1 (en) * | 2015-01-30 | 2016-08-04 | Vanderbilt University | Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| CN108473497B (zh) | 2015-10-16 | 2021-09-10 | 卫材R&D 管理有限公司 | Ep4拮抗剂 |
| WO2018133835A1 (en) * | 2017-01-20 | 2018-07-26 | National Institute Of Biological Sciences, Beijing | Nucleoside analogue regulating mammalian circadian rhythm |
| BR112019022465A2 (pt) * | 2017-04-27 | 2020-05-12 | Takeda Pharmaceutical Company Limited | Composto, medicamento, métodos para antagonizar um receptor sensor de cálcio em um mamífero e para prevenir ou tratar insuficiência cardíaca e hipertensão pulmona em um mamífero, e, uso do composto. |
| CN110582499B (zh) | 2017-04-27 | 2022-04-29 | 武田药品工业株式会社 | 杂环化合物 |
| CN113354644B (zh) * | 2020-03-04 | 2023-07-04 | 烟台药物研究所 | 一类用作dpp-iv抑制剂的吡唑并嘧啶结构的化合物及应用 |
| CN116023382B (zh) * | 2023-02-22 | 2025-09-23 | 北京师范大学 | 一种合成手性四氢吡唑并[1,5-a]嘧啶的方法 |
Family Cites Families (9)
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| US4847256A (en) * | 1986-10-16 | 1989-07-11 | American Cyanamid Company | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines |
| EP0264773A1 (en) | 1986-10-16 | 1988-04-27 | American Cyanamid Company | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines |
| NZ233641A (en) * | 1989-05-16 | 1992-07-28 | Merrell Dow Pharma | Quinoline and thienopyridine derivatives and excitatory amino acid antagonistic pharmaceutical compositions |
| GB9206266D0 (en) * | 1992-03-23 | 1992-05-06 | Merck Sharp & Dohme | Therapeutic agents |
| FR2717812B1 (fr) * | 1994-03-28 | 1996-05-10 | Rhone Poulenc Rorer Sa | Indeno[1,2-e]pyrazine-4-ones, leur préparation et les médicaments les contenant. |
| FR2722786B1 (fr) * | 1994-07-20 | 1996-08-23 | Rhone Poulenc Rorer Sa | Derives de 4-hydroxy-3-phenyl-indeno(1,2-b)pyridine-2(1h)- one, leur preparation et les medicaments les contenant |
| DE4444815A1 (de) * | 1994-12-15 | 1996-06-20 | Merck Patent Gmbh | Thienopyridone |
| JP2003288537A (ja) | 2000-09-25 | 2003-10-10 | Everyd.Com:Kk | 商品宅配システムおよび方法 |
| DE10112197A1 (de) | 2001-03-14 | 2002-09-19 | Gruenenthal Gmbh | Substituierte Pyrazolo- und Thiazolopyrimidine |
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