BR0208244A - Pirazolo-e tiazolopirinidinas substituìdas - Google Patents

Pirazolo-e tiazolopirinidinas substituìdas

Info

Publication number
BR0208244A
BR0208244A BR0208244-6A BR0208244A BR0208244A BR 0208244 A BR0208244 A BR 0208244A BR 0208244 A BR0208244 A BR 0208244A BR 0208244 A BR0208244 A BR 0208244A
Authority
BR
Brazil
Prior art keywords
diseases
compounds
thiazolopyrimidines
schizophrenia
pain
Prior art date
Application number
BR0208244-6A
Other languages
English (en)
Inventor
Matthias Gerlach
Corinna Maul
Bernd Sundermann
Utz-Peter Jagusch
Martin Fuhr
Adriaan P Ijzerman
Miriam Dissen-De Groote
Original Assignee
Gr Nenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2001112197 external-priority patent/DE10112197A1/de
Priority claimed from DE2001153344 external-priority patent/DE10153344A1/de
Application filed by Gr Nenthal Gmbh filed Critical Gr Nenthal Gmbh
Publication of BR0208244A publication Critical patent/BR0208244A/pt

Links

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"PIRAZOLO- E TIAZOLOPIRIMIDINAS SUBSTITUìDAS". A presente invenção refere-se a pirazolopirimidinas e tiazolopirimidinas substituídas, com a estrutura geral (IA), (IB) e (II), a um método para a sua obtenção, a bibliotecas de substâncias, contendo as mesmas, a medicamentos contendo tais compostos, o emprego de tais compostos na obtenção de medicamentos para o tratamento da dor, epilepsia, esquizofrenia, enfermidades neurodegenerativas, especialmente a doença de Alzheimer, de Huntington e Parkinson, para o tratamento de isquemias cerebrais e infartos, de psicoses resultantes de níveis majorados de aminoácidos, edemas cerebrais, estados de subnutrição do sistema nervoso central, especialmente nas hipoxias, especialmente na hipoxia do recem-nascido, e anoxias, de AIDS-Demens, de encefalomielite, da síndrome de Tourette, da asfixia perinatal, no Tinnitus, na dor de origem neuropática, enfermidades das vias respiratórias, câncer, arritmias cardíacas, deficientes e enfermidades imunológicas, estados e enfermidades inflamatórias, enfermidades neurodegenerativas, Morbus Parkinson , deficiências renais, esquizofrenia, perturbações do sono, ataque de apoplexia, tromboses, incontinência urinária, diabetes, psoríase, choque séptico, traumatismo craniano, glaucoma e/ou congestão cardíaca. A invenção também se refere a composições farmacêuticas, contendo os citados compostos.
BR0208244-6A 2001-03-14 2002-03-13 Pirazolo-e tiazolopirinidinas substituìdas BR0208244A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2001112197 DE10112197A1 (de) 2001-03-14 2001-03-14 Substituierte Pyrazolo- und Thiazolopyrimidine
DE2001153344 DE10153344A1 (de) 2001-10-29 2001-10-29 Verwendung von substituierten Pyrazolopyrimidinen als Liganden von Nucleosid-Transport-Proteinen und/oder von Purinorezeptoren
PCT/EP2002/002722 WO2002072585A2 (de) 2001-03-14 2002-03-13 Substituierte pyrazolo- und thiazolopyrimidine als analgetika

Publications (1)

Publication Number Publication Date
BR0208244A true BR0208244A (pt) 2004-03-02

Family

ID=26008763

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208244-6A BR0208244A (pt) 2001-03-14 2002-03-13 Pirazolo-e tiazolopirinidinas substituìdas

Country Status (25)

Country Link
US (1) US7135568B2 (pt)
EP (2) EP1368355B1 (pt)
JP (1) JP2004527508A (pt)
KR (1) KR20030082982A (pt)
CN (1) CN1318422C (pt)
AT (2) ATE404568T1 (pt)
AU (1) AU2002302419B2 (pt)
BR (1) BR0208244A (pt)
CA (1) CA2440760C (pt)
CY (1) CY1105507T1 (pt)
CZ (1) CZ20032474A3 (pt)
DE (2) DE50212652D1 (pt)
DK (1) DK1368355T3 (pt)
ES (2) ES2311920T3 (pt)
HK (1) HK1061034A1 (pt)
HU (1) HUP0401211A3 (pt)
IL (2) IL157895A0 (pt)
MX (1) MXPA03008291A (pt)
NO (1) NO20034031L (pt)
NZ (2) NZ528639A (pt)
PL (1) PL364388A1 (pt)
PT (1) PT1368355E (pt)
RU (1) RU2003129060A (pt)
SK (1) SK11542003A3 (pt)
WO (1) WO2002072585A2 (pt)

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UA81453C2 (en) * 2003-02-27 2008-01-10 Pyrazolopyridine derivates
GB0404434D0 (en) 2004-02-27 2004-03-31 Novartis Ag Organic compounds
US20080287405A1 (en) * 2004-05-14 2008-11-20 Thannickal Victor J Compositions and Methods Relating to Protein Kinase Inhibitors
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
EP1736475A1 (en) * 2005-06-21 2006-12-27 Ferrer Internacional, S.A. Halogenated pyrazolo[1,5-a]pyrimidines, processes, uses, compositions and intermediates
KR100838692B1 (ko) 2007-07-11 2008-06-16 한국화학연구원 7-(3′,4′-디알콕시페닐)-4,5,6,7-테트라히드로피라졸로[1,5-a]피리미딘 화합물, 이의 제조방법 및 이를 포함하는천식 및 만성폐쇄성 폐질환을 포함한 염증관련 질환,관절염, 아토피 피부염, 암 및 뇌질환의 치료 및 예방을위한 약제학적 조성물
KR20100119776A (ko) * 2008-01-24 2010-11-10 알라 캠, 엘엘씨 2-알킬아미노-3-아릴설포닐-사이클로알카노[e 또는 d]피라졸로[1,5-A]피리미딘/세로토닌 5-HT6 수용체의 길항제, 이의 제조방법 및 이의 용도
KR20100119777A (ko) * 2008-01-24 2010-11-10 알라 캠, 엘엘씨 치환된 사이클로알카노[e 및 d] 피라졸로 [1,5―A]피리미딘/세로토닌 5―HT6 수용체의 길항제 및 이의 제조방법 및 이의 용도
EP3020719B1 (en) 2008-10-06 2017-09-20 Alla Chem, LLC. Substituted 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines, serotonin 5-ht6 receptor antagonists and methods for the production and use thereof and methods for the production and use thereof
JP2012513400A (ja) * 2008-12-22 2012-06-14 シェーリング コーポレイション γ−セクレターゼ調節剤
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
CN102775412B (zh) * 2012-08-21 2013-05-01 四川大学 一种镇静催眠的化合物及其制备方法和用途
CN102977106B (zh) * 2012-12-12 2014-12-10 中国药科大学 一类具有外周镇痛作用的κ阿片受体激动剂
BR112015022096A8 (pt) 2013-03-15 2019-11-26 Chromocell Corp compostos moduladores de canal de sódio, composição que os compreende e uso dos mesmos
ES2687598T3 (es) * 2013-09-10 2018-10-26 Chromocell Corporation Moduladores del canal de sodio para el tratamiento del dolor y la diabetes
US10526323B2 (en) 2015-01-30 2020-01-07 Vanderbilt University Indazole and azaindazole substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
MX2018004664A (es) 2015-10-16 2018-08-24 Eisai R&D Man Co Ltd Antagonistas de ep4.
WO2018133835A1 (en) * 2017-01-20 2018-07-26 National Institute Of Biological Sciences, Beijing Nucleoside analogue regulating mammalian circadian rhythm
EP3617209A4 (en) * 2017-04-27 2020-08-26 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND
CN113354644B (zh) * 2020-03-04 2023-07-04 烟台药物研究所 一类用作dpp-iv抑制剂的吡唑并嘧啶结构的化合物及应用

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Also Published As

Publication number Publication date
CA2440760A1 (en) 2002-09-19
WO2002072585A2 (de) 2002-09-19
DE50212652D1 (de) 2008-09-25
PT1368355E (pt) 2006-09-29
EP1368355B1 (de) 2006-06-07
EP1368355A2 (de) 2003-12-10
CZ20032474A3 (cs) 2003-12-17
US20040127508A1 (en) 2004-07-01
NZ540574A (en) 2006-11-30
ATE328886T1 (de) 2006-06-15
NO20034031D0 (no) 2003-09-11
HUP0401211A3 (en) 2008-03-28
AU2002302419B2 (en) 2007-01-18
ATE404568T1 (de) 2008-08-15
EP1637533A1 (de) 2006-03-22
ES2311920T3 (es) 2009-02-16
CY1105507T1 (el) 2010-04-28
MXPA03008291A (es) 2003-12-11
EP1637533B1 (de) 2008-08-13
JP2004527508A (ja) 2004-09-09
US7135568B2 (en) 2006-11-14
PL364388A1 (en) 2004-12-13
DE50207103D1 (en) 2006-07-20
CN1318422C (zh) 2007-05-30
HK1061034A1 (en) 2004-09-03
NZ528639A (en) 2005-07-29
KR20030082982A (ko) 2003-10-23
HUP0401211A2 (hu) 2004-10-28
ES2263779T3 (es) 2006-12-16
DK1368355T3 (da) 2006-10-09
RU2003129060A (ru) 2005-04-10
CN1507447A (zh) 2004-06-23
WO2002072585A3 (de) 2003-02-20
CA2440760C (en) 2010-02-09
IL157895A0 (en) 2004-03-28
SK11542003A3 (sk) 2004-07-07
IL157895A (en) 2009-12-24
NO20034031L (no) 2003-10-21

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements