DE60142236D1 - Substituierte 5-alkinyl-pyrimidine mit neurotropher wirkung - Google Patents
Substituierte 5-alkinyl-pyrimidine mit neurotropher wirkungInfo
- Publication number
- DE60142236D1 DE60142236D1 DE60142236T DE60142236T DE60142236D1 DE 60142236 D1 DE60142236 D1 DE 60142236D1 DE 60142236 T DE60142236 T DE 60142236T DE 60142236 T DE60142236 T DE 60142236T DE 60142236 D1 DE60142236 D1 DE 60142236D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrimidines
- substituted
- alkinyl
- disorders
- neurotrophic effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22034800P | 2000-07-24 | 2000-07-24 | |
PCT/US2001/023088 WO2002008205A1 (en) | 2000-07-24 | 2001-07-20 | Substituted 5-alkynyl pyrimidines having neurotrophic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60142236D1 true DE60142236D1 (de) | 2010-07-08 |
Family
ID=22823191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60142236T Expired - Lifetime DE60142236D1 (de) | 2000-07-24 | 2001-07-20 | Substituierte 5-alkinyl-pyrimidine mit neurotropher wirkung |
Country Status (10)
Country | Link |
---|---|
US (1) | US7205297B2 (de) |
EP (1) | EP1303495B1 (de) |
JP (2) | JP5154728B2 (de) |
AT (1) | ATE469132T1 (de) |
AU (1) | AU2001273574A1 (de) |
CA (1) | CA2416442C (de) |
DE (1) | DE60142236D1 (de) |
DK (1) | DK1303495T3 (de) |
ES (1) | ES2346513T3 (de) |
WO (1) | WO2002008205A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005524712A (ja) * | 2002-05-07 | 2005-08-18 | ニューロサーチ、アクティーゼルスカブ | 新規アザシクロエチニル誘導体 |
US7531529B2 (en) | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
UA80888C2 (en) | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
MXPA05013233A (es) | 2003-06-12 | 2006-03-09 | Hoffmann La Roche | Derivados de imidazol heteroaril-substituidos como antagonistas del receptor de glutamato. |
US20060205740A1 (en) * | 2003-08-14 | 2006-09-14 | Reno Michael J | Chemical compounds |
ATE402705T1 (de) * | 2003-12-24 | 2008-08-15 | Astrazeneca Ab | Pyrimidine mit tie2 (tek) aktivität |
JP2007517007A (ja) * | 2003-12-24 | 2007-06-28 | アストラゼネカ アクチボラグ | Tie2(TEK)活性を持つピリミジン |
JP4690395B2 (ja) | 2004-06-01 | 2011-06-01 | エフ.ホフマン−ラ ロシュ アーゲー | mGlu5レセプターアンタゴニストとしてのピリジン−4−エチニル−イミダゾール及びピラゾール |
US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
WO2006055831A2 (en) * | 2004-11-17 | 2006-05-26 | Miikana Therapeutics, Inc. | Kinase inhibitors |
JP2008528663A (ja) * | 2005-02-01 | 2008-07-31 | アストラゼネカ アクチボラグ | Ties(TEK)阻害活性を有するピリミジン化合物 |
JP4993205B2 (ja) * | 2005-03-30 | 2012-08-08 | 塩野義製薬株式会社 | チロシンキナーゼ阻害作用を有するピリミジン誘導体 |
ES2535854T3 (es) * | 2005-09-30 | 2015-05-18 | Miikana Therapeutics, Inc. | Compuestos de pirazol sustituidos |
US7858782B2 (en) | 2006-12-15 | 2010-12-28 | Abraxis Bioscience, Llc | Triazine derivatives and their therapeutical applications |
AU2007336369B2 (en) | 2006-12-21 | 2013-01-17 | F. Hoffmann-La Roche Ag | Polymorphs of a mGluR5 receptor antagonist |
CA2683152A1 (en) * | 2007-06-11 | 2008-12-18 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
WO2009102427A2 (en) * | 2008-02-11 | 2009-08-20 | Rxi Pharmaceuticals Corp. | Modified rnai polynucleotides and uses thereof |
WO2010008582A2 (en) | 2008-07-18 | 2010-01-21 | Rxi Pharmaceuticals Corporation | Phagocytic cell drug delivery system |
PL2323992T3 (pl) | 2008-07-29 | 2017-01-31 | Boehringer Ingelheim International Gmbh | 5-alkinylo-pirymidyny |
AR072938A1 (es) | 2008-08-20 | 2010-09-29 | Southern Res Inst | Derivados de piridina y pirimidina azosustituidos y su uso en el tratamiento de infecciones virales |
TW201020238A (en) | 2008-08-20 | 2010-06-01 | Schering Corp | Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
TW201020245A (en) * | 2008-08-20 | 2010-06-01 | Schering Corp | Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
TWI409265B (zh) | 2008-08-20 | 2013-09-21 | Merck Sharp & Dohme | 經取代之吡啶及嘧啶衍生物及彼等於治療病毒感染之用途 |
AU2009293658A1 (en) | 2008-09-22 | 2010-03-25 | James Cardia | Reduced size self-delivering RNAi compounds |
WO2010059226A2 (en) | 2008-11-19 | 2010-05-27 | Rxi Pharmaceuticals Corporation | Inhibition of map4k4 through rnai |
WO2010078536A1 (en) | 2009-01-05 | 2010-07-08 | Rxi Pharmaceuticals Corporation | Inhibition of pcsk9 through rnai |
US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
AU2010258853B2 (en) | 2009-06-09 | 2014-07-31 | Nantbio, Inc. | Triazine derivatives and their therapeutical applications |
AU2010258964B2 (en) | 2009-06-09 | 2014-09-11 | Nantbio, Inc. | Benzyl substituted triazine derivatives and their therapeutical applications |
RU2554870C2 (ru) | 2009-10-30 | 2015-06-27 | Янссен Фармацевтика Нв | Феноксизамещенные пиримидины для использования в качестве модуляторов опиоидных рецепторов |
UY33198A (es) * | 2010-01-26 | 2011-08-31 | Boehringer Ingelheim Int | 5-alquinil-pirimidinas. |
US8633183B2 (en) | 2010-01-26 | 2014-01-21 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyrimidines |
WO2011119852A1 (en) | 2010-03-24 | 2011-09-29 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
EP2550001B1 (de) | 2010-03-24 | 2019-05-22 | Phio Pharmaceuticals Corp. | Rna-interferenz bei augenerkrankungen |
EP3560503B1 (de) | 2010-03-24 | 2021-11-17 | Phio Pharmaceuticals Corp. | Rna-interferenz bei dermalen und fibrotischen erkrankungen |
UA110995C2 (uk) * | 2011-10-07 | 2016-03-10 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як модулятори метаботропного глутаматного рецептора |
RU2744194C2 (ru) | 2013-12-02 | 2021-03-03 | Фио Фармасьютикалс Корп | Иммунотерапия рака |
EP3077050B1 (de) | 2013-12-04 | 2020-10-21 | Phio Pharmaceuticals Corp. | Verfahren zur behandlung von wundheilung mit chemisch modifizierten oligonukleotiden |
WO2015168108A2 (en) | 2014-04-28 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treating cancer using nucleic targeting mdm2 or mycn |
JP2017514908A (ja) | 2014-05-01 | 2017-06-08 | アールエックスアイ ファーマシューティカルズ コーポレーション | 核酸分子を利用する目の前部における障害の処置のための方法 |
KR102506169B1 (ko) | 2014-09-05 | 2023-03-08 | 피오 파마슈티칼스 코프. | Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법 |
US10808247B2 (en) | 2015-07-06 | 2020-10-20 | Phio Pharmaceuticals Corp. | Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach |
CN108135923B (zh) | 2015-07-06 | 2021-03-02 | 菲奥医药公司 | 靶向超氧化物歧化酶1(sod1)的核酸分子 |
EP3365446A4 (de) | 2015-10-19 | 2019-06-26 | Phio Pharmaceuticals Corp. | Gegen lange nichtcodierende rna gerichtete kleine selbstfreisetzende nukleinsäureverbindungen |
JP2023501445A (ja) | 2019-11-08 | 2023-01-18 | フィオ ファーマシューティカルズ コーポレーション | 免疫治療のためのブロモドメイン含有タンパク質4(brd4)を標的とする化学修飾されたオリゴヌクレオチド |
EP4085136A1 (de) | 2019-12-31 | 2022-11-09 | Phio Pharmaceuticals Corp. | Chemisch modifizierte oligonukleotide mit verbesserter systemischer abgabe |
WO2023015264A1 (en) | 2021-08-04 | 2023-02-09 | Phio Pharmaceuticals Corp. | Immunotherapy of cancer utilizing natural killer cells treated with chemically modified oligonucleotides |
KR20240041973A (ko) | 2021-08-04 | 2024-04-01 | 피오 파마슈티칼스 코프. | 화학적으로 변형된 올리고뉴클레오티드 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2691655A (en) | 1952-05-24 | 1954-10-12 | Burroughs Wellcome Co | 2-amino-4-substituted amino-6-aryl pyrimidines and process of preparing same |
GB951432A (en) | 1959-03-17 | 1964-03-04 | Wellcome Found | Pyrimidine derivatives and the manufacture thereof |
US3862190A (en) | 1972-09-08 | 1975-01-21 | Pfizer | 5-(unsubstituted and substituted phenoxy)-4-amino pyrimidines |
DK397574A (de) | 1973-08-24 | 1975-04-28 | Ciba Geigy Ag | |
GB1523274A (en) | 1974-08-05 | 1978-08-31 | Ici Ltd | Herbicidal compositions containing substituted pyrimidine |
FR2358148A1 (fr) | 1976-07-12 | 1978-02-10 | Dick Pr | Derives de 2,4-diaminopyrimidines et leur mise en solution en association avec des sulfamides |
FR2397407A2 (fr) | 1977-07-11 | 1979-02-09 | Dick Pierre | Derives de 2,4-diamino pyrimidines et leur mise en solution en association avec des sulfamides |
US4508560A (en) | 1981-11-11 | 1985-04-02 | Ciba Geigy Corporation | Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use |
US4663334A (en) * | 1985-12-11 | 1987-05-05 | Mcneilab, Inc. | Heteroaromatic acetylenes useful as antihypertensive agents |
FI895821A0 (fi) * | 1988-12-07 | 1989-12-05 | Wellcome Found | Farmaceutiskt aktiva cns foereningar. |
GB9012316D0 (en) * | 1990-06-01 | 1990-07-18 | Wellcome Found | Pharmacologically active cns compounds |
IE912114A1 (en) | 1990-07-02 | 1992-01-15 | Union Pharma Scient Appl | Novel pyrimidine derivatives which are angiotensin ii¹receptor antagonists, their methods of preparation and¹pharmaceutical compositions in which they are present |
US5075305A (en) | 1991-03-18 | 1991-12-24 | Warner-Lambert Company | Compound, composition and use |
US5250532A (en) * | 1991-04-11 | 1993-10-05 | Dowelanco | 3,4,N-trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides |
WO1992018498A1 (en) | 1991-04-17 | 1992-10-29 | Pfizer Inc. | Pyrimidine derivatives for enhancing antitumor activity |
US5336677A (en) | 1991-10-24 | 1994-08-09 | American Home Products Corporation | Substituted aminopyrimidines as antihypertensives |
GB9125842D0 (en) | 1991-12-04 | 1992-02-05 | Ici Plc | Heterocyclic derivatives |
WO1994014780A1 (en) | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
JP3526575B2 (ja) | 1993-03-08 | 2004-05-17 | エーザイ株式会社 | ホスホン酸誘導体 |
DE69408750T2 (de) | 1993-08-26 | 1998-07-23 | Ono Pharmaceutical Co | 4-Aminopyrimidin Derivate |
JPH08283246A (ja) | 1994-06-01 | 1996-10-29 | Nippon Soda Co Ltd | ピリミジン誘導体、その製造方法及び有害生物防除剤 |
WO1996031488A1 (fr) | 1995-04-03 | 1996-10-10 | Sumitomo Pharmaceuticals Company, Limited | Nouveaux derives de pyrimidine efficaces en tant que medicament psychotrope et leur procede de fabrication |
TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
US6440965B1 (en) * | 1997-10-15 | 2002-08-27 | Krenitsky Pharmaceuticals, Inc. | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system |
US6583148B1 (en) | 1999-04-08 | 2003-06-24 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic substituted pyrimidines |
-
2001
- 2001-07-20 US US10/333,447 patent/US7205297B2/en not_active Expired - Lifetime
- 2001-07-20 AU AU2001273574A patent/AU2001273574A1/en not_active Abandoned
- 2001-07-20 ES ES01952859T patent/ES2346513T3/es not_active Expired - Lifetime
- 2001-07-20 WO PCT/US2001/023088 patent/WO2002008205A1/en active Application Filing
- 2001-07-20 AT AT01952859T patent/ATE469132T1/de not_active IP Right Cessation
- 2001-07-20 DK DK01952859.5T patent/DK1303495T3/da active
- 2001-07-20 EP EP01952859A patent/EP1303495B1/de not_active Expired - Lifetime
- 2001-07-20 CA CA2416442A patent/CA2416442C/en not_active Expired - Fee Related
- 2001-07-20 DE DE60142236T patent/DE60142236D1/de not_active Expired - Lifetime
- 2001-07-20 JP JP2002514111A patent/JP5154728B2/ja not_active Expired - Lifetime
-
2012
- 2012-06-11 JP JP2012132101A patent/JP2012229218A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP5154728B2 (ja) | 2013-02-27 |
US20040087789A1 (en) | 2004-05-06 |
JP2012229218A (ja) | 2012-11-22 |
EP1303495B1 (de) | 2010-05-26 |
CA2416442A1 (en) | 2002-01-31 |
ES2346513T3 (es) | 2010-10-18 |
EP1303495A1 (de) | 2003-04-23 |
WO2002008205A1 (en) | 2002-01-31 |
AU2001273574A1 (en) | 2002-02-05 |
JP2004504386A (ja) | 2004-02-12 |
CA2416442C (en) | 2010-06-08 |
US7205297B2 (en) | 2007-04-17 |
ATE469132T1 (de) | 2010-06-15 |
DK1303495T3 (da) | 2010-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60142236D1 (de) | Substituierte 5-alkinyl-pyrimidine mit neurotropher wirkung | |
ATE377592T1 (de) | Neurotropische substituierte pyrimidine | |
EA200701296A1 (ru) | 3,5-дизамещенные и 3,5,7-тризамещенные 3h-оксазоло- и 3h-тиазоло[4,5-d] пиримидин-2-оны и их пролекарства | |
IL225192A (en) | Combinations of dextromethorphan and quinidine for the preparation of mental illness, neuropathic pain or brain injury | |
DE122005000044I2 (de) | R-Enantiomer des N-Propargyl-1-Aminoindan zur Behandlung verschiedener Krankheiten und Mesylat, Esylat und Sulfat davon | |
AP2004003069A0 (en) | 3-beta-d-ribofuranosynthiazolo [4-5-d] pyridimine nucleosides and uses thereof. | |
ECSP055719A (es) | Compuestos de tiazol para el tratamiento de trastornos neurodegenerativos | |
ATE253918T1 (de) | Verwendung von hymenialdisin und dessen derivaten zur herstellung therapeutischer mittel | |
WO2007100366A3 (en) | Quinolone m1 receptor positive allosteric modulators | |
WO2001009118A3 (en) | Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement | |
TR200002567T2 (tr) | Glisin naklini önleyiciler. | |
BR9908084A (pt) | Composto, processo para tratar um paciente afligido por algum distúrbio do sistema nervoso central e periférico, composição farmacêutica, e, uso de um composto | |
BRPI0407662A (pt) | derivados do ácido 1-fenilalcanocarboxìlico para o tratamento de doenças neurodegenerativas | |
SG157231A1 (en) | Substituted p-diaminobenzene derivatives | |
MY120976A (en) | 2-amino-6-(2-substituted-4-phenoxy)- substituted- pyridines | |
DE69807587T2 (de) | Quinazolin-4-on AMPA Antagonisten | |
EA200801302A1 (ru) | Композиции и способы лечения нарушений цнс | |
EA200601607A1 (ru) | Сульфонамидные соединения для лечения нейродегенеративных расстройств | |
BG108180A (en) | Novel cyano-substituted dihydropyrimidine compounds and their use to treat diseases | |
DE60233350D1 (de) | IMIDAZOi2,1-B -1,3,4-THIADIAZOLE SULFONAMIDES | |
EP1736470A3 (de) | Pyrimidin-Derivate als cb2 Cannabinoid-Rezeptor Modulatoren | |
BR9803385A (pt) | AtropisÈmeros de 2,3-dissubstituìdo-(5,6)-heteroaril condensado-pirimidin-4-onas. | |
BRPI0509559A (pt) | compostos de pirazolamina para o tratamento de distúrbios neurodegenerativos | |
WO2005046605A3 (en) | Compositions and methods of treating neurological diseases | |
TW200504036A (en) | Novel lactams and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |