ES2308477T3 - Compuestos para el tratamiento de la dislipidemia. - Google Patents
Compuestos para el tratamiento de la dislipidemia. Download PDFInfo
- Publication number
- ES2308477T3 ES2308477T3 ES05732643T ES05732643T ES2308477T3 ES 2308477 T3 ES2308477 T3 ES 2308477T3 ES 05732643 T ES05732643 T ES 05732643T ES 05732643 T ES05732643 T ES 05732643T ES 2308477 T3 ES2308477 T3 ES 2308477T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- trifluoromethyl
- methyl
- bis
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 153
- 208000032928 Dyslipidaemia Diseases 0.000 title claims abstract description 14
- 208000017170 Lipid metabolism disease Diseases 0.000 title claims abstract description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
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- 239000002253 acid Substances 0.000 claims description 174
- 125000000217 alkyl group Chemical group 0.000 claims description 142
- 150000002148 esters Chemical class 0.000 claims description 106
- 239000000203 mixture Substances 0.000 claims description 95
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 92
- PHIAJCROEOSVPR-UHFFFAOYSA-N 1h-azepine-4-carboxylic acid Chemical compound OC(=O)C1=CC=CNC=C1 PHIAJCROEOSVPR-UHFFFAOYSA-N 0.000 claims description 65
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 62
- 150000003839 salts Chemical class 0.000 claims description 49
- 125000003118 aryl group Chemical group 0.000 claims description 47
- 150000004702 methyl esters Chemical class 0.000 claims description 45
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 35
- 125000003342 alkenyl group Chemical group 0.000 claims description 28
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 28
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 28
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 27
- 239000001257 hydrogen Substances 0.000 claims description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 22
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- 239000003814 drug Substances 0.000 claims description 14
- 125000000304 alkynyl group Chemical group 0.000 claims description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims description 13
- FQFILJKFZCVHNH-UHFFFAOYSA-N tert-butyl n-[3-[(5-bromo-2-chloropyrimidin-4-yl)amino]propyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCNC1=NC(Cl)=NC=C1Br FQFILJKFZCVHNH-UHFFFAOYSA-N 0.000 claims description 13
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- 238000008214 LDL Cholesterol Methods 0.000 claims description 9
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 8
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- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims description 6
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- 125000004994 halo alkoxy alkyl group Chemical group 0.000 claims description 5
- 125000005842 heteroatom Chemical group 0.000 claims description 5
- 208000006575 hypertriglyceridemia Diseases 0.000 claims description 5
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims description 5
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- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 4
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 4
- 125000004104 aryloxy group Chemical group 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
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- 239000011593 sulfur Substances 0.000 claims description 4
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- 125000004429 atom Chemical group 0.000 claims description 3
- 208000027866 inflammatory disease Diseases 0.000 claims description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 2
- DTRBIIDYMYVRNE-UHFFFAOYSA-N 1h-azepine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC=CN1 DTRBIIDYMYVRNE-UHFFFAOYSA-N 0.000 claims description 2
- IUODKKZYQULRJQ-UHFFFAOYSA-N 2-[4-[[9-[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyltetrazol-5-yl)amino]-2-methyl-3-(trifluoromethyl)-6,7,8,9-tetrahydropyrido[3,2-b]azepin-5-yl]methyl]cyclohexyl]acetic acid Chemical compound C1=2C=C(C(F)(F)F)C(C)=NC=2C(N(CC=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)C2=NN(C)N=N2)CCCN1CC1CCC(CC(O)=O)CC1 IUODKKZYQULRJQ-UHFFFAOYSA-N 0.000 claims description 2
- 125000003302 alkenyloxy group Chemical group 0.000 claims description 2
- 150000003973 alkyl amines Chemical class 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 68
- 229910052700 potassium Inorganic materials 0.000 abstract description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 122
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 description 56
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 51
- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 description 48
- 102100037637 Cholesteryl ester transfer protein Human genes 0.000 description 48
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 47
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- 238000002360 preparation method Methods 0.000 description 40
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- 238000003756 stirring Methods 0.000 description 30
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- 239000012074 organic phase Substances 0.000 description 24
- 230000000694 effects Effects 0.000 description 23
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 19
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- 235000011152 sodium sulphate Nutrition 0.000 description 14
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- 230000015572 biosynthetic process Effects 0.000 description 12
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 10
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- 238000006268 reductive amination reaction Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55713404P | 2004-03-26 | 2004-03-26 | |
| US557134P | 2004-03-26 | ||
| US62116204P | 2004-10-22 | 2004-10-22 | |
| US621162P | 2004-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2308477T3 true ES2308477T3 (es) | 2008-12-01 |
Family
ID=34963426
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05732643T Expired - Lifetime ES2308477T3 (es) | 2004-03-26 | 2005-03-17 | Compuestos para el tratamiento de la dislipidemia. |
| ES05725968T Expired - Lifetime ES2326326T3 (es) | 2004-03-26 | 2005-03-17 | Compuestos y procedimientos para tratar la dislipidemia. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05725968T Expired - Lifetime ES2326326T3 (es) | 2004-03-26 | 2005-03-17 | Compuestos y procedimientos para tratar la dislipidemia. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7470705B2 (enExample) |
| EP (2) | EP1735320B1 (enExample) |
| JP (1) | JP2007530550A (enExample) |
| KR (1) | KR20070007112A (enExample) |
| AT (2) | ATE433984T1 (enExample) |
| AU (1) | AU2005230915A1 (enExample) |
| BR (1) | BRPI0508966A (enExample) |
| CA (1) | CA2557010A1 (enExample) |
| CY (1) | CY1110398T1 (enExample) |
| DE (2) | DE602005014955D1 (enExample) |
| DK (1) | DK1732933T3 (enExample) |
| EA (1) | EA200601785A1 (enExample) |
| EC (1) | ECSP066886A (enExample) |
| ES (2) | ES2308477T3 (enExample) |
| IL (1) | IL177962A0 (enExample) |
| MA (1) | MA28550B1 (enExample) |
| NO (1) | NO20064763L (enExample) |
| PL (1) | PL1732933T3 (enExample) |
| PT (1) | PT1732933E (enExample) |
| SI (1) | SI1732933T1 (enExample) |
| WO (2) | WO2005097805A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06003927A (es) * | 2003-10-08 | 2008-02-07 | Lilly Co Eli | Compuestos y metodos para tratar dislipidemia. |
| ATE433984T1 (de) * | 2004-03-26 | 2009-07-15 | Lilly Co Eli | Verbindungen und verfahren zur behandlung von dyslipidämie |
| MY139887A (en) * | 2004-04-02 | 2009-11-30 | Mitsubishi Tanabe Pharma Corp | Tetrahydronaphthyridine derivatives and a process for preparing the same. |
| EA200700119A1 (ru) | 2004-06-24 | 2007-10-26 | Эли Лилли Энд Компани | Соединения и способы лечения дислипидемии |
| WO2006069162A1 (en) | 2004-12-20 | 2006-06-29 | Reddy Us Therapeutics, Inc. | Novel heterocyclic compounds and their pharmaceutical compositions |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| ES2644450T3 (es) | 2004-12-31 | 2017-11-29 | Dr. Reddy's Laboratories Ltd. | Nuevos derivados de bencilamina como inhibidores de CETP |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| JP4681526B2 (ja) * | 2005-09-29 | 2011-05-11 | 田辺三菱製薬株式会社 | 医薬組成物 |
| US7790770B2 (en) | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7652023B2 (en) | 2005-11-23 | 2010-01-26 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| UY30244A1 (es) | 2006-03-30 | 2007-11-30 | Tanabe Seiyaku Co | Un proceso para preparar derivados de tetrahidroquinolina |
| SI2207775T1 (sl) | 2007-11-05 | 2012-05-31 | Novartis Ag | benzilamino karboksiacil piperidinski derivati kot inhibitorji CETP uporabni za zdravljenje bolezni kot je hiperlipidemija ali arterioskleroza |
| EP2404901B1 (en) | 2007-12-03 | 2013-05-22 | Novartis AG | 1,2-Disubstituted 4-benzylamino-pyrrolidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
| JP2011506441A (ja) * | 2007-12-12 | 2011-03-03 | アムジエン・インコーポレーテツド | グリシン輸送体−１阻害薬 |
| JP5586585B2 (ja) * | 2009-03-27 | 2014-09-10 | 興和株式会社 | 縮合ピペリジン化合物及びこれを含有する医薬 |
| KR20120036850A (ko) | 2009-05-15 | 2012-04-18 | 노파르티스 아게 | 알도스테론 신타제 억제제로서의 벤족사졸론 유도체 |
| MX2011012198A (es) | 2009-05-15 | 2011-12-08 | Novartis Ag | Aril-piridinas como inhibidoras de sintasa de aldosterona. |
| EA201101672A1 (ru) | 2009-05-28 | 2012-06-29 | Новартис Аг | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина |
| JP5420761B2 (ja) | 2009-05-28 | 2014-02-19 | ノバルティス アーゲー | ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体 |
| TWI450896B (zh) | 2009-06-30 | 2014-09-01 | Lilly Co Eli | 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸 |
| US8519134B2 (en) | 2009-11-17 | 2013-08-27 | Novartis Ag | Aryl-pyridine derivatives as aldosterone synthase inhibitors |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| ES2472446T3 (es) | 2009-11-30 | 2014-07-01 | Novartis Ag | Derivados de imidazol como inhibidores de aldosterona sintasa |
| JP5964247B2 (ja) * | 2010-02-24 | 2016-08-03 | レリプサ， インコーポレイテッド | 胆汁酸捕捉剤として使用するためのポリイミダゾール |
| NZ603453A (en) | 2010-05-06 | 2014-12-24 | Alphacore Pharma Llc | Delivery of cholesteryl ester to steroidogenic tissues |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
| TWI627167B (zh) | 2011-07-08 | 2018-06-21 | 諾華公司 | 用於高三酸甘油酯個體治療動脈粥狀硬化之方法 |
| US9199967B2 (en) | 2011-08-18 | 2015-12-01 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors |
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| JO3210B1 (ar) | 2011-10-28 | 2018-03-08 | Merck Sharp & Dohme | مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة |
| US20140303198A1 (en) | 2011-11-29 | 2014-10-09 | Kowa Company, Ltd. | Agent for inhibiting expression of npc1l1 and/or lipg mrna and agent for preventing and/or treating obesity |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| EP2956464B1 (en) | 2013-02-14 | 2018-03-28 | Novartis AG | Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors |
| TW201536814A (zh) | 2013-07-25 | 2015-10-01 | Novartis Ag | 用於治療心臟衰竭之合成環狀多肽 |
| BR112016001376A2 (pt) | 2013-07-25 | 2017-10-24 | Novartis Ag | bioconjugados de polipeptídeos de apelin sintéticos |
| BR112017014194A2 (pt) | 2015-01-23 | 2018-01-09 | Novartis Ag | conjugados de ácido graxo de apelina sintéticos com meia-vida melhorada |
| JOP20190086A1 (ar) | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
| AR127698A1 (es) | 2021-11-23 | 2024-02-21 | Novartis Ag | Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno |
| US20240391941A1 (en) | 2023-05-24 | 2024-11-28 | Novartis Ag | Naphthyridinone derivatives for the treatment of a disease or disorder |
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| GB1515540A (en) * | 1975-12-16 | 1978-06-28 | Labaz | 4-amino-trans-decahydroquinoline derivatives |
| US6207671B1 (en) | 1996-07-08 | 2001-03-27 | Bayer Aktiengesellschaft | Cycloalkano-pyridines |
| DE19627431A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Heterocyclisch kondensierte Pyridine |
| DE19627430A1 (de) | 1996-07-08 | 1998-01-15 | Bayer Ag | Bicyclisch kondensierte Pyridine |
| HRP970330B1 (en) | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
| WO1998035967A2 (en) * | 1997-02-18 | 1998-08-20 | Neurocrine Biosciences, Inc. | Biazacyclic crf antagonists |
| DE19709125A1 (de) | 1997-03-06 | 1998-09-10 | Bayer Ag | Substituierte Chinoline |
| JPH10287662A (ja) | 1997-04-08 | 1998-10-27 | Kitasato Inst:The | Ｆｏ−５６３７ａ物質及びｂ物質並びにそれらの製造法 |
| US6147089A (en) | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
| US6147090A (en) | 1998-09-17 | 2000-11-14 | Pfizer Inc. | 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
| GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
| US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| DE10148436A1 (de) | 2001-10-01 | 2003-04-17 | Bayer Ag | Tetrahydrochinoline |
| EP1466904A4 (en) * | 2001-12-28 | 2005-12-14 | Takeda Pharmaceutical | BIARYL CONNECTION AND ITS USE |
| JP2005522424A (ja) | 2002-02-01 | 2005-07-28 | ファイザー・プロダクツ・インク | コレステリルエステル転移タンパク質インヒビターの制御放出性薬剤投与形態 |
| JP2003321472A (ja) | 2002-02-26 | 2003-11-11 | Takeda Chem Ind Ltd | Ｇｒｋ阻害剤 |
| SK2332004A3 (en) | 2002-08-30 | 2004-12-01 | Japan Tobacco Inc | Dibenzylamine compound and medicinal use thereof |
| EP1556047A4 (en) * | 2002-10-04 | 2009-09-30 | Millennium Pharm Inc | ANTAGONISTS AGAINST THE PGD2 RECEPTOR FOR THE TREATMENT OF INFLAMMATORY DISEASES |
| MXPA06003927A (es) * | 2003-10-08 | 2008-02-07 | Lilly Co Eli | Compuestos y metodos para tratar dislipidemia. |
| ATE433984T1 (de) | 2004-03-26 | 2009-07-15 | Lilly Co Eli | Verbindungen und verfahren zur behandlung von dyslipidämie |
| MY139887A (en) * | 2004-04-02 | 2009-11-30 | Mitsubishi Tanabe Pharma Corp | Tetrahydronaphthyridine derivatives and a process for preparing the same. |
| EA200700119A1 (ru) | 2004-06-24 | 2007-10-26 | Эли Лилли Энд Компани | Соединения и способы лечения дислипидемии |
-
2005
- 2005-03-17 AT AT05725968T patent/ATE433984T1/de not_active IP Right Cessation
- 2005-03-17 AT AT05732643T patent/ATE402180T1/de not_active IP Right Cessation
- 2005-03-17 WO PCT/US2005/009294 patent/WO2005097805A1/en not_active Ceased
- 2005-03-17 PL PL05732643T patent/PL1732933T3/pl unknown
- 2005-03-17 BR BRPI0508966-2A patent/BRPI0508966A/pt not_active Application Discontinuation
- 2005-03-17 WO PCT/US2005/009301 patent/WO2005097806A1/en not_active Ceased
- 2005-03-17 CA CA002557010A patent/CA2557010A1/en not_active Abandoned
- 2005-03-17 DK DK05732643T patent/DK1732933T3/da active
- 2005-03-17 US US10/598,473 patent/US7470705B2/en not_active Expired - Fee Related
- 2005-03-17 PT PT05732643T patent/PT1732933E/pt unknown
- 2005-03-17 EP EP05725968A patent/EP1735320B1/en not_active Expired - Lifetime
- 2005-03-17 JP JP2007505054A patent/JP2007530550A/ja active Pending
- 2005-03-17 EA EA200601785A patent/EA200601785A1/ru unknown
- 2005-03-17 SI SI200530352T patent/SI1732933T1/sl unknown
- 2005-03-17 DE DE602005014955T patent/DE602005014955D1/de not_active Expired - Fee Related
- 2005-03-17 ES ES05732643T patent/ES2308477T3/es not_active Expired - Lifetime
- 2005-03-17 AU AU2005230915A patent/AU2005230915A1/en not_active Abandoned
- 2005-03-17 EP EP05732643A patent/EP1732933B1/en not_active Expired - Lifetime
- 2005-03-17 DE DE602005008416T patent/DE602005008416D1/de not_active Expired - Fee Related
- 2005-03-17 ES ES05725968T patent/ES2326326T3/es not_active Expired - Lifetime
- 2005-03-17 US US10/598,686 patent/US20070208003A1/en not_active Abandoned
- 2005-03-17 KR KR1020067019800A patent/KR20070007112A/ko not_active Ceased
-
2006
- 2006-09-07 IL IL177962A patent/IL177962A0/en unknown
- 2006-09-26 EC EC2006006886A patent/ECSP066886A/es unknown
- 2006-10-20 NO NO20064763A patent/NO20064763L/no not_active Application Discontinuation
- 2006-10-23 MA MA29410A patent/MA28550B1/fr unknown
-
2008
- 2008-09-24 CY CY20081101030T patent/CY1110398T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20064763L (no) | 2006-11-22 |
| KR20070007112A (ko) | 2007-01-12 |
| EP1735320A1 (en) | 2006-12-27 |
| BRPI0508966A (pt) | 2007-08-21 |
| DE602005008416D1 (de) | 2008-09-04 |
| US7470705B2 (en) | 2008-12-30 |
| DE602005014955D1 (de) | 2009-07-30 |
| AU2005230915A1 (en) | 2005-10-20 |
| EA200601785A1 (ru) | 2007-02-27 |
| CA2557010A1 (en) | 2005-10-20 |
| JP2007530550A (ja) | 2007-11-01 |
| IL177962A0 (en) | 2006-12-31 |
| DK1732933T3 (da) | 2008-10-27 |
| PT1732933E (pt) | 2008-10-20 |
| US20070208003A1 (en) | 2007-09-06 |
| EP1732933A1 (en) | 2006-12-20 |
| ATE433984T1 (de) | 2009-07-15 |
| WO2005097805A1 (en) | 2005-10-20 |
| ECSP066886A (es) | 2006-11-24 |
| SI1732933T1 (sl) | 2008-10-31 |
| CY1110398T1 (el) | 2015-04-29 |
| ES2326326T3 (es) | 2009-10-07 |
| ATE402180T1 (de) | 2008-08-15 |
| EP1732933B1 (en) | 2008-07-23 |
| WO2005097806A1 (en) | 2005-10-20 |
| MA28550B1 (fr) | 2007-04-03 |
| US20070173526A1 (en) | 2007-07-26 |
| PL1732933T3 (pl) | 2008-12-31 |
| EP1735320B1 (en) | 2009-06-17 |
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