ES2288988T3 - Antagonistas de benzamida-neurokinina ciclados para su uso en terapia. - Google Patents
Antagonistas de benzamida-neurokinina ciclados para su uso en terapia. Download PDFInfo
- Publication number
- ES2288988T3 ES2288988T3 ES01970480T ES01970480T ES2288988T3 ES 2288988 T3 ES2288988 T3 ES 2288988T3 ES 01970480 T ES01970480 T ES 01970480T ES 01970480 T ES01970480 T ES 01970480T ES 2288988 T3 ES2288988 T3 ES 2288988T3
- Authority
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- Prior art keywords
- alkyl
- disorders
- cyano
- carbamoyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical compound C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/22—Eight-membered rings
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- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0003476A SE0003476D0 (sv) | 2000-09-28 | 2000-09-28 | Compounds |
| SE0003476 | 2000-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2288988T3 true ES2288988T3 (es) | 2008-02-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01970480T Expired - Lifetime ES2288988T3 (es) | 2000-09-28 | 2001-09-27 | Antagonistas de benzamida-neurokinina ciclados para su uso en terapia. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6924277B2 (enExample) |
| EP (1) | EP1324992B1 (enExample) |
| JP (1) | JP2004509954A (enExample) |
| AT (1) | ATE369348T1 (enExample) |
| AU (1) | AU2001290480A1 (enExample) |
| DE (1) | DE60129829T2 (enExample) |
| ES (1) | ES2288988T3 (enExample) |
| SE (1) | SE0003476D0 (enExample) |
| WO (1) | WO2002026724A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006013205A1 (en) * | 2004-08-04 | 2006-02-09 | Solvay Pharmaceuticals B.V. | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation |
| US20060030556A1 (en) * | 2004-08-04 | 2006-02-09 | Solvay Pharmaceuticals B.V. | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation, including testosterone deficiency |
| DE102004038134B4 (de) | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| US20060030600A1 (en) * | 2004-08-06 | 2006-02-09 | Patrick Schnider | Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia |
| US20100048713A1 (en) * | 2006-01-06 | 2010-02-25 | Aarhus Universitet | Compounds acting on the serotonin transporter |
| US8093268B2 (en) | 2007-01-24 | 2012-01-10 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-) |
| WO2012061754A2 (en) * | 2010-11-05 | 2012-05-10 | The Broad Institute, Inc. | Compounds and methods for treating autoimmune diseases |
| EP2691391A4 (en) | 2011-03-29 | 2014-09-10 | Broad Inst Inc | COMPOUNDS AND METHODS OF TREATING DISORDERS MEDIATED BY ISOCITRATE DEHYDROGENASE |
| WO2013004766A1 (en) | 2011-07-04 | 2013-01-10 | Ferrari Giulio | Nk-1 receptor antagonists for treating corneal neovascularisation |
| TWI598325B (zh) * | 2012-10-12 | 2017-09-11 | Ｈ 朗德貝克公司 | 苯甲醯胺類 |
| TW201427947A (zh) | 2012-10-12 | 2014-07-16 | Lundbeck & Co As H | 環狀胺 |
| RU2020131446A (ru) | 2018-02-26 | 2022-03-28 | Оспедале Сан Раффаэле С.Р.Л. | Антагонисты nk-1 для применения в лечении глазной боли |
| RU2697414C1 (ru) | 2018-05-11 | 2019-08-14 | Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" | Новый антагонист тахикининовых рецепторов и его применение |
| NZ773110A (en) | 2018-09-18 | 2024-11-29 | Terns Inc | Compounds for treating certain leukemias |
| EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
| KR20240089224A (ko) * | 2021-09-30 | 2024-06-20 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 4-원 융합 고리형 화합물 및 이의 제조방법 및 용도 |
Family Cites Families (9)
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| JP2935541B2 (ja) * | 1990-06-28 | 1999-08-16 | サントリー株式会社 | 縮合複素環化合物 |
| US5525600A (en) * | 1994-11-28 | 1996-06-11 | American Home Products Corporation | (Thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides |
| GB9505084D0 (en) * | 1995-03-14 | 1995-05-03 | Pfizer Ltd | Benzamide derivative |
| US5541179A (en) * | 1995-05-02 | 1996-07-30 | American Home Products Corporation | Tropon-2-one piperazine carboxamides as serotonergic agents |
| US5998439A (en) * | 1996-02-21 | 1999-12-07 | Hoescht Marion Roussel, Inc. | Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
| US5789422A (en) * | 1996-10-28 | 1998-08-04 | Schering Corporation | Substituted arylalkylamines as neurokinin antagonists |
| GB9922521D0 (en) * | 1998-10-07 | 1999-11-24 | Zeneca Ltd | Compounds |
| FR2792835B3 (fr) * | 1999-04-27 | 2001-05-25 | Sanofi Sa | Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression |
| ES2307605T3 (es) * | 2000-04-06 | 2008-12-01 | Astrazeneca Ab | Nuevos antagonistas de neuroquininas para su uso como medicamentos. |
-
2000
- 2000-09-28 SE SE0003476A patent/SE0003476D0/xx unknown
-
2001
- 2001-09-27 US US10/381,755 patent/US6924277B2/en not_active Expired - Fee Related
- 2001-09-27 WO PCT/SE2001/002100 patent/WO2002026724A1/en not_active Ceased
- 2001-09-27 DE DE60129829T patent/DE60129829T2/de not_active Expired - Fee Related
- 2001-09-27 JP JP2002531108A patent/JP2004509954A/ja active Pending
- 2001-09-27 ES ES01970480T patent/ES2288988T3/es not_active Expired - Lifetime
- 2001-09-27 AU AU2001290480A patent/AU2001290480A1/en not_active Abandoned
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- 2001-09-27 EP EP01970480A patent/EP1324992B1/en not_active Expired - Lifetime
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2005
- 2005-04-27 US US11/115,572 patent/US20050192318A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6924277B2 (en) | 2005-08-02 |
| DE60129829T2 (de) | 2008-04-30 |
| DE60129829D1 (de) | 2007-09-20 |
| EP1324992A1 (en) | 2003-07-09 |
| JP2004509954A (ja) | 2004-04-02 |
| EP1324992B1 (en) | 2007-08-08 |
| WO2002026724A1 (en) | 2002-04-04 |
| SE0003476D0 (sv) | 2000-09-28 |
| US20040029850A1 (en) | 2004-02-12 |
| AU2001290480A1 (en) | 2002-04-08 |
| US20050192318A1 (en) | 2005-09-01 |
| ATE369348T1 (de) | 2007-08-15 |
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