JP2004509954A - 治療に用いるための環化したベンズアミドニューロキニンアンタゴニスト - Google Patents
治療に用いるための環化したベンズアミドニューロキニンアンタゴニスト Download PDFInfo
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- JP2004509954A JP2004509954A JP2002531108A JP2002531108A JP2004509954A JP 2004509954 A JP2004509954 A JP 2004509954A JP 2002531108 A JP2002531108 A JP 2002531108A JP 2002531108 A JP2002531108 A JP 2002531108A JP 2004509954 A JP2004509954 A JP 2004509954A
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- alkyl
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- alkylcarbamoyl
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- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
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- 229960003733 phenylephrine hydrochloride Drugs 0.000 description 1
- OCYSGIYOVXAGKQ-FVGYRXGTSA-N phenylephrine hydrochloride Chemical compound [H+].[Cl-].CNC[C@H](O)C1=CC=CC(O)=C1 OCYSGIYOVXAGKQ-FVGYRXGTSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- 239000002504 physiological saline solution Substances 0.000 description 1
- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
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- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- ZHNFLHYOFXQIOW-LPYZJUEESA-N quinine sulfate dihydrate Chemical compound [H+].[H+].O.O.[O-]S([O-])(=O)=O.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 ZHNFLHYOFXQIOW-LPYZJUEESA-N 0.000 description 1
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- 239000002002 slurry Substances 0.000 description 1
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- 230000003595 spectral effect Effects 0.000 description 1
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- 239000012258 stirred mixture Substances 0.000 description 1
- 108010078913 substance P (6-11) Proteins 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- 229950000244 sulfanilic acid Drugs 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
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- LJJKNPQAGWVLDQ-SNVBAGLBSA-N thiorphan Chemical compound OC(=O)CNC(=O)[C@@H](CS)CC1=CC=CC=C1 LJJKNPQAGWVLDQ-SNVBAGLBSA-N 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/22—Eight-membered rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
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- Addiction (AREA)
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- Endocrinology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0003476A SE0003476D0 (sv) | 2000-09-28 | 2000-09-28 | Compounds |
| PCT/SE2001/002100 WO2002026724A1 (en) | 2000-09-28 | 2001-09-27 | Cyclized benzamide neurokinin antagonists for use in therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004509954A true JP2004509954A (ja) | 2004-04-02 |
| JP2004509954A5 JP2004509954A5 (enExample) | 2008-11-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2002531108A Pending JP2004509954A (ja) | 2000-09-28 | 2001-09-27 | 治療に用いるための環化したベンズアミドニューロキニンアンタゴニスト |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6924277B2 (enExample) |
| EP (1) | EP1324992B1 (enExample) |
| JP (1) | JP2004509954A (enExample) |
| AT (1) | ATE369348T1 (enExample) |
| AU (1) | AU2001290480A1 (enExample) |
| DE (1) | DE60129829T2 (enExample) |
| ES (1) | ES2288988T3 (enExample) |
| SE (1) | SE0003476D0 (enExample) |
| WO (1) | WO2002026724A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008509103A (ja) * | 2004-08-06 | 2008-03-27 | エフ．ホフマン−ラ ロシュ アーゲー | 統合失調症に対するｎｋ１／ｎｋ３二重アンタゴニスト |
| JP2015534576A (ja) * | 2012-10-12 | 2015-12-03 | ハー・ルンドベック・アクチエゼルスカベット | ベンズアミド |
| US10124010B2 (en) | 2012-10-12 | 2018-11-13 | Mindimmune Therapeutics, Inc. | Cyclic amines |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006013205A1 (en) * | 2004-08-04 | 2006-02-09 | Solvay Pharmaceuticals B.V. | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation |
| US20060030556A1 (en) * | 2004-08-04 | 2006-02-09 | Solvay Pharmaceuticals B.V. | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation, including testosterone deficiency |
| DE102004038134B4 (de) | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
| US20100048713A1 (en) * | 2006-01-06 | 2010-02-25 | Aarhus Universitet | Compounds acting on the serotonin transporter |
| US8093268B2 (en) | 2007-01-24 | 2012-01-10 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-) |
| WO2012061754A2 (en) * | 2010-11-05 | 2012-05-10 | The Broad Institute, Inc. | Compounds and methods for treating autoimmune diseases |
| EP2691391A4 (en) | 2011-03-29 | 2014-09-10 | Broad Inst Inc | COMPOUNDS AND METHODS OF TREATING DISORDERS MEDIATED BY ISOCITRATE DEHYDROGENASE |
| WO2013004766A1 (en) | 2011-07-04 | 2013-01-10 | Ferrari Giulio | Nk-1 receptor antagonists for treating corneal neovascularisation |
| RU2020131446A (ru) | 2018-02-26 | 2022-03-28 | Оспедале Сан Раффаэле С.Р.Л. | Антагонисты nk-1 для применения в лечении глазной боли |
| RU2697414C1 (ru) | 2018-05-11 | 2019-08-14 | Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" | Новый антагонист тахикининовых рецепторов и его применение |
| NZ773110A (en) | 2018-09-18 | 2024-11-29 | Terns Inc | Compounds for treating certain leukemias |
| EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
| KR20240089224A (ko) * | 2021-09-30 | 2024-06-20 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 4-원 융합 고리형 화합물 및 이의 제조방법 및 용도 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0459775A (ja) * | 1990-06-28 | 1992-02-26 | Suntory Ltd | 縮合複素環化合物 |
| WO1996028158A1 (en) * | 1995-03-14 | 1996-09-19 | Pfizer Limited | Benzamide derivative for treating incontinence |
| WO2000020389A1 (en) * | 1998-10-07 | 2000-04-13 | Astrazeneca Ab | Naphthalenecarboxamides as tachykinin receptor antagonists |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525600A (en) * | 1994-11-28 | 1996-06-11 | American Home Products Corporation | (Thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides |
| US5541179A (en) * | 1995-05-02 | 1996-07-30 | American Home Products Corporation | Tropon-2-one piperazine carboxamides as serotonergic agents |
| US5998439A (en) * | 1996-02-21 | 1999-12-07 | Hoescht Marion Roussel, Inc. | Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
| US5789422A (en) * | 1996-10-28 | 1998-08-04 | Schering Corporation | Substituted arylalkylamines as neurokinin antagonists |
| FR2792835B3 (fr) * | 1999-04-27 | 2001-05-25 | Sanofi Sa | Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression |
| ES2307605T3 (es) * | 2000-04-06 | 2008-12-01 | Astrazeneca Ab | Nuevos antagonistas de neuroquininas para su uso como medicamentos. |
-
2000
- 2000-09-28 SE SE0003476A patent/SE0003476D0/xx unknown
-
2001
- 2001-09-27 US US10/381,755 patent/US6924277B2/en not_active Expired - Fee Related
- 2001-09-27 WO PCT/SE2001/002100 patent/WO2002026724A1/en not_active Ceased
- 2001-09-27 DE DE60129829T patent/DE60129829T2/de not_active Expired - Fee Related
- 2001-09-27 JP JP2002531108A patent/JP2004509954A/ja active Pending
- 2001-09-27 ES ES01970480T patent/ES2288988T3/es not_active Expired - Lifetime
- 2001-09-27 AU AU2001290480A patent/AU2001290480A1/en not_active Abandoned
- 2001-09-27 AT AT01970480T patent/ATE369348T1/de not_active IP Right Cessation
- 2001-09-27 EP EP01970480A patent/EP1324992B1/en not_active Expired - Lifetime
-
2005
- 2005-04-27 US US11/115,572 patent/US20050192318A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0459775A (ja) * | 1990-06-28 | 1992-02-26 | Suntory Ltd | 縮合複素環化合物 |
| WO1996028158A1 (en) * | 1995-03-14 | 1996-09-19 | Pfizer Limited | Benzamide derivative for treating incontinence |
| WO2000020389A1 (en) * | 1998-10-07 | 2000-04-13 | Astrazeneca Ab | Naphthalenecarboxamides as tachykinin receptor antagonists |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008509103A (ja) * | 2004-08-06 | 2008-03-27 | エフ．ホフマン−ラ ロシュ アーゲー | 統合失調症に対するｎｋ１／ｎｋ３二重アンタゴニスト |
| JP2015534576A (ja) * | 2012-10-12 | 2015-12-03 | ハー・ルンドベック・アクチエゼルスカベット | ベンズアミド |
| US10124010B2 (en) | 2012-10-12 | 2018-11-13 | Mindimmune Therapeutics, Inc. | Cyclic amines |
Also Published As
| Publication number | Publication date |
|---|---|
| US6924277B2 (en) | 2005-08-02 |
| DE60129829T2 (de) | 2008-04-30 |
| DE60129829D1 (de) | 2007-09-20 |
| EP1324992A1 (en) | 2003-07-09 |
| ES2288988T3 (es) | 2008-02-01 |
| EP1324992B1 (en) | 2007-08-08 |
| WO2002026724A1 (en) | 2002-04-04 |
| SE0003476D0 (sv) | 2000-09-28 |
| US20040029850A1 (en) | 2004-02-12 |
| AU2001290480A1 (en) | 2002-04-08 |
| US20050192318A1 (en) | 2005-09-01 |
| ATE369348T1 (de) | 2007-08-15 |
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