ES2271102T3 - Un procedimiento para la preparacion de acido 1-(aminometil) ciclohexanacetico. - Google Patents

Un procedimiento para la preparacion de acido 1-(aminometil) ciclohexanacetico. Download PDF

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Publication number
ES2271102T3
ES2271102T3 ES01990454T ES01990454T ES2271102T3 ES 2271102 T3 ES2271102 T3 ES 2271102T3 ES 01990454 T ES01990454 T ES 01990454T ES 01990454 T ES01990454 T ES 01990454T ES 2271102 T3 ES2271102 T3 ES 2271102T3
Authority
ES
Spain
Prior art keywords
gabapentin
hydrochloride
amine
alcohol
procedure according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01990454T
Other languages
English (en)
Spanish (es)
Inventor
Massimo Ferrari
Marcello Ghezzi
Paolo Belotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Erregierre SpA
Original Assignee
Erregierre SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erregierre SpA filed Critical Erregierre SpA
Application granted granted Critical
Publication of ES2271102T3 publication Critical patent/ES2271102T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES01990454T 2000-12-01 2001-11-29 Un procedimiento para la preparacion de acido 1-(aminometil) ciclohexanacetico. Expired - Lifetime ES2271102T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI00A2608 2000-12-01
IT2000MI002608A IT1319674B1 (it) 2000-12-01 2000-12-01 Processo per la preparazione dell'acido1-(aminometil)cicloesanacetico.

Publications (1)

Publication Number Publication Date
ES2271102T3 true ES2271102T3 (es) 2007-04-16

Family

ID=11446165

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01990454T Expired - Lifetime ES2271102T3 (es) 2000-12-01 2001-11-29 Un procedimiento para la preparacion de acido 1-(aminometil) ciclohexanacetico.

Country Status (19)

Country Link
US (1) US7393974B2 (https=)
EP (1) EP1347951B1 (https=)
JP (1) JP2004521875A (https=)
AT (1) ATE339400T1 (https=)
AU (2) AU2002229575B2 (https=)
BR (1) BR0115755A (https=)
CA (1) CA2436908A1 (https=)
DE (1) DE60123125T2 (https=)
ES (1) ES2271102T3 (https=)
HR (1) HRP20030438A2 (https=)
HU (1) HU228047B1 (https=)
IL (2) IL156185A0 (https=)
IT (1) IT1319674B1 (https=)
MX (1) MXPA03004775A (https=)
NZ (1) NZ526370A (https=)
PL (1) PL361886A1 (https=)
RU (1) RU2289572C2 (https=)
WO (1) WO2002044123A1 (https=)
ZA (1) ZA200304484B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2472815A1 (en) 2002-11-18 2004-06-03 Nicholas Piramal India Limited Improved process for preparation of gabapentin
EP1603863B1 (en) 2002-11-20 2010-01-13 Hikal Ltd. Process for the preparation of amino methyl cyclo alkane acetic acids
US7439387B2 (en) 2003-04-21 2008-10-21 Matrix Laboratories Ltd. Process for the preparation of Gabapentin form-II
WO2004101489A1 (en) * 2003-05-19 2004-11-25 Shasun Chemicals And Drugs Limited Process for the preparation of gabapentin
ITMI20042418A1 (it) * 2004-12-17 2005-03-17 Zambon Spa Processo per la purificazione della gabapentina
US7071356B1 (en) 2005-12-01 2006-07-04 Isp Investments Inc. Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
WO2009015685A1 (en) 2007-07-27 2009-02-05 Medichem, S.A. Method for preparing polymorph form ii of gabapentin
EP2368872A1 (en) 2010-03-25 2011-09-28 Serichim S.r.l. Process for the preparation of Gabapentin
ITMI20131757A1 (it) 2013-10-22 2015-04-23 Zach System Spa Processo di preparazione di gabapentina
EP3018127A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
EP3018131A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4960931A (en) 1988-05-02 1990-10-02 Warner-Lambert Company Gabapentin mohohydrate and a process for producing the same
DE3928184A1 (de) 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
FI905584A7 (fi) * 1989-11-16 1991-05-17 Lonza Ag Menetelmä 1-(aminometyyli)sykloheksaanietikkahapon valmistamiseksi
IL119890A (en) * 1996-12-24 2002-03-10 Teva Pharma Gabapentin form iii and preparation of gabapentin form ii
US6255526B1 (en) * 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin

Also Published As

Publication number Publication date
IL156185A0 (en) 2003-12-23
HUP0302642A3 (en) 2010-01-28
WO2002044123A1 (en) 2002-06-06
BR0115755A (pt) 2003-12-30
EP1347951B1 (en) 2006-09-13
EP1347951A1 (en) 2003-10-01
IL156185A (en) 2008-08-07
AU2002229575B2 (en) 2006-12-07
NZ526370A (en) 2003-08-29
ATE339400T1 (de) 2006-10-15
AU2957502A (en) 2002-06-11
IT1319674B1 (it) 2003-10-23
HUP0302642A2 (hu) 2003-11-28
DE60123125T2 (de) 2007-03-01
DE60123125D1 (de) 2006-10-26
CA2436908A1 (en) 2002-06-06
ITMI20002608A1 (it) 2002-06-01
ZA200304484B (en) 2004-09-09
HRP20030438A2 (en) 2004-08-31
JP2004521875A (ja) 2004-07-22
HU228047B1 (en) 2012-09-28
PL361886A1 (en) 2004-10-04
RU2289572C2 (ru) 2006-12-20
MXPA03004775A (es) 2004-12-03
US7393974B2 (en) 2008-07-01
US20050049432A1 (en) 2005-03-03

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