HUP0302642A2 - Eljárás N,N'-szubsztituált 5-amino-1,3-benzol-dikarboxamidok előállítására - Google Patents

Eljárás N,N'-szubsztituált 5-amino-1,3-benzol-dikarboxamidok előállítására

Info

Publication number
HUP0302642A2
HUP0302642A2 HU0302642A HUP0302642A HUP0302642A2 HU P0302642 A2 HUP0302642 A2 HU P0302642A2 HU 0302642 A HU0302642 A HU 0302642A HU P0302642 A HUP0302642 A HU P0302642A HU P0302642 A2 HUP0302642 A2 HU P0302642A2
Authority
HU
Hungary
Prior art keywords
general formula
formula
dihydroxy
compounds
benzenedicarboxamides
Prior art date
Application number
HU0302642A
Other languages
English (en)
Inventor
Pier Lucio Anelli
Marino Brocchetta
Enrico Cappelletti
Giovanna Lux
Original Assignee
Bracco Imaging S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging S.P.A. filed Critical Bracco Imaging S.P.A.
Priority claimed from PCT/EP2001/013879 external-priority patent/WO2002044125A1/en
Publication of HUP0302642A2 publication Critical patent/HUP0302642A2/hu
Publication of HUP0302642A3 publication Critical patent/HUP0302642A3/hu
Publication of HU228047B1 publication Critical patent/HU228047B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya eljárás (I) általános képletű vegyületekelőállítására - a képletben R jelentés; 2,3-dihidroxi-l-propil- vagy1,3-dihidroxi-2-propil-csoport - oly módon, hogy egy (V) általánosképletű 5-amino-benzoldikarbonsav-dialkil-észtert - a képletben R1jelentése egyenes vagy elágazó láncú 1-4 szénatomos alkilcsoport -legalább 2 mol mennyiségű H2NR általános képletű aminnal - a képletbenR jelentése a fenti - reagáltatnak. A találmány vonatkozik továbbá az(I) általános képletű vegyületek intermedierként való alkalmazásávalkülönböző röntgen kontrasztanyagok, így iopamidolt, iohexolt,ioverzolt és iomeprolt előállítási eljárásra is. Ó
HU0302642A 2000-12-01 2001-11-28 A process for the preparation of n,n'-substituted 5-amino-1,3-benzenedicarboxamides HU228047B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI002608A IT1319674B1 (it) 2000-12-01 2000-12-01 Processo per la preparazione dell'acido1-(aminometil)cicloesanacetico.
PCT/EP2001/013879 WO2002044125A1 (en) 2000-12-01 2001-11-28 A process for the preparation of n,n'-substituted 5-amino-1,3-benzenedicarboxamides

Publications (3)

Publication Number Publication Date
HUP0302642A2 true HUP0302642A2 (hu) 2003-11-28
HUP0302642A3 HUP0302642A3 (en) 2010-01-28
HU228047B1 HU228047B1 (en) 2012-09-28

Family

ID=11446165

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302642A HU228047B1 (en) 2000-12-01 2001-11-28 A process for the preparation of n,n'-substituted 5-amino-1,3-benzenedicarboxamides

Country Status (19)

Country Link
US (1) US7393974B2 (hu)
EP (1) EP1347951B1 (hu)
JP (1) JP2004521875A (hu)
AT (1) ATE339400T1 (hu)
AU (2) AU2957502A (hu)
BR (1) BR0115755A (hu)
CA (1) CA2436908A1 (hu)
DE (1) DE60123125T2 (hu)
ES (1) ES2271102T3 (hu)
HR (1) HRP20030438A2 (hu)
HU (1) HU228047B1 (hu)
IL (2) IL156185A0 (hu)
IT (1) IT1319674B1 (hu)
MX (1) MXPA03004775A (hu)
NZ (1) NZ526370A (hu)
PL (1) PL361886A1 (hu)
RU (1) RU2289572C2 (hu)
WO (1) WO2002044123A1 (hu)
ZA (1) ZA200304484B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196216B2 (en) 2002-11-18 2007-03-27 Nicholas Piramal India Limited Process for preparation of Gabapentin
ES2339756T3 (es) 2002-11-20 2010-05-25 Hikal Ltd. Procedimiento mejorado para la preparacion de acidos aminometilcicloalcanaceticos.
US7439387B2 (en) 2003-04-21 2008-10-21 Matrix Laboratories Ltd. Process for the preparation of Gabapentin form-II
AU2003259544A1 (en) * 2003-05-19 2004-12-03 Shasun Chemicals And Drugs Limited Process for the preparation of gabapentin
ITMI20042418A1 (it) * 2004-12-17 2005-03-17 Zambon Spa Processo per la purificazione della gabapentina
US7071356B1 (en) 2005-12-01 2006-07-04 Isp Investments Inc. Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
EP2183211A1 (en) 2007-07-27 2010-05-12 Medichem, S.A. Method for preparing polymorph form ii of gabapentin
EP2368872A1 (en) 2010-03-25 2011-09-28 Serichim S.r.l. Process for the preparation of Gabapentin
ITMI20131757A1 (it) 2013-10-22 2015-04-23 Zach System Spa Processo di preparazione di gabapentina
EP3018131A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
EP3018127A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (de) 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4960931A (en) 1988-05-02 1990-10-02 Warner-Lambert Company Gabapentin mohohydrate and a process for producing the same
DE3928184A1 (de) 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
US6255526B1 (en) * 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
IL119890A (en) * 1996-12-24 2002-03-10 Teva Pharma Gabapentin form iii and preparation of gabapentin form ii

Also Published As

Publication number Publication date
HU228047B1 (en) 2012-09-28
NZ526370A (en) 2003-08-29
IL156185A (en) 2008-08-07
IL156185A0 (en) 2003-12-23
US7393974B2 (en) 2008-07-01
US20050049432A1 (en) 2005-03-03
AU2957502A (en) 2002-06-11
HUP0302642A3 (en) 2010-01-28
DE60123125T2 (de) 2007-03-01
IT1319674B1 (it) 2003-10-23
ITMI20002608A1 (it) 2002-06-01
RU2289572C2 (ru) 2006-12-20
HRP20030438A2 (en) 2004-08-31
WO2002044123A1 (en) 2002-06-06
EP1347951B1 (en) 2006-09-13
AU2002229575B2 (en) 2006-12-07
BR0115755A (pt) 2003-12-30
CA2436908A1 (en) 2002-06-06
ATE339400T1 (de) 2006-10-15
DE60123125D1 (de) 2006-10-26
JP2004521875A (ja) 2004-07-22
ZA200304484B (en) 2004-09-09
EP1347951A1 (en) 2003-10-01
PL361886A1 (en) 2004-10-04
MXPA03004775A (es) 2004-12-03
ES2271102T3 (es) 2007-04-16

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