AU2002229575B2 - A process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid - Google Patents

A process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid Download PDF

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Publication number
AU2002229575B2
AU2002229575B2 AU2002229575A AU2002229575A AU2002229575B2 AU 2002229575 B2 AU2002229575 B2 AU 2002229575B2 AU 2002229575 A AU2002229575 A AU 2002229575A AU 2002229575 A AU2002229575 A AU 2002229575A AU 2002229575 B2 AU2002229575 B2 AU 2002229575B2
Authority
AU
Australia
Prior art keywords
gabapentin
hydrochloride
process according
amine
stage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002229575A
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English (en)
Other versions
AU2002229575A1 (en
Inventor
Paolo Belotti
Massimo Ferrari
Marcello Ghezzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Erregierre SpA
Original Assignee
Erregierre SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erregierre SpA filed Critical Erregierre SpA
Publication of AU2002229575A1 publication Critical patent/AU2002229575A1/en
Application granted granted Critical
Publication of AU2002229575B2 publication Critical patent/AU2002229575B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2002229575A 2000-12-01 2001-11-29 A process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid Ceased AU2002229575B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI00A2608 2000-12-01
IT2000MI002608A IT1319674B1 (it) 2000-12-01 2000-12-01 Processo per la preparazione dell'acido1-(aminometil)cicloesanacetico.
PCT/EP2001/013953 WO2002044123A1 (en) 2000-12-01 2001-11-29 A process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid

Publications (2)

Publication Number Publication Date
AU2002229575A1 AU2002229575A1 (en) 2002-08-15
AU2002229575B2 true AU2002229575B2 (en) 2006-12-07

Family

ID=11446165

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002229575A Ceased AU2002229575B2 (en) 2000-12-01 2001-11-29 A process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
AU2957502A Pending AU2957502A (en) 2000-12-01 2001-11-29 A process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2957502A Pending AU2957502A (en) 2000-12-01 2001-11-29 A process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid

Country Status (19)

Country Link
US (1) US7393974B2 (https=)
EP (1) EP1347951B1 (https=)
JP (1) JP2004521875A (https=)
AT (1) ATE339400T1 (https=)
AU (2) AU2002229575B2 (https=)
BR (1) BR0115755A (https=)
CA (1) CA2436908A1 (https=)
DE (1) DE60123125T2 (https=)
ES (1) ES2271102T3 (https=)
HR (1) HRP20030438A2 (https=)
HU (1) HU228047B1 (https=)
IL (2) IL156185A0 (https=)
IT (1) IT1319674B1 (https=)
MX (1) MXPA03004775A (https=)
NZ (1) NZ526370A (https=)
PL (1) PL361886A1 (https=)
RU (1) RU2289572C2 (https=)
WO (1) WO2002044123A1 (https=)
ZA (1) ZA200304484B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2472815A1 (en) 2002-11-18 2004-06-03 Nicholas Piramal India Limited Improved process for preparation of gabapentin
EP1603863B1 (en) 2002-11-20 2010-01-13 Hikal Ltd. Process for the preparation of amino methyl cyclo alkane acetic acids
US7439387B2 (en) 2003-04-21 2008-10-21 Matrix Laboratories Ltd. Process for the preparation of Gabapentin form-II
WO2004101489A1 (en) * 2003-05-19 2004-11-25 Shasun Chemicals And Drugs Limited Process for the preparation of gabapentin
ITMI20042418A1 (it) * 2004-12-17 2005-03-17 Zambon Spa Processo per la purificazione della gabapentina
US7071356B1 (en) 2005-12-01 2006-07-04 Isp Investments Inc. Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
WO2009015685A1 (en) 2007-07-27 2009-02-05 Medichem, S.A. Method for preparing polymorph form ii of gabapentin
EP2368872A1 (en) 2010-03-25 2011-09-28 Serichim S.r.l. Process for the preparation of Gabapentin
ITMI20131757A1 (it) 2013-10-22 2015-04-23 Zach System Spa Processo di preparazione di gabapentina
EP3018127A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
EP3018131A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028255A1 (en) * 1996-12-24 1998-07-02 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4960931A (en) 1988-05-02 1990-10-02 Warner-Lambert Company Gabapentin mohohydrate and a process for producing the same
DE3928184A1 (de) 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
FI905584A7 (fi) * 1989-11-16 1991-05-17 Lonza Ag Menetelmä 1-(aminometyyli)sykloheksaanietikkahapon valmistamiseksi
US6255526B1 (en) * 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028255A1 (en) * 1996-12-24 1998-07-02 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin

Also Published As

Publication number Publication date
IL156185A0 (en) 2003-12-23
HUP0302642A3 (en) 2010-01-28
WO2002044123A1 (en) 2002-06-06
BR0115755A (pt) 2003-12-30
EP1347951B1 (en) 2006-09-13
EP1347951A1 (en) 2003-10-01
IL156185A (en) 2008-08-07
ES2271102T3 (es) 2007-04-16
NZ526370A (en) 2003-08-29
ATE339400T1 (de) 2006-10-15
AU2957502A (en) 2002-06-11
IT1319674B1 (it) 2003-10-23
HUP0302642A2 (hu) 2003-11-28
DE60123125T2 (de) 2007-03-01
DE60123125D1 (de) 2006-10-26
CA2436908A1 (en) 2002-06-06
ITMI20002608A1 (it) 2002-06-01
ZA200304484B (en) 2004-09-09
HRP20030438A2 (en) 2004-08-31
JP2004521875A (ja) 2004-07-22
HU228047B1 (en) 2012-09-28
PL361886A1 (en) 2004-10-04
RU2289572C2 (ru) 2006-12-20
MXPA03004775A (es) 2004-12-03
US7393974B2 (en) 2008-07-01
US20050049432A1 (en) 2005-03-03

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired