ES2270981T3 - Procedimiento de tratamiento de la neurodegeneracion. - Google Patents
Procedimiento de tratamiento de la neurodegeneracion. Download PDFInfo
- Publication number
- ES2270981T3 ES2270981T3 ES01906242T ES01906242T ES2270981T3 ES 2270981 T3 ES2270981 T3 ES 2270981T3 ES 01906242 T ES01906242 T ES 01906242T ES 01906242 T ES01906242 T ES 01906242T ES 2270981 T3 ES2270981 T3 ES 2270981T3
- Authority
- ES
- Spain
- Prior art keywords
- nefiracetam
- stroke
- post
- improvement
- recovery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 20
- 230000004770 neurodegeneration Effects 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title description 2
- NGHTXZCKLWZPGK-UHFFFAOYSA-N nefiracetam Chemical compound CC1=CC=CC(C)=C1NC(=O)CN1C(=O)CCC1 NGHTXZCKLWZPGK-UHFFFAOYSA-N 0.000 claims abstract description 68
- 229950004663 nefiracetam Drugs 0.000 claims abstract description 65
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- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 208000006011 Stroke Diseases 0.000 claims description 43
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- 230000006872 improvement Effects 0.000 claims description 23
- 238000011084 recovery Methods 0.000 claims description 23
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- IHLAQQPQKRMGSS-UHFFFAOYSA-N oxiracetam Chemical compound NC(=O)CN1CC(O)CC1=O IHLAQQPQKRMGSS-UHFFFAOYSA-N 0.000 description 2
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- 230000002555 anti-neurodegenerative effect Effects 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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- 230000001777 nootropic effect Effects 0.000 description 1
- 239000008203 oral pharmaceutical composition Substances 0.000 description 1
- 229960001227 oxiracetam Drugs 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 229960004526 piracetam Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical class O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51195200A | 2000-02-23 | 2000-02-23 | |
| US511952 | 2000-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2270981T3 true ES2270981T3 (es) | 2007-04-16 |
Family
ID=24037094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01906242T Expired - Lifetime ES2270981T3 (es) | 2000-02-23 | 2001-02-23 | Procedimiento de tratamiento de la neurodegeneracion. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6423739B1 (enExample) |
| EP (1) | EP1171123B1 (enExample) |
| JP (1) | JP2003523385A (enExample) |
| KR (1) | KR20010110798A (enExample) |
| CN (1) | CN1362877A (enExample) |
| AR (1) | AR030551A1 (enExample) |
| AT (1) | ATE336246T1 (enExample) |
| AU (1) | AU784418B2 (enExample) |
| BR (1) | BR0104586A (enExample) |
| CA (1) | CA2368352C (enExample) |
| DE (1) | DE60122252T2 (enExample) |
| DK (1) | DK1171123T3 (enExample) |
| ES (1) | ES2270981T3 (enExample) |
| HK (1) | HK1047038A1 (enExample) |
| ID (1) | ID30377A (enExample) |
| IL (1) | IL145799A (enExample) |
| MX (1) | MXPA01010749A (enExample) |
| NO (1) | NO321911B1 (enExample) |
| TW (1) | TWI289060B (enExample) |
| WO (1) | WO2001062246A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077709A1 (en) * | 1999-05-31 | 2004-04-22 | Daiichi Pharmaceutical Co., Ltd. | Neuronal death inhibitors |
| CN1484527A (zh) * | 2000-12-28 | 2004-03-24 | ��һ��������ҩ��ʽ���� | 神经性疼痛治疗和预防药 |
| US20040192759A1 (en) * | 2001-08-22 | 2004-09-30 | Eiichi Otomo | Use of nefiracetam for treating neurodegeneration |
| RU2205631C1 (ru) * | 2002-06-19 | 2003-06-10 | Закрытое акционерное общество "Брынцалов-А" | Ноотропное средство "ноотобрил" в форме таблеток |
| US20060241144A1 (en) * | 2005-04-20 | 2006-10-26 | Albert Cha | Method for treating apathy syndrome |
| ES2664727T3 (es) | 2009-10-22 | 2018-04-23 | University College Dublin National University Of Ireland, Dublin | Terapia causal de enfermedades o estados asociados con desmielinización del SNC o del SNP |
| RU2480214C1 (ru) * | 2011-09-22 | 2013-04-27 | Валентина Ивановна Ахапкина | Состав, обладающий модуляторной активностью с соразмерным влиянием, фармацевтическая субстанция (варианты), применение фармацевтической субстанции, фармацевтическая и парафармацевтическая композиция (варианты), способ получения фармацевтических составов |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2469995A (en) * | 1946-07-23 | 1949-05-10 | Schaul Martin Carl | Process for the production of food preparations from potatoes and similar farinaceoustubers |
| US3031314A (en) * | 1960-03-16 | 1962-04-24 | Carl E Hendel | Preparation of dehydrated potatoes |
| US3260607A (en) * | 1961-02-07 | 1966-07-12 | Canadian Patents Dev | Preparation of dehydrated cooked mashed potato |
| US3968265A (en) * | 1973-02-01 | 1976-07-06 | American Potato Company | Freeze-thaw stable, french fry potato product and process for producing the same |
| DE2924011C2 (de) | 1979-06-13 | 1982-04-08 | A. Nattermann & Cie GmbH, 5000 Köln | Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten |
| DE2923975A1 (de) | 1979-06-13 | 1980-12-18 | Nattermann A & Cie | Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| IT1141287B (it) | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
| SK279285B6 (sk) | 1991-05-02 | 1998-09-09 | Daiichi Pharmaceutical Co. | Použitie n-(2,6-dimetylfenyl)-2-(2-oxo-1-pyrolidin |
| US5525058A (en) | 1992-03-27 | 1996-06-11 | American Dental Technologies, Inc. | Dental treatment system |
| KR100232929B1 (ko) | 1995-07-10 | 1999-12-01 | 히로지 코데라 | 가공 선재의 접속 장치 |
| US6107330A (en) | 1995-08-07 | 2000-08-22 | Daiichi Pharmaceutical Co., Ltd. | Inhibitor for narcotic analgesic dependence/resistance acquisition |
| JP2002241272A (ja) | 1996-07-18 | 2002-08-28 | Mitsubishi Pharma Corp | 医薬処方組成物 |
| ES2185963T3 (es) | 1996-07-30 | 2003-05-01 | Ecolab Gmbh & Co Ohg | Agente filmogeno para la proteccion contra infecciones. |
| EP0953356A4 (en) | 1996-10-01 | 2002-04-17 | Daiichi Seiyaku Co | MITOCHONDRIAL MEMBRANE STABILIZER |
| US6211701B1 (en) | 1996-12-16 | 2001-04-03 | Rose Research, Llc | Low power line switching circuit, device and method |
| IT1293533B1 (it) | 1997-07-14 | 1999-03-01 | Angeletti P Ist Richerche Bio | Metodo per la selezione di molecole in grado di mimare, inibire o potenziare gli effetti della interazione tra leptina e cellule che |
| AU8131198A (en) | 1997-07-15 | 1999-02-10 | Daiichi Pharmaceutical Co., Ltd. | Prophylactic or therapeutic agent for amnesia |
| JPH1180027A (ja) | 1997-09-12 | 1999-03-23 | Dai Ichi Seiyaku Co Ltd | 向知性薬 |
| AR020115A1 (es) | 1998-08-06 | 2002-04-10 | Daiichi Seiyaku Co | Agente terapeutico o preventivo para epilepsias rebeldes y uso del compuesto para la produccion de los mismos |
| KR20020015321A (ko) | 1999-05-31 | 2002-02-27 | 스즈키 다다시 | 신경 세포사 억제제 |
-
2001
- 2001-02-16 US US09/784,048 patent/US6423739B1/en not_active Expired - Fee Related
- 2001-02-21 AR ARP010100761A patent/AR030551A1/es unknown
- 2001-02-23 HK HK02108589.8A patent/HK1047038A1/zh unknown
- 2001-02-23 ID IDW00200102283A patent/ID30377A/id unknown
- 2001-02-23 EP EP01906242A patent/EP1171123B1/en not_active Expired - Lifetime
- 2001-02-23 WO PCT/JP2001/001342 patent/WO2001062246A1/en not_active Ceased
- 2001-02-23 KR KR1020017013542A patent/KR20010110798A/ko not_active Ceased
- 2001-02-23 ES ES01906242T patent/ES2270981T3/es not_active Expired - Lifetime
- 2001-02-23 IL IL145799A patent/IL145799A/en not_active IP Right Cessation
- 2001-02-23 BR BR0104586-5A patent/BR0104586A/pt not_active Application Discontinuation
- 2001-02-23 AU AU34145/01A patent/AU784418B2/en not_active Ceased
- 2001-02-23 CA CA002368352A patent/CA2368352C/en not_active Expired - Fee Related
- 2001-02-23 AT AT01906242T patent/ATE336246T1/de not_active IP Right Cessation
- 2001-02-23 DK DK01906242T patent/DK1171123T3/da active
- 2001-02-23 TW TW090104150A patent/TWI289060B/zh not_active IP Right Cessation
- 2001-02-23 MX MXPA01010749A patent/MXPA01010749A/es active IP Right Grant
- 2001-02-23 JP JP2001561312A patent/JP2003523385A/ja active Pending
- 2001-02-23 CN CN01800298A patent/CN1362877A/zh active Pending
- 2001-02-23 DE DE60122252T patent/DE60122252T2/de not_active Expired - Lifetime
- 2001-07-17 US US09/906,077 patent/US6399650B2/en not_active Expired - Fee Related
- 2001-10-22 NO NO20015162A patent/NO321911B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20020055534A1 (en) | 2002-05-09 |
| IL145799A (en) | 2006-10-31 |
| AU3414501A (en) | 2001-09-03 |
| BR0104586A (pt) | 2002-01-08 |
| DK1171123T3 (da) | 2006-12-04 |
| ID30377A (id) | 2001-11-29 |
| IL145799A0 (en) | 2002-07-25 |
| WO2001062246A1 (en) | 2001-08-30 |
| KR20010110798A (ko) | 2001-12-13 |
| AU784418B2 (en) | 2006-03-30 |
| NO20015162L (no) | 2001-12-21 |
| AR030551A1 (es) | 2003-08-27 |
| DE60122252T2 (de) | 2007-07-05 |
| US6399650B2 (en) | 2002-06-04 |
| CN1362877A (zh) | 2002-08-07 |
| NO321911B1 (no) | 2006-07-17 |
| DE60122252D1 (de) | 2006-09-28 |
| JP2003523385A (ja) | 2003-08-05 |
| EP1171123A1 (en) | 2002-01-16 |
| US6423739B1 (en) | 2002-07-23 |
| HK1047038A1 (zh) | 2003-02-07 |
| CA2368352A1 (en) | 2001-08-30 |
| ATE336246T1 (de) | 2006-09-15 |
| TWI289060B (en) | 2007-11-01 |
| CA2368352C (en) | 2009-11-10 |
| NO20015162D0 (no) | 2001-10-22 |
| MXPA01010749A (es) | 2002-08-20 |
| EP1171123B1 (en) | 2006-08-16 |
| US20010051653A1 (en) | 2001-12-13 |
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