KR20010110798A - 신경퇴화의 치료방법 - Google Patents
신경퇴화의 치료방법 Download PDFInfo
- Publication number
- KR20010110798A KR20010110798A KR1020017013542A KR20017013542A KR20010110798A KR 20010110798 A KR20010110798 A KR 20010110798A KR 1020017013542 A KR1020017013542 A KR 1020017013542A KR 20017013542 A KR20017013542 A KR 20017013542A KR 20010110798 A KR20010110798 A KR 20010110798A
- Authority
- KR
- South Korea
- Prior art keywords
- stroke
- nepyracetam
- pharmaceutical composition
- patient
- neurodegeneration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000004770 neurodegeneration Effects 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims description 18
- 208000006011 Stroke Diseases 0.000 claims abstract description 80
- 238000011084 recovery Methods 0.000 claims abstract description 32
- NGHTXZCKLWZPGK-UHFFFAOYSA-N nefiracetam Chemical compound CC1=CC=CC(C)=C1NC(=O)CN1C(=O)CCC1 NGHTXZCKLWZPGK-UHFFFAOYSA-N 0.000 claims abstract description 27
- 230000000694 effects Effects 0.000 claims abstract description 23
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 23
- 239000004480 active ingredient Substances 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 13
- 229950004663 nefiracetam Drugs 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 18
- 241000124008 Mammalia Species 0.000 claims description 9
- 239000003937 drug carrier Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
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- GMZVRMREEHBGGF-UHFFFAOYSA-N Piracetam Chemical compound NC(=O)CN1CCCC1=O GMZVRMREEHBGGF-UHFFFAOYSA-N 0.000 description 2
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- 239000008101 lactose Substances 0.000 description 2
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- 235000019359 magnesium stearate Nutrition 0.000 description 2
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- 239000000546 pharmaceutical excipient Substances 0.000 description 2
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- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
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- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010008088 Cerebral artery embolism Diseases 0.000 description 1
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- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
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- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- 238000000692 Student's t-test Methods 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 229940051881 anilide analgesics and antipyretics Drugs 0.000 description 1
- 150000003931 anilides Chemical class 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
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- 150000002016 disaccharides Chemical class 0.000 description 1
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- 239000003623 enhancer Substances 0.000 description 1
- 229940126864 fibroblast growth factor Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 210000004295 hippocampal neuron Anatomy 0.000 description 1
- 210000001320 hippocampus Anatomy 0.000 description 1
- 229940018158 hydroxypropylcellulose 5 mg Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 201000010849 intracranial embolism Diseases 0.000 description 1
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- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004776 neurological deficiency Effects 0.000 description 1
- 230000001777 nootropic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 229960004526 piracetam Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
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- 230000006886 spatial memory Effects 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
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- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 230000006453 vascular barrier function Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51195200A | 2000-02-23 | 2000-02-23 | |
| US09/511,952 | 2000-02-23 | ||
| PCT/JP2001/001342 WO2001062246A1 (en) | 2000-02-23 | 2001-02-23 | Method for treating neurodegeneration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010110798A true KR20010110798A (ko) | 2001-12-13 |
Family
ID=24037094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020017013542A Ceased KR20010110798A (ko) | 2000-02-23 | 2001-02-23 | 신경퇴화의 치료방법 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6423739B1 (enExample) |
| EP (1) | EP1171123B1 (enExample) |
| JP (1) | JP2003523385A (enExample) |
| KR (1) | KR20010110798A (enExample) |
| CN (1) | CN1362877A (enExample) |
| AR (1) | AR030551A1 (enExample) |
| AT (1) | ATE336246T1 (enExample) |
| AU (1) | AU784418B2 (enExample) |
| BR (1) | BR0104586A (enExample) |
| CA (1) | CA2368352C (enExample) |
| DE (1) | DE60122252T2 (enExample) |
| DK (1) | DK1171123T3 (enExample) |
| ES (1) | ES2270981T3 (enExample) |
| HK (1) | HK1047038A1 (enExample) |
| ID (1) | ID30377A (enExample) |
| IL (1) | IL145799A (enExample) |
| MX (1) | MXPA01010749A (enExample) |
| NO (1) | NO321911B1 (enExample) |
| TW (1) | TWI289060B (enExample) |
| WO (1) | WO2001062246A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077709A1 (en) * | 1999-05-31 | 2004-04-22 | Daiichi Pharmaceutical Co., Ltd. | Neuronal death inhibitors |
| MXPA03005889A (es) * | 2000-12-28 | 2005-02-14 | Daiichi Seiyaku Co | Agente para tratamiento terapeutico y profilactico del dolor neuropatico. |
| ATE404192T1 (de) * | 2001-08-22 | 2008-08-15 | Hamilton Pharmaceuticals Inc | Verwendung von nefiracetam zur behandlung von postischemischer neurodegeneration |
| RU2205631C1 (ru) * | 2002-06-19 | 2003-06-10 | Закрытое акционерное общество "Брынцалов-А" | Ноотропное средство "ноотобрил" в форме таблеток |
| US20060241144A1 (en) * | 2005-04-20 | 2006-10-26 | Albert Cha | Method for treating apathy syndrome |
| US8962676B2 (en) | 2009-10-22 | 2015-02-24 | University College Dublin, National University Of Ireland, Dublin | Causal therapy of diseases or conditions associated with CNS or PNS demyelination |
| RU2480214C1 (ru) * | 2011-09-22 | 2013-04-27 | Валентина Ивановна Ахапкина | Состав, обладающий модуляторной активностью с соразмерным влиянием, фармацевтическая субстанция (варианты), применение фармацевтической субстанции, фармацевтическая и парафармацевтическая композиция (варианты), способ получения фармацевтических составов |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2469995A (en) * | 1946-07-23 | 1949-05-10 | Schaul Martin Carl | Process for the production of food preparations from potatoes and similar farinaceoustubers |
| US3031314A (en) * | 1960-03-16 | 1962-04-24 | Carl E Hendel | Preparation of dehydrated potatoes |
| US3260607A (en) * | 1961-02-07 | 1966-07-12 | Canadian Patents Dev | Preparation of dehydrated cooked mashed potato |
| US3968265A (en) * | 1973-02-01 | 1976-07-06 | American Potato Company | Freeze-thaw stable, french fry potato product and process for producing the same |
| DE2923975A1 (de) | 1979-06-13 | 1980-12-18 | Nattermann A & Cie | Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| DE2924011C2 (de) | 1979-06-13 | 1982-04-08 | A. Nattermann & Cie GmbH, 5000 Köln | Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten |
| IT1141287B (it) | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
| SK279285B6 (sk) | 1991-05-02 | 1998-09-09 | Daiichi Pharmaceutical Co. | Použitie n-(2,6-dimetylfenyl)-2-(2-oxo-1-pyrolidin |
| US5525058A (en) | 1992-03-27 | 1996-06-11 | American Dental Technologies, Inc. | Dental treatment system |
| EP0785599B1 (en) | 1995-07-10 | 2000-12-13 | Kodera Electronics Co., Ltd. | Device for inserting a wire to be worked on |
| US6107330A (en) | 1995-08-07 | 2000-08-22 | Daiichi Pharmaceutical Co., Ltd. | Inhibitor for narcotic analgesic dependence/resistance acquisition |
| JP2002241272A (ja) | 1996-07-18 | 2002-08-28 | Mitsubishi Pharma Corp | 医薬処方組成物 |
| US6042818A (en) | 1996-07-30 | 2000-03-28 | Henkel Ecolab Gmbh & Co. Ohg | Film-building agent useful to protect against infections |
| EP0953356A4 (en) | 1996-10-01 | 2002-04-17 | Daiichi Seiyaku Co | MITOCHONDRIAL MEMBRANE STABILIZER |
| US6211701B1 (en) | 1996-12-16 | 2001-04-03 | Rose Research, Llc | Low power line switching circuit, device and method |
| IT1293533B1 (it) | 1997-07-14 | 1999-03-01 | Angeletti P Ist Richerche Bio | Metodo per la selezione di molecole in grado di mimare, inibire o potenziare gli effetti della interazione tra leptina e cellule che |
| DE69823851D1 (de) | 1997-07-15 | 2004-06-17 | Daiichi Seiyaku Co | Nefiracetam zur prophylaxe und behandlung von propofol verursachtem gedächtnisschwund |
| JPH1180027A (ja) | 1997-09-12 | 1999-03-23 | Dai Ichi Seiyaku Co Ltd | 向知性薬 |
| AR020115A1 (es) | 1998-08-06 | 2002-04-10 | Daiichi Seiyaku Co | Agente terapeutico o preventivo para epilepsias rebeldes y uso del compuesto para la produccion de los mismos |
| AU5102900A (en) | 1999-05-31 | 2000-12-18 | Daiichi Pharmaceutical Co., Ltd. | Neuronal death inhibitors |
-
2001
- 2001-02-16 US US09/784,048 patent/US6423739B1/en not_active Expired - Fee Related
- 2001-02-21 AR ARP010100761A patent/AR030551A1/es unknown
- 2001-02-23 CN CN01800298A patent/CN1362877A/zh active Pending
- 2001-02-23 TW TW090104150A patent/TWI289060B/zh not_active IP Right Cessation
- 2001-02-23 EP EP01906242A patent/EP1171123B1/en not_active Expired - Lifetime
- 2001-02-23 ES ES01906242T patent/ES2270981T3/es not_active Expired - Lifetime
- 2001-02-23 HK HK02108589.8A patent/HK1047038A1/zh unknown
- 2001-02-23 BR BR0104586-5A patent/BR0104586A/pt not_active Application Discontinuation
- 2001-02-23 MX MXPA01010749A patent/MXPA01010749A/es active IP Right Grant
- 2001-02-23 DE DE60122252T patent/DE60122252T2/de not_active Expired - Lifetime
- 2001-02-23 KR KR1020017013542A patent/KR20010110798A/ko not_active Ceased
- 2001-02-23 AU AU34145/01A patent/AU784418B2/en not_active Ceased
- 2001-02-23 WO PCT/JP2001/001342 patent/WO2001062246A1/en not_active Ceased
- 2001-02-23 CA CA002368352A patent/CA2368352C/en not_active Expired - Fee Related
- 2001-02-23 ID IDW00200102283A patent/ID30377A/id unknown
- 2001-02-23 AT AT01906242T patent/ATE336246T1/de not_active IP Right Cessation
- 2001-02-23 JP JP2001561312A patent/JP2003523385A/ja active Pending
- 2001-02-23 IL IL145799A patent/IL145799A/en not_active IP Right Cessation
- 2001-02-23 DK DK01906242T patent/DK1171123T3/da active
- 2001-07-17 US US09/906,077 patent/US6399650B2/en not_active Expired - Fee Related
- 2001-10-22 NO NO20015162A patent/NO321911B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE336246T1 (de) | 2006-09-15 |
| IL145799A0 (en) | 2002-07-25 |
| AU3414501A (en) | 2001-09-03 |
| CA2368352A1 (en) | 2001-08-30 |
| US6399650B2 (en) | 2002-06-04 |
| CN1362877A (zh) | 2002-08-07 |
| ES2270981T3 (es) | 2007-04-16 |
| US6423739B1 (en) | 2002-07-23 |
| AU784418B2 (en) | 2006-03-30 |
| NO20015162D0 (no) | 2001-10-22 |
| DE60122252T2 (de) | 2007-07-05 |
| EP1171123B1 (en) | 2006-08-16 |
| ID30377A (id) | 2001-11-29 |
| HK1047038A1 (zh) | 2003-02-07 |
| TWI289060B (en) | 2007-11-01 |
| EP1171123A1 (en) | 2002-01-16 |
| NO20015162L (no) | 2001-12-21 |
| BR0104586A (pt) | 2002-01-08 |
| US20010051653A1 (en) | 2001-12-13 |
| DK1171123T3 (da) | 2006-12-04 |
| AR030551A1 (es) | 2003-08-27 |
| CA2368352C (en) | 2009-11-10 |
| US20020055534A1 (en) | 2002-05-09 |
| IL145799A (en) | 2006-10-31 |
| JP2003523385A (ja) | 2003-08-05 |
| WO2001062246A1 (en) | 2001-08-30 |
| MXPA01010749A (es) | 2002-08-20 |
| NO321911B1 (no) | 2006-07-17 |
| DE60122252D1 (de) | 2006-09-28 |
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