ES2263058T3 - Derivados de pirimidina como inhibidores selectivos de cox-2. - Google Patents

Derivados de pirimidina como inhibidores selectivos de cox-2.

Info

Publication number
ES2263058T3
ES2263058T3 ES03792369T ES03792369T ES2263058T3 ES 2263058 T3 ES2263058 T3 ES 2263058T3 ES 03792369 T ES03792369 T ES 03792369T ES 03792369 T ES03792369 T ES 03792369T ES 2263058 T3 ES2263058 T3 ES 2263058T3
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ES
Spain
Prior art keywords
alkyl
compound
formula
group
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03792369T
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English (en)
Spanish (es)
Inventor
Gordon Weingarten
Gianpaolo GlaxoSmithKline BRAVI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
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Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0219304A external-priority patent/GB0219304D0/en
Priority claimed from GB0219305A external-priority patent/GB0219305D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2263058T3 publication Critical patent/ES2263058T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
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  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
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  • Endocrinology (AREA)
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ES03792369T 2002-08-19 2003-08-15 Derivados de pirimidina como inhibidores selectivos de cox-2. Expired - Lifetime ES2263058T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0219305 2002-08-19
GB0219304A GB0219304D0 (en) 2002-08-19 2002-08-19 Pyrimidine derivatives
GB0219304 2002-08-19
GB0219305A GB0219305D0 (en) 2002-08-19 2002-08-19 Pyrimidine derivatives

Publications (1)

Publication Number Publication Date
ES2263058T3 true ES2263058T3 (es) 2006-12-01

Family

ID=31948026

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03792369T Expired - Lifetime ES2263058T3 (es) 2002-08-19 2003-08-15 Derivados de pirimidina como inhibidores selectivos de cox-2.

Country Status (8)

Country Link
US (1) US7235560B2 (enExample)
EP (1) EP1546128B1 (enExample)
JP (1) JP2006500372A (enExample)
AT (1) ATE325115T1 (enExample)
AU (1) AU2003258630A1 (enExample)
DE (1) DE60305053T2 (enExample)
ES (1) ES2263058T3 (enExample)
WO (1) WO2004018452A1 (enExample)

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Publication number Priority date Publication date Assignee Title
DE60305053T2 (de) 2002-08-19 2006-08-31 Glaxo Group Ltd., Greenford Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
EP3470064A1 (en) 2004-10-08 2019-04-17 Fwp Ip Aps Controlled release pharmaceutical compositions comprising a fumaric acid ester
ZA200802411B (en) * 2005-09-15 2009-09-30 Orchid Res Lab Ltd Novel pyrimidine carboxamides
EP1940382A2 (en) * 2005-10-07 2008-07-09 Aditech Pharma AB Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
HUE030169T2 (en) 2009-01-09 2017-05-29 Forward Pharma As Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
WO2011113309A1 (en) * 2010-03-17 2011-09-22 Glaxo Group Limited Pyrimidine derivatives for use as sphingosine 1-phosphate 1 (s1p1) receptor agonists
CA3026149A1 (en) * 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
BR112019014814B1 (pt) 2017-01-23 2024-03-12 Novartis Ag Compostos, composições farmacêuticas dos mesmos e seus usos no tratamento de doenças associadas à disfunção de canais iônicos de potássio
CA3116339A1 (en) 2018-10-22 2020-04-30 Cadent Therapeutics, Inc. Crystalline forms of potassium channel modulators
WO2021050700A1 (en) * 2019-09-13 2021-03-18 The Broad Institute, Inc. Cyclooxygenase-2 inhibitors and uses thereof

Family Cites Families (71)

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Publication number Priority date Publication date Assignee Title
US3149109A (en) * 1962-02-20 1964-09-15 Searle & Co Certain 4-trifluoromethyl-2-(oxy/thio) pyrimidines
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EP1546128B1 (en) 2006-05-03
JP2006500372A (ja) 2006-01-05
US7235560B2 (en) 2007-06-26
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EP1546128A1 (en) 2005-06-29
US20060040967A1 (en) 2006-02-23

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