ES2249888T3 - Conjugados de paclitaxel solubles en agua, combinados con irradiacion para el tratamiento del cancer. - Google Patents
Conjugados de paclitaxel solubles en agua, combinados con irradiacion para el tratamiento del cancer.Info
- Publication number
- ES2249888T3 ES2249888T3 ES99916188T ES99916188T ES2249888T3 ES 2249888 T3 ES2249888 T3 ES 2249888T3 ES 99916188 T ES99916188 T ES 99916188T ES 99916188 T ES99916188 T ES 99916188T ES 2249888 T3 ES2249888 T3 ES 2249888T3
- Authority
- ES
- Spain
- Prior art keywords
- irradiation
- combined
- water soluble
- cancer treatment
- paclitaxel conjugates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 229930012538 Paclitaxel Natural products 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 229960001592 paclitaxel Drugs 0.000 title abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 229960003668 docetaxel Drugs 0.000 abstract 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
- 229960005420 etoposide Drugs 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 abstract 1
- 229960001278 teniposide Drugs 0.000 abstract 1
Classifications
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- Health & Medical Sciences (AREA)
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Abstract
Utilización de paclitaxel, docetaxel, etopósido, tenipósido, camptotecina o un epotilón conjugado con un polímero poliaminoácido soluble en agua para la preparación de un medicamento para el tratamiento del cáncer, en el que el medicamento debe ser administrado en combinación con irradiación externa o interna.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/050,662 US6441025B2 (en) | 1996-03-12 | 1998-03-30 | Water soluble paclitaxel derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2249888T3 true ES2249888T3 (es) | 2006-04-01 |
Family
ID=21966621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99916188T Expired - Lifetime ES2249888T3 (es) | 1998-03-30 | 1999-03-30 | Conjugados de paclitaxel solubles en agua, combinados con irradiacion para el tratamiento del cancer. |
Country Status (12)
Country | Link |
---|---|
US (22) | US6441025B2 (es) |
EP (2) | EP1028756B1 (es) |
AT (1) | ATE304867T1 (es) |
AU (1) | AU3455699A (es) |
CA (1) | CA2303338C (es) |
CY (1) | CY1105547T1 (es) |
DE (1) | DE69927350T2 (es) |
DK (1) | DK1028756T3 (es) |
ES (1) | ES2249888T3 (es) |
MY (1) | MY121807A (es) |
TW (2) | TWI255183B (es) |
WO (1) | WO1999049901A1 (es) |
Families Citing this family (314)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
US20070092563A1 (en) * | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US20050163818A1 (en) * | 1996-11-05 | 2005-07-28 | Hsing-Wen Sung | Drug-eluting device chemically treated with genipin |
JP4579351B2 (ja) | 1996-12-03 | 2010-11-10 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロンの合成とその中間体及びその類似物並びにその使用 |
US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
DE59814067D1 (de) * | 1997-08-09 | 2007-09-06 | Bayer Schering Pharma Ag | Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung |
US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US20040254635A1 (en) | 1998-03-30 | 2004-12-16 | Shanley John F. | Expandable medical device for delivery of beneficial agent |
US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
US7713297B2 (en) * | 1998-04-11 | 2010-05-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US20030040790A1 (en) * | 1998-04-15 | 2003-02-27 | Furst Joseph G. | Stent coating |
US20020099438A1 (en) * | 1998-04-15 | 2002-07-25 | Furst Joseph G. | Irradiated stent coating |
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1998
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1999
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- 1999-03-30 AU AU34556/99A patent/AU3455699A/en not_active Abandoned
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- 1999-03-30 TW TW093136237A patent/TWI255183B/zh not_active IP Right Cessation
- 1999-03-30 AT AT99916188T patent/ATE304867T1/de active
- 1999-03-30 TW TW088104989A patent/TWI246922B/zh not_active IP Right Cessation
- 1999-03-30 ES ES99916188T patent/ES2249888T3/es not_active Expired - Lifetime
- 1999-03-30 EP EP05007529A patent/EP1598081A3/en not_active Withdrawn
- 1999-03-30 DE DE69927350T patent/DE69927350T2/de not_active Expired - Lifetime
- 1999-03-30 DK DK99916188T patent/DK1028756T3/da active
- 1999-03-30 WO PCT/US1999/006870 patent/WO1999049901A1/en active IP Right Grant
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2002
- 2002-05-17 US US10/146,809 patent/US6884817B2/en not_active Expired - Lifetime
- 2002-05-24 US US10/153,818 patent/US6515017B1/en not_active Expired - Lifetime
- 2002-09-12 US US10/243,045 patent/US20030114518A1/en not_active Abandoned
- 2002-09-12 US US10/243,079 patent/US20030114397A1/en not_active Abandoned
- 2002-09-12 US US10/243,080 patent/US20030114363A1/en not_active Abandoned
- 2002-09-12 US US10/243,046 patent/US20030113335A1/en not_active Abandoned
- 2002-10-28 US US10/282,570 patent/US20030134793A1/en not_active Abandoned
- 2002-10-28 US US10/282,490 patent/US7135496B2/en not_active Expired - Fee Related
- 2002-11-18 US US10/298,375 patent/US20030130341A1/en not_active Abandoned
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- 2002-11-20 US US10/300,031 patent/US6730699B2/en not_active Expired - Lifetime
- 2002-12-05 US US10/310,331 patent/US20030147807A1/en not_active Abandoned
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2004
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