DE69429278T2 - Polyaminosäure-träger für oligonukleotid - Google Patents
Polyaminosäure-träger für oligonukleotidInfo
- Publication number
- DE69429278T2 DE69429278T2 DE69429278T DE69429278T DE69429278T2 DE 69429278 T2 DE69429278 T2 DE 69429278T2 DE 69429278 T DE69429278 T DE 69429278T DE 69429278 T DE69429278 T DE 69429278T DE 69429278 T2 DE69429278 T2 DE 69429278T2
- Authority
- DE
- Germany
- Prior art keywords
- oligonucleotide
- carrier
- polyamino acid
- acid carrier
- plants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 229920005604 random copolymer Polymers 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24185393 | 1993-09-28 | ||
| PCT/JP1994/001590 WO1995009009A1 (fr) | 1993-09-28 | 1994-09-28 | Excipient constitue d'acides polyamines pour oligonucleotide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69429278D1 DE69429278D1 (de) | 2002-01-10 |
| DE69429278T2 true DE69429278T2 (de) | 2002-07-11 |
Family
ID=17080488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69429278T Expired - Fee Related DE69429278T2 (de) | 1993-09-28 | 1994-09-28 | Polyaminosäure-träger für oligonukleotid |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5912300A (de) |
| EP (1) | EP0727223B1 (de) |
| JP (1) | JP3289912B2 (de) |
| KR (1) | KR100324257B1 (de) |
| AT (1) | ATE209506T1 (de) |
| AU (1) | AU681192B2 (de) |
| CA (1) | CA2172974C (de) |
| DE (1) | DE69429278T2 (de) |
| DK (1) | DK0727223T3 (de) |
| ES (1) | ES2163453T3 (de) |
| TW (1) | TW380052B (de) |
| WO (1) | WO1995009009A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0775751A3 (de) * | 1995-11-22 | 1998-06-10 | F. Hoffmann-La Roche Ag | Zelltransfektion |
| DE69723123T2 (de) * | 1996-01-17 | 2004-04-15 | F. Hoffmann-La Roche Ag | Transfektionskompetente Moleküle |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| WO2000032764A1 (en) * | 1998-12-02 | 2000-06-08 | I.D.M. Immuno-Designed Molecules | New oligomeric conjugates liable to transfer biological molecules into cells |
| DE19858005B4 (de) * | 1998-12-16 | 2007-02-08 | november Aktiengesellschaft, Gesellschaft für Molekulare Medizin | Synthetisches Nucleinsäure-Partikel |
| AU2281201A (en) | 1999-12-29 | 2001-07-09 | A. James Mixson | Histidine copolymer and methods for using same |
| US7070807B2 (en) | 1999-12-29 | 2006-07-04 | Mixson A James | Branched histidine copolymers and methods for using same |
| WO2004048421A2 (en) | 2002-11-25 | 2004-06-10 | Mixson Archibald J | Branched cationic copolymers and methods for antimicrobial use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5718727A (en) * | 1980-07-07 | 1982-01-30 | Teijin Ltd | Reactive polymer and its preparation |
| US5132230A (en) * | 1989-03-28 | 1992-07-21 | Isolab, Inc. | Primary standard and method of making secondary standards for calibration of glycated protein assays |
| JP2626654B2 (ja) * | 1990-03-31 | 1997-07-02 | 科学技術振興事業団 | 標的指向性高分子医薬化合物及びその中間体 |
-
1994
- 1994-09-28 AT AT94927785T patent/ATE209506T1/de not_active IP Right Cessation
- 1994-09-28 ES ES94927785T patent/ES2163453T3/es not_active Expired - Lifetime
- 1994-09-28 CA CA002172974A patent/CA2172974C/en not_active Expired - Fee Related
- 1994-09-28 EP EP94927785A patent/EP0727223B1/de not_active Expired - Lifetime
- 1994-09-28 US US08/619,564 patent/US5912300A/en not_active Expired - Fee Related
- 1994-09-28 DK DK94927785T patent/DK0727223T3/da active
- 1994-09-28 AU AU77069/94A patent/AU681192B2/en not_active Ceased
- 1994-09-28 WO PCT/JP1994/001590 patent/WO1995009009A1/ja active IP Right Grant
- 1994-09-28 JP JP51021095A patent/JP3289912B2/ja not_active Expired - Fee Related
- 1994-09-28 KR KR1019960701593A patent/KR100324257B1/ko not_active IP Right Cessation
- 1994-09-28 DE DE69429278T patent/DE69429278T2/de not_active Expired - Fee Related
- 1994-10-19 TW TW083109682A patent/TW380052B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0727223B1 (de) | 2001-11-28 |
| AU7706994A (en) | 1995-04-18 |
| JP3289912B2 (ja) | 2002-06-10 |
| CA2172974A1 (en) | 1995-04-06 |
| KR960704580A (ko) | 1996-10-09 |
| CA2172974C (en) | 2005-07-12 |
| US5912300A (en) | 1999-06-15 |
| WO1995009009A1 (fr) | 1995-04-06 |
| KR100324257B1 (ko) | 2002-08-27 |
| EP0727223A4 (de) | 1998-08-12 |
| ATE209506T1 (de) | 2001-12-15 |
| AU681192B2 (en) | 1997-08-21 |
| EP0727223A1 (de) | 1996-08-21 |
| TW380052B (en) | 2000-01-21 |
| DE69429278D1 (de) | 2002-01-10 |
| DK0727223T3 (da) | 2002-02-11 |
| ES2163453T3 (es) | 2002-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |