MX9700560A - Metodo de uso de integrasa retroviral negativa transdominante en el tratamiento de infecciones retrovirales. - Google Patents

Metodo de uso de integrasa retroviral negativa transdominante en el tratamiento de infecciones retrovirales.

Info

Publication number
MX9700560A
MX9700560A MX9700560A MX9700560A MX9700560A MX 9700560 A MX9700560 A MX 9700560A MX 9700560 A MX9700560 A MX 9700560A MX 9700560 A MX9700560 A MX 9700560A MX 9700560 A MX9700560 A MX 9700560A
Authority
MX
Mexico
Prior art keywords
retroviral
transdominant negative
hiv
treatment
integrase gene
Prior art date
Application number
MX9700560A
Other languages
English (en)
Inventor
Tod Paul Holler
Annette Meyer
Gary Jan Nabel
Leonard Post
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of MX9700560A publication Critical patent/MX9700560A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un método de uso de genes integrasa negativos transdominantes para hacer al menos una célula resistente a infecciones retrovirales que incluyen infecciones retrovirales que resultan del VIH; un método de introducir un gene integrasa negativo transdominante en al menos una célula mamífera a dicha célula resistente a una infeccion retroviral así como vectores, células y métodos para construir las mismas utiles en los métodos antes citados; un método para tratar al SIDA que comprende la administracion a un paciente de una cantidad efectiva de un gen integrasa negativo transdominante solo o combinado con agentes utiles para la terapia de genes para la inhibicion de VIH, agentes antivirales o interlequina-2; y métodos de suministro farmacéutico que incluyen un gene integrasa negativo transdominante solo o combinado con agentes utiles para la terapia de genes de inhibicion de VIH, agentes antivirales o interleuquina-2.
MX9700560A 1994-08-05 1995-07-19 Metodo de uso de integrasa retroviral negativa transdominante en el tratamiento de infecciones retrovirales. MX9700560A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28657894A 1994-08-05 1994-08-05
PCT/US1995/009110 WO1996004386A1 (en) 1994-08-05 1995-07-19 Method of using transdominant negative retroviral integrase in the treatment of retroviral infection

Publications (1)

Publication Number Publication Date
MX9700560A true MX9700560A (es) 1997-05-31

Family

ID=23099243

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700560A MX9700560A (es) 1994-08-05 1995-07-19 Metodo de uso de integrasa retroviral negativa transdominante en el tratamiento de infecciones retrovirales.

Country Status (6)

Country Link
US (2) US5908923A (es)
EP (1) EP0774003A1 (es)
JP (1) JPH10503654A (es)
CA (1) CA2194488A1 (es)
MX (1) MX9700560A (es)
WO (1) WO1996004386A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0774003A1 (en) * 1994-08-05 1997-05-21 Warner-Lambert Company Method of using transdominant negative retroviral integrase in the treatment of retroviral infection
EP0893507A1 (en) * 1997-07-25 1999-01-27 Institut Gustave Roussy Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment
NZ503334A (en) * 1997-09-15 2002-05-31 Genetic Immunity Llc A gene delivering complex having a vector with a specific affinity for a foreign genetic material and a second site having a specific affinity for a receptor on an antigen presenting cell
IT1297016B1 (it) * 1997-12-23 1999-08-03 San Raffaele Centro Fond Processo di selezione di linfociti t cd4+ per la transduzione di geni anti-hiv
US6936465B1 (en) 1999-06-04 2005-08-30 Nippon Institute For Biological Science Plasmid vector comprising a retroviral integrase gene and an integrase recognition region
CA3145791A1 (en) 2019-07-16 2021-01-21 Gilead Sciences, Inc. Hiv vaccines and methods of making and using

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001810A (en) * 1989-11-20 1999-12-14 Eli Lilly And Company Methods for treating retroviral infection
AU651380B2 (en) * 1990-07-16 1994-07-21 University Of Medicine And Dentistry Of New Jersey Selection of ribozymes that efficiently cleave target RNA
WO1992003578A1 (en) * 1990-08-24 1992-03-05 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce In vitro retroviral integration assay
US5217889A (en) * 1990-10-19 1993-06-08 Roninson Igor B Methods and applications for efficient genetic suppressor elements
US5512421A (en) * 1991-02-19 1996-04-30 The Regents Of The University Of California Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors
EP0774003A1 (en) * 1994-08-05 1997-05-21 Warner-Lambert Company Method of using transdominant negative retroviral integrase in the treatment of retroviral infection
US5993972A (en) * 1996-08-26 1999-11-30 Tyndale Plains-Hunter, Ltd. Hydrophilic and hydrophobic polyether polyurethanes and uses therefor

Also Published As

Publication number Publication date
WO1996004386A1 (en) 1996-02-15
EP0774003A1 (en) 1997-05-21
US5908923A (en) 1999-06-01
CA2194488A1 (en) 1996-02-15
JPH10503654A (ja) 1998-04-07
US6303334B1 (en) 2001-10-16

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees