JPS6461422A - Water-soluble polymeric carcinostatic agent - Google Patents
Water-soluble polymeric carcinostatic agentInfo
- Publication number
- JPS6461422A JPS6461422A JP21791787A JP21791787A JPS6461422A JP S6461422 A JPS6461422 A JP S6461422A JP 21791787 A JP21791787 A JP 21791787A JP 21791787 A JP21791787 A JP 21791787A JP S6461422 A JPS6461422 A JP S6461422A
- Authority
- JP
- Japan
- Prior art keywords
- water
- formula
- soluble polymeric
- reacting
- carcinostatic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE:To provide a water-soluble polymeric carcinostatic agent containing a water-soluble polymeric aminoetoposide, exhibiting excellent antitumor effect and having remarkably high solubility in water. CONSTITUTION:An active ester is produced by reacting a part of the carboxyl group of an acidic polyamino acid of formula I (n is 1 or 2; p is 10-10,000) with a condensation agent (e.g. N-hydroxysuccinimide) in water or in a mixture of a buffer solution and dimethylformamide, etc., at -4-+80 deg.C. The objective compound of formula IV can be obtained by reacting the active ester with an alkanolamine of formula H2N-R1 (R1 is residue of monoalkanol or polyalkanol) and reacting the resultant water-soluble polyamino acid of formula II (Y is amine residue of alkanolamine; 10<l+q<10,000; n is 1 or 2) with aminoetoposide of formula III.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21791787A JPS6461422A (en) | 1987-09-02 | 1987-09-02 | Water-soluble polymeric carcinostatic agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP21791787A JPS6461422A (en) | 1987-09-02 | 1987-09-02 | Water-soluble polymeric carcinostatic agent |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6461422A true JPS6461422A (en) | 1989-03-08 |
Family
ID=16711762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP21791787A Pending JPS6461422A (en) | 1987-09-02 | 1987-09-02 | Water-soluble polymeric carcinostatic agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6461422A (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007135910A1 (en) * | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of podophyllotoxin |
US7384977B2 (en) | 1996-03-12 | 2008-06-10 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
US8188222B2 (en) | 2006-11-08 | 2012-05-29 | Nippon Kayaku Kabushiki Kaisha | High molecular weight derivative of nucleic acid antimetabolite |
US8323669B2 (en) | 2006-03-28 | 2012-12-04 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of taxane |
US8334364B2 (en) | 2006-11-06 | 2012-12-18 | Nipon Kayaku Kabushiki Kaisha | High-molecular weight derivative of nucleic acid antimetabolite |
US8703878B2 (en) | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
US8808749B2 (en) | 2009-05-15 | 2014-08-19 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of bioactive substance having hydroxy group |
US8920788B2 (en) | 2008-03-18 | 2014-12-30 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of physiologically active substances |
US9018323B2 (en) | 2010-11-17 | 2015-04-28 | Nippon Kayaku Kabushiki Kaisha | Polymer derivative of cytidine metabolic antagonist |
US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
US9346923B2 (en) | 2011-09-11 | 2016-05-24 | Nippon Kayaku Kabushiki Kaisha | Method for manufacturing block copolymer |
US9434822B2 (en) | 2004-09-22 | 2016-09-06 | Nippon Kayaku Kabushiki Kaisha | Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient |
-
1987
- 1987-09-02 JP JP21791787A patent/JPS6461422A/en active Pending
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7384977B2 (en) | 1996-03-12 | 2008-06-10 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
US9434822B2 (en) | 2004-09-22 | 2016-09-06 | Nippon Kayaku Kabushiki Kaisha | Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient |
US8323669B2 (en) | 2006-03-28 | 2012-12-04 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of taxane |
WO2007135910A1 (en) * | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of podophyllotoxin |
US8940332B2 (en) | 2006-05-18 | 2015-01-27 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of podophyllotoxins |
US8334364B2 (en) | 2006-11-06 | 2012-12-18 | Nipon Kayaku Kabushiki Kaisha | High-molecular weight derivative of nucleic acid antimetabolite |
US8188222B2 (en) | 2006-11-08 | 2012-05-29 | Nippon Kayaku Kabushiki Kaisha | High molecular weight derivative of nucleic acid antimetabolite |
US8703878B2 (en) | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
USRE46190E1 (en) | 2007-09-28 | 2016-11-01 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
US8920788B2 (en) | 2008-03-18 | 2014-12-30 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of physiologically active substances |
US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
US8808749B2 (en) | 2009-05-15 | 2014-08-19 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of bioactive substance having hydroxy group |
US9018323B2 (en) | 2010-11-17 | 2015-04-28 | Nippon Kayaku Kabushiki Kaisha | Polymer derivative of cytidine metabolic antagonist |
US9346923B2 (en) | 2011-09-11 | 2016-05-24 | Nippon Kayaku Kabushiki Kaisha | Method for manufacturing block copolymer |
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