JPS6461422A - Water-soluble polymeric carcinostatic agent - Google Patents

Water-soluble polymeric carcinostatic agent

Info

Publication number
JPS6461422A
JPS6461422A JP21791787A JP21791787A JPS6461422A JP S6461422 A JPS6461422 A JP S6461422A JP 21791787 A JP21791787 A JP 21791787A JP 21791787 A JP21791787 A JP 21791787A JP S6461422 A JPS6461422 A JP S6461422A
Authority
JP
Japan
Prior art keywords
water
formula
soluble polymeric
reacting
carcinostatic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP21791787A
Other languages
Japanese (ja)
Inventor
Takashi Seto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Nippon Kayaku Co Ltd
Original Assignee
Microbial Chemistry Research Foundation
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation, Nippon Kayaku Co Ltd filed Critical Microbial Chemistry Research Foundation
Priority to JP21791787A priority Critical patent/JPS6461422A/en
Publication of JPS6461422A publication Critical patent/JPS6461422A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE:To provide a water-soluble polymeric carcinostatic agent containing a water-soluble polymeric aminoetoposide, exhibiting excellent antitumor effect and having remarkably high solubility in water. CONSTITUTION:An active ester is produced by reacting a part of the carboxyl group of an acidic polyamino acid of formula I (n is 1 or 2; p is 10-10,000) with a condensation agent (e.g. N-hydroxysuccinimide) in water or in a mixture of a buffer solution and dimethylformamide, etc., at -4-+80 deg.C. The objective compound of formula IV can be obtained by reacting the active ester with an alkanolamine of formula H2N-R1 (R1 is residue of monoalkanol or polyalkanol) and reacting the resultant water-soluble polyamino acid of formula II (Y is amine residue of alkanolamine; 10<l+q<10,000; n is 1 or 2) with aminoetoposide of formula III.
JP21791787A 1987-09-02 1987-09-02 Water-soluble polymeric carcinostatic agent Pending JPS6461422A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP21791787A JPS6461422A (en) 1987-09-02 1987-09-02 Water-soluble polymeric carcinostatic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21791787A JPS6461422A (en) 1987-09-02 1987-09-02 Water-soluble polymeric carcinostatic agent

Publications (1)

Publication Number Publication Date
JPS6461422A true JPS6461422A (en) 1989-03-08

Family

ID=16711762

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21791787A Pending JPS6461422A (en) 1987-09-02 1987-09-02 Water-soluble polymeric carcinostatic agent

Country Status (1)

Country Link
JP (1) JPS6461422A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007135910A1 (en) * 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of podophyllotoxin
US7384977B2 (en) 1996-03-12 2008-06-10 Pg-Txl Company, L.P. Water soluble paclitaxel prodrugs
US8188222B2 (en) 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
US8703878B2 (en) 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
US8920788B2 (en) 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
US9018323B2 (en) 2010-11-17 2015-04-28 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolic antagonist
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
US9346923B2 (en) 2011-09-11 2016-05-24 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer
US9434822B2 (en) 2004-09-22 2016-09-06 Nippon Kayaku Kabushiki Kaisha Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7384977B2 (en) 1996-03-12 2008-06-10 Pg-Txl Company, L.P. Water soluble paclitaxel prodrugs
US9434822B2 (en) 2004-09-22 2016-09-06 Nippon Kayaku Kabushiki Kaisha Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
WO2007135910A1 (en) * 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of podophyllotoxin
US8940332B2 (en) 2006-05-18 2015-01-27 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
US8188222B2 (en) 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
US8703878B2 (en) 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
USRE46190E1 (en) 2007-09-28 2016-11-01 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
US8920788B2 (en) 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
US9018323B2 (en) 2010-11-17 2015-04-28 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolic antagonist
US9346923B2 (en) 2011-09-11 2016-05-24 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer

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