JPS5758651A - Preparation of diamino acid derivative - Google Patents

Preparation of diamino acid derivative

Info

Publication number
JPS5758651A
JPS5758651A JP55132390A JP13239080A JPS5758651A JP S5758651 A JPS5758651 A JP S5758651A JP 55132390 A JP55132390 A JP 55132390A JP 13239080 A JP13239080 A JP 13239080A JP S5758651 A JPS5758651 A JP S5758651A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
diamino acid
acid derivative
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55132390A
Other languages
Japanese (ja)
Inventor
Tozaburo Kurihara
Yasuo Koyama
Hiroyuki Sato
Masaru Abe
Shigenori Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KAYAKU ANTIBIOTIC RESEARCH CO
KAYAKU KK
KAYAKU KOUSEIBUTSUSHITSU KENKYUSHO KK
Original Assignee
KAYAKU ANTIBIOTIC RESEARCH CO
KAYAKU KK
KAYAKU KOUSEIBUTSUSHITSU KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KAYAKU ANTIBIOTIC RESEARCH CO, KAYAKU KK, KAYAKU KOUSEIBUTSUSHITSU KENKYUSHO KK filed Critical KAYAKU ANTIBIOTIC RESEARCH CO
Priority to JP55132390A priority Critical patent/JPS5758651A/en
Publication of JPS5758651A publication Critical patent/JPS5758651A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A diamino acid derivative of formula I (n is an integer 2W4).
EXAMPLE: (L) γ-Dimethylamino-α-aminobutyric acid hydrochloride.
USE: Useful as an antimicrobial agent against Gram-negative bacterial.
PROCESS: One mole compound expressed by formula II obtained by linking a protecting group to the amino group at the α-position of an (L) diamino acid, particularly α,γ-diaminobutyric acid, ornithine or lysine, is reacted with 2mol HCHO in the presence of a reducing agent, e.g. NaBH4, to give a compound expressed by formula IV. The protecting group of the amino group at the α-position is then removed to give the compound expressed by formula I. The reaction is easily carried out in an organic solvent mixed with water in a suitable proportion under the conditions of an alkaline pH.
COPYRIGHT: (C)1982,JPO&Japio
JP55132390A 1980-09-25 1980-09-25 Preparation of diamino acid derivative Pending JPS5758651A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55132390A JPS5758651A (en) 1980-09-25 1980-09-25 Preparation of diamino acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55132390A JPS5758651A (en) 1980-09-25 1980-09-25 Preparation of diamino acid derivative

Publications (1)

Publication Number Publication Date
JPS5758651A true JPS5758651A (en) 1982-04-08

Family

ID=15080258

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55132390A Pending JPS5758651A (en) 1980-09-25 1980-09-25 Preparation of diamino acid derivative

Country Status (1)

Country Link
JP (1) JPS5758651A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032371A1 (en) * 1995-04-13 1996-10-17 The Associated Octel Company Limited Reductive alkylation process for the preparation of compounds containing at least two amino groups
EP1021099A4 (en) * 1996-07-31 2000-12-27 Anitox Corp Anti-bacterial amine derivatives
WO2005056002A3 (en) * 2003-12-04 2006-02-23 Centre Nat Rech Scient Use of inductors of the degradation pathway of gamma-butyrolactone for inactivating the homoserine lactone n-acyl signal of gram-negative pathogenic bacteria

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032371A1 (en) * 1995-04-13 1996-10-17 The Associated Octel Company Limited Reductive alkylation process for the preparation of compounds containing at least two amino groups
US6245941B1 (en) 1995-04-13 2001-06-12 The Associated Octel Company Limited Reductive alkylation process for the preparation of compounds containing at least two amino groups
EP1021099A4 (en) * 1996-07-31 2000-12-27 Anitox Corp Anti-bacterial amine derivatives
WO2005056002A3 (en) * 2003-12-04 2006-02-23 Centre Nat Rech Scient Use of inductors of the degradation pathway of gamma-butyrolactone for inactivating the homoserine lactone n-acyl signal of gram-negative pathogenic bacteria

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