BRPI0510062A - derivados de antraciclina - Google Patents

derivados de antraciclina

Info

Publication number
BRPI0510062A
BRPI0510062A BRPI0510062-3A BRPI0510062A BRPI0510062A BR PI0510062 A BRPI0510062 A BR PI0510062A BR PI0510062 A BRPI0510062 A BR PI0510062A BR PI0510062 A BRPI0510062 A BR PI0510062A
Authority
BR
Brazil
Prior art keywords
anthracycline derivatives
diagnosis
radiolabelled
delivery system
drug delivery
Prior art date
Application number
BRPI0510062-3A
Other languages
English (en)
Inventor
Katarina Edwards
Stefan Sjoeberg
Joergen Carlsson
Lars Gedda
Original Assignee
Katarina Edwards
Stefan Sjoeberg
Joergen Carlsson
Lars Gedda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katarina Edwards, Stefan Sjoeberg, Joergen Carlsson, Lars Gedda filed Critical Katarina Edwards
Publication of BRPI0510062A publication Critical patent/BRPI0510062A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

DERIVADOS DE ANTRACICLINA A presente invenção refere-se a novos derivados de antraciclina e seu uso na terapia e diagnóstico de câncer. Estes derivados de antraciclina podem ser radiomarcados e utilizados como um agente de formação de imagem no diagnóstico de câncer. Os derivados de antraciclina radiomarcados podem ser utilizados também com um sistema de liberação de droga, em particular incluindo uma estratégia de orientação em duas etapas, para o tratamento de tumores sólidos e disseminados, Estes sistemas de liberação de droga podem vantajosamente ser utilizados para o tratamento e diagnóstico de câncer do seio.
BRPI0510062-3A 2004-04-22 2005-04-22 derivados de antraciclina BRPI0510062A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0401066A SE0401066D0 (sv) 2004-04-22 2004-04-22 Chemical Derivatives
PCT/SE2005/000596 WO2005103065A1 (en) 2004-04-22 2005-04-22 Anthracycline derivatives

Publications (1)

Publication Number Publication Date
BRPI0510062A true BRPI0510062A (pt) 2007-10-16

Family

ID=32322666

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510062-3A BRPI0510062A (pt) 2004-04-22 2005-04-22 derivados de antraciclina

Country Status (10)

Country Link
US (2) US20070258890A1 (pt)
EP (1) EP1740599B1 (pt)
JP (1) JP5156372B2 (pt)
CN (1) CN1956992A (pt)
AT (1) ATE499378T1 (pt)
BR (1) BRPI0510062A (pt)
DE (1) DE602005026510D1 (pt)
ES (1) ES2360708T3 (pt)
SE (1) SE0401066D0 (pt)
WO (1) WO2005103065A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2552443B1 (en) * 2010-04-01 2021-07-14 Oncorena Ab Improved treatment of renal cell carcinoma
CN102086219A (zh) * 2010-11-24 2011-06-08 河南师范大学 具有抗癌活性的蒽环类抗生素简单结构类似物及制备方法
CN102146107B (zh) * 2011-01-14 2014-12-31 河南师范大学 (s)-2-羟烷基-1,4-二羟基-9,10-蒽醌与糖基缀合物的合成及抗肿瘤活性
CN113750047A (zh) * 2020-05-28 2021-12-07 浙江大学 多功能纳米脂质体、制备方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS539756A (en) * 1976-07-14 1978-01-28 Microbial Chem Res Found Antitumers
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
GB2007645B (en) * 1977-10-17 1982-05-12 Stanford Res Inst Int Benzyl anthracyclines and pharmaceutical compositions containing them
US4250303A (en) * 1977-10-17 1981-02-10 Sri International N-Benzyl anthracyclines
CA1248944A (en) * 1982-09-28 1989-01-17 Gareth J. Thomas Anthracycline glycosides
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
DE3641833A1 (de) * 1986-12-08 1988-06-09 Behringwerke Ag Zytostatisch wirksame anthracyclinderivate
EP0308977B1 (en) * 1987-09-25 1993-12-08 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Anthracycline derivatives having inhibitory activity against reverse transcriptase of human immunodeficiency virus
US5874412A (en) * 1996-03-22 1999-02-23 Priebe; Waldemar Bis-anthracyclines with high activity against doxorubicin resistant tumors
ATE546457T1 (de) * 1999-03-19 2012-03-15 Waldemar Priebe Verfahren und zusammensetzungen zur herstellung von c-3' und c-4' -anthracyclin antibiotika
WO2003057687A1 (en) * 2001-12-27 2003-07-17 Albany Molecular Research, Inc. Methods for preparing doxorubicin derivatives

Also Published As

Publication number Publication date
EP1740599A1 (en) 2007-01-10
DE602005026510D1 (en) 2011-04-07
WO2005103065A1 (en) 2005-11-03
SE0401066D0 (sv) 2004-04-22
EP1740599B1 (en) 2011-02-23
US20100092388A1 (en) 2010-04-15
CN1956992A (zh) 2007-05-02
US20070258890A1 (en) 2007-11-08
ES2360708T3 (es) 2011-06-08
US8609135B2 (en) 2013-12-17
ATE499378T1 (de) 2011-03-15
JP5156372B2 (ja) 2013-03-06
JP2007533736A (ja) 2007-11-22

Similar Documents

Publication Publication Date Title
IL273765A (en) Combinations and forms of administration of therapeutic agents and combined treatment
MX2009006779A (es) Antagonistas especificos para terapia con adyuvantes y neo-adyuvantes y el tratamiento de tumores en etapa temprana.
RS52956B (en) CANCER TREATMENT COMPOSITIONS
WO2004113571A3 (en) Prostate specific genes and the use thereof as targets for prostate cancer therapy and diagnosis
SG166093A1 (en) Inhibitors of brutonæs tyrosine kinase
SG158919A1 (en) Constructs binding to phosphatidylserine and their use in disease treatment
EA200801853A1 (ru) Пептиды, эффективные в лечении опухолей и других заболеваний, требующих удаления или разрушения клеток
WO2009067397A3 (en) Treatment for solid tumors
MX2007006557A (es) Metodos para utilizar intratecalmente una formulacion de temozolomida en el tratamiento de canceres.
DOP2009000208A (es) Métodos de tratamiento del cáncer mediante administración de combinaciones de il-18 humana
WO2005113720A3 (en) A strategy for designing patient-specific anti-cancer drugs
BRPI0510062A (pt) derivados de antraciclina
WO2008039525A3 (en) Cadherin antagonists in combination with anticancer agents for use in cancer treatment
BRPI0810682A2 (pt) agente antitumoral em especial para o tratamento de tumores dérmicos, fármaco, kit compreendendo fármaco.
WO2006069217A3 (en) Small molecule cyclin d1 ablative agents
IL164356A (en) Use of alpha- bromo or alpha-chloro acryloyl distamycin derivatives in the preparation of medicaments for treating cancer
BRPI0409870A (pt) uso de irinotecano para tratamento de cáncer de mama resistente
MXPA05008879A (es) Una terapia combinada que comprende un derivado de indolopirrolocarbazol y otro agente antitumoral.
WO2009140572A3 (en) Combinatorial treatment with glucose regulated protein-170 and melanoma differentiation associated gene-7

Legal Events

Date Code Title Description
B25C Requirement related to requested transfer of rights

Owner name: EDWARDS, KATARINA (SE) , SJOEBERG, STEFAN (SE) , C

Free format text: AFIM DE ATENDER A TRANSFERENCIA REQUERIDA ATRAVES DA PETICAO NO 020100109007/RJ DE 22/11/2010, APRESENTE DOCUMENTOS QUE COMPROVE QUE A EMPRESA CESSIONARIA FAZ JUZ A TARIFA REDUZIDA.

B25C Requirement related to requested transfer of rights

Owner name: EDWARDS, KATARINA (SE) , SJOEBERG, STEFAN (SE) , C

Free format text: AFIM DE ATENDER AS TRANSFERENCIAS REQUERIDAS ATRAVES DAS PETICOES NO 020100108990/RJ, NO 020100108996/RJ E NO 020100109002/RJ DE 22/11/2010, APRESENTE DOCUMENTOS QUE COMPROVEM QUE A EMPRESA CESSIONARIA FAZ JUS A TARIFA REDUZIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015.

B25B Requested transfer of rights rejected

Owner name: EDWARDS, KATARINA (SE) , SJOEBERG, STEFAN (SE) , C

B25B Requested transfer of rights rejected

Owner name: EDWARDS, KATARINA (SE) , SJOEBERG, STEFAN (SE) , CARLSSON, JOERGEN (SE) , GEDDA, LARS (SE)

Free format text: INDEFERIDO O PEDIDO DE TRANSFERENCIA CONTIDO NA PETICAO 020100109007 DE 22/11/2010, CONFORME DISPOSTO NO ART. 59 DA LEI 9279/96 DE 14/05/1996, POR TER SIDO ARQUIVADO DEFINITIVAMENTE NA RPI 2326 DE 04/08/2015.

Owner name: EDWARDS, KATARINA (SE) , SJOEBERG, STEFAN (SE) , C

B25B Requested transfer of rights rejected

Owner name: EDWARDS, KATARINA (SE) , SJOEBERG, STEFAN (SE) , C

B25B Requested transfer of rights rejected

Owner name: EDWARDS, KATARINA (SE) , SJOEBERG, STEFAN (SE) , C