ES2229483T3 - Composiciones farmaceuticas para la liberacion controlada de sustancias activas. - Google Patents
Composiciones farmaceuticas para la liberacion controlada de sustancias activas.Info
- Publication number
- ES2229483T3 ES2229483T3 ES98909235T ES98909235T ES2229483T3 ES 2229483 T3 ES2229483 T3 ES 2229483T3 ES 98909235 T ES98909235 T ES 98909235T ES 98909235 T ES98909235 T ES 98909235T ES 2229483 T3 ES2229483 T3 ES 2229483T3
- Authority
- ES
- Spain
- Prior art keywords
- matrices
- release
- tablets
- active substance
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- PGLIUCLTXOYQMV-UHFFFAOYSA-N Cetirizine hydrochloride Chemical compound Cl.Cl.C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 PGLIUCLTXOYQMV-UHFFFAOYSA-N 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- OCJYIGYOJCODJL-UHFFFAOYSA-N Meclizine Chemical compound CC1=CC=CC(CN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=C1 OCJYIGYOJCODJL-UHFFFAOYSA-N 0.000 description 1
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- 229910052783 alkali metal Inorganic materials 0.000 description 1
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- 238000007796 conventional method Methods 0.000 description 1
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- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
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- 229960005181 morphine Drugs 0.000 description 1
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- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| BE9700225 | 1997-03-14 | ||
| BE9700225A BE1011045A3 (fr) | 1997-03-14 | 1997-03-14 | Compositions pharmaceutiques pour la liberation controlee de substances actives. |
Publications (1)
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|---|---|
| ES2229483T3 true ES2229483T3 (es) | 2005-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES98909235T Expired - Lifetime ES2229483T3 (es) | 1997-03-14 | 1998-03-13 | Composiciones farmaceuticas para la liberacion controlada de sustancias activas. |
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| AT (1) | ATE275943T1 (enExample) |
| AU (1) | AU736052B2 (enExample) |
| BE (1) | BE1011045A3 (enExample) |
| BR (1) | BR9808239A (enExample) |
| CA (1) | CA2283133C (enExample) |
| DE (1) | DE69826290T2 (enExample) |
| ES (1) | ES2229483T3 (enExample) |
| ID (1) | ID22980A (enExample) |
| IL (1) | IL131292A (enExample) |
| NZ (1) | NZ337345A (enExample) |
| PL (1) | PL190735B1 (enExample) |
| RO (1) | RO120602B1 (enExample) |
| RU (1) | RU2179017C2 (enExample) |
| WO (1) | WO1998041194A1 (enExample) |
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| JPH1050306A (ja) * | 1996-07-31 | 1998-02-20 | Toyota Autom Loom Works Ltd | 水素吸蔵合金電極の製造方法 |
| BE1011045A3 (fr) * | 1997-03-14 | 1999-04-06 | Ucb Sa | Compositions pharmaceutiques pour la liberation controlee de substances actives. |
| US20050085498A1 (en) * | 1998-05-28 | 2005-04-21 | Byrd Edward A. | Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate |
| WO2000018374A1 (en) * | 1998-10-01 | 2000-04-06 | Elan Pharma International, Ltd. | Controlled release nanoparticulate compositions |
| JP2001107258A (ja) * | 1999-10-06 | 2001-04-17 | Hitachi Ltd | 無電解銅めっき方法とめっき装置および多層配線基板 |
| WO2001032148A1 (en) | 1999-10-29 | 2001-05-10 | Euro-Celtique, S.A. | Controlled release hydrocodone formulations |
| US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
| EP1118321A1 (fr) * | 2000-01-14 | 2001-07-25 | Ucb, S.A. | Compositions pharmaceutiques solides pour la libération contrôlée de substances actives |
| US6242003B1 (en) | 2000-04-13 | 2001-06-05 | Novartis Ag | Organic compounds |
| GB0009522D0 (en) * | 2000-04-19 | 2000-06-07 | Smithkline Beecham Plc | Composition |
| CN101317825A (zh) | 2000-10-30 | 2008-12-10 | 欧罗赛铁克股份有限公司 | 控释氢可酮制剂 |
| US20060127474A1 (en) | 2001-04-11 | 2006-06-15 | Oskar Kalb | Pharmaceutical compositions comprising fluvastatin |
| PL206069B1 (pl) * | 2001-06-28 | 2010-06-30 | Ucb Farchim Sa | Tabletka dwuwarstwowa zawierająca cetyryzynę i pseudoefedrynę |
| HRP20031057B1 (hr) | 2001-06-28 | 2013-05-31 | Ucb Farchim Sa, Z.I. Planchy | Tableta koja sadrži cetirizin i pseudoefedrin |
| US20030092724A1 (en) * | 2001-09-18 | 2003-05-15 | Huaihung Kao | Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic |
| AU2003202550A1 (en) * | 2002-01-09 | 2003-07-24 | Ucb, S.A. | Pharmaceutical formulations with modified release |
| PL372904A1 (en) * | 2002-04-04 | 2005-08-08 | Pfizer Products Inc. | Palatable chewable tablet |
| AU2003272601B2 (en) * | 2002-09-20 | 2009-05-07 | Alpharma Pharmaceuticals, Llc | Sustained-release opioid formulations and methods of use |
| US8487002B2 (en) * | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
| TWI319713B (en) * | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
| WO2004052367A1 (en) * | 2002-12-06 | 2004-06-24 | Ucb Farchim, S.A. | Tablet comprising efletirizine and pseudoephedrine |
| US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
| US20050281875A1 (en) * | 2003-12-17 | 2005-12-22 | Sovereign Pharmaceuticals, Ltd. | Promethazine containing dosage form |
| US20050266032A1 (en) * | 2003-12-17 | 2005-12-01 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
| US20060029664A1 (en) * | 2004-08-04 | 2006-02-09 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing carbetapentane and another drug |
| US20050232987A1 (en) * | 2004-03-12 | 2005-10-20 | Viswanathan Srinivasan | Dosage form containing a morphine derivative and another drug |
| US20050232986A1 (en) * | 2003-12-17 | 2005-10-20 | David Brown | Dosage form containing promethazine and another drug |
| US9492541B2 (en) * | 2004-09-14 | 2016-11-15 | Sovereign Pharmaceuticals, Llc | Phenylepherine containing dosage form |
| US7897172B2 (en) * | 2004-05-18 | 2011-03-01 | L. Perrigo Company | Tablets exhibiting reduced drug release variability |
| US9308164B2 (en) | 2004-06-30 | 2016-04-12 | Sovereign Pharmaceuticals, Llc | Hyoscyamine dosage form |
| US20070003622A1 (en) * | 2004-12-16 | 2007-01-04 | Sovereign Pharmaceuticals, Ltd. | Diphenhydramine containing dosage form |
| WO2006022996A2 (en) * | 2004-08-04 | 2006-03-02 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
| US9592197B2 (en) * | 2004-12-16 | 2017-03-14 | Sovereign Pharmaceuticals, Llc | Dosage form containing diphenhydramine and another drug |
| US7529255B2 (en) * | 2005-04-21 | 2009-05-05 | Microsoft Corporation | Peer-to-peer multicasting using multiple transport protocols |
| SI1909764T1 (sl) * | 2005-07-26 | 2015-01-30 | Ucb Pharma, S.A. | Farmacevtski sestavki, ki obsegajo levetiracetam in postopek za njihovo pripravo |
| US8795723B2 (en) | 2005-09-09 | 2014-08-05 | Angelini Pharma Inc. | Sustained drug release compositions |
| JP5269595B2 (ja) * | 2005-09-09 | 2013-08-21 | アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー | 1日1回投与用トラゾドン組成物 |
| US20090317355A1 (en) * | 2006-01-21 | 2009-12-24 | Abbott Gmbh & Co. Kg, | Abuse resistant melt extruded formulation having reduced alcohol interaction |
| US20090022798A1 (en) * | 2007-07-20 | 2009-01-22 | Abbott Gmbh & Co. Kg | Formulations of nonopioid and confined opioid analgesics |
| JP2009523833A (ja) * | 2006-01-21 | 2009-06-25 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 乱用薬剤送達のための製剤および方法 |
| US20100172989A1 (en) * | 2006-01-21 | 2010-07-08 | Abbott Laboratories | Abuse resistant melt extruded formulation having reduced alcohol interaction |
| KR100753480B1 (ko) * | 2006-01-27 | 2007-08-31 | 씨제이 주식회사 | 잘토프로펜 함유 서방성 정제 및 그 제조방법 |
| US20070253927A1 (en) * | 2006-04-13 | 2007-11-01 | Gwenaelle Jegou | Cosmetic compositions comprising at least one dielectrophile monomer and at least one radical initiator |
| US20100172984A1 (en) * | 2006-06-06 | 2010-07-08 | Bijay Kumar Padhi | tablet dosage form comprising cetirizine and pseudoephedrine |
| US20080069891A1 (en) * | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
| WO2007149860A1 (en) * | 2006-06-19 | 2007-12-27 | Accu-Break Technologies, Inc. | Segmented pharmaceutical dosage forms |
| US8765178B2 (en) * | 2006-07-19 | 2014-07-01 | Watson Laboratories, Inc. | Controlled release formulations and associated methods |
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| US8045677B2 (en) | 2006-09-25 | 2011-10-25 | Koninklijke Philips Electronics N V Eindhoven | Shifting an object for complete trajectories in rotational X-ray imaging |
| SI2124556T1 (sl) | 2006-10-09 | 2015-01-30 | Charleston Laboratories, Inc. | Farmacevtske sestave |
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| US9833510B2 (en) * | 2007-06-12 | 2017-12-05 | Johnson & Johnson Consumer Inc. | Modified release solid or semi-solid dosage forms |
| AU2008314454A1 (en) * | 2007-10-16 | 2009-04-23 | Labopharm (Barbados) Limited | Bilayer composition for the sustained release of acetaminophen and tramadol |
| EP2219677A1 (en) * | 2007-11-21 | 2010-08-25 | The Procter & Gamble Company | Preparations, methods and kits useful for treatment of cough |
| CA2707980C (en) | 2007-12-17 | 2015-05-12 | Labopharm Inc. | Misuse preventative, controlled release formulation |
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| JP2011511782A (ja) | 2008-02-12 | 2011-04-14 | アボット・ラボラトリーズ | 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途 |
| CA2746888C (en) | 2008-12-16 | 2015-05-12 | Labopharm (Barbados) Limited | Misuse preventative, controlled release formulation |
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| BR112012008317A2 (pt) | 2009-09-17 | 2016-03-22 | Upsher Smith Lab Inc | produto de liberação sustentada compreendendo uma combinação de uma amina não-opioide e uma droga anti-inflamatória não-esteroidal |
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| CN102302497A (zh) * | 2011-05-18 | 2012-01-04 | 天圣制药集团股份有限公司 | 一种治疗过敏性鼻炎的制剂及其制备方法 |
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| KR102070076B1 (ko) * | 2013-05-03 | 2020-01-29 | 주식회사 제닉 | 탄산 함유 입자를 포함하는 필름 |
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| JP6461186B2 (ja) | 2014-03-11 | 2019-01-30 | レッド ヒル バイオファーマ リミテッドRedHill Biopharma Ltd. | 悪心、嘔吐または下痢の症状を処置するためのオンダンセトロン徐放固形製剤 |
| US10179109B2 (en) | 2016-03-04 | 2019-01-15 | Charleston Laboratories, Inc. | Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates |
| RU2687715C1 (ru) * | 2018-05-07 | 2019-05-15 | Федеральное государственное бюджетное учреждение науки Институт горного дела Дальневосточного отделения Российской академии наук | Способ комбинированной разработки россыпных месторождений золота |
| US20220062200A1 (en) | 2019-05-07 | 2022-03-03 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
| US11324707B2 (en) | 2019-05-07 | 2022-05-10 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
| KR102073185B1 (ko) * | 2019-07-16 | 2020-02-04 | (주)위바이오트리 | 활성성분을 포함하는 변성 다중층 수산화물 구조체를 포함하는 금속 수산화물 복합체 및 이의 제조 방법 |
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| US477033A (en) * | 1892-06-14 | Bicycle | ||
| US4684516A (en) | 1983-08-01 | 1987-08-04 | Alra Laboratories, Inc. | Sustained release tablets and method of making same |
| EP0205336B1 (en) * | 1985-06-11 | 1991-09-11 | Teijin Limited | Oral sustained release pharmaceutical preparation |
| DE3524572A1 (de) | 1985-07-10 | 1987-01-15 | Thomae Gmbh Dr K | Feste arzneimittelformen zur peroralen anwendung enthaltend 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethyliden)-oxy)-(9s)-erythromycin und verfahren zu ihrer herstellung |
| US4756911A (en) * | 1986-04-16 | 1988-07-12 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| JPS6396126A (ja) | 1986-10-13 | 1988-04-27 | Taisho Pharmaceut Co Ltd | 安定化組成物 |
| IT1201136B (it) | 1987-01-13 | 1989-01-27 | Resa Farma | Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive |
| GB8724763D0 (en) | 1987-10-22 | 1987-11-25 | Aps Research Ltd | Sustained-release formulations |
| IE60383B1 (en) * | 1988-05-27 | 1994-07-13 | Elan Corp Plc | Controlled release pharmaceutical formulation |
| US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
| MX9300110A (es) * | 1992-01-13 | 1994-07-29 | Gerhard Gergely | Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion. |
| IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| US5411748A (en) | 1992-10-22 | 1995-05-02 | Song Moon K | Prostate extract supplemented with zinc |
| US5314697A (en) * | 1992-10-23 | 1994-05-24 | Schering Corporation | Stable extended release oral dosage composition comprising loratadine and pseudoephedrine |
| DE69508580T2 (de) * | 1994-06-15 | 1999-09-23 | Dumex Alpharma As | Pellets |
| RU2065299C1 (ru) * | 1994-07-15 | 1996-08-20 | Акционерное общество закрытого типа "Олвик" | Ноотропное и транквилизирующее средство |
| EP0811374A1 (en) * | 1996-05-29 | 1997-12-10 | Pfizer Inc. | Combination dosage form comprising cetirizine and pseudoephedrine |
| AU5609998A (en) * | 1997-01-10 | 1998-08-03 | Abbott Laboratories | Tablet for the controlled release of active agents |
| BE1011045A3 (fr) * | 1997-03-14 | 1999-04-06 | Ucb Sa | Compositions pharmaceutiques pour la liberation controlee de substances actives. |
-
1997
- 1997-03-14 BE BE9700225A patent/BE1011045A3/fr not_active IP Right Cessation
-
1998
- 1998-03-13 KR KR10-1999-7008365A patent/KR100500775B1/ko not_active Expired - Fee Related
- 1998-03-13 IL IL13129298A patent/IL131292A/en active IP Right Grant
- 1998-03-13 AT AT98909235T patent/ATE275943T1/de not_active IP Right Cessation
- 1998-03-13 RO RO99-00963A patent/RO120602B1/ro unknown
- 1998-03-13 NZ NZ337345A patent/NZ337345A/xx unknown
- 1998-03-13 PL PL98335832A patent/PL190735B1/pl not_active IP Right Cessation
- 1998-03-13 US US09/381,044 patent/US6699502B1/en not_active Expired - Lifetime
- 1998-03-13 AU AU63873/98A patent/AU736052B2/en not_active Ceased
- 1998-03-13 BR BR9808239-6A patent/BR9808239A/pt not_active Application Discontinuation
- 1998-03-13 WO PCT/BE1998/000033 patent/WO1998041194A1/fr not_active Ceased
- 1998-03-13 JP JP53995798A patent/JP2001524950A/ja not_active Ceased
- 1998-03-13 ID IDW991007A patent/ID22980A/id unknown
- 1998-03-13 ES ES98909235T patent/ES2229483T3/es not_active Expired - Lifetime
- 1998-03-13 DE DE69826290T patent/DE69826290T2/de not_active Expired - Fee Related
- 1998-03-13 CN CN98803222A patent/CN1126536C/zh not_active Expired - Fee Related
- 1998-03-13 RU RU99119084/14A patent/RU2179017C2/ru not_active IP Right Cessation
- 1998-03-13 CA CA002283133A patent/CA2283133C/fr not_active Expired - Fee Related
- 1998-03-13 EP EP98909235A patent/EP1007005B1/fr not_active Expired - Lifetime
-
2002
- 2002-01-28 US US10/055,962 patent/US20020110596A1/en not_active Abandoned
-
2003
- 2003-06-27 US US10/607,047 patent/US7083807B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BE1011045A3 (fr) | 1999-04-06 |
| CN1250371A (zh) | 2000-04-12 |
| EP1007005A1 (fr) | 2000-06-14 |
| KR20000076269A (ko) | 2000-12-26 |
| DE69826290D1 (de) | 2004-10-21 |
| AU736052B2 (en) | 2001-07-26 |
| US7083807B2 (en) | 2006-08-01 |
| WO1998041194A1 (fr) | 1998-09-24 |
| BR9808239A (pt) | 2000-05-16 |
| US20040086563A1 (en) | 2004-05-06 |
| RU2179017C2 (ru) | 2002-02-10 |
| CN1126536C (zh) | 2003-11-05 |
| CA2283133C (fr) | 2006-07-25 |
| DE69826290T2 (de) | 2005-02-17 |
| IL131292A0 (en) | 2001-01-28 |
| US6699502B1 (en) | 2004-03-02 |
| NZ337345A (en) | 2000-04-28 |
| US20020110596A1 (en) | 2002-08-15 |
| HK1026152A1 (en) | 2000-12-08 |
| KR100500775B1 (ko) | 2005-07-12 |
| ID22980A (id) | 1999-12-23 |
| AU6387398A (en) | 1998-10-12 |
| PL190735B1 (pl) | 2005-12-30 |
| ATE275943T1 (de) | 2004-10-15 |
| RO120602B1 (ro) | 2006-05-30 |
| CA2283133A1 (fr) | 1998-09-24 |
| PL335832A1 (en) | 2000-05-22 |
| EP1007005B1 (fr) | 2004-09-15 |
| JP2001524950A (ja) | 2001-12-04 |
| IL131292A (en) | 2004-07-25 |
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