ES2209974T3 - Agonistas del receptor a2a n-pirazol. - Google Patents

Agonistas del receptor a2a n-pirazol.

Info

Publication number
ES2209974T3
ES2209974T3 ES00960112T ES00960112T ES2209974T3 ES 2209974 T3 ES2209974 T3 ES 2209974T3 ES 00960112 T ES00960112 T ES 00960112T ES 00960112 T ES00960112 T ES 00960112T ES 2209974 T3 ES2209974 T3 ES 2209974T3
Authority
ES
Spain
Prior art keywords
alkyl
aryl
optionally substituted
halo
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00960112T
Other languages
English (en)
Spanish (es)
Inventor
Jeff A. Zablocki
Elfatih O. Elzein
Venkata P. Palle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Palo Alto Inc
Original Assignee
CV Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CV Therapeutics Inc filed Critical CV Therapeutics Inc
Application granted granted Critical
Publication of ES2209974T3 publication Critical patent/ES2209974T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES00960112T 1999-06-22 2000-06-21 Agonistas del receptor a2a n-pirazol. Expired - Lifetime ES2209974T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/338,185 US6403567B1 (en) 1999-06-22 1999-06-22 N-pyrazole A2A adenosine receptor agonists
US338185 1999-06-22

Publications (1)

Publication Number Publication Date
ES2209974T3 true ES2209974T3 (es) 2004-07-01

Family

ID=23323763

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00960112T Expired - Lifetime ES2209974T3 (es) 1999-06-22 2000-06-21 Agonistas del receptor a2a n-pirazol.

Country Status (27)

Country Link
US (9) US6403567B1 (US20050276830A1-20051215-C00018.png)
EP (1) EP1189916B1 (US20050276830A1-20051215-C00018.png)
JP (1) JP4727880B2 (US20050276830A1-20051215-C00018.png)
KR (1) KR100463300B1 (US20050276830A1-20051215-C00018.png)
CN (1) CN1167709C (US20050276830A1-20051215-C00018.png)
AR (1) AR024441A1 (US20050276830A1-20051215-C00018.png)
AT (1) ATE256141T1 (US20050276830A1-20051215-C00018.png)
AU (1) AU760806B2 (US20050276830A1-20051215-C00018.png)
BE (1) BE2011C004I2 (US20050276830A1-20051215-C00018.png)
BR (1) BRPI0011856B8 (US20050276830A1-20051215-C00018.png)
CA (1) CA2377746C (US20050276830A1-20051215-C00018.png)
CY (1) CY2011002I2 (US20050276830A1-20051215-C00018.png)
DE (2) DE122011000010I1 (US20050276830A1-20051215-C00018.png)
DK (1) DK1189916T3 (US20050276830A1-20051215-C00018.png)
ES (1) ES2209974T3 (US20050276830A1-20051215-C00018.png)
FR (1) FR11C0004I2 (US20050276830A1-20051215-C00018.png)
HK (1) HK1044952B (US20050276830A1-20051215-C00018.png)
IL (2) IL147198A0 (US20050276830A1-20051215-C00018.png)
LU (1) LU91785I2 (US20050276830A1-20051215-C00018.png)
MX (1) MXPA01013325A (US20050276830A1-20051215-C00018.png)
NO (2) NO322457B1 (US20050276830A1-20051215-C00018.png)
NZ (1) NZ516334A (US20050276830A1-20051215-C00018.png)
PT (1) PT1189916E (US20050276830A1-20051215-C00018.png)
TR (1) TR200200588T2 (US20050276830A1-20051215-C00018.png)
TW (1) TWI230161B (US20050276830A1-20051215-C00018.png)
WO (1) WO2000078779A2 (US20050276830A1-20051215-C00018.png)
ZA (1) ZA200200301B (US20050276830A1-20051215-C00018.png)

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