PL2300489T3 - Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych - Google Patents

Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych

Info

Publication number
PL2300489T3
PL2300489T3 PL09759550.8T PL09759550T PL2300489T3 PL 2300489 T3 PL2300489 T3 PL 2300489T3 PL 09759550 T PL09759550 T PL 09759550T PL 2300489 T3 PL2300489 T3 PL 2300489T3
Authority
PL
Poland
Prior art keywords
alkynyl
preparing
methods
related compounds
hydroxy steroids
Prior art date
Application number
PL09759550.8T
Other languages
English (en)
Inventor
Steven K. White
Yu Ge
Yujin Huang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2300489T3 publication Critical patent/PL2300489T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL09759550.8T 2008-06-06 2009-06-05 Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych PL2300489T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5965808P 2008-06-06 2008-06-06

Publications (1)

Publication Number Publication Date
PL2300489T3 true PL2300489T3 (pl) 2016-11-30

Family

ID=41398563

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09759550.8T PL2300489T3 (pl) 2008-06-06 2009-06-05 Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych

Country Status (12)

Country Link
US (4) US8309746B2 (pl)
EP (1) EP2300489B1 (pl)
JP (2) JP5709743B2 (pl)
CN (1) CN102046647A (pl)
AU (1) AU2009256009B2 (pl)
CA (1) CA2724130C (pl)
DK (1) DK2300489T3 (pl)
ES (1) ES2562083T3 (pl)
HU (1) HUE028327T2 (pl)
IL (1) IL209693A (pl)
PL (1) PL2300489T3 (pl)
WO (1) WO2009149392A1 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102215845A (zh) * 2008-04-03 2011-10-12 哈博生物科学公司 药学试剂的固体形式
PL2300489T3 (pl) 2008-06-06 2016-11-30 Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych
GB2480632A (en) * 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
EP2667876A2 (en) * 2010-12-15 2013-12-04 Harbor BioSciences, Inc. Methods and compounds for preparing 3alpha-oxygen substituted steroids
CN103402523A (zh) * 2010-12-17 2013-11-20 哈博生物科学公司 甾族化合物四醇固体形式-2
US9296780B2 (en) * 2011-12-23 2016-03-29 Crystal Pharma, S.A.U. Process for alkynylating 16-substituted-17-keto steroids
CN102603839A (zh) * 2012-01-13 2012-07-25 宜城市共同药业有限公司 去氢表雄酮的制备方法
CN103360458B (zh) * 2012-03-26 2015-05-20 信泰制药（苏州）有限公司 一种阿比特龙的合成方法
CN104292288A (zh) * 2013-07-16 2015-01-21 天津金耀集团有限公司 一种17-乙炔基-16-烯甾体衍生物的制备方法
CN104292287A (zh) * 2013-07-16 2015-01-21 天津金耀集团有限公司 一种17-乙炔基-16-烯甾体衍生物的合成方法
CN105622713B (zh) * 2014-10-27 2020-02-18 天津金耀集团有限公司 一种甾体11位酮基还原工艺
WO2019041078A1 (en) * 2017-08-28 2019-03-07 Zhejiang Jiachi Pharmaceutical Development Ltd. ASYMMETRIC SYNTHESIS AND USES OF COMPOUNDS IN TREATMENT OF DISEASES
CN114478672B (zh) * 2022-01-27 2024-06-14 浙江仙居君业药业有限公司 一种he3286的合成方法
CN120829946A (zh) * 2024-04-19 2025-10-24 湖北大学 一种酶法与化学法相结合合成甾体he3286的方法
CN120484042B (zh) * 2025-05-16 2026-01-30 中国人民解放军军事科学院军事医学研究院 一种he3286的合成方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4898694A (en) 1987-11-25 1990-02-06 Schwartz Arthur G 17-Hydroxy-steroids
WO1993015103A2 (en) 1992-01-28 1993-08-05 Schering Corporation Novel steroid intermediates and processes for their preparation
US5922701A (en) 1992-05-01 1999-07-13 University Of Utah Research Foundation Method for enhancing or accelerating re-epithelialization or re-endothelialization of a tissue
FR2696464B1 (fr) 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
US5359071A (en) 1993-03-12 1994-10-25 Merck & Co., Inc. 15-substituted 4-azasteroids
US5476932A (en) 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
US5859000A (en) 1995-06-07 1999-01-12 University Of Utah Research Foundation Method for reducing mast cell mediated allergic reactions
US20060079492A1 (en) 1999-10-25 2006-04-13 Ahlem Clarence N Compositions and treatment methods
US20070129282A1 (en) 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
US20030060425A1 (en) 1998-11-24 2003-03-27 Ahlem Clarence N. Immune modulation method using steroid compounds
US20030083231A1 (en) 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US20080015174A1 (en) 1998-11-24 2008-01-17 Reading Christopher L Metabolic Disease Treatments
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
CA2669753C (en) 1999-09-30 2012-06-26 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment of androgen receptor driven conditions
ATE413179T1 (de) 1999-10-25 2008-11-15 Hollis Eden Pharmaceuticals Therapeutische verwendungen von steroiden bei blutzellmangelzustaenden
GB2369356B (en) 2000-09-18 2004-02-04 Phoenix Chemicals Ltd Process
FR2835839B1 (fr) * 2002-02-12 2004-04-02 Oreal Procede de preparation de la 7beta-hydroxy-dehydroepiandrosterone
AU2003213807A1 (en) * 2002-11-06 2004-06-03 Pharmacia & Upjohn Company Llc Processes for preparing 7-carboxy substituted steroids
TWI280133B (en) * 2002-11-07 2007-05-01 Upjohn Co Process for preparing C-7 substituted steroids
ES2222832B1 (es) 2003-07-30 2006-02-16 Laboratorios Del Dr. Esteve, S.A. Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
ES2222829B1 (es) 2003-07-30 2006-03-01 Laboratorios Del Dr. Esteve, S.A. Derivados de 4-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
ATE402185T1 (de) 2003-12-22 2008-08-15 Hoffmann La Roche Verfahren für fluorcytidinderivate
US7910755B2 (en) 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
US20060073099A1 (en) 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
CN1724554A (zh) * 2005-07-15 2006-01-25 四川大学 1,4－孕甾二烯－17α,21－二羟－3,20－二酮－17α,21－二醋酸酯
US7732595B2 (en) 2006-02-03 2010-06-08 Gilead Palo Alto, Inc. Process for preparing an A2A-adenosine receptor agonist and its polymorphs
KR20080112413A (ko) * 2006-04-22 2008-12-24 홀리스-에덴 파마슈티칼즈, 인코포레이티드 약물 및 그 용도
US8217025B2 (en) 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods
US20080221074A1 (en) 2006-11-17 2008-09-11 Jaime Flores-Riveros Drug Screen and Treatment Method
US20080153792A1 (en) 2006-11-17 2008-06-26 Frincke James M Drug Identification and Treatment Method
US8354396B2 (en) 2006-11-17 2013-01-15 Harbor Therapeutics, Inc. Drug identification and treatment method
CN102215845A (zh) 2008-04-03 2011-10-12 哈博生物科学公司 药学试剂的固体形式
PL2300489T3 (pl) * 2008-06-06 2016-11-30 Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych
US20100075937A1 (en) 2008-09-24 2010-03-25 Hollis-Eden Pharmaceuticals, Inc. Patient populations and treatment methods

Also Published As

Publication number Publication date
IL209693A (en) 2017-04-30
US20180215778A1 (en) 2018-08-02
JP2014231526A (ja) 2014-12-11
AU2009256009A8 (en) 2011-11-17
EP2300489A1 (en) 2011-03-30
DK2300489T3 (en) 2016-02-15
WO2009149392A1 (en) 2009-12-10
US20160039863A1 (en) 2016-02-11
EP2300489B1 (en) 2015-11-11
IL209693A0 (en) 2011-02-28
US20130066087A1 (en) 2013-03-14
US20090326251A1 (en) 2009-12-31
US9163059B2 (en) 2015-10-20
EP2300489A4 (en) 2012-03-21
US9994608B2 (en) 2018-06-12
CA2724130C (en) 2016-04-26
AU2009256009B2 (en) 2014-02-06
CA2724130A1 (en) 2009-12-10
HUE028327T2 (en) 2017-02-28
JP5709743B2 (ja) 2015-04-30
CN102046647A (zh) 2011-05-04
ES2562083T3 (es) 2016-03-02
US20180079775A9 (en) 2018-03-22
JP2011522836A (ja) 2011-08-04
AU2009256009A1 (en) 2009-12-10
US8309746B2 (en) 2012-11-13

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