ES2207171T3 - Derivados de azetidina carboxamida para tratar trastornos del sistema nervioso central. - Google Patents
Derivados de azetidina carboxamida para tratar trastornos del sistema nervioso central.Info
- Publication number
- ES2207171T3 ES2207171T3 ES99902658T ES99902658T ES2207171T3 ES 2207171 T3 ES2207171 T3 ES 2207171T3 ES 99902658 T ES99902658 T ES 99902658T ES 99902658 T ES99902658 T ES 99902658T ES 2207171 T3 ES2207171 T3 ES 2207171T3
- Authority
- ES
- Spain
- Prior art keywords
- compound according
- phenyl
- azetidin
- carboxamide
- propenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000015114 central nervous system disease Diseases 0.000 title claims abstract description 5
- PVXOUGHWLCBJOW-UHFFFAOYSA-N azetidine-1-carboxamide Chemical class NC(=O)N1CCC1 PVXOUGHWLCBJOW-UHFFFAOYSA-N 0.000 title description 3
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- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 4
- 239000001257 hydrogen Substances 0.000 claims abstract description 3
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 3
- -1 3- (trifluoromethyl) phenyl Chemical group 0.000 claims description 47
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 13
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 10
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- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims description 4
- DBBPOGGTCAKHPS-UHFFFAOYSA-N 3-[1-[3-(trifluoromethyl)phenyl]ethoxy]azetidine-1-carboxamide Chemical compound C=1C=CC(C(F)(F)F)=CC=1C(C)OC1CN(C(N)=O)C1 DBBPOGGTCAKHPS-UHFFFAOYSA-N 0.000 claims description 4
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
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- OHSGYVIGEPGGBE-UHFFFAOYSA-N 3-[[3-(trifluoromethyl)phenyl]methoxy]azetidine-1-carboxamide Chemical compound C1N(C(=O)N)CC1OCC1=CC=CC(C(F)(F)F)=C1 OHSGYVIGEPGGBE-UHFFFAOYSA-N 0.000 claims description 2
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- FAXDZWQIWUSWJH-UHFFFAOYSA-N 3-methoxypropan-1-amine Chemical compound COCCCN FAXDZWQIWUSWJH-UHFFFAOYSA-N 0.000 description 11
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
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- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9801500 | 1998-01-23 | ||
| GBGB9801500.1A GB9801500D0 (en) | 1998-01-23 | 1998-01-23 | Chemical compounds - II |
| GBGB9824457.7A GB9824457D0 (en) | 1998-11-06 | 1998-11-06 | Chemical compounds II |
| GB9824457 | 1998-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2207171T3 true ES2207171T3 (es) | 2004-05-16 |
Family
ID=26313010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99902658T Expired - Lifetime ES2207171T3 (es) | 1998-01-23 | 1999-01-22 | Derivados de azetidina carboxamida para tratar trastornos del sistema nervioso central. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6403574B1 (enExample) |
| EP (1) | EP1049672B1 (enExample) |
| JP (1) | JP4542263B2 (enExample) |
| AT (1) | ATE250027T1 (enExample) |
| AU (1) | AU2287499A (enExample) |
| DE (1) | DE69911373T2 (enExample) |
| DK (1) | DK1049672T3 (enExample) |
| ES (1) | ES2207171T3 (enExample) |
| PT (1) | PT1049672E (enExample) |
| WO (1) | WO1999037612A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9917386D0 (en) * | 1999-07-23 | 1999-09-22 | Cerebrus Ltd | Chemical compounds-II |
| EP1617839B1 (en) * | 2003-05-01 | 2008-06-18 | Vernalis Research Limited | The use of azetidinecarboxamide derivatives in therapy |
| EP1618105A1 (en) * | 2003-05-01 | 2006-01-25 | Vernalis Research Limited | Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders |
| CA2524251A1 (en) * | 2003-05-01 | 2004-11-11 | Vernalis Research Limited | Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders |
| US11141404B1 (en) * | 2020-11-18 | 2021-10-12 | Anebulo Pharmaceuticals, Inc. | Formulations and methods for treating acute cannabinoid overdose |
| AU2022362107A1 (en) | 2021-10-11 | 2024-05-02 | Anebulo Pharmaceuticals, Inc. | Crystalline forms of a cannabinoid receptor type 1 (cb1) modulator and methods of use and preparation thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB872447A (en) * | 1958-12-23 | 1961-07-12 | Lepetit Spa | 1-carbamyl-3-substituted azetidines |
| US4226861A (en) | 1978-04-18 | 1980-10-07 | A. H. Robins Company, Inc. | N-Lower-alkyl 3-phenoxy-1-azetidinecarboxamides |
| IL68699A (en) * | 1982-08-19 | 1986-08-31 | Robins Co Inc A H | 3-phenoxy-1-azetidine-carboxamides,their preparation and pharmaceutical compositions containing them |
| US4505907A (en) | 1982-09-02 | 1985-03-19 | A. H. Robins Company, Inc. | N-Formyl and N-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides |
| IE58943B1 (en) * | 1985-02-28 | 1993-12-01 | Robins Co Inc A H | 3-Aryloxy-azetidine-carboxamides |
| US4956359A (en) * | 1985-02-28 | 1990-09-11 | A. H. Robins Company, Inc. | 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics |
-
1999
- 1999-01-22 DE DE69911373T patent/DE69911373T2/de not_active Expired - Lifetime
- 1999-01-22 PT PT99902658T patent/PT1049672E/pt unknown
- 1999-01-22 EP EP99902658A patent/EP1049672B1/en not_active Expired - Lifetime
- 1999-01-22 WO PCT/GB1999/000219 patent/WO1999037612A1/en not_active Ceased
- 1999-01-22 JP JP2000528536A patent/JP4542263B2/ja not_active Expired - Lifetime
- 1999-01-22 ES ES99902658T patent/ES2207171T3/es not_active Expired - Lifetime
- 1999-01-22 AT AT99902658T patent/ATE250027T1/de not_active IP Right Cessation
- 1999-01-22 DK DK99902658T patent/DK1049672T3/da active
- 1999-01-22 US US09/600,628 patent/US6403574B1/en not_active Expired - Lifetime
- 1999-01-22 AU AU22874/99A patent/AU2287499A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE250027T1 (de) | 2003-10-15 |
| PT1049672E (pt) | 2004-02-27 |
| EP1049672A1 (en) | 2000-11-08 |
| DE69911373D1 (de) | 2003-10-23 |
| DK1049672T3 (da) | 2004-01-19 |
| JP2002501045A (ja) | 2002-01-15 |
| US6403574B1 (en) | 2002-06-11 |
| EP1049672B1 (en) | 2003-09-17 |
| AU2287499A (en) | 1999-08-09 |
| DE69911373T2 (de) | 2004-07-01 |
| JP4542263B2 (ja) | 2010-09-08 |
| WO1999037612A1 (en) | 1999-07-29 |
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