JP4542263B2 - Ｃｎｓ障害を処置するためのアゼチジンカルボキサミド誘導体 - Google Patents
Ｃｎｓ障害を処置するためのアゼチジンカルボキサミド誘導体 Download PDFInfo
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- JP4542263B2 JP4542263B2 JP2000528536A JP2000528536A JP4542263B2 JP 4542263 B2 JP4542263 B2 JP 4542263B2 JP 2000528536 A JP2000528536 A JP 2000528536A JP 2000528536 A JP2000528536 A JP 2000528536A JP 4542263 B2 JP4542263 B2 JP 4542263B2
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- Prior art keywords
- compound
- compound according
- azetidine
- carboxamide
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 208000015114 central nervous system disease Diseases 0.000 title claims abstract description 7
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- 210000000225 synapse Anatomy 0.000 description 1
- 230000007428 synaptic transmission, GABAergic Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9801500.1A GB9801500D0 (en) | 1998-01-23 | 1998-01-23 | Chemical compounds - II |
| GB9801500.1 | 1998-11-06 | ||
| GBGB9824457.7A GB9824457D0 (en) | 1998-11-06 | 1998-11-06 | Chemical compounds II |
| GB9824457.7 | 1998-11-06 | ||
| PCT/GB1999/000219 WO1999037612A1 (en) | 1998-01-23 | 1999-01-22 | Azetidinecarboxamide derivatives for treating cns disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002501045A JP2002501045A (ja) | 2002-01-15 |
| JP2002501045A5 JP2002501045A5 (enExample) | 2006-03-02 |
| JP4542263B2 true JP4542263B2 (ja) | 2010-09-08 |
Family
ID=26313010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000528536A Expired - Lifetime JP4542263B2 (ja) | 1998-01-23 | 1999-01-22 | Ｃｎｓ障害を処置するためのアゼチジンカルボキサミド誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6403574B1 (enExample) |
| EP (1) | EP1049672B1 (enExample) |
| JP (1) | JP4542263B2 (enExample) |
| AT (1) | ATE250027T1 (enExample) |
| AU (1) | AU2287499A (enExample) |
| DE (1) | DE69911373T2 (enExample) |
| DK (1) | DK1049672T3 (enExample) |
| ES (1) | ES2207171T3 (enExample) |
| PT (1) | PT1049672E (enExample) |
| WO (1) | WO1999037612A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9917386D0 (en) * | 1999-07-23 | 1999-09-22 | Cerebrus Ltd | Chemical compounds-II |
| AU2004234125A1 (en) * | 2003-05-01 | 2004-11-11 | Vernalis Research Limited | Azetidinecarboxamide derivatives and their use in the treatment of CB1 receptor mediated disorders |
| US20060276452A1 (en) * | 2003-05-01 | 2006-12-07 | Vernalis Research Limited | Use of azetidinecarboxamide derivatives in therapy |
| EP1618105A1 (en) * | 2003-05-01 | 2006-01-25 | Vernalis Research Limited | Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders |
| US11141404B1 (en) * | 2020-11-18 | 2021-10-12 | Anebulo Pharmaceuticals, Inc. | Formulations and methods for treating acute cannabinoid overdose |
| US11795146B2 (en) | 2021-10-11 | 2023-10-24 | Anebulo Pharmaceuticals, Inc. | Crystalline forms of a cannabinoid receptor type 1 (CB1) modulator and methods of use and preparation thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB872447A (en) | 1958-12-23 | 1961-07-12 | Lepetit Spa | 1-carbamyl-3-substituted azetidines |
| US4226861A (en) | 1978-04-18 | 1980-10-07 | A. H. Robins Company, Inc. | N-Lower-alkyl 3-phenoxy-1-azetidinecarboxamides |
| IL68699A (en) * | 1982-08-19 | 1986-08-31 | Robins Co Inc A H | 3-phenoxy-1-azetidine-carboxamides,their preparation and pharmaceutical compositions containing them |
| US4505907A (en) | 1982-09-02 | 1985-03-19 | A. H. Robins Company, Inc. | N-Formyl and N-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides |
| IE58943B1 (en) * | 1985-02-28 | 1993-12-01 | Robins Co Inc A H | 3-Aryloxy-azetidine-carboxamides |
| US4956359A (en) * | 1985-02-28 | 1990-09-11 | A. H. Robins Company, Inc. | 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics |
-
1999
- 1999-01-22 US US09/600,628 patent/US6403574B1/en not_active Expired - Lifetime
- 1999-01-22 WO PCT/GB1999/000219 patent/WO1999037612A1/en not_active Ceased
- 1999-01-22 AU AU22874/99A patent/AU2287499A/en not_active Abandoned
- 1999-01-22 EP EP99902658A patent/EP1049672B1/en not_active Expired - Lifetime
- 1999-01-22 AT AT99902658T patent/ATE250027T1/de not_active IP Right Cessation
- 1999-01-22 ES ES99902658T patent/ES2207171T3/es not_active Expired - Lifetime
- 1999-01-22 DK DK99902658T patent/DK1049672T3/da active
- 1999-01-22 JP JP2000528536A patent/JP4542263B2/ja not_active Expired - Lifetime
- 1999-01-22 DE DE69911373T patent/DE69911373T2/de not_active Expired - Lifetime
- 1999-01-22 PT PT99902658T patent/PT1049672E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69911373D1 (de) | 2003-10-23 |
| PT1049672E (pt) | 2004-02-27 |
| DK1049672T3 (da) | 2004-01-19 |
| ES2207171T3 (es) | 2004-05-16 |
| EP1049672A1 (en) | 2000-11-08 |
| WO1999037612A1 (en) | 1999-07-29 |
| ATE250027T1 (de) | 2003-10-15 |
| AU2287499A (en) | 1999-08-09 |
| US6403574B1 (en) | 2002-06-11 |
| JP2002501045A (ja) | 2002-01-15 |
| DE69911373T2 (de) | 2004-07-01 |
| EP1049672B1 (en) | 2003-09-17 |
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