ES2199259T3 - Derivados de huperzina, su preparacion y su utilizacion. - Google Patents

Derivados de huperzina, su preparacion y su utilizacion.

Info

Publication number
ES2199259T3
ES2199259T3 ES95941572T ES95941572T ES2199259T3 ES 2199259 T3 ES2199259 T3 ES 2199259T3 ES 95941572 T ES95941572 T ES 95941572T ES 95941572 T ES95941572 T ES 95941572T ES 2199259 T3 ES2199259 T3 ES 2199259T3
Authority
ES
Spain
Prior art keywords
huperzine
alkyl
group
hydrogen
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95941572T
Other languages
English (en)
Spanish (es)
Inventor
Dayuan Zhu
Xican Tang
Jinlai Lin
Cheng Zhu
Jingkang Shen
Guansong Wu
Shanhao Jiang
Takuji C/O Tsumura & Co. Yamaguchi
Kazuhiro Tanaka
Takeshi Wakanatsu
Hiroaki C/O Tsumura & Co. Nishimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHANGAHI INST MATERIA MEDICA
Shanghai Institute of Materia Medica
Original Assignee
SHANGAHI INST MATERIA MEDICA
Shanghai Institute of Materia Medica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHANGAHI INST MATERIA MEDICA, Shanghai Institute of Materia Medica filed Critical SHANGAHI INST MATERIA MEDICA
Application granted granted Critical
Publication of ES2199259T3 publication Critical patent/ES2199259T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
ES95941572T 1994-12-28 1995-12-26 Derivados de huperzina, su preparacion y su utilizacion. Expired - Lifetime ES2199259T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN94114057 1994-12-28
CN94114057A CN1125725A (zh) 1994-12-28 1994-12-28 一类海克林碱衍生物及它的用途

Publications (1)

Publication Number Publication Date
ES2199259T3 true ES2199259T3 (es) 2004-02-16

Family

ID=5037011

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95941572T Expired - Lifetime ES2199259T3 (es) 1994-12-28 1995-12-26 Derivados de huperzina, su preparacion y su utilizacion.

Country Status (11)

Country Link
US (1) US5929084A (enExample)
EP (1) EP0806416B1 (enExample)
JP (3) JP3545416B2 (enExample)
CN (1) CN1125725A (enExample)
AT (1) ATE239708T1 (enExample)
AU (1) AU4296696A (enExample)
DE (1) DE69530706T2 (enExample)
DK (1) DK0806416T3 (enExample)
ES (1) ES2199259T3 (enExample)
PT (1) PT806416E (enExample)
WO (1) WO1996020176A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100210590A1 (en) * 1995-09-27 2010-08-19 Northwestern University Compositions and treatments for seizure-related disorders
NL1009437C2 (nl) * 1998-06-18 1999-12-21 Xenobiosis Extractiewerkwijze.
HUP0104493A3 (en) 1998-09-30 2002-12-28 Takeda Pharmaceutical Drugs for improving vesical excretory strength
US6159986A (en) * 1999-11-02 2000-12-12 Altman; David A. Compounds and therapy for resisting memory loss in humans
US6436972B1 (en) 2000-04-10 2002-08-20 Dalhousie University Pyridones and their use as modulators of serine hydrolase enzymes
EP1283902A4 (en) * 2000-05-05 2007-05-02 Us Army Medical Res And Materi ANALYSIS FOR THE DETECTION, MEASUREMENT AND CONTROL OF PROTEIN ACTIVITIES AND CONCENTRATIONS AND METHODS OF USE
US6369052B1 (en) 2000-08-07 2002-04-09 Georgetown University Combination of huperzine and nicotinic compounds as a neuroprotective agent
KR100390777B1 (ko) * 2000-12-19 2003-07-10 한국화학연구원 피리돈 유도체의 제조방법
DE10144041B9 (de) * 2001-09-07 2012-07-26 Leica Mikrosysteme Gmbh Gerät zum selbsttätigen Zuführen von Objektträgern zu einem Eindeckautomaten
ES2312981T3 (es) * 2003-03-14 2009-03-01 Debio Recherche Pharmaceutique S.A. Sistema de suministro subcutaneo, procedimiento para la preparacion del mismo y utilizacion del mismo para el tratamiento de trastornos de deficiencia colinergica.
CN100398093C (zh) * 2003-03-14 2008-07-02 德比欧药物研究有限公司 皮下给药系统、其制备方法及其治疗胆碱能缺乏障碍的用途
CN1308312C (zh) * 2003-11-13 2007-04-04 中国科学院上海药物研究所 石杉碱乙双分子和双功能团衍生物、制备方法及它的用途
US20050222123A1 (en) 2004-01-27 2005-10-06 North Shore-Long Island Jewish Research Institute Cholinesterase inhibitors for treating inflammation
ATE523199T1 (de) * 2004-11-02 2011-09-15 Univ Northwestern Pyridazinverbindungen und verfahren
US20060264455A1 (en) * 2005-05-23 2006-11-23 Schachter Steven C Use of huperzine for disorders
WO2007056580A2 (en) * 2005-11-08 2007-05-18 Pharmadyn, Inc. Methods and compositions for treating diseases associated with pathogenic proteins
CA2650711A1 (en) * 2006-04-28 2007-11-08 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
US8097726B2 (en) * 2006-05-17 2012-01-17 Industrial Technology Research Institute Huperzine a compound for treatment of alzheimer's disease
WO2008006286A1 (fr) * 2006-07-05 2008-01-17 Tianjin Hemay Bio-Tech Co. Ltd Dérivés analgésiques 5,9 - méthanocyclo-octa (b) pyridine - 2 (1h) - one, leur procédé de préparation et leur utilisation
CN100528844C (zh) * 2007-04-20 2009-08-19 中国科学院昆明植物研究所 石杉碱甲衍生物,其制备方法和其应用
TWI404531B (zh) * 2007-05-17 2013-08-11 Ind Tech Res Inst 石杉鹼甲化合物及包含此化合物之醫藥組合物
US20110224245A1 (en) * 2008-09-04 2011-09-15 President And Fellows Of Harvard College Treatment Of Neurological Disorders Using Huperzine
CN101797223B (zh) * 2009-02-06 2012-05-23 上海交通大学医学院 石杉碱甲眼用制剂及其应用
CN116925039B (zh) * 2023-07-18 2026-04-14 陕西中药研究所(陕西医药信息中心) 一种n-(3,5,6-三甲基吡嗪-2-亚甲基)-石杉碱甲及其合成方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177082A (en) * 1985-11-05 1993-01-05 Yu Chao Mei Huperzines and analogs
US4968672A (en) * 1987-01-02 1990-11-06 The United States Of America As Represented By The Department Of Health And Human Services Adenosine receptor prodrugs
US4929731A (en) * 1989-02-21 1990-05-29 University Of Pittsburgh Method for the synthesis of huperzine A and analogs thereof and compounds useful therein
US5104880A (en) * 1991-05-01 1992-04-14 Mayo Foundation For Medical Education And Research Huperzine a analogs as acetylcholinesterase inhibitors
US5684018A (en) * 1994-12-13 1997-11-04 Merck & Co., Inc. Acyloxyisopropyl carbamates as prodrugs for amine drugs

Also Published As

Publication number Publication date
DE69530706D1 (de) 2003-06-12
EP0806416A1 (en) 1997-11-12
DK0806416T3 (da) 2003-09-01
JP2003306481A (ja) 2003-10-28
CN1125725A (zh) 1996-07-03
JP4105592B2 (ja) 2008-06-25
EP0806416B1 (en) 2003-05-07
JP2007246545A (ja) 2007-09-27
JP3545416B2 (ja) 2004-07-21
ATE239708T1 (de) 2003-05-15
JPH10511651A (ja) 1998-11-10
DE69530706T2 (de) 2004-03-25
EP0806416A4 (en) 1998-04-15
AU4296696A (en) 1996-07-19
PT806416E (pt) 2003-09-30
WO1996020176A1 (en) 1996-07-04
US5929084A (en) 1999-07-27

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