DE69530706D1 - Huperzin-derivate, ihre herstellung und ihre verwendung - Google Patents
Huperzin-derivate, ihre herstellung und ihre verwendungInfo
- Publication number
- DE69530706D1 DE69530706D1 DE69530706T DE69530706T DE69530706D1 DE 69530706 D1 DE69530706 D1 DE 69530706D1 DE 69530706 T DE69530706 T DE 69530706T DE 69530706 T DE69530706 T DE 69530706T DE 69530706 D1 DE69530706 D1 DE 69530706D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- huperzine
- derivatives
- chem
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ZQPQGKQTIZYFEF-WCVJEAGWSA-N Huperzine Natural products C1([C@H]2[C@H](O)C(=O)N[C@H]2[C@@H](O)C=2C=CC=CC=2)=CC=CC=C1 ZQPQGKQTIZYFEF-WCVJEAGWSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- -1 hydroxy, amino Chemical group 0.000 abstract 2
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- ZRJBHWIHUMBLCN-YQEJDHNASA-N huperzine A Chemical class N1C(=O)C=CC2=C1C[C@H]1\C(=C/C)[C@]2(N)CC(C)=C1 ZRJBHWIHUMBLCN-YQEJDHNASA-N 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94114057 | 1994-12-28 | ||
| CN94114057A CN1125725A (zh) | 1994-12-28 | 1994-12-28 | 一类海克林碱衍生物及它的用途 |
| PCT/CN1995/000100 WO1996020176A1 (fr) | 1994-12-28 | 1995-12-26 | Derives d'huperzine a, leur preparation et leur emploi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69530706D1 true DE69530706D1 (de) | 2003-06-12 |
| DE69530706T2 DE69530706T2 (de) | 2004-03-25 |
Family
ID=5037011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69530706T Expired - Fee Related DE69530706T2 (de) | 1994-12-28 | 1995-12-26 | Huperzin-derivate, ihre herstellung und ihre verwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5929084A (de) |
| EP (1) | EP0806416B1 (de) |
| JP (3) | JP3545416B2 (de) |
| CN (1) | CN1125725A (de) |
| AT (1) | ATE239708T1 (de) |
| AU (1) | AU4296696A (de) |
| DE (1) | DE69530706T2 (de) |
| DK (1) | DK0806416T3 (de) |
| ES (1) | ES2199259T3 (de) |
| PT (1) | PT806416E (de) |
| WO (1) | WO1996020176A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100210590A1 (en) * | 1995-09-27 | 2010-08-19 | Northwestern University | Compositions and treatments for seizure-related disorders |
| NL1009437C2 (nl) * | 1998-06-18 | 1999-12-21 | Xenobiosis | Extractiewerkwijze. |
| EP1891954A3 (de) | 1998-09-30 | 2009-01-14 | Takeda Pharmaceutical Company Limited | Wirkstoffe zur Verbesserung der Exkretionskraft der Harnblase |
| US6159986A (en) * | 1999-11-02 | 2000-12-12 | Altman; David A. | Compounds and therapy for resisting memory loss in humans |
| US6436972B1 (en) | 2000-04-10 | 2002-08-20 | Dalhousie University | Pyridones and their use as modulators of serine hydrolase enzymes |
| CA2408148A1 (en) * | 2000-05-05 | 2001-11-15 | United States Army Medical Research And Materiel Command | Assay for detecting, measuring and monitoring the activities and concentrations of proteins and methods of use thereof |
| US6369052B1 (en) | 2000-08-07 | 2002-04-09 | Georgetown University | Combination of huperzine and nicotinic compounds as a neuroprotective agent |
| KR100390777B1 (ko) * | 2000-12-19 | 2003-07-10 | 한국화학연구원 | 피리돈 유도체의 제조방법 |
| DE10144041B9 (de) * | 2001-09-07 | 2012-07-26 | Leica Mikrosysteme Gmbh | Gerät zum selbsttätigen Zuführen von Objektträgern zu einem Eindeckautomaten |
| EA011169B1 (ru) | 2003-03-14 | 2009-02-27 | Дебио Решерш Фармасётик С.А. | Система подкожной доставки, способ ее получения и ее применение для лечения холинергических дефицитных расстройств |
| CN100398093C (zh) * | 2003-03-14 | 2008-07-02 | 德比欧药物研究有限公司 | 皮下给药系统、其制备方法及其治疗胆碱能缺乏障碍的用途 |
| CN1308312C (zh) * | 2003-11-13 | 2007-04-04 | 中国科学院上海药物研究所 | 石杉碱乙双分子和双功能团衍生物、制备方法及它的用途 |
| US20050222123A1 (en) | 2004-01-27 | 2005-10-06 | North Shore-Long Island Jewish Research Institute | Cholinesterase inhibitors for treating inflammation |
| CA2589102C (en) * | 2004-11-02 | 2013-08-13 | Northwestern University | Pyridazine compounds and methods for using the compounds to treat inflammatory diseases |
| EP1901733B1 (de) | 2005-05-23 | 2016-04-06 | President and Fellows of Harvard College | Huperzin zur verwendung bei der behandlung von neuropathischen schmerzen |
| WO2007056580A2 (en) * | 2005-11-08 | 2007-05-18 | Pharmadyn, Inc. | Methods and compositions for treating diseases associated with pathogenic proteins |
| EP2015750A2 (de) * | 2006-04-28 | 2009-01-21 | Northwestern University | Zusammensetzungen und behandlungen mit pyridazinverbindungen und cholisterinasehemmern |
| US8097726B2 (en) * | 2006-05-17 | 2012-01-17 | Industrial Technology Research Institute | Huperzine a compound for treatment of alzheimer's disease |
| JP2009541368A (ja) * | 2006-07-05 | 2009-11-26 | 天津和美生物技▲術▼有限公司 | 鎮痛性５，９−メタノシクロオクタ（ｂ）ピリジン−２−（１Ｈ）−オン誘導体、その作成方法と用途 |
| CN100528844C (zh) * | 2007-04-20 | 2009-08-19 | 中国科学院昆明植物研究所 | 石杉碱甲衍生物,其制备方法和其应用 |
| TWI404531B (zh) * | 2007-05-17 | 2013-08-11 | Ind Tech Res Inst | 石杉鹼甲化合物及包含此化合物之醫藥組合物 |
| WO2010028134A2 (en) * | 2008-09-04 | 2010-03-11 | President And Fellows Of Harvard College | Treatment of neurological disorders using huperzine |
| CN101797223B (zh) * | 2009-02-06 | 2012-05-23 | 上海交通大学医学院 | 石杉碱甲眼用制剂及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5177082A (en) * | 1985-11-05 | 1993-01-05 | Yu Chao Mei | Huperzines and analogs |
| US4968672A (en) * | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
| US4929731A (en) * | 1989-02-21 | 1990-05-29 | University Of Pittsburgh | Method for the synthesis of huperzine A and analogs thereof and compounds useful therein |
| US5104880A (en) * | 1991-05-01 | 1992-04-14 | Mayo Foundation For Medical Education And Research | Huperzine a analogs as acetylcholinesterase inhibitors |
| US5684018A (en) * | 1994-12-13 | 1997-11-04 | Merck & Co., Inc. | Acyloxyisopropyl carbamates as prodrugs for amine drugs |
-
1994
- 1994-12-28 CN CN94114057A patent/CN1125725A/zh active Pending
-
1995
- 1995-12-26 PT PT95941572T patent/PT806416E/pt unknown
- 1995-12-26 DE DE69530706T patent/DE69530706T2/de not_active Expired - Fee Related
- 1995-12-26 EP EP95941572A patent/EP0806416B1/de not_active Expired - Lifetime
- 1995-12-26 DK DK95941572T patent/DK0806416T3/da active
- 1995-12-26 JP JP52010296A patent/JP3545416B2/ja not_active Expired - Fee Related
- 1995-12-26 WO PCT/CN1995/000100 patent/WO1996020176A1/zh active IP Right Grant
- 1995-12-26 AT AT95941572T patent/ATE239708T1/de not_active IP Right Cessation
- 1995-12-26 US US08/860,524 patent/US5929084A/en not_active Ceased
- 1995-12-26 ES ES95941572T patent/ES2199259T3/es not_active Expired - Lifetime
- 1995-12-26 AU AU42966/96A patent/AU4296696A/en not_active Abandoned
-
2003
- 2003-05-26 JP JP2003148129A patent/JP4105592B2/ja not_active Expired - Fee Related
-
2007
- 2007-07-02 JP JP2007174592A patent/JP2007246545A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP3545416B2 (ja) | 2004-07-21 |
| PT806416E (pt) | 2003-09-30 |
| AU4296696A (en) | 1996-07-19 |
| JPH10511651A (ja) | 1998-11-10 |
| ATE239708T1 (de) | 2003-05-15 |
| EP0806416A1 (de) | 1997-11-12 |
| CN1125725A (zh) | 1996-07-03 |
| JP4105592B2 (ja) | 2008-06-25 |
| EP0806416A4 (de) | 1998-04-15 |
| US5929084A (en) | 1999-07-27 |
| ES2199259T3 (es) | 2004-02-16 |
| DE69530706T2 (de) | 2004-03-25 |
| EP0806416B1 (de) | 2003-05-07 |
| JP2007246545A (ja) | 2007-09-27 |
| WO1996020176A1 (fr) | 1996-07-04 |
| DK0806416T3 (da) | 2003-09-01 |
| JP2003306481A (ja) | 2003-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |