ES2197466T3 - Oxazolidinonas como antagonistas de 5ht2a. - Google Patents
Oxazolidinonas como antagonistas de 5ht2a.Info
- Publication number
- ES2197466T3 ES2197466T3 ES98909397T ES98909397T ES2197466T3 ES 2197466 T3 ES2197466 T3 ES 2197466T3 ES 98909397 T ES98909397 T ES 98909397T ES 98909397 T ES98909397 T ES 98909397T ES 2197466 T3 ES2197466 T3 ES 2197466T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- oxazolidin
- compounds
- indolyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 150000001875 compounds Chemical class 0.000 claims abstract description 59
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- 239000002253 acid Substances 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 23
- -1 methylenedioxy Chemical group 0.000 claims description 20
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 10
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 6
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- VPUKSPOVPIKQCI-IBGZPJMESA-N (5s)-3-(4-chlorophenyl)-5-[[4-(1h-indol-3-yl)piperidin-1-yl]methyl]-1,3-oxazolidin-2-one Chemical compound C1=CC(Cl)=CC=C1N1C(=O)O[C@@H](CN2CCC(CC2)C=2C3=CC=CC=C3NC=2)C1 VPUKSPOVPIKQCI-IBGZPJMESA-N 0.000 claims description 2
- LNIUBKYUUPPTEB-UHFFFAOYSA-N 3-[1-[(2-oxo-3-phenyl-1,3-oxazolidin-5-yl)methyl]piperidin-4-yl]-1h-indole-5-carbonitrile Chemical compound O=C1OC(CN2CCC(CC2)C=2C3=CC(=CC=C3NC=2)C#N)CN1C1=CC=CC=C1 LNIUBKYUUPPTEB-UHFFFAOYSA-N 0.000 claims description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
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- FIZKQWKXVVHVGR-UHFFFAOYSA-N (2-oxo-3-phenyl-1,3-oxazolidin-5-yl)methyl methanesulfonate Chemical compound O=C1OC(COS(=O)(=O)C)CN1C1=CC=CC=C1 FIZKQWKXVVHVGR-UHFFFAOYSA-N 0.000 description 3
- DTUWLSRJPXHBCH-UHFFFAOYSA-N 5-[[4-(1h-indol-3-yl)piperidin-1-yl]methyl]-3-(4-methoxyphenyl)-1,3-oxazolidin-2-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)OC(CN2CCC(CC2)C=2C3=CC=CC=C3NC=2)C1 DTUWLSRJPXHBCH-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
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- Psychiatry (AREA)
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- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
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- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19707628 | 1997-02-26 | ||
| DE19707628A DE19707628A1 (de) | 1997-02-26 | 1997-02-26 | Oxazolidinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2197466T3 true ES2197466T3 (es) | 2004-01-01 |
Family
ID=7821498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98909397T Expired - Lifetime ES2197466T3 (es) | 1997-02-26 | 1998-02-06 | Oxazolidinonas como antagonistas de 5ht2a. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6462056B1 (https=) |
| EP (1) | EP0964863B1 (https=) |
| JP (2) | JP4402175B2 (https=) |
| KR (1) | KR20000075697A (https=) |
| CN (1) | CN1177847C (https=) |
| AR (1) | AR010899A1 (https=) |
| AT (1) | ATE240954T1 (https=) |
| AU (1) | AU739251B2 (https=) |
| BR (1) | BR9807765A (https=) |
| CA (1) | CA2281918C (https=) |
| CZ (1) | CZ299199A3 (https=) |
| DE (2) | DE19707628A1 (https=) |
| DK (1) | DK0964863T3 (https=) |
| ES (1) | ES2197466T3 (https=) |
| HU (1) | HUP0001093A3 (https=) |
| ID (1) | ID22838A (https=) |
| NO (1) | NO313415B1 (https=) |
| PL (1) | PL335100A1 (https=) |
| PT (1) | PT964863E (https=) |
| RU (1) | RU2196140C2 (https=) |
| SK (1) | SK112799A3 (https=) |
| TW (1) | TW531538B (https=) |
| UA (1) | UA58542C2 (https=) |
| WO (1) | WO1998038189A1 (https=) |
| ZA (1) | ZA981579B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2787328A1 (fr) | 1998-12-22 | 2000-06-23 | Sanofi Sa | Utilisation d'un antagoniste des recepteurs 5ht2a pour la preparation de medicaments utiles dans le traitement des ronflements et du syndrome de haute resistance ou de resistance des voies aeriennes superieures |
| JP2002535365A (ja) * | 1999-01-28 | 2002-10-22 | ブリストル−マイヤーズ スクイブ カンパニー | 抗うつ性複素環化合物 |
| ES2165274B1 (es) | 1999-06-04 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| US6642228B1 (en) | 1999-06-24 | 2003-11-04 | Toray Industries, Inc. | α1b-adrenergic receptor antagonists |
| GB9928568D0 (en) * | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| ES2172436B1 (es) | 2000-10-31 | 2004-01-16 | Almirall Prodesfarma Sa | Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos. |
| ES2268011T3 (es) * | 2001-04-07 | 2007-03-16 | Astrazeneca Ab | Oxazolidinonas que contienen un grupo sulfonimida como antibioticos. |
| PL371335A1 (en) * | 2002-01-22 | 2005-06-13 | Pharmacia & Upjohn Company | Infection-resistant medical devices |
| WO2004069828A1 (ja) * | 2003-02-04 | 2004-08-19 | Mitsubishi Pharma Corporation | ピペリジン化合物およびその医薬用途 |
| US20050176680A1 (en) | 2003-12-11 | 2005-08-11 | Sepracor, Inc. | Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| CL2008001002A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| ES2380398T3 (es) * | 2007-12-18 | 2012-05-11 | Actelion Pharmaceuticals Ltd. | Derivados 5-aminociclilmetil-oxazolidin-2-ona |
| KR101667066B1 (ko) * | 2008-10-10 | 2016-10-17 | 액테리온 파마슈티칼 리미티드 | 옥사졸리디닐 항생제 |
| WO2014046544A1 (en) | 2012-09-21 | 2014-03-27 | Aapa B.V. | Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3723797A1 (de) * | 1987-07-18 | 1989-01-26 | Merck Patent Gmbh | Oxazolidinone |
| DE4005371A1 (de) * | 1990-02-21 | 1991-08-22 | Merck Patent Gmbh | Oxazolidinone |
| DE4017211A1 (de) * | 1990-05-29 | 1991-12-05 | Merck Patent Gmbh | Oxazolidinone |
| DK152090D0 (da) | 1990-06-22 | 1990-06-22 | Lundbaek A S H | Piperidylsubstituerede indolderivater |
| DK158590D0 (da) * | 1990-07-02 | 1990-07-02 | Lundbeck & Co As H | Indolderivater |
| DK0579169T3 (da) * | 1992-07-14 | 1999-05-31 | Nippon Chemiphar Co | Alkylendiaminderivater |
| DE4324393A1 (de) | 1993-07-21 | 1995-01-26 | Merck Patent Gmbh | 4-Aryloxy- und 4-Arylthiopiperidinderivate |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| ZA954689B (en) * | 1994-06-08 | 1996-01-29 | Lundbeck & Co As H | 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines |
| DE19500689A1 (de) * | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
-
1997
- 1997-02-26 DE DE19707628A patent/DE19707628A1/de not_active Withdrawn
-
1998
- 1998-02-06 SK SK1127-99A patent/SK112799A3/sk unknown
- 1998-02-06 ES ES98909397T patent/ES2197466T3/es not_active Expired - Lifetime
- 1998-02-06 PL PL98335100A patent/PL335100A1/xx unknown
- 1998-02-06 US US09/380,202 patent/US6462056B1/en not_active Expired - Fee Related
- 1998-02-06 DK DK98909397T patent/DK0964863T3/da active
- 1998-02-06 RU RU99120183/04A patent/RU2196140C2/ru not_active IP Right Cessation
- 1998-02-06 AT AT98909397T patent/ATE240954T1/de not_active IP Right Cessation
- 1998-02-06 ID IDW990813D patent/ID22838A/id unknown
- 1998-02-06 AU AU63949/98A patent/AU739251B2/en not_active Ceased
- 1998-02-06 PT PT98909397T patent/PT964863E/pt unknown
- 1998-02-06 WO PCT/EP1998/000637 patent/WO1998038189A1/de not_active Ceased
- 1998-02-06 CA CA002281918A patent/CA2281918C/en not_active Expired - Fee Related
- 1998-02-06 DE DE59808461T patent/DE59808461D1/de not_active Expired - Lifetime
- 1998-02-06 CZ CZ992991A patent/CZ299199A3/cs unknown
- 1998-02-06 BR BR9807765-1A patent/BR9807765A/pt not_active IP Right Cessation
- 1998-02-06 HU HU0001093A patent/HUP0001093A3/hu unknown
- 1998-02-06 KR KR1019997007764A patent/KR20000075697A/ko not_active Ceased
- 1998-02-06 EP EP98909397A patent/EP0964863B1/de not_active Expired - Lifetime
- 1998-02-06 CN CNB988028344A patent/CN1177847C/zh not_active Expired - Fee Related
- 1998-02-06 JP JP53722398A patent/JP4402175B2/ja not_active Expired - Fee Related
- 1998-02-23 TW TW087102539A patent/TW531538B/zh not_active IP Right Cessation
- 1998-02-25 ZA ZA981579A patent/ZA981579B/xx unknown
- 1998-02-26 AR ARP980100858A patent/AR010899A1/es not_active Application Discontinuation
- 1998-06-02 UA UA99095309A patent/UA58542C2/uk unknown
-
1999
- 1999-08-25 NO NO19994106A patent/NO313415B1/no not_active IP Right Cessation
-
2009
- 2009-06-24 JP JP2009149274A patent/JP2009256363A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP4402175B2 (ja) | 2010-01-20 |
| NO994106D0 (no) | 1999-08-25 |
| EP0964863A1 (de) | 1999-12-22 |
| KR20000075697A (ko) | 2000-12-26 |
| RU2196140C2 (ru) | 2003-01-10 |
| NO313415B1 (no) | 2002-09-30 |
| CN1177847C (zh) | 2004-12-01 |
| ID22838A (id) | 1999-12-09 |
| WO1998038189A1 (de) | 1998-09-03 |
| JP2001513764A (ja) | 2001-09-04 |
| CA2281918C (en) | 2007-04-03 |
| TW531538B (en) | 2003-05-11 |
| EP0964863B1 (de) | 2003-05-21 |
| ATE240954T1 (de) | 2003-06-15 |
| JP2009256363A (ja) | 2009-11-05 |
| PT964863E (pt) | 2003-10-31 |
| HUP0001093A2 (hu) | 2001-06-28 |
| HUP0001093A3 (en) | 2001-07-30 |
| SK112799A3 (en) | 2000-06-12 |
| UA58542C2 (uk) | 2003-08-15 |
| BR9807765A (pt) | 2000-02-22 |
| CZ299199A3 (cs) | 1999-11-17 |
| NO994106L (no) | 1999-10-19 |
| DE19707628A1 (de) | 1998-08-27 |
| DE59808461D1 (de) | 2003-06-26 |
| DK0964863T3 (da) | 2003-08-04 |
| AU6394998A (en) | 1998-09-18 |
| CA2281918A1 (en) | 1998-09-03 |
| ZA981579B (en) | 1999-03-17 |
| US6462056B1 (en) | 2002-10-08 |
| PL335100A1 (en) | 2000-04-10 |
| CN1248973A (zh) | 2000-03-29 |
| AR010899A1 (es) | 2000-07-12 |
| AU739251B2 (en) | 2001-10-04 |
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