BR9807765A - Oxazolidinonas - Google Patents

Oxazolidinonas

Info

Publication number
BR9807765A
BR9807765A BR9807765-1A BR9807765A BR9807765A BR 9807765 A BR9807765 A BR 9807765A BR 9807765 A BR9807765 A BR 9807765A BR 9807765 A BR9807765 A BR 9807765A
Authority
BR
Brazil
Prior art keywords
oxazolidinones
compounds
formula
anxiolytic
depressant
Prior art date
Application number
BR9807765-1A
Other languages
English (en)
Inventor
Henning Boettcher
Helmut Pruecher
Helmut Greiner
Gerd Bartoszyk
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9807765A publication Critical patent/BR9807765A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Patente de Invenção:<B>"OXAZOLIDINONAS"<D>. A invenção refere-se a novos derivados da oxazolidina da fórmula: na qual R^ 1^, R^ 2^ e R^ 3^ tem os significados declarados na reivindicação 1, os sais dos mesmos e os processos para a preparação dos compostos de acordo com a invenção. Os compostos da fórmula I atuam como antagonistas de 5-HT~ 2A~ com um efeito de inibição da reabsorção de 5-HT, antidepressivo ou ansiolítico e pode ser usado para a produção de produtos farmacêuticos.
BR9807765-1A 1997-02-26 1998-02-06 Oxazolidinonas BR9807765A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19707628A DE19707628A1 (de) 1997-02-26 1997-02-26 Oxazolidinone
PCT/EP1998/000637 WO1998038189A1 (de) 1997-02-26 1998-02-06 Oxazolidinone als 5-ht2a-antagonisten

Publications (1)

Publication Number Publication Date
BR9807765A true BR9807765A (pt) 2000-02-22

Family

ID=7821498

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807765-1A BR9807765A (pt) 1997-02-26 1998-02-06 Oxazolidinonas

Country Status (25)

Country Link
US (1) US6462056B1 (pt)
EP (1) EP0964863B1 (pt)
JP (2) JP4402175B2 (pt)
KR (1) KR20000075697A (pt)
CN (1) CN1177847C (pt)
AR (1) AR010899A1 (pt)
AT (1) ATE240954T1 (pt)
AU (1) AU739251B2 (pt)
BR (1) BR9807765A (pt)
CA (1) CA2281918C (pt)
CZ (1) CZ299199A3 (pt)
DE (2) DE19707628A1 (pt)
DK (1) DK0964863T3 (pt)
ES (1) ES2197466T3 (pt)
HU (1) HUP0001093A3 (pt)
ID (1) ID22838A (pt)
NO (1) NO313415B1 (pt)
PL (1) PL335100A1 (pt)
PT (1) PT964863E (pt)
RU (1) RU2196140C2 (pt)
SK (1) SK112799A3 (pt)
TW (1) TW531538B (pt)
UA (1) UA58542C2 (pt)
WO (1) WO1998038189A1 (pt)
ZA (1) ZA981579B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2787328A1 (fr) 1998-12-22 2000-06-23 Sanofi Sa Utilisation d'un antagoniste des recepteurs 5ht2a pour la preparation de medicaments utiles dans le traitement des ronflements et du syndrome de haute resistance ou de resistance des voies aeriennes superieures
TR200101939T2 (tr) * 1999-01-28 2002-05-21 Bristol-Myers Squibb Company Antidepresan heterosiklik bileşikler
ES2165274B1 (es) 1999-06-04 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AU5567000A (en) * 1999-06-24 2001-01-09 Toray Industries, Inc. Alpha1b-adrenergic receptor antagonists
GB9928568D0 (en) * 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
ES2172436B1 (es) 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
EP1385844B1 (en) * 2001-04-07 2006-07-05 Astrazeneca AB Oxazolidinones containing a sulfonimid group as antibiotics
JPWO2004069828A1 (ja) * 2003-02-04 2006-05-25 三菱ウェルファーマ株式会社 ピペリジン化合物およびその医薬用途
DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
CL2008001002A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
US9505750B2 (en) * 2007-12-18 2016-11-29 Actelion Pharmaceuticals Ltd. 5-aminocyclylmethyl-oxazolidin-2-one derivatives
MX2011003188A (es) * 2008-10-10 2011-04-27 Actelion Pharmaceuticals Ltd Antibioticos de oxazolidinilo.
WO2014046544A1 (en) 2012-09-21 2014-03-27 Aapa B.V. Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3723797A1 (de) 1987-07-18 1989-01-26 Merck Patent Gmbh Oxazolidinone
DE4005371A1 (de) * 1990-02-21 1991-08-22 Merck Patent Gmbh Oxazolidinone
DE4017211A1 (de) 1990-05-29 1991-12-05 Merck Patent Gmbh Oxazolidinone
DK152090D0 (da) 1990-06-22 1990-06-22 Lundbaek A S H Piperidylsubstituerede indolderivater
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
DE4324393A1 (de) 1993-07-21 1995-01-26 Merck Patent Gmbh 4-Aryloxy- und 4-Arylthiopiperidinderivate
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
IL114026A (en) * 1994-06-08 1999-06-20 Lundbeck & Co As H 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzo thiophenemethyl) piperidines tetrahydropyridines or piperazines and pharmaceutical compositions containing them
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate

Also Published As

Publication number Publication date
AU6394998A (en) 1998-09-18
TW531538B (en) 2003-05-11
SK112799A3 (en) 2000-06-12
JP4402175B2 (ja) 2010-01-20
KR20000075697A (ko) 2000-12-26
DE19707628A1 (de) 1998-08-27
NO313415B1 (no) 2002-09-30
AU739251B2 (en) 2001-10-04
US6462056B1 (en) 2002-10-08
CN1177847C (zh) 2004-12-01
ID22838A (id) 1999-12-09
JP2001513764A (ja) 2001-09-04
CN1248973A (zh) 2000-03-29
AR010899A1 (es) 2000-07-12
NO994106D0 (no) 1999-08-25
PL335100A1 (en) 2000-04-10
PT964863E (pt) 2003-10-31
UA58542C2 (uk) 2003-08-15
DK0964863T3 (da) 2003-08-04
EP0964863A1 (de) 1999-12-22
CA2281918C (en) 2007-04-03
CA2281918A1 (en) 1998-09-03
DE59808461D1 (de) 2003-06-26
HUP0001093A2 (hu) 2001-06-28
EP0964863B1 (de) 2003-05-21
RU2196140C2 (ru) 2003-01-10
CZ299199A3 (cs) 1999-11-17
NO994106L (no) 1999-10-19
ATE240954T1 (de) 2003-06-15
ES2197466T3 (es) 2004-01-01
HUP0001093A3 (en) 2001-07-30
WO1998038189A1 (de) 1998-09-03
JP2009256363A (ja) 2009-11-05
ZA981579B (en) 1999-03-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A,8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1888 DE 13/03/2007.