ES2196723T3 - Procedimiento de purificacion de precursores de ester carbazol del acido 6-cloro-alfa-metil-carbazol-2-acetico. - Google Patents

Procedimiento de purificacion de precursores de ester carbazol del acido 6-cloro-alfa-metil-carbazol-2-acetico.

Info

Publication number
ES2196723T3
ES2196723T3 ES99303509T ES99303509T ES2196723T3 ES 2196723 T3 ES2196723 T3 ES 2196723T3 ES 99303509 T ES99303509 T ES 99303509T ES 99303509 T ES99303509 T ES 99303509T ES 2196723 T3 ES2196723 T3 ES 2196723T3
Authority
ES
Spain
Prior art keywords
carbazol
ester
acid
chlorine
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99303509T
Other languages
English (en)
Inventor
Philip Dietrich Hammen
Peter Robert Rose
Diane Marie Rescek
John Lloyd Tucker
Keith Michael Devries
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Application granted granted Critical
Publication of ES2196723T3 publication Critical patent/ES2196723T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/84—Separation, e.g. from tar; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PURIFICACION DE UN DI(ALQUIL C 1 - C 6 )ESTER DE ACIDO (6 - CLORO - 2 CARBAZOLIL)METIL - MALONICO, DE FORMULA (I): DONDE R A Y R B DEBEN SER IGUALES Y SE SELECCIONAN A PARTIR DEL GRUPO FORMADO POR ALQUILO C 1 - C 6 . DICHO PROCEDIMIEN TO CONSISTE EN SEPARAR FASES DE UNA O MAS IMPUREZAS A PARTIR DE DICHO ESTER DE CARBAZOL AL MENOS UNA VEZ, UTILIZANDOSE ACIDO ACETICO COMO DISOLVENTE EN DICHA SEPARACION DE FASES. EN UNA REALIZACION PREFERIDA DE LA INVENCION, DICHO ACIDO ACETICO ES ACIDO ACETICO GLACIAL, QUE SE MANTIENE A UNA TEMPERATURA ENTRE APROX. 30 Y 110 C, Y DICHO ESTER DE CARBAZOL SE OBTIENE CON UNA PUREZA DE AL MENOS 99,90 % EN PESO, DE FORMA QUE LA CANTIDAD DE IMPUREZAS PRESENTES EN EL MISMO ES DEL 0,10 % EN PESO, O INFERIOR. EN UNA REALIZACION CON MAYOR PREFERENCIA DE LA INVENCION, DICHA TEMPEARTURA DE REACCION ESTA COMPRENDIDA ENTRE APROX. 50 Y 70 C, Y DICHA SEPARACION DE FASES SE LLEVA A CABO SOLO UNA VEZ.
ES99303509T 1998-06-16 1999-05-05 Procedimiento de purificacion de precursores de ester carbazol del acido 6-cloro-alfa-metil-carbazol-2-acetico. Expired - Lifetime ES2196723T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8948098P 1998-06-16 1998-06-16

Publications (1)

Publication Number Publication Date
ES2196723T3 true ES2196723T3 (es) 2003-12-16

Family

ID=22217887

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99303509T Expired - Lifetime ES2196723T3 (es) 1998-06-16 1999-05-05 Procedimiento de purificacion de precursores de ester carbazol del acido 6-cloro-alfa-metil-carbazol-2-acetico.

Country Status (26)

Country Link
US (1) US6013808A (es)
EP (1) EP0965586B1 (es)
JP (1) JP3449602B2 (es)
KR (1) KR100342148B1 (es)
CN (1) CN1119329C (es)
AR (1) AR016726A1 (es)
AT (1) ATE237588T1 (es)
AU (1) AU745058C (es)
BR (1) BR9902279A (es)
CA (1) CA2274355C (es)
CZ (1) CZ293399B6 (es)
DE (1) DE69906876T2 (es)
DK (1) DK0965586T3 (es)
ES (1) ES2196723T3 (es)
HK (1) HK1023999A1 (es)
HU (1) HUP9901989A3 (es)
ID (1) ID23297A (es)
IL (1) IL130428A (es)
PL (1) PL333741A1 (es)
PT (1) PT965586E (es)
RU (1) RU2182148C2 (es)
SG (1) SG76627A1 (es)
TR (1) TR199901330A2 (es)
TW (1) TW491839B (es)
YU (1) YU26999A (es)
ZA (1) ZA993974B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020049283A (ko) * 2000-12-19 2002-06-26 이계안 하이브리드 전기 자동차용 토크 제어 시동방법
JP4467880B2 (ja) 2002-12-09 2010-05-26 株式会社日立製作所 プロジェクトの評価システムおよび方法
TWI692598B (zh) 2019-05-03 2020-05-01 愛烙達股份有限公司 可變形之燭芯及設置該燭芯之燃燒裝置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193923A (en) * 1978-08-21 1980-03-18 Hoffmann-La Roche Inc. Tetrahydro 2-carbazolyl methyl malonate derivatives
CH637117A5 (de) * 1979-03-02 1983-07-15 Hoffmann La Roche Verfahren zur herstellung eines carbazolderivates.
JPS62263153A (ja) * 1986-05-28 1987-11-16 エフ・ホフマン―ラ　ロシユ　アーゲー カルバゾ−ル誘導体
DE3814887C1 (es) * 1988-05-02 1989-09-21 Medice Chem.-Pharm. Fabrik Puetter Gmbh & Co Kg, 5860 Iserlohn, De

Also Published As

Publication number Publication date
AR016726A1 (es) 2001-07-25
KR20000006168A (ko) 2000-01-25
ZA993974B (en) 2000-12-15
RU2182148C2 (ru) 2002-05-10
BR9902279A (pt) 2000-02-29
SG76627A1 (en) 2000-11-21
ID23297A (id) 2000-04-05
ATE237588T1 (de) 2003-05-15
AU745058B2 (en) 2002-03-07
DE69906876T2 (de) 2003-12-24
TR199901330A2 (xx) 2000-01-21
HUP9901989A3 (en) 2001-01-29
EP0965586B1 (en) 2003-04-16
IL130428A0 (en) 2000-06-01
HUP9901989A2 (hu) 2000-03-28
CN1242362A (zh) 2000-01-26
HK1023999A1 (en) 2000-09-29
CZ214299A3 (cs) 2000-04-12
US6013808A (en) 2000-01-11
KR100342148B1 (ko) 2002-06-27
YU26999A (sh) 2002-12-10
PT965586E (pt) 2003-06-30
JP2000007656A (ja) 2000-01-11
EP0965586A1 (en) 1999-12-22
PL333741A1 (en) 1999-12-20
TW491839B (en) 2002-06-21
CA2274355A1 (en) 1999-12-16
DE69906876D1 (de) 2003-05-22
HU9901989D0 (en) 1999-08-30
IL130428A (en) 2003-12-10
CA2274355C (en) 2004-08-10
AU745058C (en) 2002-11-07
CN1119329C (zh) 2003-08-27
JP3449602B2 (ja) 2003-09-22
CZ293399B6 (cs) 2004-04-14
AU3503899A (en) 1999-12-23
DK0965586T3 (da) 2003-08-04

Similar Documents

Publication Publication Date Title
JP4728317B2 (ja) Ｎ−保護４−ケトプロリン誘導体の製造方法
JP2008516005A (ja) レトロゾールの改良された調製方法
BR112013004827B1 (pt) Processo para a produção de derivados de 1-triazol-2-butanol
JP2006160748A (ja) エルゴチオネインの新規合成方法
IE913785A1 (en) Indole-and benzimidazole-substituted imidazole and¹benzimidazole derivatives
Bergman et al. Synthesis of quinazolines
CN107722012A (zh) 制备4‑氯‑7H‑吡咯并[2,3‑d]嘧啶的方法
ES2196723T3 (es) Procedimiento de purificacion de precursores de ester carbazol del acido 6-cloro-alfa-metil-carbazol-2-acetico.
WO2005051943A1 (en) Processes for the preparation of highly pure irbesartan
KR20140005925A (ko) Ｎ-술포닐-치환된 옥신돌의 제조 방법
Richter et al. Synthesis of peptide nucleic acids (PNA) by submonomer solid-phase synthesis
ES2955674T3 (es) Método para producir derivados de espirocíclicos cis-alcoxi-sustituidos 1-h-pirrolidina-2,4-diona
KR101968889B1 (ko) 아픽사반을 제조하는 개선된 공정
US4467119A (en) Phenolic antioxidant
KR100809159B1 (ko) 로사탄의 개선된 제조방법
Norris et al. CXXXIV.—The formation and stability of spiro-compounds. Part V. Derivatives of cyclo hexane spirocyclo hexane and of cyclo pentanes pirocyclo hexane
Sápi et al. Simple and condensed β-lactams. Part 29. Synthesis and base-catalyzed ring transformation of 4-[(2RS, 3SR)-3-hydroxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl)] thiazol-2 (3H)-one
SE528435C2 (sv) Tillverkningsprocess av estrar av delta-ftalimidolevulin- eller succinimidolevulinsyra och trans-4-oxo-2-pentenoater
Gupta et al. Azabenzocycloheptenones. Part XII. Application of the Lansbury synthesis to the preparation of tetrahydro-1-benzazepin-3-ones
Zlatev et al. Convenient synthesis of N2-isobutyryl-2′-O-methyl guanosine by efficient alkylation of O6-trimethylsilylethyl-3′, 5′-di-tert-butylsilanediyl guanosine
US6342600B1 (en) Process for preparing 2-methoxy-4-methyl-6-methylamino-1,3,5-triazine
PL183095B1 (pl) Sposób wytwarzania kwasu 4-(3-cyjanofenylo)-2-trifluorometylo-5-okso-1,4,5,6,7,8-heksahydrochinolino-3-karboksylowego
JP2002503240A (ja) カルボニルジイミダゾール、そのエステル誘導体およびその製造方法
Rakib et al. Research in 7-aminoindazole series: Synthesis of new halo-7 H-4-Methylpyrazolo [l, 5, 4-ef][1, 5] benzodiazepin-6-ones and 5H-9-halo-6-methylpyrazolo [1, 5, 4-ef][1, 5] benzodiazepin-4-ones
BR9814310A (pt) Processo de cloropirimidina