ES2196474T3 - Formulaciones liquidas que contienen una gonadotropina. - Google Patents

Formulaciones liquidas que contienen una gonadotropina.

Info

Publication number
ES2196474T3
ES2196474T3 ES98200068T ES98200068T ES2196474T3 ES 2196474 T3 ES2196474 T3 ES 2196474T3 ES 98200068 T ES98200068 T ES 98200068T ES 98200068 T ES98200068 T ES 98200068T ES 2196474 T3 ES2196474 T3 ES 2196474T3
Authority
ES
Spain
Prior art keywords
gonadotropine
thioeter
preferibly
salt
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98200068T
Other languages
English (en)
Inventor
A T P Skrabanja
Den Oetelaar P J M Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2196474T3 publication Critical patent/ES2196474T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION CONCIERNE UNA FORMULACION DE GONADOTROPINA LIQUIDA QUE SE CARACTERIZA PORQUE LA FORMULACION COMPRENDE UNA GONADOTROPINA Y CANTIDADES ESTABILIZANTES DE UN ACIDO POLICARBOXILICO, O UNA SAL DE ESTE, Y DE UN COMPUESTO TIOETER. LAS PROTEINAS PARTICULARES (POR EJEMPLO, LH, TSH, FSH O HCG) ESTAN EN MEZCLA CON LOS ESTABILIZADORES PARTICULARES EN UNA SOLUCION ACUOSA. LAS PREPARACIONES CONTIENEN UNA SUFICIENTE CANTIDAD DEL ACIDO POLICARBOXILICO O UNA SAL DE ESTE, PREFERIBLEMENTE CITRATO SODICO, Y UNA CANTIDAD SUFICIENTE DEL COMPUESTO TIOETER, PREFERIBLEMENTE METIONINA, PARA ESTABILIZAR LA PROTEINA. LAS PREPARACIONES TAMBIEN INCLUYEN PREFERIBLEMENTE UN DISACARIDO NO REDUCTOR COMO SACAROSA Y UNSURFACTANTE NO IONICO.
ES98200068T 1997-01-15 1998-01-13 Formulaciones liquidas que contienen una gonadotropina. Expired - Lifetime ES2196474T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97200099 1997-01-15

Publications (1)

Publication Number Publication Date
ES2196474T3 true ES2196474T3 (es) 2003-12-16

Family

ID=8227932

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98200068T Expired - Lifetime ES2196474T3 (es) 1997-01-15 1998-01-13 Formulaciones liquidas que contienen una gonadotropina.

Country Status (30)

Country Link
US (1) US5929028A (es)
EP (2) EP0853945B1 (es)
JP (1) JP4353549B2 (es)
KR (1) KR100498531B1 (es)
CN (1) CN1165341C (es)
AR (1) AR011410A1 (es)
AT (1) ATE237348T1 (es)
AU (1) AU736339B2 (es)
BR (1) BR9800323B1 (es)
CA (1) CA2226803A1 (es)
CZ (1) CZ297419B6 (es)
DE (2) DE69813322T2 (es)
DK (1) DK0853945T3 (es)
ES (1) ES2196474T3 (es)
FR (1) FR10C0024I2 (es)
HK (1) HK1010150A1 (es)
HU (1) HU227154B1 (es)
ID (1) ID19499A (es)
IL (1) IL122732A0 (es)
LU (1) LU91655I2 (es)
MX (1) MX9800438A (es)
NO (3) NO322509B1 (es)
NZ (1) NZ329572A (es)
PL (1) PL190103B1 (es)
PT (1) PT853945E (es)
RU (1) RU2203086C2 (es)
SA (1) SA98181124B1 (es)
TR (1) TR199800062A2 (es)
TW (1) TW518235B (es)
ZA (1) ZA9883B (es)

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US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
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ATE386501T1 (de) * 1999-07-12 2008-03-15 Sandoz Ag Formulierungen von wachstumshormonen
EA004385B1 (ru) * 2000-02-22 2004-04-29 Апплайд Резеч Системз Арс Холдинг Н.В. Способ выделения лютеинизирующего гормона
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DK1610822T4 (en) 2003-04-02 2019-01-14 Ares Trading Sa Liquid pharmaceutical FSH and LH formulations together with a nonionic surfactant
US20040248784A1 (en) * 2003-06-03 2004-12-09 Marco Filicori Unitary combinations of FSH and hCG
CA2526099C (en) * 2003-06-20 2013-02-05 Ares Trading Sa Freeze-dried fsh / lh formulations
JP4412989B2 (ja) * 2003-12-15 2010-02-10 株式会社日立製作所 複数の記憶システムを有するデータ処理システム
KR100587535B1 (ko) * 2004-02-04 2006-06-08 충남대학교산학협력단 재조합 ｈＦＳＨ 유전자 및 이를 내장하는 발현용 벡터
TWI369401B (en) 2005-07-05 2012-08-01 Ares Trading Sa Serum-free culture medium for the production of recombinant gonadotropins
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
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US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
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Also Published As

Publication number Publication date
DK0853945T3 (da) 2003-08-04
PL324279A1 (en) 1998-07-20
RU2203086C2 (ru) 2003-04-27
CN1191139A (zh) 1998-08-26
FR10C0024I1 (es) 2010-05-21
HU9800056D0 (en) 1998-03-02
DE69813322D1 (de) 2003-05-22
NO980177L (no) 1998-07-16
IL122732A0 (en) 1998-08-16
ZA9883B (en) 1998-07-08
DE122010000011I1 (de) 2010-07-08
EP0853945B1 (en) 2003-04-16
PL190103B1 (pl) 2005-10-31
NZ329572A (en) 1999-05-28
JPH10203997A (ja) 1998-08-04
NO2021001I1 (no) 2021-01-12
HU227154B1 (en) 2010-08-30
AU5205998A (en) 1998-07-23
PT853945E (pt) 2003-08-29
NO2010013I1 (no) 2010-06-07
HUP9800056A2 (hu) 1998-08-28
LU91655I2 (fr) 2010-04-26
NO980177D0 (no) 1998-01-14
CA2226803A1 (en) 1998-07-15
CZ13598A3 (cs) 1998-08-12
AR011410A1 (es) 2000-08-16
MX9800438A (es) 1998-11-30
EP1285665A1 (en) 2003-02-26
BR9800323A (pt) 1999-06-29
TR199800062A2 (xx) 1998-08-21
US5929028A (en) 1999-07-27
NO2010013I2 (no) 2015-05-18
NO322509B1 (no) 2006-10-16
EP0853945A1 (en) 1998-07-22
ATE237348T1 (de) 2003-05-15
BR9800323B1 (pt) 2011-04-19
AU736339B2 (en) 2001-07-26
JP4353549B2 (ja) 2009-10-28
HK1010150A1 (en) 1999-06-17
HUP9800056A3 (en) 2001-01-29
KR19980070493A (ko) 1998-10-26
FR10C0024I2 (fr) 2011-04-01
CN1165341C (zh) 2004-09-08
KR100498531B1 (ko) 2005-09-30
CZ297419B6 (cs) 2006-12-13
TW518235B (en) 2003-01-21
SA98181124B1 (ar) 2006-07-10
DE69813322T2 (de) 2004-02-19
ID19499A (id) 1998-07-16

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