ES2057731T3 - Preparaciones que contienen gonadotropinas estabilizadas. - Google Patents
Preparaciones que contienen gonadotropinas estabilizadas.Info
- Publication number
- ES2057731T3 ES2057731T3 ES91200483T ES91200483T ES2057731T3 ES 2057731 T3 ES2057731 T3 ES 2057731T3 ES 91200483 T ES91200483 T ES 91200483T ES 91200483 T ES91200483 T ES 91200483T ES 2057731 T3 ES2057731 T3 ES 2057731T3
- Authority
- ES
- Spain
- Prior art keywords
- preparations
- lyophilized
- dicarboxylic acid
- disclosed
- acid salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE EXPONEN PREPARADOS QUE CONTIENEN GONADATROPINA LIOFILIZADA QUE CONTIENEN UN ESTABILIZADOR DE UNA SAL DE ACIDO DICARBOXILICO. LAS PROTEINAS INDIVIDUALES (POR EJEMPLO, LH, TSH, FSH, O HCG) ESTAN MEZCLADAS CON EL ESTABILIZADOR EN FORMA LIOFILIZADA, Y SON CAPACES, AL MENOS PARCIALMENTE, DE ESTABILIZACION MEDIANTE DICHO ESTABILIZADOR. LOS PREPARADOS CONTIENEN UNA CANTIDAD SUFICIENTE DE SAL DE ACIDO DICARBOXILICO COMO PARA ESTABILIZAR LA PROTEINA EN UNA FORMA CONGELADA-DESECADA DURANTE EL TIEMPO DESEADO A LA TEMPERATURA DESEADA. LAS TIPICAS SALES DE ACIDO DICARBOXILICO EXPUESTAS SON LAS SALES DE LOS ACIDOS CITRICO, TARTARICO Y ASPARTICO. LOS PREPARADOS INCLUYEN PREFERENTEMENTE UN DISACARIDO NO REDUCTOR PARA AUMENTAR LA TEMPERATURA DE COLAPSO DE LA SOLUCION QUE SE HA DE LIOFILIZAR. SE EXPONEN TAMBIEN METODOS DE FABRICACION DE LOS PREPARADOS EN FORMA LIOFILIZADA Y LOS PREPARADOS INYECTABLES RESULTANTES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90200665 | 1990-03-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2057731T3 true ES2057731T3 (es) | 1994-10-16 |
Family
ID=8204967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91200483T Expired - Lifetime ES2057731T3 (es) | 1990-03-20 | 1991-03-06 | Preparaciones que contienen gonadotropinas estabilizadas. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0448146B1 (es) |
JP (1) | JP3031570B2 (es) |
KR (1) | KR100221123B1 (es) |
AT (1) | ATE107172T1 (es) |
AU (1) | AU631730B2 (es) |
CA (1) | CA2037884C (es) |
DE (1) | DE69102465T2 (es) |
DK (1) | DK0448146T3 (es) |
ES (1) | ES2057731T3 (es) |
FI (1) | FI101194B (es) |
HK (1) | HK1002494A1 (es) |
ID (1) | ID905B (es) |
IE (1) | IE64738B1 (es) |
NZ (1) | NZ237458A (es) |
PT (1) | PT97074B (es) |
ZA (1) | ZA911659B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1250075B (it) * | 1991-12-18 | 1995-03-30 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti gonadotropine. |
US5656597A (en) * | 1993-04-28 | 1997-08-12 | Akzo Nobel N.V. | Lyospheres comprising gonadotropin |
JP4165878B2 (ja) * | 1993-06-03 | 2008-10-15 | 株式会社林原生物化学研究所 | トレハロース遊離酵素とその製造方法並びに用途 |
US5556771A (en) * | 1995-02-10 | 1996-09-17 | Gen-Probe Incorporated | Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification |
KR100377967B1 (ko) * | 1995-03-21 | 2003-06-12 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | Hcg액상조성물 |
IL120202A (en) | 1996-03-07 | 2001-03-19 | Akzo Nobel Nv | Container with freeze-dried vaccine components |
TW518235B (en) * | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
NZ508874A (en) * | 1998-07-23 | 2004-03-26 | Lilly Co Eli | FSH and FSH variant formulations, products and methods of treating infertility. |
US20030166525A1 (en) | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
AU779869B2 (en) | 1999-04-13 | 2005-02-17 | Nektar Therapeutics | Pulmonary administration of dry powder formulations for treating infertility |
WO2002036145A2 (en) | 2000-10-31 | 2002-05-10 | Pharma Mar, S.A. | Kahalalide f formulation |
EP1356809A4 (en) * | 2000-12-28 | 2008-05-14 | Takeda Pharmaceutical | SUSTAINED RELEASE PREPARATIONS |
GB0207092D0 (en) * | 2002-03-26 | 2002-05-08 | Sod Conseils Rech Applic | Stable pharmaceutical composition containing factor VIII |
RS57872B1 (sr) * | 2003-04-02 | 2018-12-31 | Ares Trading Sa | Tečne farmaceutske formulacije fsh i lh zajedno sa nejonskim surfaktantom |
US20040248784A1 (en) | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
DK1638595T3 (da) | 2003-06-20 | 2013-04-08 | Ares Trading Sa | Frysetørrede FSH-/LH-formuleringer |
DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
MXPA06011580A (es) | 2004-04-08 | 2007-05-04 | Biomatrica Inc | Integracion de almacenamiento de muestras y administracion de muestras para las ciencias de la vida. |
AU2007215012A1 (en) * | 2006-02-15 | 2007-08-23 | Imclone Llc | Antibody formulation |
CN101842083B (zh) * | 2007-11-01 | 2012-11-14 | 默克雪兰诺有限公司 | Lh液体制剂 |
CN101269215B (zh) * | 2008-05-15 | 2011-03-23 | 上海天伟生物制药有限公司 | 一种糖蛋白激素组合物 |
CA2761675A1 (en) | 2009-05-11 | 2010-11-18 | Biomatrica, Inc. | Compositions and methods for biological sample storage |
US9845489B2 (en) | 2010-07-26 | 2017-12-19 | Biomatrica, Inc. | Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
EP2598660B1 (en) | 2010-07-26 | 2017-03-15 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
MX347503B (es) | 2010-11-05 | 2017-04-26 | Baxalta Inc | Una variante nueva del factor viii antihemofílico que tiene actividad específica incrementada. |
CN102293756A (zh) * | 2011-08-24 | 2011-12-28 | 蚌埠丰原涂山制药有限公司 | 一种尿促性素冻干粉针剂及其制备方法 |
SG11201401857WA (en) | 2011-10-28 | 2014-09-26 | Neotope Biosciences Ltd | Humanized antibodies that recognize alpha-synuclein |
UA115439C2 (uk) | 2012-01-27 | 2017-11-10 | Протена Біосаєнсиз Лімітед | Гуманізоване антитіло, яке розпізнає альфа-синуклеїн |
UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
US9725703B2 (en) | 2012-12-20 | 2017-08-08 | Biomatrica, Inc. | Formulations and methods for stabilizing PCR reagents |
US10513555B2 (en) | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
EP3154338B1 (en) | 2014-06-10 | 2020-01-29 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
KR102589056B1 (ko) | 2015-12-08 | 2023-10-12 | 바이오매트리카 인코포레이티드 | 적혈구 침강 속도의 감소 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932943A (en) * | 1970-08-14 | 1976-01-20 | E. I. Du Pont De Nemours And Company | Method of preparation of lyophilized biological products |
IT1057895B (it) * | 1975-02-17 | 1982-03-30 | Serono Lab | Gonadotropina corionica umana parzialmente desalinizzata per indurre l'ouvulazione |
ATE31023T1 (de) * | 1983-04-28 | 1987-12-15 | Armour Pharma | Pharmazeutische zubereitung mit gehalt an gereinigtem fibrinonectin. |
GB8604983D0 (en) * | 1986-02-28 | 1986-04-09 | Biocompatibles Ltd | Protein preservation |
US5059587A (en) * | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
-
1991
- 1991-03-05 IE IE73291A patent/IE64738B1/en not_active IP Right Cessation
- 1991-03-06 DK DK91200483.5T patent/DK0448146T3/da active
- 1991-03-06 DE DE69102465T patent/DE69102465T2/de not_active Expired - Lifetime
- 1991-03-06 EP EP91200483A patent/EP0448146B1/en not_active Expired - Lifetime
- 1991-03-06 ZA ZA911659A patent/ZA911659B/xx unknown
- 1991-03-06 ES ES91200483T patent/ES2057731T3/es not_active Expired - Lifetime
- 1991-03-06 AT AT91200483T patent/ATE107172T1/de not_active IP Right Cessation
- 1991-03-08 CA CA002037884A patent/CA2037884C/en not_active Expired - Lifetime
- 1991-03-18 NZ NZ237458A patent/NZ237458A/en unknown
- 1991-03-18 FI FI911309A patent/FI101194B/fi active
- 1991-03-19 KR KR1019910004303A patent/KR100221123B1/ko not_active IP Right Cessation
- 1991-03-19 JP JP3054865A patent/JP3031570B2/ja not_active Expired - Lifetime
- 1991-03-19 PT PT97074A patent/PT97074B/pt not_active IP Right Cessation
- 1991-03-19 AU AU73623/91A patent/AU631730B2/en not_active Expired
-
1992
- 1992-01-31 ID IDP219492A patent/ID905B/id unknown
-
1998
- 1998-02-11 HK HK98101030A patent/HK1002494A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT97074B (pt) | 1998-10-30 |
CA2037884C (en) | 2003-10-21 |
NZ237458A (en) | 1992-02-25 |
EP0448146B1 (en) | 1994-06-15 |
PT97074A (pt) | 1991-10-31 |
JP3031570B2 (ja) | 2000-04-10 |
DK0448146T3 (da) | 1994-10-24 |
FI911309A (fi) | 1991-09-21 |
HK1002494A1 (en) | 1998-08-28 |
DE69102465T2 (de) | 1995-03-02 |
ZA911659B (en) | 1991-12-24 |
KR100221123B1 (ko) | 1999-09-15 |
CA2037884A1 (en) | 1991-09-21 |
FI101194B1 (fi) | 1998-05-15 |
ID905B (id) | 1996-09-10 |
IE910732A1 (en) | 1991-09-25 |
KR910016340A (ko) | 1991-11-05 |
EP0448146A1 (en) | 1991-09-25 |
FI911309A0 (fi) | 1991-03-18 |
DE69102465D1 (de) | 1994-07-21 |
FI101194B (fi) | 1998-05-15 |
AU7362391A (en) | 1991-09-26 |
IE64738B1 (en) | 1995-09-06 |
ATE107172T1 (de) | 1994-07-15 |
JPH04217630A (ja) | 1992-08-07 |
AU631730B2 (en) | 1992-12-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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