ZA911659B - Stabilized gonadotropin containing preparations - Google Patents

Stabilized gonadotropin containing preparations

Info

Publication number
ZA911659B
ZA911659B ZA911659A ZA911659A ZA911659B ZA 911659 B ZA911659 B ZA 911659B ZA 911659 A ZA911659 A ZA 911659A ZA 911659 A ZA911659 A ZA 911659A ZA 911659 B ZA911659 B ZA 911659B
Authority
ZA
South Africa
Prior art keywords
preparations
lyophilized
dicarboxylic acid
disclosed
acid salt
Prior art date
Application number
ZA911659A
Other languages
English (en)
Inventor
Andreas Leo Johannes De Meere
Leo Johannes De Meere Andreas
Marinus Arie De Ruiter
Arie De Ruiter Marinus
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of ZA911659B publication Critical patent/ZA911659B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
ZA911659A 1990-03-20 1991-03-06 Stabilized gonadotropin containing preparations ZA911659B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90200665 1990-03-20

Publications (1)

Publication Number Publication Date
ZA911659B true ZA911659B (en) 1991-12-24

Family

ID=8204967

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA911659A ZA911659B (en) 1990-03-20 1991-03-06 Stabilized gonadotropin containing preparations

Country Status (16)

Country Link
EP (1) EP0448146B1 (xx)
JP (1) JP3031570B2 (xx)
KR (1) KR100221123B1 (xx)
AT (1) ATE107172T1 (xx)
AU (1) AU631730B2 (xx)
CA (1) CA2037884C (xx)
DE (1) DE69102465T2 (xx)
DK (1) DK0448146T3 (xx)
ES (1) ES2057731T3 (xx)
FI (1) FI101194B (xx)
HK (1) HK1002494A1 (xx)
ID (1) ID905B (xx)
IE (1) IE64738B1 (xx)
NZ (1) NZ237458A (xx)
PT (1) PT97074B (xx)
ZA (1) ZA911659B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
CA2150251C (en) * 1993-04-28 2005-02-22 Arnold Titus Philip Skrabanja Lyospheres comprising gonadotropin
JP4165878B2 (ja) * 1993-06-03 2008-10-15 株式会社林原生物化学研究所 トレハロース遊離酵素とその製造方法並びに用途
US5556771A (en) * 1995-02-10 1996-09-17 Gen-Probe Incorporated Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification
DE69524456T2 (de) * 1995-03-21 2002-08-01 Applied Research Systems Flüssige hcg-formulierungen
IL120202A (en) 1996-03-07 2001-03-19 Akzo Nobel Nv Container with freeze-dried vaccine components
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
BR9912243A (pt) * 1998-07-23 2001-10-16 Lilly Co Eli Formulações de fsh e variantes de fsh, produtos e processos
US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
US7112341B1 (en) 1999-04-13 2006-09-26 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
DK1330258T3 (da) * 2000-10-31 2006-05-22 Pharma Mar Sa Kahalalid F-formulering
CA2433037C (en) * 2000-12-28 2010-12-21 Takeda Chemical Industries, Ltd. Sustained-release preparation
GB0207092D0 (en) * 2002-03-26 2002-05-08 Sod Conseils Rech Applic Stable pharmaceutical composition containing factor VIII
AR043972A1 (es) 2003-04-02 2005-08-17 Ares Trading Sa Formulaciones farmaceuticas de fsh y lh
US20040248784A1 (en) 2003-06-03 2004-12-09 Marco Filicori Unitary combinations of FSH and hCG
PT1638595E (pt) 2003-06-20 2013-04-26 Ares Trading Sa Fsh liofilizada / formulações de hl
DE10333317A1 (de) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
CA2560513A1 (en) 2004-04-08 2005-12-01 Biomatrica, Inc. Integration of sample storage and sample management for life science
EP1987067A4 (en) * 2006-02-15 2012-01-25 Imclone Llc ANTIBODY FORMULATION
MX2010004639A (es) 2007-11-01 2010-08-04 Merck Serono Sa Formulaciones liquidas de hormona luteinizante (lh).
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
WO2010132508A2 (en) 2009-05-11 2010-11-18 Biomatrica, Inc. Compositions and methods for biological sample storage
CA2806734A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
JP5933544B2 (ja) 2010-07-26 2016-06-08 バイオマトリカ， インコーポレーテッド 外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物
KR101948337B1 (ko) 2010-11-05 2019-02-14 박스알타 인코퍼레이티드 증가된 특이 활성도를 갖는 항혈우병 인자 ｖｉｉｉ의 신규 변이체
CN102293756A (zh) * 2011-08-24 2011-12-28 蚌埠丰原涂山制药有限公司 一种尿促性素冻干粉针剂及其制备方法
ES2937409T3 (es) 2011-10-28 2023-03-28 Prothena Biosciences Ltd Anticuerpos humanizados que reconocen la alfa-sinucleína
MY171140A (en) 2012-01-27 2019-09-27 Prothena Biosciences Ltd Humanized antibodies that recognize alpha-synuclein
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
EP2934572A4 (en) 2012-12-20 2016-11-23 Biomatrica Inc FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
US10513555B2 (en) * 2013-07-04 2019-12-24 Prothena Biosciences Limited Antibody formulations and methods
CN106572650B (zh) 2014-06-10 2021-08-31 生物马特里卡公司 在环境温度下稳定凝血细胞
KR20230145258A (ko) 2015-12-08 2023-10-17 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932943A (en) * 1970-08-14 1976-01-20 E. I. Du Pont De Nemours And Company Method of preparation of lyophilized biological products
IT1057895B (it) * 1975-02-17 1982-03-30 Serono Lab Gonadotropina corionica umana parzialmente desalinizzata per indurre l'ouvulazione
ATE31023T1 (de) * 1983-04-28 1987-12-15 Armour Pharma Pharmazeutische zubereitung mit gehalt an gereinigtem fibrinonectin.
GB8604983D0 (en) * 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
US5059587A (en) * 1987-08-03 1991-10-22 Toyo Jozo Company, Ltd. Physiologically active peptide composition for nasal administration

Also Published As

Publication number Publication date
AU631730B2 (en) 1992-12-03
EP0448146A1 (en) 1991-09-25
FI101194B1 (fi) 1998-05-15
ATE107172T1 (de) 1994-07-15
KR100221123B1 (ko) 1999-09-15
AU7362391A (en) 1991-09-26
IE64738B1 (en) 1995-09-06
PT97074A (pt) 1991-10-31
FI911309A0 (fi) 1991-03-18
IE910732A1 (en) 1991-09-25
ID905B (id) 1996-09-10
CA2037884C (en) 2003-10-21
HK1002494A1 (en) 1998-08-28
JP3031570B2 (ja) 2000-04-10
DE69102465D1 (de) 1994-07-21
ES2057731T3 (es) 1994-10-16
DK0448146T3 (da) 1994-10-24
CA2037884A1 (en) 1991-09-21
NZ237458A (en) 1992-02-25
JPH04217630A (ja) 1992-08-07
PT97074B (pt) 1998-10-30
KR910016340A (ko) 1991-11-05
FI101194B (fi) 1998-05-15
FI911309A (fi) 1991-09-21
DE69102465T2 (de) 1995-03-02
EP0448146B1 (en) 1994-06-15

Similar Documents

Publication Publication Date Title
ZA911659B (en) Stabilized gonadotropin containing preparations
CA2125855A1 (en) A stabilized pharmaceutical formulation comprising growth hormone and histidine
EP0355460A3 (en) Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization
AR011410A1 (es) Una formulacion liquida que contiene gonadotrofinas, un metodo para preparar una composicion liquida de gonadotrofinas, un cartucho que contiene una formulacion liquida esteril, un dispositivo para administrar la formulacion y utilizacion de la formulacion que contiene la gonadotrofinas para la elab
RU98100930A (ru) Жидкие композиции, содержащие гонадотропин
HUT54895A (en) Process for producing stabilized fgf composition
DE3881281T2 (de) Stabilisierter attenuierter lebender impfstoff und seine herstellung.
CA2124801A1 (en) Gonadotropin containing pharmaceutical compositions with sucrose stabilizer
KR970706841A (ko) 성장호르몬 및 루신으로 이루어진 약학적 조성물(a pharmaceutical formulation comprising a growth hormone and leucine)
MX9302509A (es) Composiciones de polipeptidos estables en almacenamiento y metodo para su preparacion.
RU2001102616A (ru) Затравочные кристаллы для получения пептидов или протеинов
EP0294667A3 (en) (2-cyano-2-oximinoacetyl)-amino acid derivatives
CA2069256A1 (en) Method of preparing .alpha.-l-aspartyl-l-phenylalanine methyl ester
EP0294668A3 (en) (2-cyano-2-oximinoacetyl)-amino acid derivatives
Slyvchuk et al. Stabilizing the gonadotropin activity with the use of organic compounds
DE59008754D1 (de) Verfahren zur Herstellung von granuliertem Natriumacetat-Trihydrat.