ES2180650T3 - Modelo optico pseudo-telecentrico de analizador de celulas sanguineas por citometria de flujo. - Google Patents

Modelo optico pseudo-telecentrico de analizador de celulas sanguineas por citometria de flujo.

Info

Publication number
ES2180650T3
ES2180650T3 ES95928685T ES95928685T ES2180650T3 ES 2180650 T3 ES2180650 T3 ES 2180650T3 ES 95928685 T ES95928685 T ES 95928685T ES 95928685 T ES95928685 T ES 95928685T ES 2180650 T3 ES2180650 T3 ES 2180650T3
Authority
ES
Spain
Prior art keywords
light
detectors
condensing lens
direct
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95928685T
Other languages
English (en)
Inventor
Vernon L Chupp
Suresh N Mehta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/488,532 external-priority patent/US5631165A/en
Priority claimed from US08/482,678 external-priority patent/US5656499A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2180650T3 publication Critical patent/ES2180650T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B01F25/3132—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
    • B01F25/31324—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices arranged concentrically
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/012—Red blood cells
    • G01N2015/014—Reticulocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/018—Platelets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1413—Hydrodynamic focussing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00524—Mixing by agitating sample carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1032—Dilution or aliquotting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Landscapes

  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Optical Measuring Cells (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

SE PRESENTA UN SISTEMA OPTICO CITOMETRICO DE FLUJO PSEUDOTELECENTRICO PARA LA DETECCION SIMULTANEA DE VARIAS CARACTERISTICAS DE PARTICULAS SUSPENDIDAS EN UN MEDIO DE FLUJO. EL SISTEMA ESTA CONSTITUIDO POR UNA CELDA DE FLUJO (128) A TRAVES DE LA CUAL PASAN LAS PARTICULAS SUBSTANCIALMENTE UNA PARTICULA CADA VEZ, UN SISTEMA OPTICO PARA DIRIGIR LUZ (121) DESDE UNA FUENTE DE LUZ (120) SOBRE LAS PARTICULAS QUE FLUYEN EN LA CELDA DE FLUJO, UN SISTEMA DE RECOGIDA OPTICA DE ANGULO LATERAL (150) PARA RECIBIR LA LUZ DE LAS PARTICULAS Y PARA DIRIGIR LA LUZ HACIA UNO O MAS DE UN PRIMER CONJUNTO DE DETECTORES, Y UN SISTEMA DE RECOGIDA DE ANGULO DELANTERO (160) PARA RECIBIR LA LUZ DE LAS PARTICULAS QUE FLUYEN Y PARA DIRIGIR LA LUZ HACIA UNO O MAS DE UN SEGUNDO CONJUNTO DE DETECTORES. EL SISTEMA DE RECOGIDA OPTICA DE ANGULO LATERAL PUEDE INCLUIR UNA LENTE CONDENSADORA (132) PARA DIRIGIR LA LUZ HACIA EL PRIMER CONJUNTO DE DETECTORES CON UNA PUPILA DE SALIDA (151) DE LA LENTE CONDENSADORA SITUADA EN EL PLANOFOCAL TRASERO DE LA LENTE CONDENSADORA; UNA SUPERFICIE FOTOSENSIBLE DE UNO O MAS DEL PRIMER CONJUNTO DE DETECTORES (141, 142, 143, 144) SE SITUA EN PUNTOS CONJUGADOS DEL PLANO FOCAL TRASERO DE LA LENTE CONDENSADORA DE MANERA QUE UNA IMAGEN DE LA PUPILA DE SALIDA SE POSICIONE EN LA SUPERFICIE FOTOSENSIBLE DE UNO O MAS DEL PRIMER CONJUNTO DE DETECTORES. EL SISTEMA DE RECOGIDA OPTICA DE ANGULO DELANTERO PUEDE INCLUIR UNA LENTE CONDENSADORA (130) PARA DIRIGIR LA LUZ HACIA EL SEGUNDO CONJUNTO DE DETECTORES (131) EN DONDE LA PUPILA DE SALIDA DE LA LENTE CONDENSADORA SE SITUA EN EL PLANO FOCAL TRASERO DE LA LENTE CONDENSADORA Y UNA SUPERFICIE FOTOSENSIBLE DE UNO O MAS DEL SEGUNDO CONJUNTO DE DETECTORES SE SITUA EN EL PLANO FOCAL TRASERO DE LA LENTE CONDENSADORA.
ES95928685T 1994-08-01 1995-07-28 Modelo optico pseudo-telecentrico de analizador de celulas sanguineas por citometria de flujo. Expired - Lifetime ES2180650T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28337994A 1994-08-01 1994-08-01
US08/488,532 US5631165A (en) 1994-08-01 1995-06-07 Method for performing automated hematology and cytometry analysis
US08/482,678 US5656499A (en) 1994-08-01 1995-06-07 Method for performing automated hematology and cytometry analysis

Publications (1)

Publication Number Publication Date
ES2180650T3 true ES2180650T3 (es) 2003-02-16

Family

ID=27403380

Family Applications (4)

Application Number Title Priority Date Filing Date
ES95928685T Expired - Lifetime ES2180650T3 (es) 1994-08-01 1995-07-28 Modelo optico pseudo-telecentrico de analizador de celulas sanguineas por citometria de flujo.
ES95929329T Expired - Lifetime ES2251722T3 (es) 1994-08-01 1995-07-28 Procedimiento y aparato para la realizacion de analisis automatizados.
ES97113064T Expired - Lifetime ES2210426T3 (es) 1994-08-01 1995-07-28 Metodo y aparato de preparacion de un fluido.
ES03015537T Expired - Lifetime ES2311659T3 (es) 1994-08-01 1995-07-28 Metodo y aparato de preparacion de un fluido.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES95929329T Expired - Lifetime ES2251722T3 (es) 1994-08-01 1995-07-28 Procedimiento y aparato para la realizacion de analisis automatizados.
ES97113064T Expired - Lifetime ES2210426T3 (es) 1994-08-01 1995-07-28 Metodo y aparato de preparacion de un fluido.
ES03015537T Expired - Lifetime ES2311659T3 (es) 1994-08-01 1995-07-28 Metodo y aparato de preparacion de un fluido.

Country Status (9)

Country Link
US (1) US5631730A (es)
EP (4) EP0774112B1 (es)
JP (3) JPH09508705A (es)
AT (4) ATE220200T1 (es)
AU (2) AU3271895A (es)
CA (2) CA2192835C (es)
DE (4) DE69527292T2 (es)
ES (4) ES2180650T3 (es)
WO (2) WO1996004544A1 (es)

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EP1356859A1 (en) 2003-10-29
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EP0774112B1 (en) 2002-07-03
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EP0810026A1 (en) 1997-12-03
DE69535807D1 (de) 2008-09-18
CA2192835A1 (en) 1996-02-15
ATE304170T1 (de) 2005-09-15
DE69534429D1 (de) 2005-10-13
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ATE252938T1 (de) 2003-11-15
JPH09508705A (ja) 1997-09-02
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US5631730A (en) 1997-05-20
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ATE403491T1 (de) 2008-08-15
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EP1356859B1 (en) 2008-08-06
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DE69534429T2 (de) 2006-06-22

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