ES2173481T3 - Derivados del acido4,7-dialcoxi-n-acetilneuraminico y metodos para la deteccion de virus de la gripe de tipos a y b en muestras clinicas. - Google Patents

Derivados del acido4,7-dialcoxi-n-acetilneuraminico y metodos para la deteccion de virus de la gripe de tipos a y b en muestras clinicas.

Info

Publication number
ES2173481T3
ES2173481T3 ES97940823T ES97940823T ES2173481T3 ES 2173481 T3 ES2173481 T3 ES 2173481T3 ES 97940823 T ES97940823 T ES 97940823T ES 97940823 T ES97940823 T ES 97940823T ES 2173481 T3 ES2173481 T3 ES 2173481T3
Authority
ES
Spain
Prior art keywords
viruses
type
substrates
dialkoxy
clinical samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97940823T
Other languages
English (en)
Inventor
Avraham Liav
Joyce Anne Hansjergen
Craig David Shimasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oklahoma Medical Research Foundation
Original Assignee
Oklahoma Medical Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Medical Research Foundation filed Critical Oklahoma Medical Research Foundation
Application granted granted Critical
Publication of ES2173481T3 publication Critical patent/ES2173481T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/027—Keto-aldonic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/50—Indoles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)

Abstract

SE PROPORCIONAN SUSTRATOS DEL ACIDO 4,7 - DIALCOXI - N ACETILNEURAMINICO CROMOGENOS Y FLUOROGENOS DE FORMULA GENERAL (I) EN LA QUE R 1 Y R 2 SON GRUPOS ALQUILO QUE CONTIENEN ENTRE 1 Y 4 ATOMOS DE CARBONO Y R 3 ES UN GRUPO CROMOGENO O FLUOROGENO. ESTOS SUSTRATOS SE PUEDEN UTILIZAR PARA DETECTAR LOS VIRUS DE LA INFLUENCIA DEL TIPO A Y B EN MUESTRAS O ESPECIMENES CLINICOS. MAS PARTICULARMENTE, ESTOS SUSTRATOS DE ACIDO 4,7 - DIALCOXI - N - ACETILNEURAMINICO SE PUEDEN USAR PARA DISTINGUIR ENTRE VARIOS VIRUS QUE TIENEN REACTIVIDAD NEURAMIDINASA. ASI, LOS VIRUS DE LA INFLUENZA DE TIPO A Y B SE PUEDEN DISTINGUIR DE LOS DEL VIRUS DE LA PARAINFLUENZA DEL TIPO 1, 2, 3 Y 4 Y DEL VIRUS DE LA PAROTIDITIS UTILIZANDO LOS DERIVADOS DE ACIDO 4,7 - DIALCOXI - N - ACETILNEURAMINICO DE ESTA INVENCION. SE EMPLEAN METODOS DIAGNOSTICOS QUE UTILIZAN ESTOS SUSTRATOS PARA IDENTIFICAR LOS VIRUS DE LA INFLUENZA DE TIPO A Y B EN ESPECIMENES CLINICOS Y PARA DISTINGUIR ENTRE OTROS VIRUS QUE TIENEN ACTIVIDAD NEURAMINIDASA.
ES97940823T 1996-09-25 1997-09-05 Derivados del acido4,7-dialcoxi-n-acetilneuraminico y metodos para la deteccion de virus de la gripe de tipos a y b en muestras clinicas. Expired - Lifetime ES2173481T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/718,666 US5719020A (en) 1996-09-25 1996-09-25 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens

Publications (1)

Publication Number Publication Date
ES2173481T3 true ES2173481T3 (es) 2002-10-16

Family

ID=24886990

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97940823T Expired - Lifetime ES2173481T3 (es) 1996-09-25 1997-09-05 Derivados del acido4,7-dialcoxi-n-acetilneuraminico y metodos para la deteccion de virus de la gripe de tipos a y b en muestras clinicas.

Country Status (16)

Country Link
US (1) US5719020A (es)
EP (1) EP0888371B1 (es)
JP (1) JP4070817B2 (es)
CN (2) CN1091447C (es)
AT (1) ATE217879T1 (es)
AU (1) AU716275B2 (es)
BR (1) BR9706776A (es)
CA (1) CA2237790A1 (es)
DE (1) DE69712747T2 (es)
ES (1) ES2173481T3 (es)
HK (1) HK1016988A1 (es)
IL (1) IL124511A (es)
NO (1) NO310822B1 (es)
NZ (1) NZ330443A (es)
PL (1) PL327109A1 (es)
WO (1) WO1998013372A1 (es)

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US6667161B1 (en) * 1997-10-27 2003-12-23 Ibbex, Inc. Chromogenic substrates of sialidase of bacterial, viral, protozoa, and vertebrate origin and methods of making and using the same
CA2314431A1 (en) * 1997-12-18 1999-06-24 Sepracor Inc. Screening assays for the detection and diagnosis of influenza virus
US6303764B1 (en) 1998-09-24 2001-10-16 Zymetx, Inc. Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
US6555698B1 (en) * 1998-11-17 2003-04-29 Tropix, Inc. Chemiluminescent substrates for neuraminidase, assays for detection of neuraminidase and kits therefor
WO2000063423A2 (en) * 1999-04-16 2000-10-26 Zymetx, Inc. Viral detection method using viral encoded enzymes and chemiluminescent substrates
US6420552B1 (en) 1999-09-10 2002-07-16 Zymetx, Inc. Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
US6627396B1 (en) * 1999-10-28 2003-09-30 The Regents Of The University Of California Influenza sensor
SE9904289D0 (sv) * 1999-11-26 1999-11-26 Niklas Arnberg Method and camposition for the treatment of adenovairal ocular infections
WO2003077865A2 (en) * 2002-03-15 2003-09-25 Baxter International Inc. Methods and compositions for directing cells to target organs
CA2501527A1 (en) * 2002-10-10 2004-04-22 Catherine A. Phillips Detection, localization and staging of tumors using labeled activated lymphocytes directed to a tumor specific epitope
EA014533B1 (ru) * 2006-05-18 2010-12-30 Ветеринермедицинише Универзитет Вин Способы обнаружения вирусов гриппа
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US20090098527A1 (en) * 2006-09-12 2009-04-16 Fischer Gerald W Biological organism identification product and methods
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
AU2008293504B2 (en) 2007-08-27 2012-04-12 Longhorn Vaccines & Diagnostics, Llc Immunogenic compositions and methods
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
DK2535428T3 (en) * 2007-10-01 2015-11-23 Longhorn Vaccines & Diagnostics Llc Biological prøvesamlings- and transport system, and methods of using
US9119866B2 (en) * 2008-04-08 2015-09-01 Huiru Wang Glycan-based drugs, therapies and biomarkers
CN104203272A (zh) 2012-01-26 2014-12-10 长角牛疫苗和诊断有限责任公司 复合抗原序列及疫苗
AU2014248225B2 (en) 2013-04-01 2020-06-25 Becton, Dickinson And Company Methods and kits for the diagnosis of influenza
CA2985652C (en) 2015-05-14 2020-03-10 Gerald W. FISHER Rapid methods for the extraction of nucleic acids from biological samples
PT3516067T (pt) * 2016-09-19 2022-06-29 Univ Wuerzburg J Maximilians Composto e pastilha elástica compreendendo o composto para deteção de vírus pelo sabor
TWI631340B (zh) * 2017-06-16 2018-08-01 國立臺北科技大學 檢測神經胺酸酶活性的方法
CN107446004B (zh) * 2017-08-10 2020-05-01 济南山目生物医药科技有限公司 一种2-(4’-甲基伞形酮)-alpha-N-乙酰基神经氨酸钠的合成方法
CN113518828A (zh) 2019-03-05 2021-10-19 国立研究开发法人科学技术振兴机构 用于流感病毒检测的方法及试剂盒、以及流感病毒感染的诊断方法

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Also Published As

Publication number Publication date
DE69712747T2 (de) 2002-11-21
AU4251297A (en) 1998-04-17
NO982343D0 (no) 1998-05-22
CA2237790A1 (en) 1998-04-02
CN1324954A (zh) 2001-12-05
IL124511A0 (en) 1998-12-06
ATE217879T1 (de) 2002-06-15
CN1147589C (zh) 2004-04-28
EP0888371A1 (en) 1999-01-07
BR9706776A (pt) 1999-05-18
NO310822B1 (no) 2001-09-03
CN1091447C (zh) 2002-09-25
US5719020A (en) 1998-02-17
IL124511A (en) 2002-08-14
DE69712747D1 (de) 2002-06-27
WO1998013372A1 (en) 1998-04-02
HK1016988A1 (en) 1999-11-12
CN1205011A (zh) 1999-01-13
AU716275B2 (en) 2000-02-24
JP2000501748A (ja) 2000-02-15
NO982343L (no) 1998-07-01
NZ330443A (en) 1998-12-23
EP0888371B1 (en) 2002-05-22
PL327109A1 (en) 1998-11-23
JP4070817B2 (ja) 2008-04-02

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