ATE145673T1 - Verfahren zur diagnostizierung von menschlicher grippe und in position 4 modifizierte chromogene n-acetylneuraminsäure substrate zur verwendung in diesen verfahren - Google Patents
Verfahren zur diagnostizierung von menschlicher grippe und in position 4 modifizierte chromogene n-acetylneuraminsäure substrate zur verwendung in diesen verfahrenInfo
- Publication number
- ATE145673T1 ATE145673T1 AT91902414T AT91902414T ATE145673T1 AT E145673 T1 ATE145673 T1 AT E145673T1 AT 91902414 T AT91902414 T AT 91902414T AT 91902414 T AT91902414 T AT 91902414T AT E145673 T1 ATE145673 T1 AT E145673T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxyl group
- substrates
- influenza
- acid substrates
- replacing
- Prior art date
Links
- 206010022000 influenza Diseases 0.000 title abstract 5
- 239000000758 substrate Substances 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 102000005348 Neuraminidase Human genes 0.000 abstract 2
- 108010006232 Neuraminidase Proteins 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical class CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 abstract 1
- 238000007398 colorimetric assay Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000009257 reactivity Effects 0.000 abstract 1
- 238000009120 supportive therapy Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/075—Benzo[b]pyran-2-ones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45880589A | 1989-12-29 | 1989-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE145673T1 true ATE145673T1 (de) | 1996-12-15 |
Family
ID=23822154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91902414T ATE145673T1 (de) | 1989-12-29 | 1990-12-27 | Verfahren zur diagnostizierung von menschlicher grippe und in position 4 modifizierte chromogene n-acetylneuraminsäure substrate zur verwendung in diesen verfahren |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0507854B1 (de) |
| JP (1) | JP3134999B2 (de) |
| AT (1) | ATE145673T1 (de) |
| AU (1) | AU656721B2 (de) |
| CA (1) | CA2072368C (de) |
| DE (1) | DE69029276T2 (de) |
| DK (1) | DK0507854T3 (de) |
| ES (1) | ES2097804T3 (de) |
| GR (1) | GR3022421T3 (de) |
| WO (1) | WO1991009972A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0566633B1 (de) * | 1990-12-31 | 1999-08-04 | Oklahoma Medical Research Foundation | Verfahren zum visuellen nachweis der anwesenheit eines virus in einer klinischen probe |
| EP0746564B1 (de) * | 1994-02-25 | 1998-12-02 | E.I. Du Pont De Nemours And Company | 4-n substituierte sialinsäuren und deren sialoside |
| US5556963A (en) * | 1994-08-05 | 1996-09-17 | Oklahoma Medical Research Foundation | Synthesis of 4-alkoxy-N-acetylneuraminic acid |
| CA2245680C (en) * | 1996-03-01 | 2005-09-27 | Biota Scientific Management Pty. Ltd. | Method of detection of influenza virus and compounds for use therein |
| US5719020A (en) * | 1996-09-25 | 1998-02-17 | Oklahoma Medical Research Foundation | 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens |
| US6303764B1 (en) | 1998-09-24 | 2001-10-16 | Zymetx, Inc. | Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids |
| ES2253833T3 (es) * | 1998-10-27 | 2006-06-01 | Ibbex, Inc. C/O Gryphus Diagnostics, L.L.C. | Sustratos cromogenicos de sialidasa y procedimientos para la preparacion y la utilizacion de los mismos. |
| US6555698B1 (en) * | 1998-11-17 | 2003-04-29 | Tropix, Inc. | Chemiluminescent substrates for neuraminidase, assays for detection of neuraminidase and kits therefor |
| US6420552B1 (en) | 1999-09-10 | 2002-07-16 | Zymetx, Inc. | Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids |
| JPWO2006064914A1 (ja) * | 2004-12-17 | 2008-06-12 | 独立行政法人産業技術総合研究所 | ノイラミニダーゼ阻害剤 |
| JP6591398B2 (ja) * | 2013-04-01 | 2019-10-16 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | インフルエンザ診断のための方法及びキット |
| US10408783B2 (en) | 2014-05-30 | 2019-09-10 | Georgia State University Research Foundation, Inc. | Electrochemical methods and compounds for the detection of enzymes |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7176091A (en) * | 1989-12-29 | 1991-07-24 | Symex Corp. | Chromogenic 7- or 8-position modified n-acetylneuraminic acid substrates and methods for diagnosing human influenza therewith |
| AU7150891A (en) * | 1990-01-10 | 1991-08-05 | Symex Corp. | Chromogenic 9-position modified n-acetylneuraminic acid substrates and methods for diagnosing human influenza therewith |
-
1990
- 1990-12-27 ES ES91902414T patent/ES2097804T3/es not_active Expired - Lifetime
- 1990-12-27 JP JP03502946A patent/JP3134999B2/ja not_active Expired - Fee Related
- 1990-12-27 AT AT91902414T patent/ATE145673T1/de not_active IP Right Cessation
- 1990-12-27 DK DK91902414.1T patent/DK0507854T3/da active
- 1990-12-27 EP EP91902414A patent/EP0507854B1/de not_active Expired - Lifetime
- 1990-12-27 CA CA002072368A patent/CA2072368C/en not_active Expired - Fee Related
- 1990-12-27 DE DE69029276T patent/DE69029276T2/de not_active Expired - Fee Related
- 1990-12-27 AU AU71647/91A patent/AU656721B2/en not_active Ceased
- 1990-12-27 WO PCT/US1990/007681 patent/WO1991009972A1/en not_active Ceased
-
1997
- 1997-01-29 GR GR970400145T patent/GR3022421T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU656721B2 (en) | 1995-02-16 |
| EP0507854A1 (de) | 1992-10-14 |
| DK0507854T3 (da) | 1997-05-12 |
| DE69029276T2 (de) | 1997-04-17 |
| EP0507854A4 (en) | 1992-10-21 |
| JP3134999B2 (ja) | 2001-02-13 |
| DE69029276D1 (de) | 1997-01-09 |
| GR3022421T3 (en) | 1997-04-30 |
| CA2072368C (en) | 1998-06-30 |
| CA2072368A1 (en) | 1991-06-30 |
| WO1991009972A1 (en) | 1991-07-11 |
| ES2097804T3 (es) | 1997-04-16 |
| EP0507854B1 (de) | 1996-11-27 |
| AU7164791A (en) | 1991-07-24 |
| JPH05505099A (ja) | 1993-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |