ES2097804T3 - Metodos para diagnosticar la gripe humana y sustratos cromogenos de acido n-acetilneuraminico para usar en estos metodos. - Google Patents

Metodos para diagnosticar la gripe humana y sustratos cromogenos de acido n-acetilneuraminico para usar en estos metodos.

Info

Publication number
ES2097804T3
ES2097804T3 ES91902414T ES91902414T ES2097804T3 ES 2097804 T3 ES2097804 T3 ES 2097804T3 ES 91902414 T ES91902414 T ES 91902414T ES 91902414 T ES91902414 T ES 91902414T ES 2097804 T3 ES2097804 T3 ES 2097804T3
Authority
ES
Spain
Prior art keywords
methods
substrates
acetylneuraminic acid
hydroxyl group
influenza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91902414T
Other languages
English (en)
Inventor
Gregory A Turner
James F Maher
C Worth Clinkscales
Michael C Roark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oklahoma Medical Research Foundation
Original Assignee
Oklahoma Medical Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Medical Research Foundation filed Critical Oklahoma Medical Research Foundation
Application granted granted Critical
Publication of ES2097804T3 publication Critical patent/ES2097804T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyrane Compounds (AREA)

Abstract

METODO PARA EL DIAGNOSTICO DE LA GRIPE HUMANA Y SUSTRATOS DE ACIDO N-ACETILNEURAMINICO CROMOGENICO MODIFICADOS EN LA POSICION 4 PARA UTILIZARLOS EN EL MISMO DERIVADOS CROMOGENICOS DEL ACIDO N-ACETILNEURAMINICO MODIFICADOS EN LA POSICION 4 A BASE DE ELIMINAR EL GRUPO HIDROXILO, DE SUSTITUIR EL GRUPO HIDROXILO POR FLUOR O DE SUSTITUIR EL HIDROGENO DEL GRUPO HIDROXILO POR METILO QUE SE UTILIZAN COMO SUSTRATOS EN ENSAYOS COLORIMETRICOS PARA DETERMINAR LA ACTIVIDAD DE LA NEURAMINIDASA DE LA GRIPE HUMANA EN MUESTRAS CLINICAS CON EL FIN DE DIAGNOSTICAR SELECTIVAMENTE LA INFECCION DE LA GRIPE. LOS SUSTRATOS PUEDEN PRESENTAR UNA REACTIVIDAD DIFERENTE CON LOS DISTINTOS TIPOS DE NEURAMINIDASAS DE LA GRIPE, PERMITIENDONOS ASI DISTINGUIR EL TIPO ESPECIFICO DE LA INFECCION DE LA GRIPE Y DETERMINAR EL TRATAMIENTO APROPIADO Y/O LA TERAPIA TOLERANTE PARA LA MISMA.
ES91902414T 1989-12-29 1990-12-27 Metodos para diagnosticar la gripe humana y sustratos cromogenos de acido n-acetilneuraminico para usar en estos metodos. Expired - Lifetime ES2097804T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45880589A 1989-12-29 1989-12-29

Publications (1)

Publication Number Publication Date
ES2097804T3 true ES2097804T3 (es) 1997-04-16

Family

ID=23822154

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91902414T Expired - Lifetime ES2097804T3 (es) 1989-12-29 1990-12-27 Metodos para diagnosticar la gripe humana y sustratos cromogenos de acido n-acetilneuraminico para usar en estos metodos.

Country Status (10)

Country Link
EP (1) EP0507854B1 (es)
JP (1) JP3134999B2 (es)
AT (1) ATE145673T1 (es)
AU (1) AU656721B2 (es)
CA (1) CA2072368C (es)
DE (1) DE69029276T2 (es)
DK (1) DK0507854T3 (es)
ES (1) ES2097804T3 (es)
GR (1) GR3022421T3 (es)
WO (1) WO1991009972A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69131504T2 (de) * 1990-12-31 1999-11-18 Oklahoma Med Res Found Verfahren zum visuellen nachweis der anwesenheit eines virus in einer klinischen probe
EP0746564B1 (en) * 1994-02-25 1998-12-02 E.I. Du Pont De Nemours And Company 4-n-substituted sialic acids and their sialosides
US5556963A (en) * 1994-08-05 1996-09-17 Oklahoma Medical Research Foundation Synthesis of 4-alkoxy-N-acetylneuraminic acid
NZ331189A (en) 1996-03-01 1999-06-29 Biota Scient Management Method of detection of influenza virus using neuraminidase binders
US5719020A (en) * 1996-09-25 1998-02-17 Oklahoma Medical Research Foundation 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
US6303764B1 (en) 1998-09-24 2001-10-16 Zymetx, Inc. Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
ES2253833T3 (es) * 1998-10-27 2006-06-01 Ibbex, Inc. C/O Gryphus Diagnostics, L.L.C. Sustratos cromogenicos de sialidasa y procedimientos para la preparacion y la utilizacion de los mismos.
US6555698B1 (en) * 1998-11-17 2003-04-29 Tropix, Inc. Chemiluminescent substrates for neuraminidase, assays for detection of neuraminidase and kits therefor
US6420552B1 (en) 1999-09-10 2002-07-16 Zymetx, Inc. Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
JPWO2006064914A1 (ja) * 2004-12-17 2008-06-12 独立行政法人産業技術総合研究所 ノイラミニダーゼ阻害剤
BR112015025042B1 (pt) * 2013-04-01 2023-11-14 Becton, Dickinson And Company Sistema de diagnóstico e método para detectar vírus influenza, composto inibidor de máscara e kit
WO2015184442A1 (en) 2014-05-30 2015-12-03 Georgia State University Research Foundation Electrochemical methods and compounds for the detection of enzymes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7176091A (en) * 1989-12-29 1991-07-24 Symex Corp. Chromogenic 7- or 8-position modified n-acetylneuraminic acid substrates and methods for diagnosing human influenza therewith
AU7150891A (en) * 1990-01-10 1991-08-05 Symex Corp. Chromogenic 9-position modified n-acetylneuraminic acid substrates and methods for diagnosing human influenza therewith

Also Published As

Publication number Publication date
EP0507854B1 (en) 1996-11-27
JP3134999B2 (ja) 2001-02-13
CA2072368A1 (en) 1991-06-30
ATE145673T1 (de) 1996-12-15
WO1991009972A1 (en) 1991-07-11
EP0507854A1 (en) 1992-10-14
DE69029276D1 (de) 1997-01-09
JPH05505099A (ja) 1993-08-05
CA2072368C (en) 1998-06-30
EP0507854A4 (en) 1992-10-21
AU7164791A (en) 1991-07-24
GR3022421T3 (en) 1997-04-30
AU656721B2 (en) 1995-02-16
DE69029276T2 (de) 1997-04-17
DK0507854T3 (da) 1997-05-12

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