DK0419387T3 - Hidtil ukendte hydrofile derivater, terapeutisk og diagnostisk anvendelse, diagnostiske eller terapeutiske kit og immunologiske reagenser - Google Patents

Hidtil ukendte hydrofile derivater, terapeutisk og diagnostisk anvendelse, diagnostiske eller terapeutiske kit og immunologiske reagenser

Info

Publication number
DK0419387T3
DK0419387T3 DK90430018.3T DK90430018T DK0419387T3 DK 0419387 T3 DK0419387 T3 DK 0419387T3 DK 90430018 T DK90430018 T DK 90430018T DK 0419387 T3 DK0419387 T3 DK 0419387T3
Authority
DK
Denmark
Prior art keywords
therapeutic
diagnostic
immunological reagents
kits
hydrophilic derivatives
Prior art date
Application number
DK90430018.3T
Other languages
English (en)
Inventor
Jean-Marc Le Doussal
Jacques Barbet
Michel Delaage
Anne Gruaz-Guyon
Original Assignee
Immunotech Partners Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunotech Partners Sa filed Critical Immunotech Partners Sa
Application granted granted Critical
Publication of DK0419387T3 publication Critical patent/DK0419387T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK90430018.3T 1989-09-21 1990-09-20 Hidtil ukendte hydrofile derivater, terapeutisk og diagnostisk anvendelse, diagnostiske eller terapeutiske kit og immunologiske reagenser DK0419387T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8912622A FR2652004B1 (fr) 1989-09-21 1989-09-21 Nouveaux derives hydrophiles, application au diagnostic et a la therapeutique, kits diagnostiques ou therapeutiques et reactifs immunologiques.

Publications (1)

Publication Number Publication Date
DK0419387T3 true DK0419387T3 (da) 1997-04-07

Family

ID=9385847

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90430018.3T DK0419387T3 (da) 1989-09-21 1990-09-20 Hidtil ukendte hydrofile derivater, terapeutisk og diagnostisk anvendelse, diagnostiske eller terapeutiske kit og immunologiske reagenser

Country Status (11)

Country Link
US (1) US5274076A (da)
EP (1) EP0419387B1 (da)
JP (1) JP2914737B2 (da)
KR (1) KR0166075B1 (da)
AT (1) ATE145338T1 (da)
AU (1) AU638488B2 (da)
CA (1) CA2025607C (da)
DE (1) DE69029184T2 (da)
DK (1) DK0419387T3 (da)
ES (1) ES2094750T3 (da)
FR (1) FR2652004B1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4118120A1 (de) * 1991-06-03 1992-12-10 Behringwerke Ag Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
CA2115275A1 (en) * 1991-08-09 1993-02-18 David L. White Amino acid, ester and/or catechol contrast agents for mri
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
US6096289A (en) * 1992-05-06 2000-08-01 Immunomedics, Inc. Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy
CA2094785A1 (en) * 1992-05-08 1993-11-09 Jean Gariepy Metal chelating peptide
US6228362B1 (en) 1992-08-21 2001-05-08 Immunomedics, Inc. Boron neutron capture therapy using pre-targeting methods
FR2697255B1 (fr) * 1992-10-27 1995-01-13 Immunotech Partners Nouveaux dérivés bihaptènes liant le technétium, application au diagnostic et à la thérapeutique, kits et réactifs immunologiques les mettant en Óoeuvre.
DE4428874A1 (de) * 1994-08-08 1996-02-22 Schering Ag Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19533477C2 (de) * 1995-09-12 1997-10-23 Pharma Beratung Dr Klaus Hoffm Verwendung von Diethylentriaminpentaessigsäure (DTPA) mit immunsuppressiver Wirkung
US7521531B2 (en) * 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
CA2263985A1 (en) * 1996-08-28 1998-03-05 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US20040096394A1 (en) * 1996-08-28 2004-05-20 Immunomedics, Inc. Stable radioiodine conjugates and methods for their systhesis
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US6663866B1 (en) 1996-08-28 2003-12-16 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US6071490A (en) * 1998-05-07 2000-06-06 Immunomedics, Inc. Position emission tomography using gallium-68 chelates
JP2002513776A (ja) * 1998-05-07 2002-05-14 イムノメディクス， インコーポレイテッド ガリウム−６８キレートを使用した陽電子放射断層撮影法
US6962702B2 (en) * 1998-06-22 2005-11-08 Immunomedics Inc. Production and use of novel peptide-based agents for use with bi-specific antibodies
US7138103B2 (en) * 1998-06-22 2006-11-21 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US7833528B2 (en) * 1998-06-22 2010-11-16 Immunomedics, Inc. Use of multispecific, non-covalent complexes for targeted delivery of therapeutics
US7387772B1 (en) 1999-06-22 2008-06-17 Immunimedics, Inc. Chimeric, human and humanized anti-CSAP monoclonal antibodies
US7052872B1 (en) 1999-06-22 2006-05-30 Immunomedics, Inc. Bi-specific antibodies for pre-targeting diagnosis and therapy
WO1999066951A2 (en) * 1998-06-22 1999-12-29 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US7405320B2 (en) 1998-06-22 2008-07-29 Immunomedics, Inc. Therapeutic and diagnostic conjugates for use with multispecific antibodies
FR2816620B1 (fr) * 2000-11-16 2003-02-21 Inst Nat Sante Rech Med Nouveaux composes pour des applications a la radioimmunoscintingraphie et/ou a la radioimmunotherapie des cancers
US20030026764A1 (en) * 2001-07-31 2003-02-06 Immunomedics, Inc. Polymeric delivery systems
AU2002365649A1 (en) * 2001-11-28 2003-06-17 Immunomedics, Inc. Anti-dota antibody
US7172751B2 (en) * 2003-06-13 2007-02-06 Immunomedics, Inc. D-amino acid peptides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2437398A1 (fr) * 1978-06-20 1980-04-25 Commissariat Energie Atomique Compose iode utilisable comme traceur en radio-immunologie
ES8504461A1 (es) * 1982-04-12 1985-04-16 Hybritech Inc Un procedimiento para obtener un polidoma.
US4479930A (en) * 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
CA1282069C (en) * 1985-09-12 1991-03-26 Damon L. Meyer Antibody complexes of hapten-modified diagnostic or therapeutic agents
US4863713A (en) * 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
FR2604092B1 (fr) * 1986-09-19 1990-04-13 Immunotech Sa Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo
ES2058492T3 (es) * 1988-02-03 1994-11-01 Hybritech Inc Mejoras en o relativas a haptenos modificados utiles como agentes terapeuticos y de formacion de imagenes.
JPH02503921A (ja) * 1988-02-08 1990-11-15 サイトゲン　コーポレーション 化合物の部位特異結合のための新規で改良された抗体

Also Published As

Publication number Publication date
KR0166075B1 (ko) 1999-01-15
DE69029184D1 (de) 1997-01-02
ATE145338T1 (de) 1996-12-15
US5274076A (en) 1993-12-28
DE69029184T2 (de) 1997-06-05
AU6303490A (en) 1991-03-28
AU638488B2 (en) 1993-07-01
JPH03173900A (ja) 1991-07-29
EP0419387B1 (fr) 1996-11-20
ES2094750T3 (es) 1997-02-01
JP2914737B2 (ja) 1999-07-05
CA2025607A1 (en) 1991-03-22
FR2652004B1 (fr) 1994-10-28
KR910005862A (ko) 1991-04-27
EP0419387A1 (fr) 1991-03-27
CA2025607C (en) 2001-08-07
FR2652004A1 (fr) 1991-03-22

Similar Documents

Publication Publication Date Title
DK0419387T3 (da) Hidtil ukendte hydrofile derivater, terapeutisk og diagnostisk anvendelse, diagnostiske eller terapeutiske kit og immunologiske reagenser
ATE130197T1 (de) Heterofunktionelle zellular immunologische reagenzien, impfstoffe daraus und verwendungsverfahren.
DK609985A (da) Adhesin-antigener, antistoffer mod disse og dna-fragmenter, som indkoder antigenerne
SE7906148L (sv) Forfarande for framstellning av en biologisk komposition for anvendning sasom referenskontroll vid diagnostiska tester
KR870003195A (ko) 단일클론 항체를 이용한 그램 네가티브 박테리아 감염증의 검진 방법
SE8202012L (sv) Humaninterferon-beslektade peptider, antigener, antikroppar och forfarande for framstellning derav
LV10538A (lv) Imunologiski saistamas vielas noteiksanas panemiens biologiska skidruma un diagnostikas lidzeklis
DE3587724D1 (de) Antikörper verwendende diagnostische Methoden.
DE69531345D1 (de) Rekombinant pgp3, verfahren zu dessen herstellung, und dessen verwendung in der diagnose und therapie
DK614987D0 (da) Syntetiske htlv-iii peptider, praeparater og anvendelser deraf
BR8300656A (pt) Ensaio para determinar a concentracao de antigenos, processo para determinar o periodo fertil do ciclo menstrual, conjunto de reagente, e molecula ligante
RU94046284A (ru) Способ обнаружения антител, способ с-крекинга компонентов крови, набор для обнаружения антител к hcv
NO169243C (no) Monoklonalt antistoff, hybridcellelinje og anvendelse av det monoklonale antistoffet for analyse av leukocytt-populasjonen i en proeve av humant perifert blod
SE8701905D0 (sv) A method and a kit for the diagnosis of iga nephropathy
BE883905A (fr) Tests et reactifs de diagnostic par agglutination
DE69713146T2 (de) Helicobacter pylori diagnostika
DE3884731D1 (de) Monoklonaler Antikörper gegen Methamphetamin, seine Herstellung, Testverfahren und Testsatz für Methamphetamin.
IT1074288B (it) Coloranti complessi cromiferi reagenti,loro preparazione e loro applicazione
DE3650635T2 (de) Monoklonale Antikörper
Toussaint et al. An indirect fluorescent antibody technique using soluble antigens for serodiagnosis of Trypanosoma cruzi infection
SU1425549A1 (ru) Способ радиоиммунологического определени антигенов
SU1163864A1 (ru) Способ определени антиэритроцитарных антител
Foster et al. Reiter's Protein Complement-Fixation Test Report of a Trial in 1,000 Unselected Cases
Foster et al. Further Assessment of the Reiter Protein Complement-Fixation Test in a Routine Serological Laboratory
ATE110470T1 (de) Immuntestverfahren von chondrocalcin.