DE69029184T2 - Hydrophile Derivate, diagnostische und therapeutische Anwendungen, diagnostische oder therapeutische Reagenziensätze und immunologische Reagenzien - Google Patents

Hydrophile Derivate, diagnostische und therapeutische Anwendungen, diagnostische oder therapeutische Reagenziensätze und immunologische Reagenzien

Info

Publication number
DE69029184T2
DE69029184T2 DE69029184T DE69029184T DE69029184T2 DE 69029184 T2 DE69029184 T2 DE 69029184T2 DE 69029184 T DE69029184 T DE 69029184T DE 69029184 T DE69029184 T DE 69029184T DE 69029184 T2 DE69029184 T2 DE 69029184T2
Authority
DE
Germany
Prior art keywords
diagnostic
therapeutic
immunological reagents
reagent kits
hydrophilic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69029184T
Other languages
English (en)
Other versions
DE69029184D1 (de
Inventor
Jacques Barbet
Michel Delaage
Anne Gruaz-Guyon
Jean-Marc Le Doussal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunotech SAS
Original Assignee
Immunotech Partners SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunotech Partners SA filed Critical Immunotech Partners SA
Application granted granted Critical
Publication of DE69029184D1 publication Critical patent/DE69029184D1/de
Publication of DE69029184T2 publication Critical patent/DE69029184T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/5743—Specifically defined cancers of skin, e.g. melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69029184T 1989-09-21 1990-09-20 Hydrophile Derivate, diagnostische und therapeutische Anwendungen, diagnostische oder therapeutische Reagenziensätze und immunologische Reagenzien Expired - Fee Related DE69029184T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8912622A FR2652004B1 (fr) 1989-09-21 1989-09-21 Nouveaux derives hydrophiles, application au diagnostic et a la therapeutique, kits diagnostiques ou therapeutiques et reactifs immunologiques.

Publications (2)

Publication Number Publication Date
DE69029184D1 DE69029184D1 (de) 1997-01-02
DE69029184T2 true DE69029184T2 (de) 1997-06-05

Family

ID=9385847

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69029184T Expired - Fee Related DE69029184T2 (de) 1989-09-21 1990-09-20 Hydrophile Derivate, diagnostische und therapeutische Anwendungen, diagnostische oder therapeutische Reagenziensätze und immunologische Reagenzien

Country Status (11)

Country Link
US (1) US5274076A (de)
EP (1) EP0419387B1 (de)
JP (1) JP2914737B2 (de)
KR (1) KR0166075B1 (de)
AT (1) ATE145338T1 (de)
AU (1) AU638488B2 (de)
CA (1) CA2025607C (de)
DE (1) DE69029184T2 (de)
DK (1) DK0419387T3 (de)
ES (1) ES2094750T3 (de)
FR (1) FR2652004B1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4118120A1 (de) * 1991-06-03 1992-12-10 Behringwerke Ag Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
WO1993003351A1 (en) * 1991-08-09 1993-02-18 The Regents Of The University Of California Amino acid, ester and/or catechol contrast agents for mri
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
US6096289A (en) * 1992-05-06 2000-08-01 Immunomedics, Inc. Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy
CA2094785A1 (en) * 1992-05-08 1993-11-09 Jean Gariepy Metal chelating peptide
US6228362B1 (en) 1992-08-21 2001-05-08 Immunomedics, Inc. Boron neutron capture therapy using pre-targeting methods
FR2697255B1 (fr) * 1992-10-27 1995-01-13 Immunotech Partners Nouveaux dérivés bihaptènes liant le technétium, application au diagnostic et à la thérapeutique, kits et réactifs immunologiques les mettant en Óoeuvre.
DE4428874A1 (de) * 1994-08-08 1996-02-22 Schering Ag Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19533477C2 (de) * 1995-09-12 1997-10-23 Pharma Beratung Dr Klaus Hoffm Verwendung von Diethylentriaminpentaessigsäure (DTPA) mit immunsuppressiver Wirkung
US20040096394A1 (en) * 1996-08-28 2004-05-20 Immunomedics, Inc. Stable radioiodine conjugates and methods for their systhesis
US7521531B2 (en) * 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
ATE194143T1 (de) * 1996-08-28 2000-07-15 Immunomedics Inc Stabile radioiodium-konjugate und verfahren zu deren herstellung
US6663866B1 (en) 1996-08-28 2003-12-16 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US6558669B1 (en) * 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US6071490A (en) * 1998-05-07 2000-06-06 Immunomedics, Inc. Position emission tomography using gallium-68 chelates
EP1075287B1 (de) * 1998-05-07 2004-02-18 Immunomedics, Inc. Positronenemissions-tomographie mit benutzung von gallium-68 chelaten
US7405320B2 (en) 1998-06-22 2008-07-29 Immunomedics, Inc. Therapeutic and diagnostic conjugates for use with multispecific antibodies
US7387772B1 (en) * 1999-06-22 2008-06-17 Immunimedics, Inc. Chimeric, human and humanized anti-CSAP monoclonal antibodies
US7052872B1 (en) 1999-06-22 2006-05-30 Immunomedics, Inc. Bi-specific antibodies for pre-targeting diagnosis and therapy
AU760854B2 (en) * 1998-06-22 2003-05-22 Immunomedics Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US7138103B2 (en) * 1998-06-22 2006-11-21 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US6962702B2 (en) * 1998-06-22 2005-11-08 Immunomedics Inc. Production and use of novel peptide-based agents for use with bi-specific antibodies
US7833528B2 (en) * 1998-06-22 2010-11-16 Immunomedics, Inc. Use of multispecific, non-covalent complexes for targeted delivery of therapeutics
FR2816620B1 (fr) * 2000-11-16 2003-02-21 Inst Nat Sante Rech Med Nouveaux composes pour des applications a la radioimmunoscintingraphie et/ou a la radioimmunotherapie des cancers
IL160126A0 (en) * 2001-07-31 2004-06-20 Immunomedics Inc A kit for targeting a target site containing a polymer conjugate
US7230085B2 (en) * 2001-11-28 2007-06-12 Immunomedics, Inc. Anti-DOTA antibody
CA2529027C (en) 2003-06-13 2013-09-10 Immunomedics, Inc. D-amino acid peptides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2437398A1 (fr) * 1978-06-20 1980-04-25 Commissariat Energie Atomique Compose iode utilisable comme traceur en radio-immunologie
CA1213229A (en) * 1982-04-12 1986-10-28 Gary S. David Antibodies having dual specificities, their preparation and uses therefor
US4479930A (en) * 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
CA1282069C (en) * 1985-09-12 1991-03-26 Damon L. Meyer Antibody complexes of hapten-modified diagnostic or therapeutic agents
US4863713A (en) * 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
FR2604092B1 (fr) * 1986-09-19 1990-04-13 Immunotech Sa Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo
EP0327365B1 (de) * 1988-02-03 1994-06-15 Hybritech Incorporated Modifizierte Haptene, nützlich als bildformendes Agens und als Arzneimittel
DE68914356D1 (de) * 1988-02-08 1994-05-11 Cytogen Corp Antikörper für die spezifische bindung an verbindungen.

Also Published As

Publication number Publication date
KR910005862A (ko) 1991-04-27
EP0419387A1 (de) 1991-03-27
US5274076A (en) 1993-12-28
AU638488B2 (en) 1993-07-01
ATE145338T1 (de) 1996-12-15
CA2025607C (en) 2001-08-07
EP0419387B1 (de) 1996-11-20
DK0419387T3 (da) 1997-04-07
CA2025607A1 (en) 1991-03-22
AU6303490A (en) 1991-03-28
JP2914737B2 (ja) 1999-07-05
FR2652004A1 (fr) 1991-03-22
FR2652004B1 (fr) 1994-10-28
DE69029184D1 (de) 1997-01-02
ES2094750T3 (es) 1997-02-01
KR0166075B1 (ko) 1999-01-15
JPH03173900A (ja) 1991-07-29

Similar Documents

Publication Publication Date Title
DE69029184D1 (de) Hydrophile Derivate, diagnostische und therapeutische Anwendungen, diagnostische oder therapeutische Reagenziensätze und immunologische Reagenzien
ATE130197T1 (de) Heterofunktionelle zellular immunologische reagenzien, impfstoffe daraus und verwendungsverfahren.
LV10538A (lv) Imunologiski saistamas vielas noteiksanas panemiens biologiska skidruma un diagnostikas lidzeklis
SE7512192L (sv) Cancerantigen, cancerterapi och cancerdiagnostikum
DE68926779D1 (de) Zusammensetzung und Methoden zur Bestimmung der Anwesenheit von Amphetaminen in einer Probe, die in Verdacht steht, Amphetamine und/oder Metamphetamine zu enthalten
Nopparatana et al. Purification of Gnathostoma spinigerum specific antigen and immunodiagnosis of human gnathostomiasis
BR0114343A (pt) Ensaio de microdisposição de alérgenos
Julander et al. The role of antibodies against alpha-toxin and teichoic acid in the diagnosis of staphylococcal infections
BR8300656A (pt) Ensaio para determinar a concentracao de antigenos, processo para determinar o periodo fertil do ciclo menstrual, conjunto de reagente, e molecula ligante
DE69531345D1 (de) Rekombinant pgp3, verfahren zu dessen herstellung, und dessen verwendung in der diagnose und therapie
ES512498A0 (es) "metodo y su correspondiente aparato para el ensayo de anticuerpos con respecto a antigenos solubles".
BR7505850A (pt) Processo e reagente para determinacao conjunto de todas ou varias isoenzimas de lactatodesidrogenase,aplicacao do dito processo,e agentes diagnosticos
DE69333076D1 (de) Test und behandlung von demyelinierenden krankheiten wie multiple sklerosis
BE883905A (fr) Tests et reactifs de diagnostic par agglutination
DE69018968T2 (de) BLUTGERINNUNGSFAKTOR BETA XIIa MONOKLONALE ANTIKÖRPER UND IMMUNANALYSE.
Turner et al. Simple method of subtyping human G-myeloma proteins based on sensitivity to pepsin digestion
DE69713146D1 (de) Helicobacter pylori diagnostika
Scalarone Use of a urease-antibody conjugate in an enzyme immunoassay for the detection of blastomycosis
ATE73463T1 (de) Monoklonale antikoerper.
ES546338A0 (es) Procedimiento para la determinacion de una sustancia capaz de fijarse inmunologicamente
Yamada et al. Detection of antibody to Staphylococcus aureus teichoic acid by enzyme-linked immunosorbent assay
FR2376864A1 (fr) Reactif et procede de determination du cholecalciferol
SU1425549A1 (ru) Способ радиоиммунологического определени антигенов
KR950703658A (ko) Hiv감염자 및 그들의 처치 정도를 확인하는 방법 및 진단물질
DK510183A (da) Fremgangsmaade og middel til paavisning og maaling af antistreptolysin o, isaer i blodproever

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee